{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:35:11Z","timestamp":1793216111604,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Advances"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jacadv.2026.103268","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:14:30Z","timestamp":1790180070000},"page":"103268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Venous Thromboembolism in Severe Renal Insufficiency"],"prefix":"10.1016","volume":"5","author":[{"given":"Patricia","family":"Sig\u00fcenza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"L\u00f3pez-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Hern\u00e1ndez-Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Luisa","family":"Peris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Covadonga","family":"G\u00f3mez-Cuervo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Ferreiro-Celeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-6224","authenticated-orcid":false,"given":"Juan Esteban","family":"G\u00f3mez-Mesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-7721","authenticated-orcid":false,"given":"David","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-879X","authenticated-orcid":false,"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-0767","authenticated-orcid":false,"given":"Manuel","family":"Monreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacadv.2026.103268_bib1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1681\/ASN.2007030308","article-title":"Chronic kidney disease increases risk for venous thromboembolism","volume":"19","author":"Wattanakit","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jacadv.2026.103268_bib2","first-page":"838","article-title":"Chronic kidney disease stages and the risk of venous thromboembolism","volume":"112","author":"Ocak","year":"2014","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jacadv.2026.103268_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.22886","article-title":"Assessment of outcomes among patients with venous thromboembolism with and without chronic kidney disease","volume":"3","author":"Goto","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jacadv.2026.103268_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/bjh.18903","article-title":"Navigating through the haemostatic paradox in kidney failure","volume":"202","author":"Caruana","year":"2023","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jacadv.2026.103268_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212237","article-title":"Evaluation of hemostasis in patients with end-stage renal disease","volume":"14","author":"G\u00e4ckler","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jacadv.2026.103268_bib6","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41581-022-00616-6","article-title":"Epidemiology and risk of cardiovascular disease in populations with chronic kidney disease","volume":"18","author":"Matsushita","year":"2022","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jacadv.2026.103268_bib7","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/ki.2015.228","article-title":"Comorbidity as a driver of adverse outcomes in people with chronic kidney disease","volume":"88","author":"Tonelli","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.jacadv.2026.103268_bib8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1538-7836.2007.02507.x","article-title":"Frequency of renal impairment, advanced age, obesity and cancer in venous thromboembolism patients in clinical practice","volume":"5","author":"Cook","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacadv.2026.103268_bib9","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa0906598","article-title":"Dabigatran versus warfarin in the treatment of acute venous thromboembolism","volume":"361","author":"Schulman","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacadv.2026.103268_bib10","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1113572","article-title":"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism","volume":"366","author":"B\u00fcller","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacadv.2026.103268_bib11","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1302507","article-title":"Oral apixaban for the treatment of acute venous thromboembolism","volume":"369","author":"Agnelli","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacadv.2026.103268_bib12","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1056\/NEJMoa1306638","article-title":"Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism","volume":"369","author":"B\u00fcller","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacadv.2026.103268_bib13","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1182\/bloodadvances.2020001830","article-title":"American society of hematology 2020 guidelines for management of venous thromboembolism","volume":"4","author":"Ortel","year":"2020","journal-title":"Blood Adv"},{"key":"10.1016\/j.jacadv.2026.103268_bib14","doi-asserted-by":"crossref","first-page":"e545","DOI":"10.1016\/j.chest.2021.07.055","article-title":"Antithrombotic therapy for VTE disease: CHEST guideline update","volume":"160","author":"Stevens","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.jacadv.2026.103268_bib15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"ESC guidelines for diagnosis and management of acute pulmonary embolism","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacadv.2026.103268_bib16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1160\/TH17-07-0511","article-title":"Rationale, design and methodology of the RIETE registry","volume":"118","author":"Bikdeli","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jacadv.2026.103268_bib17","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.amjmed.2006.04.028","article-title":"Venous thromboembolism in patients with renal insufficiency: findings from the RIETE registry","volume":"119","author":"Monreal","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.jacadv.2026.103268_bib18","first-page":"1255","article-title":"Elevated creatinine levels and clinical outcome in patients with acute venous thromboembolism: findings from the RIETE registry","volume":"7","author":"Trujillo-Santos","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacadv.2026.103268_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.thromres.2022.08.001","article-title":"Long-term clinical outcomes in older patients with acute venous thromboembolism who have renal impairment","volume":"218","author":"Messi","year":"2022","journal-title":"Thromb Res"}],"container-title":["JACC: Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26006897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772963X26006897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:22:41Z","timestamp":1793215361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772963X26006897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2772963X26006897"],"URL":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.103268","relation":{},"ISSN":["2772-963X"],"issn-type":[{"value":"2772-963X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Venous Thromboembolism in Severe Renal Insufficiency","name":"articletitle","label":"Article Title"},{"value":"JACC: Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacadv.2026.103268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"103268"}}