{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:26:47Z","timestamp":1788470807521,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Asia"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jacasi.2026.07.021","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:47:24Z","timestamp":1788378444000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporal Analysis of Acute Aortic Syndrome in Jiangsu, China From Medical Record Front Page Registry"],"prefix":"10.1016","author":[{"given":"Ziwei","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenda","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaochu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzhi","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1132-1796","authenticated-orcid":false,"given":"Yongyue","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-7531","authenticated-orcid":false,"given":"Qingguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"41","key":"10.1016\/j.jacasi.2026.07.021_bib1","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"issue":"17","key":"10.1016\/j.jacasi.2026.07.021_bib2","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the international registry of acute aortic dissection: a 20-Year experience of collaborative clinical research","volume":"137","author":"Evangelista","year":"2018","journal-title":"Circulation"},{"issue":"9632","key":"10.1016\/j.jacasi.2026.07.021_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0140-6736(08)60994-0","article-title":"Acute aortic dissection","volume":"372","author":"Golledge","year":"2008","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jacasi.2026.07.021_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacasi.2026.07.021_bib5","doi-asserted-by":"crossref","first-page":"d8290","DOI":"10.1136\/bmj.d8290","article-title":"The diagnosis and management of aortic dissection","volume":"344","author":"Thrumurthy","year":"2011","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.jacasi.2026.07.021_bib6","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1161\/01.CIR.0000027568.39540.4B","article-title":"Chronobiological patterns of acute aortic dissection","volume":"106","author":"Mehta","year":"2002","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.jacasi.2026.07.021_bib7","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jama.283.7.897","article-title":"The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease","volume":"283","author":"Hagan","year":"2000","journal-title":"Jama"},{"issue":"9970","key":"10.1016\/j.jacasi.2026.07.021_bib8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0140-6736(14)61005-9","article-title":"Management of acute aortic dissection","volume":"385","author":"Nienaber","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jacasi.2026.07.021_bib9","first-page":"100280","article-title":"Incidence and survival of aortic dissection in urban China: results from the national insurance claims for epidemiological research (NICER) study","volume":"17","author":"Tang","year":"2021","journal-title":"Lancet Reg Health West Pac"},{"issue":"4","key":"10.1016\/j.jacasi.2026.07.021_bib10","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ejvs.2024.12.003","article-title":"Aortic dissection incidence and risk factor analysis: findings from the China Kadoorie Biobank","volume":"69","author":"Chen","year":"2025","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jacasi.2026.07.021_bib11","first-page":"100021","article-title":"Incidence of neuromyelitis optica spectrum disorder (NMOSD) in China: a national population-based study","volume":"2","author":"Tian","year":"2020","journal-title":"Lancet Reg Health West Pac"},{"issue":"10002","key":"10.1016\/j.jacasi.2026.07.021_bib12","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0140-6736(15)00343-8","article-title":"Achieving best outcomes for patients with cardiovascular disease in China by enhancing the quality of medical care and establishing a learning health-care system","volume":"386","author":"Jiang","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jacasi.2026.07.021_bib13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2471\/BLT.15.153148","article-title":"An integrated national mortality surveillance system for death registration and mortality surveillance, China","volume":"94","author":"Liu","year":"2016","journal-title":"Bull World Health Organ"},{"issue":"3","key":"10.1016\/j.jacasi.2026.07.021_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z","article-title":"Permutation tests for joinpoint regression with applications to cancer rates","volume":"19","author":"Kim","year":"2000","journal-title":"Stat Med"},{"issue":"3","key":"10.1016\/j.jacasi.2026.07.021_bib16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/096228029200100306","article-title":"Analysing the temporal effects of age, period and cohort","volume":"1","author":"Holford","year":"1992","journal-title":"Stat Methods Med Res"},{"issue":"11","key":"10.1016\/j.jacasi.2026.07.021_bib17","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1158\/1055-9965.EPI-14-0300","article-title":"A web tool for age-period-cohort analysis of cancer incidence and mortality rates","volume":"23","author":"Rosenberg","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"10.1016\/j.jacasi.2026.07.021_bib19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4065\/79.2.176","article-title":"Acute aortic dissection: population-based incidence compared with degenerative aortic aneurysm rupture","volume":"79","author":"Clouse","year":"2004","journal-title":"Mayo Clin Proc"},{"issue":"24","key":"10.1016\/j.jacasi.2026.07.021_bib20","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1161\/CIRCULATIONAHA.106.630400","article-title":"Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002","volume":"114","author":"Olsson","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.jacasi.2026.07.021_bib21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jvs.2021.08.080","article-title":"A systematic review and meta-analysis of the incidence of acute aortic dissections in population-based studies","volume":"75","author":"Gouveia","year":"2022","journal-title":"J Vasc Surg"},{"issue":"6","key":"10.1016\/j.jacasi.2026.07.021_bib22","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.jtcvs.2014.07.068","article-title":"Clinical features of acute aortic dissection from the registry of aortic dissection in China","volume":"148","author":"Wang","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"8","key":"10.1016\/j.jacasi.2026.07.021_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.118.004689","article-title":"Population-based assessment of the incidence of aortic dissection, intramural hematoma, and penetrating ulcer, and its associated mortality from 1995 to 2015","volume":"11","author":"DeMartino","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"40","key":"10.1016\/j.jacasi.2026.07.021_bib24","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.3346\/jkms.2020.35.e360","article-title":"Incidence and mortality rates of thoracic aortic dissection in Korea - inferred from the nationwide health insurance claims","volume":"35","author":"Lee","year":"2020","journal-title":"J Korean Med Sci"},{"issue":"6","key":"10.1016\/j.jacasi.2026.07.021_bib25","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1016\/j.ijcard.2012.07.008","article-title":"Acute aortic dissection: epidemiology and outcomes","volume":"167","author":"Pacini","year":"2013","journal-title":"Int J Cardiol"},{"issue":"6","key":"10.1016\/j.jacasi.2026.07.021_bib26","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1536\/ihj.18-532","article-title":"Influence of age on clinical presentation, therapeutic options, and outcome in Chinese patients with acute aortic dissection","volume":"60","author":"Huang","year":"2019","journal-title":"Int Heart J"},{"issue":"2","key":"10.1016\/j.jacasi.2026.07.021_bib27","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1093\/ejcts\/ezv356","article-title":"Mortality in patients with acute aortic dissection type A: analysis of pre- and intraoperative risk factors from the German registry for acute aortic dissection type A (GERAADA)","volume":"49","author":"Conzelmann","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"issue":"3","key":"10.1016\/j.jacasi.2026.07.021_bib28","first-page":"278","article-title":"Incidence, risk factors, outcome and projected future burden of acute aortic dissection","volume":"3","author":"Howard","year":"2014","journal-title":"Ann Cardiothorac Surg"},{"issue":"6","key":"10.1016\/j.jacasi.2026.07.021_bib29","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.jtcvs.2017.11.105","article-title":"Epidemiology and management of thoracic aortic dissections and thoracic aortic aneurysms in Ontario, Canada: a population-based study","volume":"155","author":"McClure","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"11","key":"10.1016\/j.jacasi.2026.07.021_bib30","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1080\/07420528.2018.1490744","article-title":"Circadian variations in the onset of aortic dissection in northern China","volume":"35","author":"Zhang","year":"2018","journal-title":"Chronobiol Int"},{"issue":"4","key":"10.1016\/j.jacasi.2026.07.021_bib31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/icvts\/ivy110","article-title":"Morphological features of the thoracic aorta and supra-aortic branches in patients with acute type A aortic dissection in China","volume":"27","author":"Wu","year":"2018","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"5","key":"10.1016\/j.jacasi.2026.07.021_bib32","first-page":"4281","article-title":"Analysis of the contribution of 129 candidate genes to thoracic aortic aneurysm or dissection of a mixed cohort of sporadic and familial cases in South China","volume":"13","author":"Li","year":"2021","journal-title":"Am J Transl Res"},{"issue":"3","key":"10.1016\/j.jacasi.2026.07.021_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/08941939.2018.1489916","article-title":"Acute aortic dissection in young adult patients: clinical characteristics, management, and perioperative outcomes","volume":"33","author":"Zhu","year":"2020","journal-title":"J Invest Surg"},{"issue":"11","key":"10.1016\/j.jacasi.2026.07.021_bib34","first-page":"1726","article-title":"Preliminary characterization of acute aortic dissection in the mainland of China","volume":"124","author":"Wang","year":"2011","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"10.1016\/j.jacasi.2026.07.021_bib35","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/1742-6723.13472","article-title":"Incidence and outcomes of aortic dissection for emergency departments in New South Wales, Australia 2017-2018: a data linkage study","volume":"32","author":"Dinh","year":"2020","journal-title":"Emerg Med Australas"},{"issue":"25","key":"10.1016\/j.jacasi.2026.07.021_bib36","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1161\/CIRCULATIONAHA.122.061065","article-title":"Clinical characteristics, incidences, and mortality rates for type A and B aortic dissections: a nationwide Danish population-based cohort study from 1996 to 2016","volume":"146","author":"Obel","year":"2022","journal-title":"Circulation"},{"issue":"26","key":"10.1016\/j.jacasi.2026.07.021_bib37","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1093\/eurheartj\/ehaa446","article-title":"Sex differences and temporal trends in aortic dissection: a population-based study of incidence, treatment strategies, and outcome in Swedish patients during 15 years","volume":"41","author":"Smedberg","year":"2020","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.jacasi.2026.07.021_bib38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/j.1440-1843.2011.02062.x","article-title":"Tobacco smoking in China: prevalence, disease burden, challenges and future strategies","volume":"16","author":"Zhang","year":"2011","journal-title":"Respirology"},{"issue":"12","key":"10.1016\/j.jacasi.2026.07.021_bib39","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.4103\/0366-6999.233943","article-title":"Correlation between sex and prognosis of acute aortic dissection in the Chinese population","volume":"131","author":"Liu","year":"2018","journal-title":"Chin Med J"},{"issue":"4","key":"10.1016\/j.jacasi.2026.07.021_bib40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.7326\/0003-4819-85-4-447","article-title":"Menopause and risk of cardiovascular disease: the Framingham study","volume":"85","author":"Kannel","year":"1976","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.jacasi.2026.07.021_bib41","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jtcvs.2019.11.039","article-title":"Gender-related differences in patients with acute aortic dissection type A","volume":"162","author":"Rylski","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"10.1016\/j.jacasi.2026.07.021_bib42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0014-4800(80)90003-9","article-title":"Influence of contraceptive and other sex steroids on aortic collagen and elastin","volume":"33","author":"Fischer","year":"1980","journal-title":"Exp Mol Pathol"},{"issue":"7","key":"10.1016\/j.jacasi.2026.07.021_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181166","article-title":"Sex, pregnancy and aortic disease in Marfan syndrome","volume":"12","author":"Renard","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jacasi.2026.07.021_bib44","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0735-1097(97)00191-5","article-title":"Hormonal therapy increases arterial compliance in postmenopausal women","volume":"30","author":"Rajkumar","year":"1997","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.jacasi.2026.07.021_bib45","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.4065\/79.10.1252","article-title":"Association of painless acute aortic dissection with increased mortality","volume":"79","author":"Park","year":"2004","journal-title":"Mayo Clin Proc"},{"issue":"20","key":"10.1016\/j.jacasi.2026.07.021_bib46","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1161\/CIRCULATIONAHA.110.988568","article-title":"Sensitivity of the aortic dissection detection risk score, a novel guideline-based tool for identification of acute aortic dissection at initial presentation: results from the international registry of acute aortic dissection","volume":"123","author":"Rogers","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacasi.2026.07.021_bib47","first-page":"100033","article-title":"Geographical variations in cardiovascular health in China: a nationwide population-based survey of 74,726 adults","volume":"3","author":"Zhang","year":"2020","journal-title":", Lancet Reg Health West Pac"},{"issue":"22","key":"10.1016\/j.jacasi.2026.07.021_bib48","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.117.032380","article-title":"Status of hypertension in China: results from the China hypertension survey, 2012-2015","volume":"137","author":"Wang","year":"2018","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.jacasi.2026.07.021_bib49","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.athoracsur.2023.06.019","article-title":"Characteristics and outcomes in patients with acute aortic dissection: a nationwide registry study","volume":"116","author":"Pedersen","year":"2023","journal-title":"Ann Thorac Surg"}],"container-title":["JACC: Asia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772374726006137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772374726006137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:07:41Z","timestamp":1788469661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772374726006137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S2772374726006137"],"URL":"https:\/\/doi.org\/10.1016\/j.jacasi.2026.07.021","relation":{},"ISSN":["2772-3747"],"issn-type":[{"value":"2772-3747","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatiotemporal Analysis of Acute Aortic Syndrome in Jiangsu, China From Medical Record Front Page Registry","name":"articletitle","label":"Article Title"},{"value":"JACC: Asia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacasi.2026.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}