{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T20:53:01Z","timestamp":1757623981302,"version":"3.44.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Asia"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jacasi.2023.08.004","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T13:57:35Z","timestamp":1698155855000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Review of Bleeding and Thrombotic Risks Associated With Antithrombotic Therapy\u00a0After Transcatheter Structural\u00a0Heart Interventions"],"prefix":"10.1016","volume":"4","author":[{"given":"Hideyuki","family":"Kawashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Numasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigemitsu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-0427","authenticated-orcid":false,"given":"Sho","family":"Torii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Ueshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Hishikari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-8450","authenticated-orcid":false,"given":"Hirofumi","family":"Hioki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-5303","authenticated-orcid":false,"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yae","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-1982","authenticated-orcid":false,"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Jujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaku","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacasi.2023.08.004_bib1","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1093\/eurheartj\/ehz372","article-title":"Defining high bleeding risk in patients undergoing percutaneous coronary intervention: a consensus document from the Academic Research Consortium for High Bleeding Risk","volume":"40","author":"Urban","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2023.08.004_bib2","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib3","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.jcin.2017.04.034","article-title":"Frequency, timing, and impact of access-site and non-access-site bleeding on mortality among patients undergoing transcatheter aortic valve replacement","volume":"10","author":"Piccolo","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacasi.2023.08.004_bib4","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1056\/NEJMoa1915152","article-title":"Anticoagulation with or without clopidogrel after transcatheter aortic-valve implantation","volume":"382","author":"Nijenhuis","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis","volume":"349","author":"Vincentelli","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib6","doi-asserted-by":"crossref","first-page":"oeab036","DOI":"10.1093\/ehjopen\/oeab036","article-title":"Academic Research Consortium High Bleeding Risk Criteria associated with 2-year bleeding events and mortality after transcatheter aortic valve replacement discharge: a Japanese Multicentre Prospective OCEAN-TAVI Registry Study","volume":"1","author":"Mizutani","year":"2021","journal-title":"Eur Heart J Open"},{"key":"10.1016\/j.jacasi.2023.08.004_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000511621","article-title":"Temporary trends in fever following transcatheter aortic valve implantation","volume":"146","author":"Witberg","year":"2021","journal-title":"Cardiology"},{"key":"10.1016\/j.jacasi.2023.08.004_bib8","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib9","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib10","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1056\/NEJMc1408396","article-title":"Transcatheter aortic-valve replacement with a self-expanding prosthesis","volume":"371","author":"Adams","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jacc.2015.05.025","article-title":"The incidence and predictors of early- and mid-term clinically relevant neurological events after transcatheter aortic valve replacement in real-world patients","volume":"66","author":"Bosmans","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2023.08.004_bib12","doi-asserted-by":"crossref","first-page":"9593","DOI":"10.1038\/s41598-021-89217-0","article-title":"Late stroke after transcatheter aortic valve replacement: a nationwide study","volume":"11","author":"Bjursten","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacasi.2023.08.004_bib13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jcin.2016.10.043","article-title":"Left atrial appendage thrombus in transcatheter aortic valve replacement: incidence, clinical impact, and the role of cardiac computed tomography","volume":"10","author":"Palmer","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacasi.2023.08.004_bib14","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.jcin.2018.09.001","article-title":"Incidence, clinical characteristics, and impact of acute coronary syndrome following transcatheter aortic valve replacement","volume":"11","author":"Vilalta","year":"2018","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacasi.2023.08.004_bib15","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1056\/NEJMoa2111016","article-title":"Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR","volume":"385","author":"Van Mieghem","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib16","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMoa1509233","article-title":"Possible subclinical leaflet thrombosis in bioprosthetic aortic valves","volume":"373","author":"Makkar","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jcin.2017.01.045","article-title":"Clinical bioprosthetic heart valve thrombosis after transcatheter aortic valve replacement: incidence, characteristics, and treatment outcomes","volume":"10","author":"Jose","year":"2017","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacasi.2023.08.004_bib18","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0140-6736(17)30757-2","article-title":"Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study","volume":"389","author":"Chakravarty","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jacasi.2023.08.004_bib19","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/eurheartj\/ehx369","article-title":"Natural history of subclinical leaflet thrombosis affecting motion in bioprosthetic aortic valves","volume":"38","author":"Sondergaard","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2023.08.004_bib20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1056\/NEJMoa1911426","article-title":"Reduced leaflet motion after transcatheter aortic-valve replacement","volume":"382","author":"De Backer","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib21","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jacasi.2023.08.004_bib22","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2023.08.004_bib23","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1253\/circj.CJ-20-0135","article-title":"JCS\/JSCS\/JATS\/JSVS 2020 guidelines on the management of valvular heart disease","volume":"84","author":"Izumi","year":"2020","journal-title":"Circ J"},{"key":"10.1016\/j.jacasi.2023.08.004_bib24","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1016\/j.jcin.2020.09.013","article-title":"Direct oral anticoagulants versus vitamin k antagonists in patients with atrial fibrillation after TAVR","volume":"13","author":"Kawashima","year":"2020","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacasi.2023.08.004_bib25","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1056\/NEJMoa2111016","article-title":"Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR","volume":"385","author":"Van Mieghem","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib26","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1093\/eurheartj\/ehac242","article-title":"Apixaban vs. standard of care after transcatheter aortic valve implantation: the ATLANTIS trial","volume":"43","author":"Collet","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2023.08.004_bib27","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa1911425","article-title":"A\u00a0Controlled trial of rivaroxaban after transcatheter aortic-valve replacement","volume":"382","author":"Dangas","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib28","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1056\/NEJMoa2017815","article-title":"Aspirin with or without clopidogrel after transcatheter aortic-valve implantation","volume":"383","author":"Brouwer","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jcin.2022.10.010","article-title":"No antithrombotic therapy after transcatheter aortic valve replacement: insight from the OCEAN-TAVI registry","volume":"16","author":"Kobari","year":"2023","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacasi.2023.08.004_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.120.010097","article-title":"Aspirin versus clopidogrel as single antithrombotic therapy after transcatheter aortic valve replacement: insight from the OCEAN-TAVI Registry","volume":"14","author":"Kobari","year":"2021","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jacasi.2023.08.004_bib31","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"Feldman","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib32","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jacc.2013.10.021","article-title":"Improved functional status and quality of life in prohibitive surgical risk patients with degenerative mitral regurgitation after transcatheter mitral valve repair","volume":"64","author":"Lim","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2023.08.004_bib33","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0735-1097(02)01922-8","article-title":"Atrial fibrillation complicating the course of degenerative mitral regurgitation: determinants and long-term outcome","volume":"40","author":"Grigioni","year":"2002","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2023.08.004_bib34","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacasi.2023.08.004_bib35","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/STROKEAHA.120.029267","article-title":"Prevalence and outcome of potential candidates for left atrial appendage closure after stroke with atrial fibrillation: WATCH-AF Registry","volume":"51","author":"Ong","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.jacasi.2023.08.004_bib36","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","article-title":"Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial","volume":"374","author":"Holmes","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jacasi.2023.08.004_bib37","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1161\/CIRCULATIONAHA.112.114389","article-title":"Percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation: 2.3-Year Follow-up of the PROTECT AF (Watchman Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation) Trial","volume":"127","author":"Reddy","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacasi.2023.08.004_bib38","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1001\/jama.2014.15192","article-title":"Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial","volume":"312","author":"Reddy","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jacasi.2023.08.004_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2014.04.029","article-title":"Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial","volume":"64","author":"Holmes","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2023.08.004_bib40","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1016\/j.jacc.2013.03.035","article-title":"Left atrial appendage closure with the Watchman device in patients with a contraindication for oral anticoagulation: the ASAP study (ASA Plavix Feasibility Study With Watchman Left Atrial Appendage Closure Technology)","volume":"61","author":"Reddy","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2023.08.004_bib41","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1093\/eurheartj\/ehv730","article-title":"Implant success and safety of left atrial appendage closure with the WATCHMAN device: peri-procedural outcomes from the EWOLUTION registry","volume":"37","author":"Boersma","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2023.08.004_bib42","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jcin.2019.04.004","article-title":"Propensity-matched comparison of oral anticoagulation versus antiplatelet therapy after left atrial appendage closure with WATCHMAN","volume":"12","author":"Sondergaard","year":"2019","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacasi.2023.08.004_bib43","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.jacc.2022.02.047","article-title":"Antithrombotic therapy after left atrial appendage occlusion in patients with atrial fibrillation","volume":"79","author":"Freeman","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2023.08.004_bib44","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrcardio.2014.104","article-title":"Expert consensus document: World Heart Federation expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI","volume":"11","author":"Levine","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacasi.2023.08.004_bib45","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1253\/circj.CJ-21-0162","article-title":"JCS\/JHRS 2021 guideline focused update on non-pharmacotherapy of cardiac arrhythmias","volume":"86","author":"Nogami","year":"2022","journal-title":"Circ J"}],"container-title":["JACC: Asia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772374723002387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772374723002387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T09:58:28Z","timestamp":1757411908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772374723002387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S2772374723002387"],"URL":"https:\/\/doi.org\/10.1016\/j.jacasi.2023.08.004","relation":{},"ISSN":["2772-3747"],"issn-type":[{"type":"print","value":"2772-3747"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Review of Bleeding and Thrombotic Risks Associated With Antithrombotic Therapy\u00a0After Transcatheter Structural\u00a0Heart Interventions","name":"articletitle","label":"Article Title"},{"value":"JACC: Asia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacasi.2023.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}