{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:54:35Z","timestamp":1775134475237,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jacbts.2017.03.014","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T14:16:50Z","timestamp":1503929810000},"page":"398-414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The IL-1RI Co-Receptor TILRR (FREM1\u00a0Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease"],"prefix":"10.1016","volume":"2","author":[{"given":"Sarah A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriy O.","family":"Samokhin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabruka","family":"Alfaidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emer C.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Mike L.","family":"Holcombe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endre","family":"Kiss-Toth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Storey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu-Pok","family":"Yee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila E.","family":"Francis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva E.","family":"Qwarnstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2017.03.014_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.biochem.76.060305.151318","article-title":"Structure and function of Toll-like receptors and their ligands","volume":"76","author":"Gay","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jacbts.2017.03.014_bib2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/414756a","article-title":"Drosophila Toll is activated by gram-positive bacteria through a circulating peptideglycan recognition protein","volume":"414","author":"Michel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jacbts.2017.03.014_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nature02761","article-title":"Inferences, questions and possibilities in toll-like receptor signalling","volume":"430","author":"Beutler","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jacbts.2017.03.014_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of Toll-like receptors - redefining innate immunity","volume":"13","author":"O'Neill","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tibs.2005.09.003","article-title":"Cell-surface co-receptors: emerging roles in signaling and human disease","volume":"30","author":"Kirkbride","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jacbts.2017.03.014_bib6","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1073\/pnas.1117885109","article-title":"Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization of ischemic muscle","volume":"109","author":"Jang","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2017.03.014_bib7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrm2262","article-title":"Extracellular control of TGF\u03b2 signalling in vascular development and disease","volume":"8","author":"ten Dijke","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ni1207","article-title":"CD14 is required for MyD88-independent LPS signaling","volume":"6","author":"Jiang","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrd3800","article-title":"Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases","volume":"11","author":"Dinarello","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jacbts.2017.03.014_bib10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/CIRCRESAHA.110.226928","article-title":"Multiple facets of NF-kappaB in the heart: to be or not to NF-kappaB","volume":"108","author":"Gordon","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2017.03.014_bib11","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1161\/CIRCULATIONAHA.113.003199","article-title":"Targeting interleukin-1 in heart disease","volume":"128","author":"Van Tassell","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2017.03.014_bib12","unstructured":"National Center for Biotechnology Information. FREM1 FRAS1 related extracellular matrix 1 [Homo sapiens (human)]. Available at: http:\/\/www.ncbi.nlm.nih.gov\/gene?term=NM_001177704.1. Accessed August 2017."},{"key":"10.1016\/j.jacbts.2017.03.014_bib13","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.1074\/jbc.M109.073429","article-title":"TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB","volume":"285","author":"Zhang","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jacbts.2017.03.014_bib14","doi-asserted-by":"crossref","first-page":"12348","DOI":"10.1074\/jbc.C111.321711","article-title":"Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR","volume":"287","author":"Zhang","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jacbts.2017.03.014_bib15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/geno.2000.6451","article-title":"A\u00a0highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA","volume":"73","author":"Lee","year":"2001","journal-title":"Genomics"},{"key":"10.1016\/j.jacbts.2017.03.014_bib16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1101\/gr.749203","article-title":"A\u00a0highly efficient recombineering-based method for generating conditional knockout mutations","volume":"13","author":"Liu","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.jacbts.2017.03.014_bib17","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.2353\/ajpath.2006.051054","article-title":"Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice","volume":"168","author":"Chamberlain","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib18","doi-asserted-by":"crossref","first-page":"e92404","DOI":"10.1371\/journal.pone.0092404","article-title":"Protective role of properdin in progression of experimental murine atherosclerosis","volume":"9","author":"Steiner","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2017.03.014_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-60761-247-6_1","article-title":"Modes of defining atherosclerosis in mouse models: relative merits and evolving standards","volume":"573","author":"Daugherty","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/cvr\/cvu028","article-title":"Vessel wall, not platelet, P2Y(12) potentiates early atherogenesis","volume":"102","author":"West","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2017.03.014_bib21","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1002\/eji.201041316","article-title":"Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis","volume":"41","author":"Freigang","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0008-6363(99)00175-3","article-title":"Temporal and spatial distribution of interleukin-1 beta in balloon injured porcine coronary arteries","volume":"44","author":"Chamberlain","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2017.03.014_bib23","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.2353\/ajpath.2010.090857","article-title":"ApoE-deficient mice on cholate-containing high-fat diet reveal a pathology similar to lung sarcoidosis","volume":"176","author":"Samokhin","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib24","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2144\/000112729","article-title":"Standardized quantification of pulmonary fibrosis in histological samples","volume":"44","author":"Hubner","year":"2008","journal-title":"Biotechniques"},{"key":"10.1016\/j.jacbts.2017.03.014_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jacbts.2017.03.014_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jacbts.2017.03.014_bib27","doi-asserted-by":"crossref","first-page":"e0129888","DOI":"10.1371\/journal.pone.0129888","article-title":"Computational modeling of NF-kappa B activation by IL-1RI and its co-receptor TILRR, predicts a role for cytoskeletal sequestration of I kappa B alpha in inflammatory signalling","volume":"10","author":"Rhodes","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2017.03.014_bib28","doi-asserted-by":"crossref","first-page":"e0002367","DOI":"10.1371\/journal.pone.0002367","article-title":"Introducing spatial information into predictive NF-kappa B modeling - an agent-based approach","volume":"3","author":"Pogson","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2017.03.014_bib29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1039\/C1IB00042J","article-title":"Modeling complex biological systems using an agent-based approach","volume":"4","author":"Holcombe","year":"2012","journal-title":"Integr Biol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3390\/computation2040131","article-title":"Computational models of the NF-\u03baB signalling pathway","volume":"2","author":"Williams","year":"2014","journal-title":"Computation"},{"key":"10.1016\/j.jacbts.2017.03.014_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scisignal.aac6503","article-title":"The rise in computational systems biology approaches for understanding NF-kappa B signaling dynamics","volume":"8","author":"Williams","year":"2015","journal-title":"Sci Signal"},{"key":"10.1016\/j.jacbts.2017.03.014_bib32","unstructured":"Sourceforge. IL1R TILRR FlameGPU: Agent based model of IL1R1 signalling for FLAME GPU.\u00a0Available at: https:\/\/sourceforge.net\/projects\/il1r-tilrr-flamegpu\/. Accessed August 2017."},{"key":"10.1016\/j.jacbts.2017.03.014_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jacbts.2017.03.014_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modeling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jacbts.2017.03.014_bib35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nsmb.2260","article-title":"Structure of the activating IL-1 receptor signaling complex","volume":"19","author":"Thomas","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/nar\/gkl206","article-title":"GRAMM-X public web server for protein-protein docking","volume":"34","author":"Tovchigrechko","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jacbts.2017.03.014_bib37","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tibs.2005.12.006","article-title":"Disseminating structural genomics data to the public: from a data dump to an animated story","volume":"31","author":"Abagyan","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jacbts.2017.03.014_bib38","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/prot.20264","article-title":"Scoring function for automated assessment of protein structure template quality","volume":"57","author":"Zhang","year":"2007","journal-title":"Proteins"},{"key":"10.1016\/j.jacbts.2017.03.014_bib39","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3390\/biology1030484","article-title":"Bioinformatic analysis of the FREM1 gene-evolutionary development of the IL-1RI co-receptor, TILRR","volume":"1","author":"Hudson","year":"2012","journal-title":"Biology"},{"key":"10.1016\/j.jacbts.2017.03.014_bib40","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/cbic.200800769","article-title":"A\u00a0peptide antagonist of the TLR4-MD2 interaction","volume":"10","author":"Slivka","year":"2009","journal-title":"Chembiochem"},{"key":"10.1016\/j.jacbts.2017.03.014_bib41","doi-asserted-by":"crossref","first-page":"7657","DOI":"10.1038\/srep07657","article-title":"Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection","volume":"5","author":"Anwar","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacbts.2017.03.014_bib42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/intimm\/dxs084","article-title":"Human TLR4 polymorphism D299G\/T399I alters TLR4\/MD-2 conformation and response to a weak ligand monophosphoryl lipid A","volume":"25","author":"Yamakawa","year":"2013","journal-title":"Int Immunol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib43","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.cardiores.2005.01.008","article-title":"Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice","volume":"66","author":"Merhi-Soussi","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2017.03.014_bib44","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/CIRCGENETICS.111.960773","article-title":"A\u00a0gene expression signature that classifies human atherosclerotic plaque by relative inflammation status","volume":"4","author":"Puig","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jacbts.2017.03.014_bib45","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/eurheartj\/ehu369","article-title":"Anti-inflammatory therapies in acute coronary syndromes: is IL-1 blockade a solution?","volume":"36","author":"Abbate","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2017.03.014_bib46","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/ni.2711","article-title":"IL-1 signaling in atherosclerosis: sibling rivalry","volume":"14","author":"Sheedy","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib47","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1161\/ATVBAHA.116.306874","article-title":"Do the Apoe\u2013\/\u2013 and Ldlr \u2013\/\u2013 mice yield the same insight on atherogenesis?","volume":"36","author":"Getz","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1172\/JCI43713","article-title":"Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice","volume":"122","author":"Alexander","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacbts.2017.03.014_bib49","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.4049\/jimmunol.159.5.2452","article-title":"Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice","volume":"159","author":"Labow","year":"1997","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib50","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1161\/ATVBAHA.115.305896","article-title":"Senescent vascular smooth muscle cells drive inflammation through an interleukin-1\u03b1\u2013dependent senescence- associated secretory phenotype","volume":"35","author":"Gardner","year":"2015","journal-title":"Atheroscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacbts.2017.03.014_bib51","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nm1459","article-title":"Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis","volume":"12","author":"Clark","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jacbts.2017.03.014_bib52","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000087480.94275.97","article-title":"From\u00a0vulnerable plaque to vulnerable patient - a call for new definitions and risk assessment strategies: part I","volume":"108","author":"Naghavi","year":"2003","journal-title":"Circulation"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X1730133X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X1730133X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:19:00Z","timestamp":1762820340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X1730133X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S2452302X1730133X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2017.03.014","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The IL-1RI Co-Receptor TILRR (FREM1\u00a0Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2017.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2017.06.001","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}