{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:54:08Z","timestamp":1792439648773,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006149","name":"Oxford University Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006149","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jacadv.2025.101893","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T16:44:28Z","timestamp":1750697068000},"page":"101893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Stent-Retriever Thrombectomy in STEMI With Large Thrombus Burden"],"prefix":"10.1016","volume":"4","author":[{"given":"Rafail A.","family":"Kotronias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Andreaggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Portolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Maino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikboljon","family":"Sobirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Cahill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lucking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Costello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fraile Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrinda","family":"Haridas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Shaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector M.","family":"Garcia-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Channon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian P.","family":"Banning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Langrish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-1855","authenticated-orcid":false,"given":"Giovanni Luigi","family":"De Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jacadv.2025.101893_bib1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.4244\/EIJ-D-17-00367","volume":"13","author":"De Maria","year":"2017","journal-title":"EuroIntervention"},{"issue":"7","key":"10.1016\/j.jacadv.2025.101893_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41569-024-01020-2","article-title":"Interventional thrombus modification in STEMI","volume":"21","author":"Walsh","year":"2024","journal-title":"Nat Rev Cardiol"},{"issue":"14","key":"10.1016\/j.jacadv.2025.101893_bib3","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/eurheartj\/ehs456","article-title":"Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study\u2014TROFI trial","volume":"34","author":"Onuma","year":"2013","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.jacadv.2025.101893_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/CIRCULATIONAHA.116.025371","article-title":"Thrombus aspiration in ST-segment-elevation myocardial infarction: an individual patient meta-analysis: thrombectomy trialists collaboration","volume":"135","author":"Jolly","year":"2017","journal-title":"Circulation"},{"issue":"29","key":"10.1016\/j.jacadv.2025.101893_bib5","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1093\/eurheartj\/ehv176","article-title":"Culprit lesion thrombus burden after manual thrombectomy or percutaneous coronary intervention-alone in ST-segment elevation myocardial infarction: the optical coherence tomography sub-study of the TOTAL (ThrOmbecTomy versus PCI ALone) trial","volume":"36","author":"Bhindi","year":"2015","journal-title":"Eur Heart J"},{"issue":"19","key":"10.1016\/j.jacadv.2025.101893_bib6","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.jcin.2024.07.016","article-title":"Failed thrombus aspiration and reduced myocardial perfusion in patients with STEMI and large thrombus burden","volume":"17","author":"Jeon","year":"2024","journal-title":"JACC Cardiovasc Interv"},{"issue":"5","key":"10.1016\/j.jacadv.2025.101893_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.121.011336","article-title":"Prognostic role of residual thrombus burden following thrombectomy: insights from the TOTAL trial","volume":"15","author":"Alkhalil","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"issue":"10029","key":"10.1016\/j.jacadv.2025.101893_bib8","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"The Lancet"},{"issue":"3","key":"10.1016\/j.jacadv.2025.101893_bib9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4244\/EIJ-D-21-00741","article-title":"A prospective, first-in-human use of the NeVa mechanical thrombectomy device for patients with acute coronary syndromes","volume":"18","author":"Spirito","year":"2022","journal-title":"EuroIntervention"},{"issue":"3","key":"10.1016\/j.jacadv.2025.101893_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s12928-024-00998-3","article-title":"Initial experience with a novel stent-based mechanical thrombectomy device for management of acute myocardial infarction cases with large thrombus burden","volume":"39","author":"Zhi","year":"2024","journal-title":"Cardiovasc Interv Ther"},{"key":"10.1016\/j.jacadv.2025.101893_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.carrev.2023.02.012","article-title":"Rationale and design of a randomized controlled pilot trial to assess stent retriever thrombectomy for thrombus burden reduction in patients with acute myocardial infarction: the RETRIEVE-AMI study","volume":"52","author":"Kotronias","year":"2023","journal-title":"Cardiovasc Revasc Med"},{"issue":"1","key":"10.1016\/j.jacadv.2025.101893_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ehjci\/jeu175","article-title":"Feasibility and repeatability of optical coherence tomography measurements of pre-stent thrombus burden in patients with STEMI treated with primary PCI","volume":"16","author":"Kajander","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"Suppl 1","key":"10.1016\/j.jacadv.2025.101893_bib13","first-page":"S7","article-title":"The MLD MAX OCT algorithm: an imaging-based workflow for percutaneous coronary intervention","volume":"100","author":"Shlofmitz","year":"2022","journal-title":"Catheter Cardiovasc Interv"},{"issue":"4","key":"10.1016\/j.jacadv.2025.101893_bib14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00062-018-0702-4","article-title":"The SAVE technique","volume":"29","author":"Maus","year":"2019","journal-title":"Clinical Neuroradiology"},{"issue":"7","key":"10.1016\/j.jacadv.2025.101893_bib15","doi-asserted-by":"crossref","first-page":"e379","DOI":"10.4244\/EIJ-D-24-00989","article-title":"Coronary stent retriever-assisted thrombectomy","volume":"21","author":"Walsh","year":"2025","journal-title":"EuroIntervention"},{"issue":"6","key":"10.1016\/j.jacadv.2025.101893_bib16","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s10554-021-02254-8","article-title":"Angiography-derived index of microcirculatory resistance (IMR(angio)) as a novel pressure-wire-free tool to assess coronary microvascular dysfunction in acute coronary syndromes and stable coronary artery disease","volume":"37","author":"Scarsini","year":"2021","journal-title":"Int J Cardiovasc Imaging"},{"issue":"4","key":"10.1016\/j.jacadv.2025.101893_bib17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/ehjci\/jeu228","article-title":"Intra-coronary thrombus evolution during acute coronary syndrome: regression assessment by serial optical coherence tomography analyses","volume":"16","author":"Amabile","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"7","key":"10.1016\/j.jacadv.2025.101893_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jacc.2007.04.059","article-title":"Angiographic stent thrombosis after routine use of drug-eluting stents in ST-segment elevation myocardial infarction: the importance of thrombus burden","volume":"50","author":"Sianos","year":"2007","journal-title":"J Am Coll Cardiol"},{"issue":"38","key":"10.1016\/j.jacadv.2025.101893_bib19","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur Heart J"},{"issue":"2","key":"10.1016\/j.jacadv.2025.101893_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.amjcard.2012.09.015","article-title":"Incidence and outcomes of no-reflow phenomenon during percutaneous coronary intervention among patients with acute myocardial infarction","volume":"111","author":"Harrison","year":"2013","journal-title":"Am J Cardiol"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X25003138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X25003138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:14:16Z","timestamp":1774577656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X25003138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2772963X25003138"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2025.101893","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stent-Retriever Thrombectomy in STEMI With Large Thrombus Burden","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2025.101893","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101893"}}