{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:34:28Z","timestamp":1780626868068,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016323","name":"Fujian Provincial Maternity and Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024GGA056"],"award-info":[{"award-number":["2024GGA056"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaapos.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of American Association for Pediatric Ophthalmology and Strabismus"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jaapos.2025.104697","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:58:21Z","timestamp":1763765901000},"page":"104697","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of persistent avascular retina in retinopathy of prematurity treated with intravitreal ranibizumab"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7617-2584","authenticated-orcid":false,"given":"Jin-Guo","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Xin","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Qing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-Yu","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaapos.2025.104697_bib1","article-title":"Vascular development analysis: a study for tertiary anti-vascular endothelial growth factor therapy after second reactivation of retinopathy of prematurity","volume":"11","author":"Zhang","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jaapos.2025.104697_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102567","article-title":"Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): five-year outcomes of a randomised trial","volume":"71","author":"Marlow","year":"2024","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jaapos.2025.104697_bib3","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/ICU.0000000000000786","article-title":"Description and management of retinopathy of prematurity reactivation after intravitreal antivascular endothelial growth factor therapy","volume":"32","author":"Valikodath","year":"2021","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.jaapos.2025.104697_bib4","first-page":"1317","article-title":"Angiographic findings in cases with a history of severe retinopathy of prematurity treated with anti-VEGFs follow-up to age 6 years","author":"Celiker","year":"2021","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.jaapos.2025.104697_bib5","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.ophtha.2017.03.018","article-title":"Ranibizumab injection as primary treatment in patients with retinopathy of prematurity: anatomic outcomes and influencing factors","volume":"124","author":"Huang","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jaapos.2025.104697_bib6","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.ophtha.2021.05.031","article-title":"International Classification of Retinopathy of Prematurity, Third Edition","volume":"128","author":"Chiang","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jaapos.2025.104697_bib7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.oret.2019.06.017","article-title":"Retinopathy of prematurity reactivated 28 months after injection of ranibizumab","volume":"3","author":"Ji","year":"2019","journal-title":"Ophthalmology Retina"},{"key":"10.1016\/j.jaapos.2025.104697_bib8","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1007\/s00417-023-06227-6","article-title":"Visual field after anti-vascular endothelial growth factor therapy and laser treatment for retinopathy of prematurity","volume":"261","author":"Obata","year":"2023","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.jaapos.2025.104697_bib9","article-title":"Comparison of intravitreal ranibizumab and laser photocoagulation in the treatment of type I retinopathy of prematurity in Malaysia: a one-year follow-up study","volume":"16","author":"Wardati","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.jaapos.2025.104697_bib10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12886-019-1067-4","article-title":"Ranibizumab injection and laser photocoagulation to treat type 1 retinopathy of prematurity after 40 weeks post menstrual age: a retrospective case series study","volume":"19","author":"Lyu","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.jaapos.2025.104697_bib11","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1001\/jamapediatrics.2017.4838","article-title":"Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity (CARE-ROP) Study Group. Comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity","volume":"172","author":"Stahl","year":"2018","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jaapos.2025.104697_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-82445-0","article-title":"A comparation of three different anti-VEGF drugs in development of persistent avascular retina in premature children","volume":"14","author":"\u00dcnal","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaapos.2025.104697_bib13","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"6","author":"Fierson","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaapos.2025.104697_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-66483-2","article-title":"Characteristics of retinal vascularization in reactivated retinopathy of prematurity requiring treatment and clinical outcome after reinjection of ranibizumab","volume":"14","author":"Jang","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaapos.2025.104697_bib15","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1177\/11206721211064019","article-title":"Inter-eye comparison of retinal vascular growth rate and angiographic findings following unilateral bevacizumab treatment","volume":"32","author":"Bayramoglu","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.jaapos.2025.104697_bib16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJMoa1007374","article-title":"Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity","volume":"364","author":"Helen","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaapos.2025.104697_bib17","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1097\/IAE.0000000000004206","article-title":"Short-term reactivation of retinopathy of prematurity following primary ranibizumab treatment","volume":"44","author":"Strawbridge","year":"2024","journal-title":"Retina"},{"key":"10.1016\/j.jaapos.2025.104697_bib18","first-page":"560","volume":"38","author":"Fenton","year":"2024"},{"key":"10.1016\/j.jaapos.2025.104697_bib19","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41433-019-0605-x","article-title":"Is the severity of refractive error dependent on the quantity and extent of retinal laser ablation for retinopathy of prematurity?","volume":"34","author":"Young-Zvandasara","year":"2019","journal-title":"Eye"},{"key":"10.1016\/j.jaapos.2025.104697_bib20","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1007\/s00417-022-05628-3","article-title":"Repeated intravitreal ranibizumab for reactivated retinopathy of prematurity after intravitreal ranibizumab monotherapy: vascular development analysis","volume":"9","author":"Xia","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.jaapos.2025.104697_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/IAE.0000000000001126","article-title":"Retinal vascular development with 0.312 mg intravitreal bevacizumab to treat severe posterior retinopathy of prematurity: a longitudinal fluorescein angiographic study","volume":"1","author":"Lorenz","year":"2017","journal-title":"Retina"},{"key":"10.1016\/j.jaapos.2025.104697_bib22","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.ophtha.2016.04.028","article-title":"Clinical management of recurrent retinopathy of prematurity after intravitreal bevacizumab monotherapy","volume":"123","author":"Mintz-Hittner","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jaapos.2025.104697_bib23","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/bjophthalmol-2017-311662","article-title":"Efficacy of intravitreal conbercept injection in the treatment of retinopathy of prematurity","volume":"103","author":"Bai","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jaapos.2025.104697_bib24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ophtha.2017.08.005","article-title":"Follow-up to age 4 years of treatment of type 1 retinopathy of prematurity intravitreal bevacizumab injection versus laser: fluorescein angiographic findings","volume":"125","author":"Lepore","year":"2018","journal-title":"Ophthalmology"}],"container-title":["Journal of American Association for Pediatric Ophthalmology and Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091853125005956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091853125005956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:59:00Z","timestamp":1766145540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091853125005956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1091853125005956"],"URL":"https:\/\/doi.org\/10.1016\/j.jaapos.2025.104697","relation":{},"ISSN":["1091-8531"],"issn-type":[{"value":"1091-8531","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictors of persistent avascular retina in retinopathy of prematurity treated with intravitreal ranibizumab","name":"articletitle","label":"Article Title"},{"value":"Journal of American Association for Pediatric Ophthalmology and Strabismus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaapos.2025.104697","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of the American Association for Pediatric Ophthalmology and Strabismus.","name":"copyright","label":"Copyright"}],"article-number":"104697"}}