{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T21:14:01Z","timestamp":1784150041187,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Asia"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jacasi.2026.02.016","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:19:51Z","timestamp":1775899191000},"page":"1179-1188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Complete Right Bundle Branch Block and Vascular Endothelial Function"],"prefix":"10.1016","volume":"6","author":[{"given":"Aya","family":"Mizobuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Maruhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farina Mohamad","family":"Yusoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kajikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumu","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5813-3672","authenticated-orcid":false,"given":"Yukihito","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacasi.2026.02.016_bib1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.017430","article-title":"Mortality in patients with right bundle-branch block in the absence of cardiovascular disease","volume":"9","author":"Gaba","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacasi.2026.02.016_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/13814788.2019.1639667","article-title":"Right bundle branch block: prevalence, incidence, and cardiovascular morbidity and mortality in the general population","volume":"25","author":"Alventosa-Zaidin","year":"2019","journal-title":"Eur J Gen Pract"},{"key":"10.1016\/j.jacasi.2026.02.016_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.CIR.51.3.477","article-title":"A clinical and follow-up study of right and left bundle branch block","volume":"51","author":"Rotman","year":"1975","journal-title":"Circulation"},{"key":"10.1016\/j.jacasi.2026.02.016_bib4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/clc.22454","article-title":"The prognostic significance of right bundle branch block: a meta-analysis of prospective cohort studies","volume":"38","author":"Xiong","year":"2015","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib5","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1016\/j.jelectrocard.2019.09.004","article-title":"Evaluation of mortality in bundle branch block patients from an electronic cohort: Clinical Outcomes in Digital Electrocardiography (CODE) study","volume":"57S","author":"Paixao","year":"2019","journal-title":"J Electrocardiol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1378\/chest.108.1.83","article-title":"Prediction on admission of in-hospital mortality in patients older than 70 years with acute myocardial infarction","volume":"108","author":"Su\u00e1rez","year":"1995","journal-title":"Chest"},{"key":"10.1016\/j.jacasi.2026.02.016_bib7","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1016\/j.hrthm.2024.06.057","article-title":"Bundle branch blocks and cardiovascular mortality in chronic coronary syndrome","volume":"21","author":"Gelbenegger","year":"2024","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacasi.2026.02.016_bib8","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1093\/eurheartj\/14.12.1590","article-title":"The epidemiology of right bundle branch block and its association with cardiovascular morbidity--the Reykjavik Study","volume":"14","author":"Thrainsdottir","year":"1993","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.jacasi.2026.02.016_bib9","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.jacc.2018.10.043","volume":"74","author":"Kusumoto","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib10","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1016\/j.jacc.2017.10.054","volume":"72","author":"Al-Khatib","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib11","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2026.02.016_bib12","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","volume":"42","author":"Visseren","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2026.02.016_bib13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.CIR.0000153339.27064.14","article-title":"Endothelial function: cardiac events","volume":"111","author":"Lerman","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacasi.2026.02.016_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"Corretti","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib15","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1161\/01.CIR.0000095273.92468.D9","article-title":"Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index","volume":"108","author":"Brevetti","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacasi.2026.02.016_bib16","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1136\/heartjnl-2013-304739","article-title":"Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study","volume":"99","author":"Maruhashi","year":"2013","journal-title":"Heart"},{"key":"10.1016\/j.jacasi.2026.02.016_bib17","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1253\/circj.CJ-08-1102","article-title":"Endothelial function and oxidative stress in cardiovascular diseases","volume":"73","author":"Higashi","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.jacasi.2026.02.016_bib18","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1161\/HYPERTENSIONAHA.115.06839","article-title":"Combination of flow-mediated vasodilation and nitroglycerine-induced vasodilation is more effective for prediction of cardiovascular events","volume":"67","author":"Kajikawa","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.jacasi.2026.02.016_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s12872-023-03235-6","article-title":"A nomogram based on endothelial function and conventional risk factors predicts coronary artery disease in hypertensives","volume":"23","author":"Huang","year":"2023","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.jacasi.2026.02.016_bib20","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.jacasi.2026.02.016_bib21","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"issue":"suppl 1","key":"10.1016\/j.jacasi.2026.02.016_bib22","first-page":"S1","article-title":"clinical practice recommendations 1999","volume":"22","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jacasi.2026.02.016_bib23","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.amjmed.2006.06.040","article-title":"Prevalence of the metabolic syndrome in individuals with hyperuricemia","volume":"120","author":"Choi","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.jacasi.2026.02.016_bib24","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1161\/ATVBAHA.112.300934","article-title":"Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation","volume":"33","author":"Maruhashi","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib25","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/eurheartj\/ehz350","article-title":"Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans","volume":"40","author":"Thijssen","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2026.02.016_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0287759","article-title":"Intra and inter-rater repeatability of brachial artery ultrasound estimates of flow-mediated slowing and flow-mediated dilation","volume":"18","author":"Mar\u00f4co","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jacasi.2026.02.016_bib27","article-title":"Prevalence and clinical significance of electrocardiographic complete right bundle branch block in young individuals","author":"MacLachlan","year":"2024","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib28","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/eurheartj\/ehs291","article-title":"Right bundle branch block: prevalence, risk factors, and outcome in the general population: results from the Copenhagen City Heart Study","volume":"34","author":"Bussink","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2026.02.016_bib29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijcard.2020.12.012","article-title":"Clinical factors associated with the intraventricular conduction disturbances in Swiss middle-aged adults: the CoLaus|PsyCoLaus study","volume":"327","author":"Bay","year":"2021","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib30","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1161\/01.RES.31.4.531","article-title":"Focal lesions in the canine bundle of His: their effect on ventricular excitation","volume":"31","author":"Watt","year":"1972","journal-title":"Circulation Research"},{"key":"10.1016\/j.jacasi.2026.02.016_bib31","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1536\/ihj.16.526","article-title":"A clinicopathological study of the heart diseases in the aged. The morphological classification of the 1,000 consecutive autopsy cases","volume":"16","author":"Sugiura","year":"1975","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.jacasi.2026.02.016_bib32","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/eurheartj\/ehr291","article-title":"Primary angioplasty in acute myocardial infarction with right bundle branch block: should new onset right bundle branch block be added to future guidelines as an indication for reperfusion therapy?","volume":"33","author":"Widimsky","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacasi.2026.02.016_bib33","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.0954-6820.1978.tb14920.x","article-title":"Left anterior hemiblock in acute myocardial infarction. Incidence and clinical significance in relation to the presence of bundle branch block and to the absence of intraventricular conduction defects","volume":"203","author":"Otterstad","year":"1978","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.jacasi.2026.02.016_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.amjms.2015.10.005","article-title":"Comorbidities of chronic complete right bundle branch block and correlations with coronary angiographic findings","volume":"351","author":"Arham","year":"2016","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jacasi.2026.02.016_bib35","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/s41440-019-0240-8","article-title":"Relationship between home blood pressure and vascular function in patients receiving antihypertensive drug treatment","volume":"42","author":"Maruhashi","year":"2019","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jacasi.2026.02.016_bib36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijcard.2017.11.022","article-title":"Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension","volume":"253","author":"Tomiyama","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacasi.2026.02.016_bib37","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s00380-019-01523-w","article-title":"The impact of right bundle branch block on right ventricular size and function assessed by three-dimensional speckle-tracking echocardiography","volume":"35","author":"Nakazawa","year":"2020","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jacasi.2026.02.016_bib38","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.21037\/qims-23-959","article-title":"Ventricular dysfunction consequences of mechanical dyssynchrony in isolated complete right bundle branch block versus left bundle branch block","volume":"14","author":"Chen","year":"2024","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.jacasi.2026.02.016_bib39","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1536\/ihj.18-495","article-title":"Early assessment of left ventricular function by layer-specific strain and its relationship to pulsatile arterial load in patients with coronary slow flow","volume":"60","author":"Shi","year":"2019","journal-title":"Int Heart J"}],"container-title":["JACC: Asia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772374726001134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772374726001134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:38:01Z","timestamp":1784147881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772374726001134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2772374726001134"],"URL":"https:\/\/doi.org\/10.1016\/j.jacasi.2026.02.016","relation":{},"ISSN":["2772-3747"],"issn-type":[{"value":"2772-3747","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association Between Complete Right Bundle Branch Block and Vascular Endothelial Function","name":"articletitle","label":"Article Title"},{"value":"JACC: Asia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacasi.2026.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}