{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:14:07Z","timestamp":1786680847630,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jacadv.2024.101039","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T01:34:24Z","timestamp":1718242464000},"page":"101039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"P1","title":["The Oxygen Cascade According to\u00a0HFpEF Likelihood"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-0825","authenticated-orcid":false,"given":"Jan","family":"Verwerft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-5051","authenticated-orcid":false,"given":"Youri","family":"Bekhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-9166","authenticated-orcid":false,"given":"Sara","family":"Moura-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Falter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hoedemakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Jasaityte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Stassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Herbots","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-3784","authenticated-orcid":false,"given":"Andre","family":"La Gerche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Haykowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Claessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jacadv.2024.101039_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/CIRCULATIONAHA.118.034271","article-title":"Sex differences in cardiovascular pathophysiology: why women are overrepresented in heart failure with preserved ejection fraction","volume":"138","author":"Beale","year":"2018","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.jacadv.2024.101039_bib2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1001\/jamacardio.2022.1916","article-title":"Diagnosis of heart failure with preserved ejection fraction among patients with unexplained dyspnea","volume":"7","author":"Reddy","year":"2022","journal-title":"JAMA Cardiol"},{"issue":"9","key":"10.1016\/j.jacadv.2024.101039_bib3","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/CIRCULATIONAHA.118.034646","article-title":"A\u00a0simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction","volume":"138","author":"Reddy","year":"2018","journal-title":"Circulation"},{"issue":"40","key":"10.1016\/j.jacadv.2024.101039_bib4","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","article-title":"How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart\u00a0Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"40","author":"Pieske","year":"2019","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101039_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.hfc.2014.04.001","article-title":"Exercise physiology in heart failure and preserved ejection fraction","volume":"10","author":"Haykowsky","year":"2014","journal-title":"Heart Fail Clin"},{"key":"10.1016\/j.jacadv.2024.101039_bib6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijcard.2018.04.102","article-title":"Patient reported outcome in HFpEF: sex-specific differences in quality of life and association with outcome","volume":"267","author":"Fax\u00e9n","year":"2018","journal-title":"Int J Cardiol"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101039_bib7","article-title":"Sex differences in heart failure with preserved ejection fraction","volume":"10","author":"Sotomi","year":"2021","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101039_bib8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cardfail.2021.10.019","article-title":"Arterial stiffness and vascular load in HFpEF: differences among women and men","volume":"28","author":"Lau","year":"2022","journal-title":"J\u00a0Card Fail"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101039_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jchf.2019.01.004","article-title":"Sex differences in heart failure with preserved ejection fraction pathophysiology: a detailed invasive hemodynamic and echocardiographic analysis","volume":"7","author":"Beale","year":"2019","journal-title":"JACC Heart Fail"},{"issue":"7","key":"10.1016\/j.jacadv.2024.101039_bib10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/2047487319838221","article-title":"Exercise training in women with cardiovascular disease: Differential response and barriers - review and perspective","volume":"28","author":"Witvrouwen","year":"2021","journal-title":"Eur J Prev Cardiol"},{"issue":"8","key":"10.1016\/j.jacadv.2024.101039_bib11","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/ejhf.2563","article-title":"Sex and central obesity in heart failure with preserved ejection fraction","volume":"24","author":"Sorimachi","year":"2022","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101039_bib12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/CIRCULATIONAHA.117.029058","article-title":"Exercise intolerance in heart failure with preserved ejection fraction: diagnosing and ranking its causes using personalized O(2) pathway analysis","volume":"137","author":"Houstis","year":"2018","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.jacadv.2024.101039_bib13","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/eurheartj\/ehad141","article-title":"Heart failure with preserved ejection fraction: relevance of a dedicated dyspnoea clinic","volume":"44","author":"Verwerft","year":"2023","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101039_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jchf.2022.11.004","article-title":"Cardiopulmonary exercise testing with simultaneous echocardiography: blueprints of a dyspnea clinic for suspected HFpEF","volume":"11","author":"Verwerft","year":"2023","journal-title":"JACC Heart Fail"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101039_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s12265-021-10142-8","article-title":"Cardiopulmonary exercise testing with echocardiography to identify mechanisms of unexplained dyspnea","volume":"15","author":"Martens","year":"2022","journal-title":"J\u00a0Cardiovasc Transl Res"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101039_bib16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ejhf.1739","article-title":"Haemodynamic and metabolic phenotyping of hypertensive patients with and without heart failure by combining cardiopulmonary and echocardiographic stress test","volume":"22","author":"Pugliese","year":"2020","journal-title":"Eur J Heart Fail"},{"issue":"13","key":"10.1016\/j.jacadv.2024.101039_bib17","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.jacc.2017.08.012","article-title":"Cardiopulmonary exercise testing: what is its value?","volume":"70","author":"Guazzi","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101039_bib18","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jcmg.2015.06.018","article-title":"Accuracy of echocardiography to evaluate pulmonary vascular and RV function during exercise","volume":"9","author":"Claessen","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacadv.2024.101039_bib19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijcard.2021.02.004","article-title":"Responses to exercise training in patients with heart failure. Analysis by oxygen transport steps","volume":"330","author":"Legendre","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacadv.2024.101039_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10974-022-09636-y","article-title":"Determinants of maximal oxygen consumption","volume":"44","author":"Wagner","year":"2023","journal-title":"J\u00a0Muscle Res Cell Motil"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101039_bib21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/CIRCHEARTFAILURE.114.001825","article-title":"Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction","volume":"8","author":"Dhakal","year":"2015","journal-title":"Circ Heart Fail"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101039_bib22","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/CIRCHEARTFAILURE.113.000383","article-title":"Longitudinal changes in left ventricular stiffness","volume":"6","author":"Borlaug","year":"2013","journal-title":"Circ Heart Fail"},{"issue":"4","key":"10.1016\/j.jacadv.2024.101039_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ejhf.2827","article-title":"Deep phenotype characterization of hypertensive response to exercise: implications on functional capacity and prognosis across the heart failure spectrum","volume":"25","author":"Pugliese","year":"2023","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101039_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/CIRCULATIONAHA.118.034271","article-title":"Sex differences in cardiovascular pathophysiology","volume":"138","author":"Beale","year":"2018","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101039_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/CIRCIMAGING.108.819938","article-title":"Age-related left ventricular remodeling and associated risk for cardiovascular outcomes","volume":"2","author":"Cheng","year":"2009","journal-title":"Circ Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.jacadv.2024.101039_bib26","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jcmg.2022.12.009","article-title":"Too little of a good thing: strong associations between cardiac size and fitness among women","volume":"16","author":"Foulkes","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"issue":"12","key":"10.1016\/j.jacadv.2024.101039_bib27","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.jacc.2022.07.011","article-title":"Heart failure with preserved ejection fraction as an exercise deficiency syndrome: JACC focus seminar 2\/4","volume":"80","author":"La Gerche","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101039_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ejhf.2843","article-title":"Ventricular stiffening and chamber contracture in heart failure with higher ejection fraction","volume":"25","author":"Popovic","year":"2023","journal-title":"Eur J Heart Fail"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101039_bib29","doi-asserted-by":"crossref","first-page":"B71","DOI":"10.1093\/geronj\/47.3.B71","article-title":"Histochemical and enzymatic comparison of the gastrocnemius muscle of young and elderly men and women","volume":"47","author":"Coggan","year":"1992","journal-title":"J\u00a0Gerontol"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101039_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pcad.2017.07.001","article-title":"Exercise training for prevention and treatment of heart failure","volume":"60","author":"Kondamudi","year":"2017","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacadv.2024.101039_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113833","article-title":"Skeletal muscle mitochondrial remodeling in heart failure: an update on mechanisms and therapeutic opportunities","volume":"155","author":"Lv","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"10.1016\/j.jacadv.2024.101039_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.009124","article-title":"Impact of different training modalities on molecular alterations in skeletal muscle of patients with heart failure with preserved ejection fraction: a substudy of the OptimEx trial","volume":"15","author":"Winzer","year":"2022","journal-title":"Circ Heart Fail"},{"issue":"15","key":"10.1016\/j.jacadv.2024.101039_bib33","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15419","article-title":"Isolated knee extensor exercise training improves skeletal muscle vasodilation, blood flow, and functional capacity in patients with HFpEF","volume":"10","author":"Hearon","year":"2022","journal-title":"Physiol Rep"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X24002308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X24002308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T09:30:41Z","timestamp":1722159041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X24002308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2772963X24002308"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2024.101039","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Oxygen Cascade According to\u00a0HFpEF Likelihood","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2024.101039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101039"}}