{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:54:33Z","timestamp":1793141673193,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jacadv.2024.101563","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T14:52:48Z","timestamp":1737211968000},"page":"101563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Association of Fontan Pathophysiology With Plasma Bile Acids"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9396-7178","authenticated-orcid":false,"given":"Ashish H.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Surendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedram","family":"Hassan-Tash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Nolan","family":"Turnbull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goodlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin A.","family":"Ducas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Renner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Duhamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Aliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ravandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Krasuski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jacadv.2024.101563_bib1","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/01.CIR.81.5.1520","article-title":"Outcome after a \"perfect\" Fontan operation","volume":"81","author":"Fontan","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2024.101563_bib2","first-page":"e234","article-title":"Evaluation and management of the child and adult with fontan circulation: a scientific statement from the\u00a0American heart association","volume":"140(6)","author":"Rychik","year":"2019","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.jacadv.2024.101563_bib3","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1161\/CIRCRESAHA.117.311002","article-title":"Cardiovascular metabolomics","volume":"122","author":"McGarrah","year":"2018","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101563_bib4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.clnu.2011.04.001","article-title":"Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population","volume":"30","author":"Ling","year":"2011","journal-title":"Clin Nutr"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101563_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/clc.23118","article-title":"Bioelectrical impedance analysis of body composition and survival in patients with heart failure","volume":"42","author":"Thomas","year":"2019","journal-title":"Clin Cardiol"},{"issue":"9","key":"10.1016\/j.jacadv.2024.101563_bib6","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1253\/circj.CJ-13-0172","article-title":"Noninvasive and simple assessment of cardiac output and pulmonary vascular resistance with whole-body impedance cardiography is useful for monitoring patients with pulmonary hypertension","volume":"77","author":"Taniguchi","year":"2013","journal-title":"Circ J"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101563_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-48227-9","article-title":"Metabolomic characterization of myocardial ischemia-reperfusion injury in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention","volume":"9","author":"Surendran","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101563_bib8","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1021\/ac503816u","article-title":"Metabolic profiling of bile acids in human and mouse blood by LC-MS\/MS in combination with phospholipid-depletion solid-phase extraction","volume":"87","author":"Han","year":"2015","journal-title":"Anal Chem"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101563_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.21037\/atm.2020.01.103","article-title":"Changes in plasma bile acid profiles after partial internal biliary diversion in PFIC2 patients","volume":"8","author":"Liu","year":"2020","journal-title":"Ann Transl Med"},{"issue":"10","key":"10.1016\/j.jacadv.2024.101563_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11306-021-01846-8","article-title":"Metabolic profiles identify circulating biomarkers associated with heart failure in young\u00a0single ventricle patients","volume":"17","author":"O'Connell","year":"2021","journal-title":"Metabolomics"},{"issue":"24","key":"10.1016\/j.jacadv.2024.101563_bib11","article-title":"Body composition and exercise performance in youth with a fontan circulation: a bio-impedance based study","volume":"9","author":"Powell","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"8","key":"10.1016\/j.jacadv.2024.101563_bib12","article-title":"Body composition in young adults living with a fontan circulation: the myopenic profile","volume":"9","author":"Tran","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"19","key":"10.1016\/j.jacadv.2024.101563_bib13","article-title":"Prognostic value of psoas muscle mass index in patients with NonST-SegmentElevation myocardial infarction: a prospective observational study","volume":"9","author":"Matsumoto","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101563_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.amjcard.2018.03.020","article-title":"Usefulness of psoas muscle area and volume and frailty scoring to predict outcomes after transcatheter aortic valve implantation","volume":"122","author":"Kleczynski","year":"2018","journal-title":"Am J Cardiol"},{"issue":"6","key":"10.1016\/j.jacadv.2024.101563_bib15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nrcardio.2017.51","article-title":"Muscle wasting and cachexia in heart failure: mechanisms and therapies","volume":"14","author":"von Haehling","year":"2017","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"10.1016\/j.jacadv.2024.101563_bib16","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2169\/internalmedicine.56.7796","article-title":"The associations between circulating bile acids and the muscle volume in patients with non-alcoholic fatty liver disease (NAFLD)","volume":"56","author":"Kobayashi","year":"2017","journal-title":"Intern Med"},{"issue":"20","key":"10.1016\/j.jacadv.2024.101563_bib17","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1136\/heartjnl-2013-304249","article-title":"Skeletal muscle abnormalities and exercise capacity in adults with a Fontan circulation","volume":"99","author":"Cordina","year":"2013","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101563_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jcp.29839","article-title":"Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor","volume":"236","author":"Abrigo","year":"2021","journal-title":"J\u00a0Cell Physiol"},{"issue":"21","key":"10.1016\/j.jacadv.2024.101563_bib19","doi-asserted-by":"crossref","first-page":"7922","DOI":"10.3390\/ijms21217922","article-title":"Sarcopenia induced by chronic liver disease in mice requires the expression of the bile acids membrane receptor TGR5","volume":"21","author":"Abrigo","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101563_bib20","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/07853890.2021.1900593","article-title":"Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15\/19 signalling","volume":"53","author":"Qiu","year":"2021","journal-title":"Ann Med"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101563_bib21","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ehf2.12155","article-title":"Heart failure is associated with depletion of core intestinal microbiota","volume":"4","author":"Luedde","year":"2017","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jacadv.2024.101563_bib22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijcard.2020.12.066","article-title":"Impact of adiposity on clinical outcomes in people living with a Fontan circulation","volume":"329","author":"Cao","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacadv.2024.101563_bib23","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ahj.2017.04.009","article-title":"Decline in peak oxygen consumption over time predicts death or transplantation in adults with a Fontan circulation","volume":"189","author":"Cunningham","year":"2017","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacadv.2024.101563_bib24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijcard.2017.02.140","article-title":"Cardiopulmonary exercise test in adults with prior Fontan operation: the prognostic value of serial testing","volume":"235","author":"Egbe","year":"2017","journal-title":"Int J Cardiol"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101563_bib25","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0735-1097(86)80227-3","article-title":"Exercise tolerance and cardiorespiratory response to exercise after the Fontan operation for tricuspid atresia or functional single ventricle","volume":"7","author":"Driscoll","year":"1986","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101563_bib26","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1748-1716.2011.02341.x","article-title":"Attenuated relationship between cardiac output and oxygen uptake during high-intensity exercise","volume":"204","author":"Trinity","year":"2012","journal-title":"Acta Physiol"},{"issue":"7","key":"10.1016\/j.jacadv.2024.101563_bib27","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.amjcard.2016.12.011","article-title":"Influence of left ventricular stroke volume on incident heart failure in a population with preserved ejection fraction (from the strong heart study)","volume":"119","author":"De Marco","year":"2017","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101563_bib28","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2018-000812","article-title":"Prognostic power of cardiopulmonary exercise testing in Fontan patients: a systematic review","volume":"5","author":"Udholm","year":"2018","journal-title":"Open Heart"},{"issue":"2","key":"10.1016\/j.jacadv.2024.101563_bib29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gut.12.2.145","article-title":"Serum bile acids in liver disease","volume":"12","author":"Neale","year":"1971","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.jacadv.2024.101563_bib30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/CIRCRESAHA.113.302095","article-title":"Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes","volume":"113","author":"Kolwicz","year":"2013","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101563_bib31","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1053\/jhep.2001.22702","article-title":"Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition","volume":"33","author":"Yerushalmi","year":"2001","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101563_bib32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1385\/CT:5:1:063","article-title":"Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies?","volume":"5","author":"Ferreira","year":"2005","journal-title":"Cardiovasc Toxicol"},{"issue":"1","key":"10.1016\/j.jacadv.2024.101563_bib33","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hep.28890","article-title":"Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart","volume":"65","author":"Desai","year":"2017","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.jacadv.2024.101563_bib34","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/hep.23585","article-title":"Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis","volume":"51","author":"Desai","year":"2010","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.jacadv.2024.101563_bib35","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/MEG.0000000000001043","article-title":"Total bile acid levels are associated with left atrial volume and cardiac output in patients with cirrhosis","volume":"30","author":"Voiosu","year":"2018","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.jacadv.2024.101563_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009689","article-title":"Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes","volume":"5","author":"Sheikh Abdul Kadir","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jacadv.2024.101563_bib37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European working group on sarcopenia in older people","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X24008445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X24008445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:14:35Z","timestamp":1768965275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X24008445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2772963X24008445"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2024.101563","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Fontan Pathophysiology With Plasma Bile Acids","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2024.101563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101563"}}