{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:00:42Z","timestamp":1789466442470,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jacadv.2025.102370","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:18:15Z","timestamp":1764087495000},"page":"102370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"P2","title":["Sex Differences in the Clinical Recognition of Significant Aortic Stenosis"],"prefix":"10.1016","volume":"4","author":[{"given":"Daniela","family":"Crousillat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayana","family":"Shariff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Tanguturi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy","family":"Elmariah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacadv.2025.102370_bib1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.amjcard.2015.03.053","article-title":"Trends of hospitalizations in the United States from 2000 to 2012 of patients >60 years with aortic valve disease","volume":"116","author":"Badheka","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacadv.2025.102370_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.038463","article-title":"Sex-associated disparities in surgical and percutaneous management of aortic stenosis with severe features: retrospective analysis from the national readmission database","volume":"14","author":"Castaldi","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.102370_bib3","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006370","article-title":"Sex differences in the utilization and outcomes of surgical aortic valve replacement for severe aortic stenosis","volume":"6","author":"Chaker","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.102370_bib4","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.jacc.2014.01.036","article-title":"Sex-related differences in outcomes after transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis","volume":"63","author":"Williams","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2025.102370_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijcard.2017.05.047","article-title":"Female-specific survival advantage from transcatheter aortic valve implantation over surgical aortic valve replacement: meta-analysis of the gender subgroups of randomised controlled trials including 3758 patients","volume":"250","author":"Panoulas","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacadv.2025.102370_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.amjcard.2021.05.046","article-title":"Outcomes following aortic stenosis treatment (transcatheter vs surgical replacement) in women vs men (from a nationwide analysis)","volume":"154","author":"Deharo","year":"2021","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacadv.2025.102370_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jcmg.2023.06.005","article-title":"Aortic stenosis risk and management","volume":"17","author":"Pellikka","year":"2024","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacadv.2025.102370_bib8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s13670-024-00419-6","article-title":"Gender disparities in valvular heart disease and treatment in the aging population","volume":"13","author":"Desmarais","year":"2024","journal-title":"Curr Geriatr Rep"},{"key":"10.1016\/j.jacadv.2025.102370_bib9","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018816","article-title":"Excess mortality and undertreatment of women with severe aortic stenosis","volume":"10","author":"Tribouilloy","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.102370_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015610","article-title":"Age, sex, and valve phenotype differences in fibro-calcific remodeling of calcified aortic valve","volume":"9","author":"Voisine","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.102370_bib11","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jcmg.2022.10.009","article-title":"Aortic stenosis progression","volume":"16","author":"Willner","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacadv.2025.102370_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/heartjnl-2014-306078","article-title":"Sex differences in cardiovascular outcome during progression of aortic valve stenosis","volume":"101","author":"Cramariuc","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.jacadv.2025.102370_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jcmg.2016.02.006","article-title":"Sex differences in the progression of aortic stenosis and prognostic implication","volume":"9","author":"Nguyen","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"issue":"18","key":"10.1016\/j.jacadv.2025.102370_bib14","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American college of cardiology\/American heart Association Joint Committee on clinical practice guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2025.102370_bib15","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.025692","article-title":"Racial and ethnic differences in the clinical diagnosis of aortic stenosis","volume":"11","author":"Crousillat","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.102370_bib16","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease","volume":"77","author":"Otto","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2025.102370_bib17","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jclinepi.2010.10.004","article-title":"A combined comorbidity score predicted mortality in elderly patients better than existing scores","volume":"64","author":"Gagne","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jacadv.2025.102370_bib18","author":"Sjoberg"},{"key":"10.1016\/j.jacadv.2025.102370_bib19","author":"Gerds"},{"key":"10.1016\/j.jacadv.2025.102370_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.025164","article-title":"Impact of managing provider type on severe aortic stenosis management and mortality","volume":"11","author":"Pellikka","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.102370_bib21","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.jacc.2019.08.004","article-title":"Poor long-term survival in patients with moderate aortic stenosis","volume":"74","author":"Strange","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2025.102370_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020490","article-title":"Association between patient survival and clinician variability in treatment rates for aortic valve stenosis","volume":"10","author":"Brennan","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2025.102370_bib23","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.jacc.2021.11.060","article-title":"Trends in utilization of aortic valve replacement for severe aortic stenosis","volume":"79","author":"Li","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jacadv.2025.102370_bib24","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.122.009712","article-title":"Target aortic stenosis: a national initiative to improve quality of care and outcomes for patients with aortic stenosis","volume":"16","author":"Lindman","year":"2023","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jacadv.2025.102370_bib25","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jcmg.2022.02.007","article-title":"Sex differences in LV remodeling and hemodynamics in aortic stenosis","volume":"15","author":"Ito","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jacadv.2025.102370_bib26","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/eurheartj\/ehw096","article-title":"Low-gradient aortic stenosis","volume":"37","author":"Clavel","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2025.102370_bib27","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.pcad.2018.11.006","article-title":"Low-gradient aortic stenosis: solving the conundrum using multi-modality imaging","volume":"61","author":"Messika-Zeitoun","year":"2018","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacadv.2025.102370_bib28","doi-asserted-by":"crossref","DOI":"10.15420\/ecr.2022.13","article-title":"Grading of aortic stenosis: is it more complicated in women?","volume":"17","author":"Cramariuc","year":"2022","journal-title":"Eur Cardiol"},{"key":"10.1016\/j.jacadv.2025.102370_bib29","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/eurheartj\/ehab242","article-title":"Impact of sex on the management and outcome of aortic stenosis patients","volume":"42","author":"Bienjonetti-Boudreau","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2025.102370_bib30","article-title":"Detection of severe aortic stenosis by clinicians versus artificial intelligence: a retrospective clinical cohort study","volume":"48","author":"Strange","year":"2024","journal-title":"Am Heart J Plus Cardiol Res Pract"},{"key":"10.1016\/j.jacadv.2025.102370_bib31","article-title":"Electronic provider notification to facilitate the recognition and management of severe aortic stenosis: a randomized clinical trial","volume":"125","author":"Tanguturi","year":"2025","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.jacadv.2025.102370_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.122.009162","article-title":"Characterizing the accuracy of international classification of diseases, tenth revision administrative claims for aortic valve disease","volume":"15","author":"Strom","year":"2022","journal-title":"Circ Cardiovasc Qual Outcomes"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X25008002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X25008002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T20:07:55Z","timestamp":1771358875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X25008002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2772963X25008002"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2025.102370","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex Differences in the Clinical Recognition of Significant Aortic Stenosis","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2025.102370","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"102370"}}