{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:11:30Z","timestamp":1778051490992,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Asia"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jacasi.2026.01.036","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:42:43Z","timestamp":1778010163000},"page":"709-720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Persistent Atrial Fibrillation With Conduction System Pacing or Pulmonary Vein Isolation"],"prefix":"10.1016","volume":"6","author":[{"given":"Shengjie","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxuan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihe","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-569X","authenticated-orcid":false,"given":"Kenneth A.","family":"Ellenbogen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacasi.2026.01.036_bib1","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart Disease and Stroke Statistics-2023 Update: a report from the American Heart Association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jacasi.2026.01.036_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jacc.2023.08.017","article-title":"2023 ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"83","author":"Writing Committee Members","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib3","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/j.jacep.2023.07.014","article-title":"Catheter ablation of persistent atrial fibrillation: are we better than we think?","volume":"9","author":"Bennett","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijcard.2022.06.058","article-title":"Atrioventricular node ablation and pacing for atrial tachyarrhythmias: a meta-analysis of postoperative outcomes","volume":"363","author":"Baudo","year":"2022","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib5","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.hrthm.2022.07.009","article-title":"His-bundle pacing vs biventricular pacing following atrioventricular nodal ablation in patients with atrial fibrillation and reduced ejection fraction: a multicenter, randomized, crossover study-The ALTERNATIVE-AF trial","volume":"19","author":"Huang","year":"2022","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacasi.2026.01.036_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014253","article-title":"Feasibility and efficacy of His bundle pacing or left bundle pacing combined with atrioventricular node ablation in patients with persistent atrial fibrillation and implantable cardioverter-defibrillator therapy","volume":"8","author":"Wang","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacasi.2026.01.036_bib7","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1093\/eurheartj\/ehae656","article-title":"Atrioventricular node ablation for atrial fibrillation in the era of conduction system pacing","volume":"45","author":"Joza","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2026.01.036_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euaf050","volume":"27","author":"Glikson","year":"2025","journal-title":"Europace"},{"key":"10.1016\/j.jacasi.2026.01.036_bib9","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.hrthm.2023.03.1538","article-title":"2023 HRS\/APHRS\/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure","volume":"20","author":"Chung","year":"2023","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacasi.2026.01.036_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ccep.2018.05.016","article-title":"Pacing treatment of atrial fibrillation patients with heart failure: His bundle pacing combined with atrioventricular node ablation","volume":"10","author":"Huang","year":"2018","journal-title":"Card Electrophysiol Clin"},{"key":"10.1016\/j.jacasi.2026.01.036_bib11","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005309","article-title":"Benefits of permanent his bundle pacing combined with atrioventricular node ablation in atrial fibrillation patients with heart failure with both preserved and reduced left ventricular ejection fraction","volume":"6","author":"Huang","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacasi.2026.01.036_bib12","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.hrthm.2019.06.016","article-title":"A beginner's guide to permanent left bundle branch pacing","volume":"16","author":"Huang","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacasi.2026.01.036_bib13","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.jacep.2021.02.018","article-title":"Evaluation of the criteria to distinguish left bundle branch pacing from left ventricular septal pacing","volume":"7","author":"Wu","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/europace\/euaa344","article-title":"Cryoablation vs. radiofrequency ablation of the atrioventricular node in patients with His-bundle pacing","volume":"23","author":"Zweerink","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.jacasi.2026.01.036_bib15","article-title":"Which is better? Rate versus rhythm control in atrial fibrillation: a systematic review","volume":"15","author":"Olanisa","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.jacasi.2026.01.036_bib16","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.124.012988","article-title":"Rate versus rhythm control for atrial fibrillation: the epilogue of the tale of two rhythms","volume":"17","author":"Al-Khatib","year":"2024","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib17","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1161\/CIRCULATIONAHA.121.057095","article-title":"Randomized ablation-based rhythm-control versus rate-control trial in patients with heart failure and atrial fibrillation: results from the RAFT-AF trial","volume":"145","author":"Parkash","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jacasi.2026.01.036_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/eurheartj\/ehad572","article-title":"Atrial fibrillation progression after cryoablation vs. radiofrequency ablation: the CIRCA-DOSE trial","volume":"45","author":"Andrade","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2026.01.036_bib19","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1046\/j.1471-4159.2001.00207.x","article-title":"Steroidogenic factor-1 expression in marmoset and rat hippocampus: co-localization with StAR and aromatase","volume":"76","author":"Wehrenberg","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.jacasi.2026.01.036_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.115.003669","article-title":"Radiofrequency ablation of persistent atrial fibrillation: diagnosis-to-ablation time, markers of pathways of atrial remodeling, and outcomes","volume":"9","author":"Hussein","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib21","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.hrthm.2014.12.031","article-title":"Electrical dyssynchrony induced by biventricular pacing: implications for patient selection and therapy improvement","volume":"12","author":"Ploux","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacasi.2026.01.036_bib22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jce.12322","article-title":"Fusion-optimized intervals (FOI): a new method to achieve the narrowest QRS for optimization of the AV and VV intervals in patients undergoing cardiac resynchronization therapy","volume":"25","author":"Arbelo","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib23","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/clc.22312","article-title":"Effects of atrioventricular nodal ablation on permanent atrial fibrillation patients with cardiac resynchronization therapy: a systematic review and meta-analysis","volume":"37","author":"Yin","year":"2014","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib24","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1056\/NEJMoa0708234","article-title":"Pulmonary-vein isolation for atrial fibrillation in patients with heart failure","volume":"359","author":"Khan","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacasi.2026.01.036_bib25","first-page":"319","article-title":"Left bundle branch pacing for cardiac resynchronization therapy: nonrandomized on-treatment comparison with his bundle pacing and biventricular pacing","volume":"37","author":"Wu","year":"2021","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1355696","article-title":"Conduction system pacing upgrade versus biventricular pacing on pacemaker-induced cardiomyopathy: a retrospective observational study","volume":"15","author":"Pei-Pei","year":"2024","journal-title":"Front Physiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib27","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/01.CIR.101.8.869","article-title":"Permanent, direct His-bundle pacing: a novel approach to cardiac pacing in patients with normal His-Purkinje activation","volume":"101","author":"Deshmukh","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacasi.2026.01.036_bib28","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.122.010926","article-title":"Left bundle branch pacing postatrioventricular junction ablation for atrial fibrillation: propensity score matching with His bundle pacing","volume":"15","author":"Cai","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib29","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/ehf2.13181","article-title":"Impact of QRS morphology on response to conduction system pacing after atrioventricular junction ablation","volume":"8","author":"Wu","year":"2021","journal-title":"ESC Heart Failure"},{"key":"10.1016\/j.jacasi.2026.01.036_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132475","article-title":"Sex differences outcomes in conduction system pacing for patients with typical left bundle branch block","volume":"415","author":"Wu","year":"2024","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib31","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/clc.23455","article-title":"Outcome of catheter ablation in the very elderly-insights from a large matched analysis","volume":"43","author":"Willy","year":"2020","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/jce.12849","article-title":"The impact of age on 5-year outcomes after atrial fibrillation catheter ablation","volume":"27","author":"Bunch","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacasi.2026.01.036_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euae043","article-title":"2024 European Heart Rhythm Association\/Heart Rhythm Society\/Asia Pacific Heart Rhythm Society\/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation","volume":"26","author":"Tzeis","year":"2024","journal-title":"Europace"}],"container-title":["JACC: Asia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772374726001572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772374726001572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:43:47Z","timestamp":1778010227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772374726001572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2772374726001572"],"URL":"https:\/\/doi.org\/10.1016\/j.jacasi.2026.01.036","relation":{},"ISSN":["2772-3747"],"issn-type":[{"value":"2772-3747","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistent Atrial Fibrillation With Conduction System Pacing or Pulmonary Vein Isolation","name":"articletitle","label":"Article Title"},{"value":"JACC: Asia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacasi.2026.01.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}