{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:34:40Z","timestamp":1793237680363,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jacadv.2026.102981","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:22:45Z","timestamp":1783945365000},"page":"102981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased Platelet Fc\u0263RIIa Identifies Patients at Greater Risk of Multiple Cardiovascular Events After Myocardial Infarction"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2751-6870","authenticated-orcid":false,"given":"David J.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick J.","family":"Angiolillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homam","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Gurbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timir K.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R.","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"DiBattiste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacadv.2026.102981_bib1","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMra071014","article-title":"Platelet activation and atherothrombosis","volume":"357","author":"Dav\u00ec","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacadv.2026.102981_bib2","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1182\/blood.V60.6.1277.1277","article-title":"Characterization of the IgG-Fc receptor on human platelets","volume":"60","author":"Karas","year":"1982","journal-title":"Blood"},{"key":"10.1016\/j.jacadv.2026.102981_bib3","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1182\/blood-2008-02-142125","article-title":"Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets","volume":"112","author":"Boylan","year":"2008","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.jacadv.2026.102981_bib4","doi-asserted-by":"crossref","first-page":"12009","DOI":"10.1074\/jbc.M111803200","article-title":"A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets","volume":"277","author":"Lova","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacadv.2026.102981_bib5","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1182\/blood-2012-07-443325","article-title":"Cooperative integrin\/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo","volume":"121","author":"Zhi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jacadv.2026.102981_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1477-9560-5-7","article-title":"Increased platelet expression of FcGammaRIIa and its potential impact on platelet reactivity in patients with end stage renal disease","volume":"5","author":"Serrano","year":"2007","journal-title":"Thromb J"},{"issue":"19-20","key":"10.1016\/j.jacadv.2026.102981_bib7","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1080\/17576180.2024.2395706","article-title":"Assessing prognosis by quantifying Fc\u03b3RIIa on fixed platelets","volume":"16","author":"Schneider","year":"2024","journal-title":"Bioanalysis"},{"issue":"2","key":"10.1016\/j.jacadv.2026.102981_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jacc.2018.04.046","article-title":"Fc\u03b3RIIa: a new cardiovascular risk marker","volume":"72","author":"Schneider","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.jacadv.2026.102981_bib9","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.jacc.2024.08.051","article-title":"Platelet Fc\u03b3RIIa as a marker of cardiovascular risk after myocardial infarction","volume":"84","author":"Schneider","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"23","key":"10.1016\/j.jacadv.2026.102981_bib10","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.102981_bib11","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth universal definition of myocardial infarction","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.102981_bib12","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1161\/STR.0b013e318296aeca","article-title":"An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"44","author":"Sacco","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.jacadv.2026.102981_bib13","article-title":"Prognostic implications over time of platelet Fc\u0263RIIa expression in patients with myocardial infarction: a secondary analysis","volume":"37","author":"Schneider","year":"2025","journal-title":"J Invasive Cardiol"},{"key":"10.1016\/j.jacadv.2026.102981_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.120.009177","article-title":"Impact of bleeding and myocardial infarction on mortality in all-comer patients undergoing percutaneous coronary intervention","volume":"13","author":"Hara","year":"2020","journal-title":"Circ Cardiovasc Interv"},{"issue":"7","key":"10.1016\/j.jacadv.2026.102981_bib15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1056\/NEJMoa010746","article-title":"Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation","volume":"345","author":"Yusuf","year":"2001","journal-title":"N Engl J Med"},{"issue":"20","key":"10.1016\/j.jacadv.2026.102981_bib16","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1056\/NEJMoa0706482","article-title":"Prasugrel versus clopidogrel in patients with acute coronary syndromes","volume":"357","author":"Wiviott","year":"2007","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.jacadv.2026.102981_bib17","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","article-title":"Ticagrelor versus clopidogrel in patients with acute coronary syndromes","volume":"36","author":"Wallentin","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jacadv.2026.102981_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41569-021-00598-1","article-title":"Bleeding avoidance strategies in percutaneous coronary intervention","volume":"19","author":"Capodanno","year":"2022","journal-title":"Nat Rev Cardiol"},{"issue":"12","key":"10.1016\/j.jacadv.2026.102981_bib19","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41569-023-00901-2","article-title":"De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a consensus statement from an international expert panel on coronary thrombosis","volume":"20","author":"Gorog","year":"2023","journal-title":"Nat Rev Cardiol"},{"issue":"2","key":"10.1016\/j.jacadv.2026.102981_bib20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","article-title":"Inflammation in acute myocardial infarction: the good, the bad and the ugly","volume":"45","author":"Matter","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2026.102981_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0021-9150(02)00179-X","article-title":"Potential role of platelet FcgammaRIIA in collagen-mediated platelet activation associated with atherothrombosis","volume":"164","author":"Calverley","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacadv.2026.102981_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1365-2141.2003.04233.x","article-title":"Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitus","volume":"121","author":"Calverley","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jacadv.2026.102981_bib23","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1001\/jama.2010.181","article-title":"Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation","volume":"303","author":"Breet","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.jacadv.2026.102981_bib24","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/jth.12538","article-title":"Platelet-reactivity tests identify patients at risk of secondary cardiovascular events: a systematic review and meta-analysis","volume":"12","author":"Wisman","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacadv.2026.102981_bib25","first-page":"844","article-title":"Vascular risk levels affect the predictive value of platelet reactivity for the occurrence of MACE in patients on clopidogrel. Systematic review and meta-analysis of individual patient data","volume":"115","author":"Reny","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jacadv.2026.102981_bib26","doi-asserted-by":"crossref","first-page":"6902","DOI":"10.1038\/s41467-024-50994-7","article-title":"A Platelet Reactivity ExpreSsion Score derived from patients with peripheral artery disease predicts cardiovascular risk","volume":"15","author":"Berger","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jacadv.2026.102981_bib27","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/CIRCRESAHA.124.325701","article-title":"TRIPLE score: GPVI and CD36 expression predict a prothrombotic platelet function phenotype","volume":"136","author":"Bye","year":"2025","journal-title":"Circ Res"},{"key":"10.1016\/j.jacadv.2026.102981_bib28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11239-019-01852-7","article-title":"Variation in platelet expression of Fc\u03b3RIIa after myocardial infarction","volume":"48","author":"McMahon","year":"2019","journal-title":"J Thromb Thrombolysis"},{"key":"10.1016\/j.jacadv.2026.102981_bib29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jacc.2014.03.051","article-title":"Variability of individual platelet reactivity over time in patients treated with clopidogrel: insights from the ELEVATE-TIMI 56 trial","volume":"64","author":"Hochholzer","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2026.102981_bib30","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1160\/TH15-03-0257","article-title":"Temporal variability in the antiplatelet effects of clopidogrel and aspirin after elective drug-eluting stent implantation. An ADAPT-DES substudy","volume":"114","author":"N\u00fchrenberg","year":"2015","journal-title":"Thromb Haemost"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26004023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26004023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:26:05Z","timestamp":1793237165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X26004023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2772963X26004023"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.102981","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Platelet Fc\u0263RIIa Identifies Patients at Greater Risk of Multiple Cardiovascular Events After Myocardial Infarction","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.102981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"102981"}}