{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:27:23Z","timestamp":1793924843320,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jacadv.2026.102725","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:36:27Z","timestamp":1775781387000},"page":"102725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early Diagnosis of ATTR-CM by Age- and Carpal Tunnel Biopsy-Guided Screening"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-7652","authenticated-orcid":false,"given":"Sie Kronborg","family":"Fensman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil Thyrsted","family":"Ladefoged","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Hartig-Andreasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Stilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-0373","authenticated-orcid":false,"given":"Ali Hussein Jaber","family":"Mejren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7763-3637","authenticated-orcid":false,"given":"Hans Christian","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor Skibsted","family":"Clemmensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen Hvitfeldt","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.jacadv.2026.102725_bib1","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.jacc.2019.04.003","article-title":"Transthyretin amyloid cardiomyopathy: JACC state-of-the-art review","volume":"73","author":"Ruberg","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2026.102725_bib2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijcard.2019.12.063","article-title":"Diagnostic delay in wild type transthyretin cardiac amyloidosis - a clinical challenge","volume":"304","author":"Ladefoged","year":"2020","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/CIRCULATIONAHA.118.038169","article-title":"Natural history, quality of life, and outcome in cardiac transthyretin amyloidosis","volume":"140","author":"Lane","year":"2019","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.jacadv.2026.102725_bib4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jacadv.2026.102725_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1056\/NEJMoa2305434","article-title":"Efficacy and safety of acoramidis in transthyretin amyloid cardiomyopathy","volume":"390","author":"Gillmore","year":"2024","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jacadv.2026.102725_bib6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/ehf2.14622","article-title":"Musculoskeletal co-morbidities in patients with transthyretin amyloid cardiomyopathy: a systematic review","volume":"11","author":"Formiga","year":"2024","journal-title":"ESC Heart Fail"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1186\/s12891-023-06853-5","article-title":"Musculoskeletal manifestations associated with transthyretin-mediated (ATTR) amyloidosis: a systematic review","volume":"24","author":"Aldinc","year":"2023","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"10.1016\/j.jacadv.2026.102725_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/ejhf.1742","article-title":"Carpal tunnel syndrome in cardiac amyloidosis: implications for early diagnosis and prognostic role across the spectrum of aetiologies","volume":"22","author":"Milandri","year":"2020","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/13506129.2015.1135792","article-title":"Carpal tunnel syndrome: a common initial symptom of systemic wild-type ATTR (ATTRwt) amyloidosis","volume":"23","author":"Nakagawa","year":"2016","journal-title":"Amyloid"},{"issue":"5","key":"10.1016\/j.jacadv.2026.102725_bib10","doi-asserted-by":"crossref","DOI":"10.1097\/GOX.0000000000006816","article-title":"Amyloidosis screening by biopsy during carpal tunnel release: a systematic review and meta-analysis","volume":"13","author":"Ferrin","year":"2025","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12891-020-03912-z","article-title":"Musculoskeletal pathology as an early warning sign of systemic amyloidosis: a systematic review of amyloid deposition and orthopedic surgery","volume":"22","author":"Wininger","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"issue":"2","key":"10.1016\/j.jacadv.2026.102725_bib12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1142\/S2424835525500274","article-title":"The higher positive amyloid deposition in electrophysiologically proven idiopathic carpal tunnel syndrome patients","volume":"30","author":"Maehara","year":"2025","journal-title":"J Hand Surg Asian Pac"},{"issue":"15","key":"10.1016\/j.jacadv.2026.102725_bib13","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.3390\/jcm13154328","article-title":"Early diagnosis of amyloidosis and cardiac involvement through carpal tunnel surgery and predictive factors","volume":"13","author":"Navarro-Saez","year":"2024","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/13506129.2019.1688289","article-title":"Immunoelectron microscopy and mass spectrometry for classification of amyloid deposits","volume":"27","author":"Abildgaard","year":"2020","journal-title":"Amyloid"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"issue":"6","key":"10.1016\/j.jacadv.2026.102725_bib16","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jacc.2005.05.073","article-title":"Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy","volume":"46","author":"Perugini","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"24","key":"10.1016\/j.jacadv.2026.102725_bib17","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/CIRCULATIONAHA.116.021612","article-title":"Nonbiopsy diagnosis of cardiac transthyretin amyloidosis","volume":"133","author":"Gillmore","year":"2016","journal-title":"Circulation"},{"issue":"30","key":"10.1016\/j.jacadv.2026.102725_bib18","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/eurheartj\/ehx589","article-title":"A new staging system for cardiac transthyretin amyloidosis","volume":"39","author":"Gillmore","year":"2018","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/13506129.2017.1313221","article-title":"Phenotypic characterization of late onset cardiac amyloidosis caused by the transthyretin mutation TTRA45S, p.(Ala65Ser)","volume":"24","author":"Mullertz","year":"2017","journal-title":"Amyloid"},{"issue":"17","key":"10.1016\/j.jacadv.2026.102725_bib20","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jacc.2018.07.092","article-title":"Tenosynovial and cardiac amyloidosis in patients undergoing carpal tunnel release","volume":"72","author":"Sperry","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.jacadv.2026.102725_bib21","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1253\/circj.CJ-23-0223","article-title":"Prevalence of cardiac amyloidosis in patients undergoing carpal tunnel release with amyloid deposition","volume":"87","author":"Takashio","year":"2023","journal-title":"Circ J"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/ehf2.14173","article-title":"Identification of wild-type transthyretin cardiac amyloidosis in patients with carpal tunnel syndrome surgery (CACTuS)","volume":"10","author":"Ladefoged","year":"2023","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jacadv.2026.102725_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132469","article-title":"Value of troponin and NT-proBNP to screen for cardiac amyloidosis after carpal tunnel syndrome surgery","volume":"415","author":"Noory","year":"2024","journal-title":"Int J Cardiol"},{"issue":"16","key":"10.1016\/j.jacadv.2026.102725_bib24","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/eurheartj\/ehab072","article-title":"Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC working group on myocardial and pericardial diseases","volume":"42","author":"Garcia-Pavia","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2026.102725_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.amjcard.2024.11.019","article-title":"The impact of active ascertainment on sex-specific differences in the prevalence and phenotype of transthyretin cardiac amyloidosis: the screening for cardiac amyloidosis with nuclear imaging in minority populations study","volume":"237","author":"Chan","year":"2025","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.jacadv.2026.102725_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40119-020-00205-3","article-title":"Estimating the gender distribution of patients with wild-type transthyretin amyloid cardiomyopathy: a systematic review and meta-analysis","volume":"10","author":"Kroi","year":"2021","journal-title":"Cardiol Ther"},{"issue":"8","key":"10.1016\/j.jacadv.2026.102725_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101086","article-title":"Age- and sex-related differences in patients with wild-type transthyretin amyloidosis: insights from THAOS","volume":"3","author":"Mora-Ayestaran","year":"2024","journal-title":"JACC Adv"},{"issue":"4","key":"10.1016\/j.jacadv.2026.102725_bib28","first-page":"281","article-title":"Principles and practice of mass screening for disease","volume":"65","author":"Wilson","year":"1968","journal-title":"Bol Oficina Sanit Panam"},{"issue":"10","key":"10.1016\/j.jacadv.2026.102725_bib29","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jacc.2024.11.042","article-title":"Efficacy of acoramidis on all-cause mortality and cardiovascular hospitalization in transthyretin amyloid cardiomyopathy","volume":"85","author":"Judge","year":"2025","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.jacadv.2026.102725_bib31","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.jhsa.2025.06.009","article-title":"Amyloid biopsy during endoscopic carpal tunnel release: a comparison of tenosynovial and antebrachial fascia specimens","volume":"50","author":"Mahmoud","year":"2025","journal-title":"J Hand Surg Am"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26001468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26001468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:56:32Z","timestamp":1793922992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X26001468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2772963X26001468"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.102725","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Diagnosis of ATTR-CM by Age- and Carpal Tunnel Biopsy-Guided Screening","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.102725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"102725"}}