{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:02:11Z","timestamp":1776384131180,"version":"3.51.2"},"reference-count":16,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Asia"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jacasi.2025.12.005","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T21:25:45Z","timestamp":1769030745000},"page":"433-435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Cholesterol"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-7287","authenticated-orcid":false,"given":"Amr A.","family":"Arafat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed M.","family":"AlAklabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jacasi.2025.12.005_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101133","article-title":"Valvular heart disease-related mortality between middle- and high-income countries during 2000 to 2019","volume":"3","author":"Hibino","year":"2024","journal-title":"JACC Adv"},{"key":"10.1016\/j.jacasi.2025.12.005_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpc.2025.100956","article-title":"The burden of cardiovascular disease in children in Asian countries (1990-2021): systematic analysis and projection of the burden of disease","volume":"21","author":"Li","year":"2025","journal-title":"Am J Prev Cardiol"},{"issue":"6","key":"10.1016\/j.jacasi.2025.12.005_bib3","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jacasi.2025.03.011","article-title":"Epidemiology of valvular heart disease in Asia Pacific region","volume":"5","author":"Chak-yu","year":"2025","journal-title":"JACC Asia"},{"key":"10.1016\/j.jacasi.2025.12.005_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.685746","article-title":"Mitral valve surgery in patients with rheumatic heart disease: repair vs. replacement","volume":"8","author":"Fu","year":"2021","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"10.1016\/j.jacasi.2025.12.005_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-03149-7","article-title":"Serum metabolic profiling in rheumatic heart disease and degenerative aortic stenosis","volume":"15","author":"Mutithu","year":"2025","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jacasi.2025.12.005_bib6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jacasi.2025.07.025","article-title":"The effect of high-density lipoprotein on the rheumatic mitral valve calcification and surgical prognosis","volume":"6","author":"Liu","year":"2026","journal-title":"JACC Asia"},{"issue":"6","key":"10.1016\/j.jacasi.2025.12.005_bib7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.numecd.2015.02.001","article-title":"The lipid theory in the pathogenesis of calcific aortic stenosis","volume":"25","author":"Parisi","year":"2015","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"10","key":"10.1016\/j.jacasi.2025.12.005_bib8","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1161\/ATVBAHA.122.318004","article-title":"High-density lipoprotein and long-term incidence and progression of aortic valve calcification: the Multi-Ethnic Study of Atherosclerosis","volume":"42","author":"Bortnick","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.jacasi.2025.12.005_bib9","article-title":"Mitral annular calcification score by computed tomography in patients undergoing mitral valve surgery","volume":"3","author":"Okushi","year":"2025","journal-title":"Eur Heart J Imaging Methods Pract"},{"issue":"3","key":"10.1016\/j.jacasi.2025.12.005_bib10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.athoracsur.2015.08.071","article-title":"Mitral valve surgery in patients with severe mitral annular calcification","volume":"101","author":"Uchimuro","year":"2016","journal-title":"Ann Thorac Surg"},{"issue":"8","key":"10.1016\/j.jacasi.2025.12.005_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezaf276","article-title":"2025 ESC\/EACTS Guidelines for the management of valvular heart disease: developed by the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"67","author":"Praz","year":"2025","journal-title":"Eur J Cardiothorac Surg"},{"issue":"5","key":"10.1016\/j.jacasi.2025.12.005_bib12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/MOL.0000000000000782","article-title":"HDL and persistent inflammation immunosuppression and catabolism syndrome","volume":"32","author":"Barker","year":"2021","journal-title":"Curr Opin Lipidol"},{"issue":"10","key":"10.1016\/j.jacasi.2025.12.005_bib13","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3390\/ph15101278","article-title":"Alterations of HDL\u2019s to piHDL\u2019s proteome in patients with chronic inflammatory diseases, and HDL-targeted therapies","volume":"15","author":"Vyletelov\u00e1","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"issue":"7","key":"10.1016\/j.jacasi.2025.12.005_bib14","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.3390\/ijms23073967","article-title":"The current status of research on high-density lipoproteins (HDL): a paradigm shift from HDL quantity to HDL quality and HDL functionality","volume":"23","author":"Cho","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.jacasi.2025.12.005_bib15","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3390\/cells10081869","article-title":"HDL in atherosclerotic cardiovascular disease: in search of a role","volume":"10","author":"Casula","year":"2021","journal-title":"Cells"},{"issue":"23","key":"10.1016\/j.jacasi.2025.12.005_bib16","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1161\/CIRCULATIONAHA.120.044221","article-title":"HDL in the 21st century: a multifunctional roadmap for future HDL research","volume":"143","author":"Rohatgi","year":"2021","journal-title":"Circulation"}],"container-title":["JACC: Asia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277237472500701X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S277237472500701X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:16:02Z","timestamp":1776381362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S277237472500701X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S277237472500701X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacasi.2025.12.005","relation":{},"ISSN":["2772-3747"],"issn-type":[{"value":"2772-3747","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond Cholesterol","name":"articletitle","label":"Article Title"},{"value":"JACC: Asia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacasi.2025.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacasi.2025.07.025","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}