{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:28:10Z","timestamp":1793924890813,"version":"4.8.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jacadv.2025.101694","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:23:37Z","timestamp":1745576617000},"page":"101694","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence, Risk Factors, and Prognosis for Fontan-Associated Liver Disease"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-7836","authenticated-orcid":false,"given":"Jacob Y.","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathyrn M.","family":"Wales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"d\u2019Udekem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Celermajer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Cordina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avik","family":"Majumdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacadv.2025.101694_bib1","first-page":"S32","article-title":"Redefining expectations of long-term survival after the Fontan procedure: twenty-five years of follow-up from the entire population of Australia and New Zealand","volume":"130","author":"d'Udekem","year":"2014","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.jacadv.2025.101694_bib2","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1016\/j.jacc.2017.10.045","article-title":"Fontan-associated liver disease: proceedings from the American college of cardiology stakeholders meeting, october 1 to 2, 2015, Washington DC","volume":"70","author":"Daniels","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib3","first-page":"II140","article-title":"The fontan procedure for tricuspid atresia","volume":"64","author":"Stanton","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2025.101694_bib4","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1002\/ehf2.13294","article-title":"Reaching consensus for unified medical language in Fontan care","volume":"8","author":"Alsaied","year":"2021","journal-title":"ESC Heart Fail"},{"issue":"5","key":"10.1016\/j.jacadv.2025.101694_bib5","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1536\/ihj.17-349","article-title":"Imaging assessment of hepatic changes after fontan surgery: computed tomography, ultrasonography, and transient elastography","volume":"59","author":"Song","year":"2018","journal-title":"Int Heart J"},{"key":"10.1016\/j.jacadv.2025.101694_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/JAHA.116.004809","article-title":"Hepatic fibrosis is universal following fontan operation, and severity is associated with time from surgery: a liver biopsy and hemodynamic study","volume":"6","author":"Goldberg","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.101694_bib7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.recesp.2021.06.016","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"74","author":"Page","year":"2021","journal-title":"Rev Esp Cardiol (Engl Ed"},{"key":"10.1016\/j.jacadv.2025.101694_bib8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1136\/heartjnl-2022-320940","article-title":"Predictors of liver cirrhosis and hepatocellular carcinoma among perioperative survivors of the Fontan operation","volume":"109","author":"Inuzuka","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.jacadv.2025.101694_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jacadv.2025.101694_bib10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/EDE.0000000000001232","article-title":"Meta-analysis of proportions using generalized linear mixed models","volume":"31","author":"Lin","year":"2020","journal-title":"Epidemiology"},{"key":"10.1016\/j.jacadv.2025.101694_bib11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.hlc.2022.12.007","article-title":"Fontan hepatopathy - managing unknowns","volume":"32","author":"Zentner","year":"2023","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.jacadv.2025.101694_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7602793","article-title":"Selective use of pulmonary vasodilators in patients with fontan physiology","volume":"2022","author":"Glenn","year":"2022","journal-title":"J Interv Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jpeds.2020.09.044","article-title":"Pretransplantation and post-transplantation liver disease assessment in adolescents undergoing isolated heart transplantation for fontan failure","volume":"229","author":"Rodriguez","year":"2021","journal-title":"J Pediatr"},{"issue":"8","key":"10.1016\/j.jacadv.2025.101694_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/petr.14094","article-title":"Heterogeneous outcomes of liver disease after heart transplantation for a failed Fontan procedure","volume":"25","author":"Ybarra","year":"2021","journal-title":"Pediatr Transpl"},{"issue":"7","key":"10.1016\/j.jacadv.2025.101694_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12071805","article-title":"Risk of liver cirrhosis and hepatocellular carcinoma after fontan operation: a need for surveillance","volume":"12","author":"Yoon","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jacadv.2025.101694_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.amjcard.2014.10.032","article-title":"Impact of liver disease after the fontan operation","volume":"115","author":"Lindsay","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.amjcard.2015.11.014","article-title":"Liver disease in patients after the fontan operation","volume":"117","author":"Pundi","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/heartjnl-2022-321435","article-title":"Haemodynamic and prognostic associations of liver fibrosis scores in Fontan-associated liver disease","volume":"109","author":"Martin de Miguel","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.jacadv.2025.101694_bib19","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.jacc.2023.03.421","article-title":"Clinical outcomes of adult fontan-associated liver disease and combined heart-liver transplantation","volume":"81","author":"Lewis","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib20","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s00246-016-1428-1","article-title":"MELD-XI scores correlate with post-fontan hepatic biopsy fibrosis scores","volume":"37","author":"Evans","year":"2016","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/heartjnl-2012-303347","article-title":"MELD-XI score and cardiac mortality or transplantation in patients after Fontan surgery","volume":"99","author":"Assenza","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.jacadv.2025.101694_bib22","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/jgh3.12967","article-title":"Poor correlation of 2D shear wave elastography and transient elastography in Fontan-associated liver disease: a head-to-head comparison","volume":"7","author":"Gill","year":"2023","journal-title":"JGH Open"},{"key":"10.1016\/j.jacadv.2025.101694_bib23","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.mayocp.2015.04.020","article-title":"Magnetic resonance elastography: a novel technique for the detection of hepatic fibrosis and hepatocellular carcinoma after the fontan operation","volume":"90","author":"Poterucha","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jacadv.2025.101694_bib24","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.amjcard.2019.07.052","article-title":"Relation of magnetic resonance elastography to fontan failure and portal hypertension","volume":"124","author":"Alsaied","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.healun.2015.01.993","article-title":"Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes","volume":"34","author":"Wu","year":"2015","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.jacadv.2025.101694_bib26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00246-012-0402-9","article-title":"Portal and sinusoidal fibrosis are common on liver biopsy after Fontan surgery","volume":"34","author":"Schwartz","year":"2013","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib27","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00246-014-0928-0","article-title":"Transvenous hepatic biopsy in stable Fontan patients undergoing cardiac catheterization","volume":"35","author":"Evans","year":"2014","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib28","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016617","article-title":"Incidence, predictors, and mortality in patients with liver cancer after fontan operation","volume":"10","author":"Ohuchi","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.101694_bib29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/CIRCULATIONAHA.117.032717","article-title":"Hepatocellular carcinoma after fontan operation: multicenter case series","volume":"138","author":"Egbe","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2025.101694_bib30","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1161\/CIRCULATIONAHA.121.056870","article-title":"Incidence and expected probability of liver cirrhosis and hepatocellular carcinoma after fontan operation","volume":"144","author":"Nii","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2025.101694_bib31","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijcard.2020.08.057","article-title":"Hepatocellular carcinoma and the Fontan circulation: clinical presentation and outcomes","volume":"322","author":"Possner","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4254\/wjh.v11.i1.1","article-title":"Hepatocellular carcinoma in non-cirrhotic liver: a comprehensive review","volume":"11","author":"Desai","year":"2019","journal-title":"World J Hepatol"},{"key":"10.1016\/j.jacadv.2025.101694_bib33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1148\/radiol.211037","article-title":"Abdominal CT and MRI findings of portal hypertension in children and adults with fontan circulation","volume":"303","author":"Zafar","year":"2022","journal-title":"Radiology"},{"key":"10.1016\/j.jacadv.2025.101694_bib34","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00246-022-03054-0","article-title":"Cardiac MRI-derived inferior vena cava cross-sectional area correlates with measures of fontan-associated liver disease","volume":"45","author":"Gunsaulus","year":"2022","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib35","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1007\/s00261-021-02994-0","article-title":"Spectrum of Fontan-associated liver disease assessed by MRI and US in young adolescents","volume":"46","author":"Thrane","year":"2021","journal-title":"Abdom Radiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib36","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.jtcvs.2021.12.028","article-title":"Noninvasive surrogates are poor predictors of liver fibrosis in patients with Fontan circulation","volume":"164","author":"Shin","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacadv.2025.101694_bib37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00535-021-01842-8","article-title":"The absence of warfarin treatment and situs inversus are associated with the occurrence of hepatocellular carcinoma after Fontan surgery","volume":"57","author":"Sakamori","year":"2022","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jacadv.2025.101694_bib38","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00247-021-05221-6","article-title":"Semiquantitative characterization of dynamic magnetic resonance perfusion of the liver in pediatric Fontan patients","volume":"52","author":"Navallas","year":"2021","journal-title":"Pediatr Radiol"},{"issue":"5","key":"10.1016\/j.jacadv.2025.101694_bib39","first-page":"611","article-title":"Blood test assessment of liver ultrasound findings in patients with fontan surgery","volume":"11","author":"Martinez-Quintana","year":"2021","journal-title":"Am J Cardiovasc Dis"},{"key":"10.1016\/j.jacadv.2025.101694_bib40","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijcard.2021.11.048","article-title":"Non-contrast enhanced magnetic resonance imaging for characterization of Fontan associated liver disease","volume":"349","author":"Langguth","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib41","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1053\/j.semtcvs.2021.04.005","article-title":"Surveillance of fontan associated liver disease in childhood and adolescence","volume":"34","author":"Hansen","year":"2021","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacadv.2025.101694_bib42","article-title":"Non-invasive biomarkers of Fontan-associated liver disease","volume":"3","author":"Emamaullee","year":"2021","journal-title":"JHEP Rep"},{"key":"10.1016\/j.jacadv.2025.101694_bib43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00431-021-04163-3","article-title":"Non-invasive assessment of liver abnormalities in pediatric Fontan patients","volume":"181","author":"De Bruyne","year":"2021","journal-title":"Eur J Pediatr"},{"issue":"10","key":"10.1016\/j.jacadv.2025.101694_bib44","first-page":"117","article-title":"Role of transient elastography to stage fontan-associated liver disease (Fald) in adults with single ventricle congenital heart disease correction","volume":"8","author":"Chemello","year":"2021","journal-title":"J Cardiovasc Development Dis"},{"key":"10.1016\/j.jacadv.2025.101694_bib45","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1136\/heartjnl-2021-319760","article-title":"Outcomes among adult survivors of total cavopulmonary Fontan palliation for single ventricle","volume":"108","author":"Anigwe","year":"2021","journal-title":"Heart"},{"key":"10.1016\/j.jacadv.2025.101694_bib46","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1136\/openhrt-2019-001224","article-title":"Atrial arrhythmias and thromboembolic complications in adults post Fontan surgery","volume":"7","author":"Wan","year":"2020","journal-title":"Open Heart"},{"key":"10.1016\/j.jacadv.2025.101694_bib47","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.jhep.2019.10.027","article-title":"Prevalence, features and predictive factors of liver nodules in Fontan surgery patients: the VALDIG Fonliver prospective cohort","volume":"72","author":"Tellez","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.jacadv.2025.101694_bib48","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1007\/s00246-020-02422-y","article-title":"Associated factors of liver disease after fontan operation in relation to ultrasound liver elastography","volume":"41","author":"Sethasathien","year":"2020","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijcard.2020.05.064","article-title":"Cardiovascular and abdominal flow alterations in adults with morphologic evidence of liver disease post Fontan palliation","volume":"317","author":"Abbasi","year":"2020","journal-title":"Int J Cardiol"},{"issue":"3","key":"10.1016\/j.jacadv.2025.101694_bib50","first-page":"181","article-title":"Noninvasive assessment of liver status in adult patients after the Fontan procedure","volume":"129","author":"SmasSuska","year":"2019","journal-title":"Pol Arch Intern Med"},{"key":"10.1016\/j.jacadv.2025.101694_bib51","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/chd.12770","article-title":"Evaluation of Fontan liver disease: correlation of transjugular liver biopsy with magnetic resonance and hemodynamics","volume":"14","author":"Silva-Sepulveda","year":"2019","journal-title":"Congenit"},{"key":"10.1016\/j.jacadv.2025.101694_bib52","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/eurheartj\/ehy620","article-title":"The clinical spectrum of Fontan-associated liver disease: results from a prospective multimodality screening cohort","volume":"40","author":"Munsterman","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2025.101694_bib53","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.xjtc.2020.03.008","article-title":"Prevalence of hepatocellular carcinoma in the entire Fontan population of Australia and New Zealand","volume":"2","author":"Wilson","year":"2020","journal-title":"JTCVS Tech"},{"key":"10.1016\/j.jacadv.2025.101694_bib54","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/chd.12650","article-title":"FibroSURE and elastography poorly predict the severity of liver fibrosis in Fontan-associated liver disease","volume":"13","author":"Schachter","year":"2018","journal-title":"Congenit"},{"key":"10.1016\/j.jacadv.2025.101694_bib55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1067\/j.cpradiol.2017.04.002","article-title":"Abdominal imaging surveillance in adult patients after Fontan procedure: risk of chronic liver disease and hepatocellular carcinoma","volume":"47","author":"Nandwana","year":"2018","journal-title":"Curr Probl Diagn Radiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00246-017-1727-1","article-title":"Hepatic stiffness using shear wave elastography and the related factors for a fontan circulation","volume":"39","author":"Kim","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib57","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ijcard.2018.05.039","article-title":"Venous congestion and pulmonary vascular function in Fontan circulation: implications for prognosis and treatment","volume":"271","author":"Egbe","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib58","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/2150135117732674","article-title":"Noninvasive liver assessment in adult patients with fontan circulation using acoustic radiation force impulse elastography and hepatic magnetic resonance imaging","volume":"9","author":"Buendia-Fuentes","year":"2018","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"10.1016\/j.jacadv.2025.101694_bib59","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.humpath.2016.07.006","article-title":"Prevalence and characterization of fibrosis in surveillance liver biopsies of patients with Fontan circulation","volume":"57","author":"Surrey","year":"2016","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jacadv.2025.101694_bib60","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijcard.2016.02.041","article-title":"Fontan circulation causes early, severe liver damage. Should we offer patients a tailored strategy?","volume":"209","author":"Agnoletti","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib61","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/jmri.24496","article-title":"Relationship of MR elastography determined liver stiffness with cardiac function after Fontan palliation","volume":"40","author":"Wallihan","year":"2014","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jacadv.2025.101694_bib62","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1016\/j.ijcard.2013.06.008","article-title":"Features of portal hypertension are associated with major adverse events in Fontan patients: the VAST study","volume":"168","author":"Elder","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib63","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00535-021-01842-8","article-title":"The absence of warfarin treatment and situs inversus are associated with the occurrence of hepatocellular carcinoma after Fontan surgery","volume":"57","author":"Sakamori","year":"2022","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jacadv.2025.101694_bib64","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.xjtc.2020.03.008","article-title":"Prevalence of hepatocellular carcinoma in the entire Fontan population of Australia and New Zealand","volume":"2","author":"Wilson","year":"2020","journal-title":"JTCVS Tech"},{"key":"10.1016\/j.jacadv.2025.101694_bib65","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/jmri.24496","article-title":"Relationship of MR elastography determined liver stiffness with cardiac function after Fontan palliation","volume":"40","author":"Wallihan","year":"2014","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jacadv.2025.101694_bib66","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1017\/S1047951122002992","article-title":"The prognostic role of liver volumetry in Fontan patients","volume":"33","author":"Najashi","year":"2022","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jacadv.2025.101694_bib67","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00246-021-02707-w","article-title":"Relation of magnetic resonance elastography to fontan circulatory failure in a cohort of pediatric and adult patients","volume":"42","author":"Brayer","year":"2021","journal-title":"Pediatr Cardiol"},{"issue":"2","key":"10.1016\/j.jacadv.2025.101694_bib68","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/jcm9020418","article-title":"Thromboembolic events are independently associated with liver stiffness in patients with fontan circulation","volume":"9","author":"Alsaied","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jacadv.2025.101694_bib69","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.amjcard.2021.10.045","article-title":"Relation of liver volume to adverse cardiovascular events in adolescents and adults with fontan circulation","volume":"165","author":"Lubert","year":"2021","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib70","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00246-015-1234-1","article-title":"Fontan outcomes and pulmonary blood flow at birth","volume":"37","author":"Evans","year":"2016","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jacadv.2025.101694_bib71","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/ejhf.1365","article-title":"Haemodynamic profiles in adult Fontan patients: associated haemodynamics and prognosis","volume":"21","author":"Miranda","year":"2019","journal-title":"Eur J Heart Fail"},{"issue":"7","key":"10.1016\/j.jacadv.2025.101694_bib72","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/hepr.13500","article-title":"Characteristics of hepatocellular carcinoma arising from Fontan-associated liver disease","volume":"50","author":"Sagawa","year":"2020","journal-title":"Hepatol"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X25001115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X25001115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T17:23:00Z","timestamp":1748452980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X25001115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2772963X25001115"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2025.101694","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence, Risk Factors, and Prognosis for Fontan-Associated Liver Disease","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2025.101694","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101694"}}