{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:16:11Z","timestamp":1788383771707,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jacadv.2026.103163","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:46:41Z","timestamp":1788252401000},"page":"103163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["E-Cigarette Use and Early Cardiovascular Risk in Young Adults"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2601-2324","authenticated-orcid":false,"given":"William A.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel B.","family":"Levitan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dona N.","family":"Sangapalaarachchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Lolacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Ilievski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1143-3920","authenticated-orcid":false,"given":"Katlyn E.","family":"McGraw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hilpert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enoch","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brulinda","family":"Frangaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli J.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi A.","family":"Fayad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Oelsner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Shimbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9824-7797","authenticated-orcid":false,"given":"Ana","family":"Navas-Acien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacadv.2026.103163_bib1","first-page":"CS356607","article-title":"Electronic cigarette use among adults in the United States, 2019\u20132023","author":"Vahratian","year":"2025","journal-title":"NCHS Data Brief"},{"issue":"19","key":"10.1016\/j.jacadv.2026.103163_bib3","first-page":"e203","article-title":"Cardiopulmonary consequences of vaping in adolescents: a scientific statement from the American Heart Association","volume":"146","author":"Wold","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.103163_bib4","series-title":"Public Health Consequences of E-Cigarettes","year":"2018"},{"issue":"3","key":"10.1016\/j.jacadv.2026.103163_bib5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1152\/japplphysiol.00713.2017","article-title":"Chronic exposure to electronic cigarettes results in impaired cardiovascular function in mice","volume":"124","author":"Olfert","year":"2018","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"10.1016\/j.jacadv.2026.103163_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11906-020-01119-0","article-title":"Electronic cigarette use and blood pressure endpoints: a systematic review","volume":"23","author":"Martinez-Morata","year":"2021","journal-title":"Curr Hypertens Rep"},{"issue":"9","key":"10.1016\/j.jacadv.2026.103163_bib7","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-Ethnic Study of Atherosclerosis: objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.jacadv.2026.103163_bib9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/tobaccocontrol-2016-052934","article-title":"Design and methods of the population assessment of tobacco and health (PATH) Study","volume":"26","author":"Hyland","year":"2017","journal-title":"Tob Control"},{"issue":"60","key":"10.1016\/j.jacadv.2026.103163_bib10","first-page":"1","article-title":"Sample design and estimation structures for the National Health Interview Survey, 2016\u20132025","volume":"1","author":"Moriarity","year":"2022","journal-title":"Vital Health Stat"},{"issue":"2","key":"10.1016\/j.jacadv.2026.103163_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00126097-200104000-00007","article-title":"Evaluation of the overall efficacy of the Omron office digital blood pressure HEM-907 monitor in adults","volume":"6","author":"White","year":"2001","journal-title":"Blood Press Monit"},{"issue":"4","key":"10.1016\/j.jacadv.2026.103163_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/MBP.0b013e32813fa386","article-title":"Validation of the Omron M5-I, R5-I and HEM-907 automated blood pressure monitors in elderly individuals according to the International Protocol of the European Society of Hypertension","volume":"12","author":"Omboni","year":"2007","journal-title":"Blood Press Monit"},{"issue":"4","key":"10.1016\/j.jacadv.2026.103163_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00126097-200208000-00006","article-title":"Validation of the Omron HEM-907 device for blood pressure measurement","volume":"7","author":"El Assaad","year":"2002","journal-title":"Blood Press Monit"},{"issue":"3","key":"10.1016\/j.jacadv.2026.103163_bib14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1161\/HYPERTENSIONAHA.110.160812","article-title":"Relation of brachial and digital measures of vascular function in the community: the Framingham Heart Study","volume":"57","author":"Hamburg","year":"2011","journal-title":"Hypertension"},{"issue":"19","key":"10.1016\/j.jacadv.2026.103163_bib15","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1161\/CIRCULATIONAHA.107.748574","article-title":"Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study","volume":"117","author":"Hamburg","year":"2008","journal-title":"Circulation"},{"issue":"199","key":"10.1016\/j.jacadv.2026.103163_bib16","doi-asserted-by":"crossref","DOI":"10.3791\/65458","article-title":"Semi-automatic graphical tool for measuring coronary artery spatially weighted calcium score from gated cardiac computed tomography images","author":"Patel","year":"2023","journal-title":"J Vis Exp"},{"issue":"1","key":"10.1016\/j.jacadv.2026.103163_bib17","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.120.011981","article-title":"Spatially weighted coronary artery calcium score and coronary heart disease events in the Multi-Ethnic Study of Atherosclerosis","volume":"14","author":"Shea","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jacadv.2026.103163_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2342-12-14","article-title":"An alternative method for quantifying coronary artery calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"12","author":"Liang","year":"2012","journal-title":"BMC Med Imaging"},{"issue":"9","key":"10.1016\/j.jacadv.2026.103163_bib19","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/ntr\/ntaf067","article-title":"E-cigarette use and incident cardiometabolic conditions in the all of us research program","volume":"27","author":"Erhabor","year":"2025","journal-title":"Nicotine Tob Res"},{"issue":"3","key":"10.1016\/j.jacadv.2026.103163_bib20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/ntr\/ntac170","article-title":"Sex differences in the association of e-cigarette and cigarette use and dual use with self-reported hypertension incidence in US adults","volume":"25","author":"Shi","year":"2023","journal-title":"Nicotine Tob Res"},{"issue":"3","key":"10.1016\/j.jacadv.2026.103163_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/toxics9030052","article-title":"Cross-sectional associations of smoking and e-cigarette use with self-reported diagnosed hypertension: findings from Wave 3 of the Population Assessment of Tobacco and Health Study","volume":"9","author":"Miller","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.jacadv.2026.103163_bib22","article-title":"The health consequences of Smoking\u201450 years of progress: a report of the surgeon general","year":"2014","journal-title":"Executive Summary"},{"issue":"26","key":"10.1016\/j.jacadv.2026.103163_bib23","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1093\/eurheartj\/ehz772","article-title":"Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2)","volume":"41","author":"Kuntic","year":"2020","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.jacadv.2026.103163_bib24","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1161\/CIRCULATIONAHA.117.029153","article-title":"Electronic cigarette smoking increases arterial stiffness and oxidative stress to a lesser extent than a single conventional cigarette: an acute and chronic study","volume":"137","author":"Ikonomidis","year":"2018","journal-title":"Circulation"},{"issue":"41","key":"10.1016\/j.jacadv.2026.103163_bib25","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1093\/eurheartj\/ehaa460","article-title":"Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes","volume":"41","author":"M\u00fcnzel","year":"2020","journal-title":"Eur Heart J"},{"issue":"11","key":"10.1016\/j.jacadv.2026.103163_bib26","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1080\/02786826.2018.1500013","article-title":"Electronic cigarette-generated aldehydes: the contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure","volume":"52","author":"Conklin","year":"2018","journal-title":"Aerosol Sci Technol"},{"issue":"pt C","key":"10.1016\/j.jacadv.2026.103163_bib27","article-title":"Effects of e-liquid flavor, nicotine content, and puff duration on metal emissions from electronic cigarettes","volume":"204","author":"Zhao","year":"2022","journal-title":"Environ Res"},{"issue":"2-4","key":"10.1016\/j.jacadv.2026.103163_bib28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/14690667211040207","article-title":"Identification of newly formed toxic chemicals in e-cigarette aerosols with Orbitrap mass spectrometry and implications on e-cigarette control","volume":"27","author":"Yan","year":"2021","journal-title":"Eur J Mass Spectrom (Chichester)"},{"issue":"6","key":"10.1016\/j.jacadv.2026.103163_bib29","article-title":"Cigarette smoking, incident coronary heart disease, and coronary artery calcification in Black adults: the Jackson Heart Study","volume":"10","author":"Oshunbade","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2026.103163_bib30","series-title":"StatPearls","article-title":"Coronary artery calcification","author":"Mohan","year":"2023"},{"issue":"16","key":"10.1016\/j.jacadv.2026.103163_bib31","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.jacc.2024.07.020","article-title":"Urinary metal levels and coronary artery calcification: longitudinal evidence in the Multi-Ethnic Study of Atherosclerosis","volume":"84","author":"McGraw","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jacadv.2026.103163_bib32","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3109\/10641963.2016.1148161","article-title":"Effects of cigarette smoking on ambulatory blood pressure, heart rate, and heart rate variability in treated hypertensive patients","volume":"38","author":"Ohta","year":"2016","journal-title":"Clin Exp Hypertens"},{"issue":"23","key":"10.1016\/j.jacadv.2026.103163_bib33","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.017317","article-title":"Twenty-four-hour cardiovascular effects of electronic cigarettes compared with cigarette smoking in dual users","volume":"9","author":"Benowitz","year":"2020","journal-title":"J Am Heart Assoc"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26005843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26005843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:23:51Z","timestamp":1788380631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X26005843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"alternative-id":["S2772963X26005843"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.103163","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"E-Cigarette Use and Early Cardiovascular Risk in Young Adults","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.103163","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"103163"}}