{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:36:49Z","timestamp":1793824609354,"version":"4.6.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jacadv.2024.101193","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T13:40:59Z","timestamp":1723729259000},"page":"101193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"P1","title":["Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5323-8521","authenticated-orcid":false,"given":"Kristine M\u00f8rk","family":"Kindberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Broch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir \u00d8ystein","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Kristine","family":"Anstensrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sissel","family":"\u00c5kra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindre","family":"Woxholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild Maria","family":"T\u00f8llefsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brage H\u00f8yem","family":"Amundsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils-Einar","family":"Kl\u00f8w","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Halvorsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuva B.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Huse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Louise","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Kristian","family":"Dam\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Opdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Wiseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Santos-Gallego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingebj\u00f8rg","family":"Seljeflot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-8153","authenticated-orcid":false,"given":"Mathis Korseberg","family":"Stokke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild","family":"Helseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacadv.2024.101193_bib1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacadv.2024.101193_bib2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacadv.2024.101193_bib3","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.jacc.2021.02.049","article-title":"Randomized trial of interleukin-6 receptor inhibition in patients with acute ST-segment elevation myocardial infarction","volume":"77","author":"Broch","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2024.101193_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228736","article-title":"Prognostic value of the myocardial salvage index measured by T2-weighted and T1-weighted late gadolinium enhancement magnetic resonance imaging after ST-segment elevation myocardial infarction: a systematic review and meta-regression analysis","volume":"15","author":"Kendziora","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jacadv.2024.101193_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104013","article-title":"Interleukin-6 inhibition in ST-elevation myocardial infarction: immune cell profile in the randomised ASSAIL-MI trial","volume":"80","author":"Huse","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jacadv.2024.101193_bib6","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jacadv.2024.101193_bib7","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1093\/cvr\/cvab217","article-title":"Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction","volume":"118","author":"Mangold","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacadv.2024.101193_bib8","article-title":"The role of extracellular traps in ischemia reperfusion injury","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jacadv.2024.101193_bib9","doi-asserted-by":"crossref","first-page":"H500","DOI":"10.1152\/ajpheart.00381.2014","article-title":"Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy","volume":"308","author":"Ge","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacadv.2024.101193_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1182\/blood-2013-07-514992","article-title":"VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia\/reperfusion injury in mice","volume":"123","author":"Savchenko","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jacadv.2024.101193_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41573-020-0061-0","article-title":"Therapeutic strategies for thrombosis: new targets and approaches","volume":"19","author":"Mackman","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jacadv.2024.101193_bib12","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Fuchs","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacadv.2024.101193_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.953129","article-title":"Platelets in the NETworks interweaving inflammation and thrombosis","volume":"13","author":"Wienkamp","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jacadv.2024.101193_bib14","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/STROKEAHA.117.019896","article-title":"Thrombus neutrophil extracellular traps content impair tPA-induced thrombolysis in acute ischemic stroke","volume":"49","author":"Ducroux","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jacadv.2024.101193_bib15","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7816491","article-title":"Neutrophil extracellular trap components associate with infarct size, ventricular function, and clinical outcome in STEMI","volume":"2019","author":"Helseth","year":"2019","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.jacadv.2024.101193_bib16","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1038\/s41598-020-61971-7","article-title":"Double-stranded DNA and NETs components in relation to clinical outcome after ST-elevation myocardial infarction","volume":"10","author":"Langseth","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacadv.2024.101193_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCRESAHA.115.306656","article-title":"From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection","volume":"118","author":"Ridker","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jacadv.2024.101193_bib18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.1959","article-title":"Netting neutrophils in autoimmune small-vessel vasculitis","volume":"15","author":"Kessenbrock","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jacadv.2024.101193_bib19","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/ehjci\/jew027","article-title":"Multi-vendor, multicentre comparison of contrast-enhanced SSFP and T2-STIR CMR for determining myocardium at risk in ST-elevation myocardial infarction","volume":"17","author":"Nordlund","year":"2016","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jacadv.2024.101193_bib20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/SHK.0000000000001518","article-title":"HDAC inhibitor attenuated NETs formation induced by activated platelets in\u00a0vitro, partially through downregulating platelet secretion","volume":"54","author":"Chen","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.jacadv.2024.101193_bib21","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.yjmcc.2019.02.013","article-title":"HDAC inhibition as a therapeutic strategy in myocardial ischemia\/reperfusion injury","volume":"129","author":"Xie","year":"2019","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacadv.2024.101193_bib22","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/rheumatology\/keu035","article-title":"Effects of IL-6 and IL-6 blockade on neutrophil function in\u00a0vitro and in\u00a0vivo","volume":"53","author":"Wright","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.jacadv.2024.101193_bib23","doi-asserted-by":"crossref","first-page":"e001492","DOI":"10.1136\/openhrt-2020-001492","article-title":"Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction","volume":"8","author":"Helseth","year":"2021","journal-title":"Open Heart"},{"key":"10.1016\/j.jacadv.2024.101193_bib24","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1093\/cvr\/cvab329","article-title":"Neutrophil extracellular traps: from physiology to pathology","volume":"118","author":"Hidalgo","year":"2022","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacadv.2024.101193_bib25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.thromres.2022.03.002","article-title":"Neutrophil extracellular traps (NETs) in patients with STEMI. Association with percutaneous coronary intervention and antithrombotic treatments","volume":"213","author":"Ferre-Vallverdu","year":"2022","journal-title":"Thromb Res"},{"key":"10.1016\/j.jacadv.2024.101193_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.clim.2012.04.006","article-title":"The origin and properties of extracellular DNA: from PAMP to DAMP","volume":"144","author":"Pisetsky","year":"2012","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jacadv.2024.101193_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10557-020-06946-6","article-title":"The role of extracellular DNA and histones in ischaemia-reperfusion injury of the myocardium","volume":"34","author":"Shah","year":"2020","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jacadv.2024.101193_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jacadv.2024.101193_bib29","doi-asserted-by":"crossref","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis","volume":"26","author":"Vande Walle","year":"2016","journal-title":"Curr Biol"},{"key":"10.1016\/j.jacadv.2024.101193_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12563","article-title":"Role of pyroptosis in cardiovascular disease","volume":"52","author":"Zhaolin","year":"2019","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jacadv.2024.101193_bib31","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.cardiores.2006.09.011","article-title":"Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response","volume":"72","author":"Boyd","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacadv.2024.101193_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3390\/biomedicines11010113","article-title":"Worsening thrombotic complication of atherosclerotic plaques due to neutrophils extracellular traps: a systematic review","volume":"11","author":"Nappi","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jacadv.2024.101193_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1724206","article-title":"Inhibition of peptidyl arginine deiminase-4 prevents renal ischemia-reperfusion-induced remote lung injury","volume":"2020","author":"Du","year":"2020","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.jacadv.2024.101193_bib34","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.aaa8064","article-title":"Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis","volume":"349","author":"Warnatsch","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jacadv.2024.101193_bib35","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1093\/eurheartj\/ehw171","article-title":"Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial","volume":"37","author":"Kleveland","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2024.101193_bib36","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jacbts.2021.01.007","article-title":"Targeting IL-6 trans-signaling: amplifying the benefits of IL-6 inhibition in myocardial infarction","volume":"6","author":"Aukrust","year":"2021","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.jacadv.2024.101193_bib37","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41577-023-00856-y","article-title":"Targeting IL-6 trans-signalling: past, present and future prospects","volume":"23","author":"Rose-John","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jacadv.2024.101193_bib38","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1038\/s41467-020-20231-y","article-title":"Neutralizing the pathological effects of extracellular histones with small polyanions","volume":"11","author":"Meara","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jacadv.2024.101193_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190728","article-title":"Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation","volume":"13","author":"Novotny","year":"2018","journal-title":"PLoS One"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X24004241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X24004241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T20:19:08Z","timestamp":1726690748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X24004241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S2772963X24004241"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2024.101193","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2024.101193","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101193"}}