{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:54:36Z","timestamp":1781808876831,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jacadv.2024.101239","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T17:51:00Z","timestamp":1725645060000},"page":"101239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cumulative Radiation Exposure and Lifetime Cancer Risk in Patients With\u00a0Tetralogy of Fallot Requiring Early\u00a0Intervention"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8508-5191","authenticated-orcid":false,"given":"Jeannette R.","family":"Wong-Siegel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Glatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"McCracken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choonsik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cari M.","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene H.S.","family":"Veiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan H.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-3048","authenticated-orcid":false,"given":"Christopher J.","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-568X","authenticated-orcid":false,"given":"Athar M.","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"George T.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery","family":"Meadows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana","family":"Shahanavaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-1634","authenticated-orcid":false,"given":"Michael L.","family":"O\u2019Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-9526","authenticated-orcid":false,"given":"Sarosh P.","family":"Batlivala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Pettus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaad","family":"Beshish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Mascio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathyrn O.","family":"Stack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivor","family":"Asztalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tacy E.","family":"Downing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Zampi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.jacadv.2024.101239_bib1","article-title":"Survival in children with congenital heart disease: have we reached a peak at 97%?","volume":"9","author":"Mandalenakis","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"7","key":"10.1016\/j.jacadv.2024.101239_bib2","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.6762","article-title":"Risk of cancer among children and young adults with congenital heart disease compared with healthy controls","volume":"2","author":"Mandalenakis","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"11","key":"10.1016\/j.jacadv.2024.101239_bib3","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.amjcard.2016.08.057","article-title":"Prevalence of cancer in adults with congenital heart disease compared with the general population","volume":"118","author":"Gurvitz","year":"2016","journal-title":"Am J Cardiol"},{"issue":"17","key":"10.1016\/j.jacadv.2024.101239_bib4","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/bdr2.1390","article-title":"Congenital heart disease complexity and childhood cancer risk","volume":"110","author":"Collins","year":"2018","journal-title":"Birth Defects Res"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101239_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116844","article-title":"The risk of cancer in patients with congenital heart disease: a nationwide population-based cohort study in Taiwan","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jacadv.2024.101239_bib6","first-page":"245","article-title":"Congenital heart disease and the risk of cancer: an update on the genetic etiology, radiation exposure damage, and future research strategies","volume":"9","author":"Campolo","year":"2022","journal-title":"J\u00a0Cardiovasc Dev Dis"},{"key":"10.1016\/j.jacadv.2024.101239_bib7","article-title":"Risk of cancer in young and older patients with congenital heart disease and the excess risk of cancer by syndromes, organ transplantation and cardiac surgery: Swedish health registry study (1930-2017)","volume":"18","author":"Karazisi","year":"2022","journal-title":"Lancet Reg Health Eur"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101239_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003903","article-title":"The relationship between congenital heart disease and cancer in Swedish children: a population-based cohort study","volume":"19","author":"Kampitsi","year":"2022","journal-title":"PLoS Med"},{"issue":"13","key":"10.1016\/j.jacadv.2024.101239_bib9","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1161\/CIRCULATIONAHA.117.029138","article-title":"Exposure to low-dose ionizing radiation from cardiac procedures and malignancy risk in adults with congenital heart disease","volume":"137","author":"Cohen","year":"2018","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.jacadv.2024.101239_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-048576","article-title":"Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: the COCCINELLE study cohort profile","volume":"11","author":"Abalo","year":"2021","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101239_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12282","article-title":"Associated radiation exposure from medical imaging and excess lifetime risk of developing cancer in pediatric patients with pulmonary hypertension","volume":"13","author":"Mahendra","year":"2023","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jacadv.2024.101239_bib12","series-title":"Division on Earth and Life Studies, Board on Radiation Effects Research, Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation. Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2","year":"2006"},{"issue":"22","key":"10.1016\/j.jacadv.2024.101239_bib13","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/eurheartj\/ehl014","article-title":"Cardiac catheterization and long-term chromosomal damage in children with\u00a0congenital heart disease","volume":"27","author":"Andreassi","year":"2006","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.jacadv.2024.101239_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.118.006765","article-title":"Projected future cancer risks in children treated with fluoroscopy-guided cardiac catheterization procedures","volume":"11","author":"Journy","year":"2018","journal-title":"Circ Cardiovasc Interv"},{"issue":"6","key":"10.1016\/j.jacadv.2024.101239_bib15","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00270-020-02752-7","article-title":"Radiation exposure in pediatric interventional procedures","volume":"44","author":"Ploussi","year":"2021","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"8","key":"10.1016\/j.jacadv.2024.101239_bib16","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jacc.2020.12.048","article-title":"Comparison of management strategies for neonates with symptomatic tetralogy of Fallot","volume":"77","author":"Goldstein","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101239_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/chd.12737","article-title":"Comprehensive comparative outcomes in children with congenital heart disease: the rationale for the Congenital Catheterization Research Collaborative","volume":"14","author":"Petit","year":"2019","journal-title":"Congenit Heart Dis"},{"issue":"4","key":"10.1016\/j.jacadv.2024.101239_bib18","doi-asserted-by":"crossref","DOI":"10.1088\/2057-1976\/acd2de","article-title":"NCIRF: an organ dose calculator for patients undergoing radiography and fluoroscopy","volume":"9","author":"Lee","year":"2023","journal-title":"Biomed Phys Eng Express"},{"issue":"4","key":"10.1016\/j.jacadv.2024.101239_bib19","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1088\/0952-4746\/35\/4\/891","article-title":"NCICT: a computational solution to estimate organ doses for pediatric and adult patients undergoing CT scans","volume":"35","author":"Lee","year":"2015","journal-title":"J\u00a0Radiol Prot"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101239_bib20","doi-asserted-by":"crossref","DOI":"10.1088\/2057-1976\/aba41e","article-title":"NCINM: organ dose calculator for patients undergoing nuclear medicine procedures","volume":"6","author":"Villoing","year":"2020","journal-title":"Biomed Phys Eng Express"},{"key":"10.1016\/j.jacadv.2024.101239_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0146-6453(99)00006-8","article-title":"Radiation dose to patients from radiopharmaceuticals (Addendum 2 to ICRP publication 53)","volume":"28","author":"Valentin","year":"1998","journal-title":"Ann ICRP"},{"issue":"4","key":"10.1016\/j.jacadv.2024.101239_bib22","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jpeds.2013.10.074","article-title":"Cumulative exposure to medical radiation for children requiring surgery for congenital heart disease","volume":"164","author":"Glatz","year":"2014","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101239_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1088\/0952-4746\/32\/3\/205","article-title":"RadRAT: a radiation risk assessment tool for lifetime cancer risk projection","volume":"32","author":"Berrington de Gonzalez","year":"2012","journal-title":"J\u00a0Radiol Prot"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101239_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/CIRCULATIONAHA.113.005425","article-title":"Cumulative radiation exposure and cancer risk estimation in children with heart disease","volume":"130","author":"Johnson","year":"2014","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101239_bib25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/CIRCULATIONAHA.115.019137","article-title":"Exposure to low-dose ionizing radiation from cardiac procedures in patients with congenital heart disease","volume":"133","author":"Ladouceur","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2024.101239_bib26","series-title":"Sources and Effects of Ionizing Radiation, United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2000 Report, Volume I: Report to the General Assembly, with Scientific Annexes-Sources","year":"2000"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101239_bib27","first-page":"1","article-title":"A\u00a0population-based case-control study of thyroid cancer","volume":"79","author":"Ron","year":"1987","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101239_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s00246-014-0984-5","article-title":"Cumulative medical radiation exposure throughout staged palliation of single ventricle congenital heart disease","volume":"36","author":"Downing","year":"2015","journal-title":"Pediatr Cardiol"},{"issue":"Suppl 2","key":"10.1016\/j.jacadv.2024.101239_bib30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00247-006-0184-4","article-title":"The ALARA (as low as reasonably achievable) concept in pediatric interventional and fluoroscopic imaging: striving to keep radiation doses as low as possible during fluoroscopy of pediatric patients--a white paper executive summary","volume":"36","author":"Strauss","year":"2006","journal-title":"Pediatr Radiol"},{"issue":"7","key":"10.1016\/j.jacadv.2024.101239_bib31","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.jcmg.2017.04.003","article-title":"Radiation Safety in children with congenital and acquired heart disease: a scientific position Statement on multimodality dose optimization from the image gently Alliance","volume":"10","author":"Hill","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"issue":"Suppl 2","key":"10.1016\/j.jacadv.2024.101239_bib32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00247-006-0194-2","article-title":"The ALARA concept in pediatric cardiac catheterization: techniques and tactics for managing radiation dose","volume":"36","author":"Justino","year":"2006","journal-title":"Pediatr Radiol"},{"issue":"Suppl 2","key":"10.1016\/j.jacadv.2024.101239_bib33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00247-006-0192-4","article-title":"Practice of ALARA in the pediatric interventional suite","volume":"36","author":"Connolly","year":"2006","journal-title":"Pediatr Radiol"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101239_bib34","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008172","article-title":"Longitudinal improvements in radiation exposure in cardiac catheterization for congenital heart disease: a prospective multicenter C3PO-QI study","volume":"13","author":"Quinn","year":"2020","journal-title":"Circ Cardiovasc Intervent"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101239_bib35","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3390\/ijms18050911","article-title":"Radiation and thyroid cancer","volume":"18","author":"Albi","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101239_bib36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1667\/RR14213.1","article-title":"Thyroid cancer after childhood exposure to external radiation: an updated pooled analysis of 12 studies","volume":"185","author":"Veiga","year":"2016","journal-title":"Radiat Res"},{"issue":"9","key":"10.1016\/j.jacadv.2024.101239_bib37","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.jacr.2020.03.024","article-title":"Patient shielding in 2020","volume":"17","author":"Marsh","year":"2020","journal-title":"J\u00a0Am Coll Radiol"},{"issue":"13","key":"10.1016\/j.jacadv.2024.101239_bib38","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab1bad","article-title":"A\u00a0scalable database of organ doses for common diagnostic fluoroscopy examinations of children: procedures of current practice at the University of Florida","volume":"64","author":"Marshall","year":"2019","journal-title":"Phys Med Biol"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101239_bib39","doi-asserted-by":"crossref","first-page":"e1502","DOI":"10.1542\/peds.2012-3435","article-title":"Temporal trends in survival among infants with critical congenital heart defects","volume":"131","author":"Oster","year":"2013","journal-title":"Pediatrics"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X24004708?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X24004708?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:48:15Z","timestamp":1770335295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X24004708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S2772963X24004708"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2024.101239","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cumulative Radiation Exposure and Lifetime Cancer Risk in Patients With\u00a0Tetralogy of Fallot Requiring Early\u00a0Intervention","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2024.101239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101239"}}