{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:18:30Z","timestamp":1788985110615,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jacadv.2026.103206","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:02:37Z","timestamp":1788984157000},"page":"103206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Evolving Burden, Disparities, Drivers, and Prevention Priorities of Heart Failure in the United States"],"prefix":"10.1016","author":[{"given":"Laiang","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl L.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-7324","authenticated-orcid":false,"given":"Nathan D.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6652-9431","authenticated-orcid":false,"given":"Wenjun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacadv.2026.103206_bib1","first-page":"e41","article-title":"2025 Heart disease and stroke statistics: a report of US and Global data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.103206_bib2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/HHF.0b013e318291329a","article-title":"Forecasting the impact of Heart Failure in the United States","volume":"6","author":"Heidenreich","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacadv.2026.103206_bib3","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.cardfail.2023.07.006","article-title":"Heart failure epidemiology and outcomes statistics: a report of the Heart Failure Society of America","volume":"29","author":"Bozkurt","year":"2023","journal-title":"J Card Fail"},{"key":"10.1016\/j.jacadv.2026.103206_bib4","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1136\/heartjnl-2021-320131","article-title":"Prevalence, incidence and survival of heart failure: a systematic review","volume":"108","author":"Emmons-Bell","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.jacadv.2026.103206_bib5","doi-asserted-by":"crossref","DOI":"10.15420\/cfr.2023.03","article-title":"Epidemiology, clinical characteristics and cause-specific outcomes in heart failure with preserved ejection fraction","volume":"9","author":"Kapelios","year":"2023","journal-title":"Card Fail Rev"},{"issue":"24","key":"10.1016\/j.jacadv.2026.103206_bib6","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1093\/eurheartj\/ehag110","article-title":"Heart failure in the elderly: epidemiology, mechanisms, and management","volume":"47","author":"de Boer","year":"2026","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2026.103206_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11897-012-0114-8","article-title":"Aging of the United States population: impact on heart failure","volume":"9","author":"Vigen","year":"2012","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.jacadv.2026.103206_bib8","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0140-6736(25)01917-8","article-title":"Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023","volume":"406","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.jacadv.2026.103206_bib9","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/S0140-6736(25)01637-X","volume":"406","author":"Hay","year":"2025","journal-title":"Lancet"},{"issue":"22","key":"10.1016\/j.jacadv.2026.103206_bib10","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.jacc.2025.08.015","article-title":"Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023","volume":"86","year":"2025","journal-title":"JACC"},{"key":"10.1016\/j.jacadv.2026.103206_bib11","doi-asserted-by":"crossref","first-page":"e808","DOI":"10.1016\/S2214-109X(25)00013-0","article-title":"Co-occurrence patterns and related risk factors of ischaemic heart disease and ischaemic stroke across 203 countries and territories: a spatial correspondence and systematic analysis","volume":"13","author":"An","year":"2025","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.jacadv.2026.103206_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchf.2025.102572","article-title":"Global burden of heart failure in adults aged 20-49 years, 1990-2021","volume":"13","author":"Hu","year":"2025","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacadv.2026.103206_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchf.2025.03.032","article-title":"Global burden and disparities in pediatric heart failure: 1990-2021","volume":"13","author":"Yuan","year":"2025","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacadv.2026.103206_bib14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1001\/jamacardio.2018.0385","article-title":"The burden of cardiovascular diseases among US states, 1990-2016","volume":"3","author":"Roth","year":"2018","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacadv.2026.103206_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/clc.70256","article-title":"States with Highest and Lowest Cardiovascular Disease-Related Mortality in the United States (1999\u22122019): top and bottom 3","volume":"49","author":"Sohail","year":"2026","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacadv.2026.103206_bib16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/HYPERTENSIONAHA.123.21354","article-title":"Social determinants of health and disparities in hypertension and cardiovascular diseases","volume":"81","author":"Chaturvedi","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.jacadv.2026.103206_bib17","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.jacc.2023.01.042","article-title":"Assessing and addressing social determinants of cardiovascular health","volume":"81","author":"Brandt","year":"2023","journal-title":"JACC"},{"key":"10.1016\/j.jacadv.2026.103206_bib18","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/j.mayocp.2020.12.034","article-title":"Geographic variation in cardiovascular health among American adults","volume":"96","author":"Parcha","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jacadv.2026.103206_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2025.101875","article-title":"Exposing inequality","volume":"4","author":"Thamman","year":"2025","journal-title":"JACC Adv"},{"key":"10.1016\/j.jacadv.2026.103206_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jacc.2024.04.054","article-title":"Geographic disparities in access to cardiologists in the United States","volume":"84","author":"Kim","year":"2024","journal-title":"JACC"},{"key":"10.1016\/j.jacadv.2026.103206_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101014","article-title":"County-level variation in triple guideline-directed medical therapy in heart failure with reduced ejection fraction","volume":"3","author":"Desai","year":"2024","journal-title":"JACC Adv"},{"key":"10.1016\/j.jacadv.2026.103206_bib22","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.jacc.2012.07.022","article-title":"The population burden of heart failure attributable to modifiable risk factors","volume":"60","author":"Avery","year":"2012","journal-title":"JACC"},{"key":"10.1016\/j.jacadv.2026.103206_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jchf.2019.11.001","article-title":"Race and sex differences in modifiable risk factors and incident heart failure","volume":"8","author":"Kubicki","year":"2020","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacadv.2026.103206_bib24","article-title":"Type 2 Diabetes Mellitus and Heart Failure: A scientific statement from the American Heart Association and the Heart Failure Society of America: This statement does not represent an update of the 2017 ACC\/AHA\/HFSA heart failure guideline update","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.103206_bib25","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jacc.2025.06.055","article-title":"The adipokine hypothesis of heart failure with a preserved ejection fraction","volume":"86","author":"Packer","year":"2025","journal-title":"JACC"},{"key":"10.1016\/j.jacadv.2026.103206_bib26","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/j.jacc.2019.01.067","article-title":"Dietary patterns and incident heart failure in U.S. adults without known coronary disease","volume":"73","author":"Lara","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacadv.2026.103206_bib27","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.jacc.2022.02.025","article-title":"Nutrition assessment and dietary interventions in heart failure","volume":"79","author":"Driggin","year":"2022","journal-title":"JACC"},{"key":"10.1016\/j.jacadv.2026.103206_bib28","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.cardfail.2015.10.004","article-title":"Nutritional interventions in heart failure: a systematic review of the literature","volume":"21","author":"Abshire","year":"2015","journal-title":"J Cardiac Fail"},{"key":"10.1016\/j.jacadv.2026.103206_bib29","doi-asserted-by":"crossref","DOI":"10.1289\/EHP11506","article-title":"Effect of air pollution on heart failure: systematic review and meta-analysis","volume":"131","author":"Jia","year":"2023","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jacadv.2026.103206_bib30","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0140-6736(13)60898-3","article-title":"Global association of air pollution and heart failure: a systematic review and meta-analysis","volume":"382","author":"Shah","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jacadv.2026.103206_bib31","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1093\/eurheartj\/ehz835","article-title":"Sex differences in heart failure","volume":"40","author":"Lam","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2026.103206_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018574","article-title":"Sex differences in heart failure with preserved ejection fraction","volume":"10","author":"Sotomi","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2026.103206_bib33","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.119.006539","article-title":"Sex-related differences in heart failure with preserved ejection fraction","volume":"12","author":"Dewan","year":"2019","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacadv.2026.103206_bib34","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.3390\/ijms25126661","article-title":"Hypertension and heart failure: from pathophysiology to treatment","volume":"25","author":"Gallo","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jacadv.2026.103206_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1161\/HYPERTENSIONAHA.122.19373","article-title":"Growing heart failure burden of hypertensive heart disease: a call to action","volume":"80","author":"D\u00edez","year":"2023","journal-title":"Hypertension"},{"key":"10.1016\/j.jacadv.2026.103206_bib36","doi-asserted-by":"crossref","first-page":"ii40","DOI":"10.1093\/europace\/euaa368","article-title":"The bidirectional interaction between atrial fibrillation and heart failure: consequences for the management of both diseases","volume":"23","author":"Verhaert","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.jacadv.2026.103206_bib37","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.108.821306","article-title":"Atrial fibrillation and heart failure","volume":"119","author":"Anter","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.103206_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2024.102621","article-title":"Trends of hypertensive heart disease prevalence and mortality in the United States between the period 1990-2019, Global Burden of Disease Database","volume":"49","author":"Abughazaleh","year":"2024","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.jacadv.2026.103206_bib39","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1161\/CIR.0000000000001256","article-title":"Forecasting the burden of cardiovascular disease and stroke in the United States through 2050-Prevalence of risk factors and disease: a presidential advisory from the American Heart Association","volume":"150","author":"Joynt Maddox","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.103206_bib40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jchf.2017.10.006","article-title":"Clinical characteristics and outcome of methamphetamine-associated pulmonary arterial hypertension and dilated cardiomyopathy","volume":"6","author":"Zhao","year":"2018","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacadv.2026.103206_bib41","article-title":"Clinical Characteristics and Management of Methamphetamine-Associated Cardiomyopathy: State-of-the-art review","year":"2026","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacadv.2026.103206_bib42","doi-asserted-by":"crossref","first-page":"e840","DOI":"10.1161\/CIR.0000000000000664","article-title":"Cardiorenal syndrome: classification, pathophysiology, diagnosis, and treatment strategies: a scientific statement from the American Heart Association","volume":"139","author":"Rangaswami","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.103206_bib43","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1161\/CIR.0000000000001273","article-title":"Evaluation and management of kidney dysfunction in advanced heart failure: a scientific statement from the American Heart Association","volume":"150","author":"Tang","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.103206_bib44","article-title":"The interplay between heart failure and chronic kidney disease","year":"2025","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jacadv.2026.103206_bib45","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1161\/CIRCULATIONAHA.124.071689","article-title":"Cardiovascular, kidney, and safety outcomes with GLP-1 receptor agonists alone and in combination with SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis","volume":"150","author":"Neuen","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jacadv.2026.103206_bib46","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.jchf.2024.07.006","article-title":"GLP-1 receptor agonists among patients with overweight or obesity, diabetes, and HFpEF on SGLT2 inhibitors","volume":"12","author":"Patel","year":"2024","journal-title":"JACC Heart Fail"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26006277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26006277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:02:43Z","timestamp":1788984163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X26006277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"alternative-id":["S2772963X26006277"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.103206","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Evolving Burden, Disparities, Drivers, and Prevention Priorities of Heart Failure in the United States","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.103206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"103206"}}