{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:51:28Z","timestamp":1791489088463,"version":"4.3.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jacbts.2017.04.003","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T14:16:16Z","timestamp":1503929776000},"page":"434-446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Fast Virtual Fractional Flow Reserve Based\u00a0Upon Steady-State Computational Fluid Dynamics Analysis"],"prefix":"10.1016","volume":"2","author":[{"given":"Paul D.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Alejandro","family":"Silva Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen F.A.","family":"Feher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Rafiroiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lungu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susheel","family":"Varma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia V.","family":"Lawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Rodney","family":"Hose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian P.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2017.04.003_bib1","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1016\/j.jacc.2011.08.006","volume":"58","author":"Levine","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2017.04.003_bib2","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1093\/eurheartj\/ehq277","volume":"31","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2017.04.003_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2010.04.012","article-title":"Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study","volume":"56","author":"Pijls","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2017.04.003_bib4","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMoa1205361","article-title":"Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease","volume":"367","author":"De Bruyne","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacbts.2017.04.003_bib5","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1161\/CIRCULATIONAHA.109.925396","article-title":"Economic evaluation of fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease","volume":"122","author":"Fearon","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2017.04.003_bib6","unstructured":"Ludman P. British Cardiovascular Society audit returns adult interventional procedures January 2013 to December 2013. Available at: https:\/\/www.bcis.org.uk\/wp-content\/uploads\/2017\/01\/BCIS-audit-2013.pdf. Accessed August 2017."},{"key":"10.1016\/j.jacbts.2017.04.003_bib7","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.jacc.2012.08.966","article-title":"A\u00a0contemporary view of diagnostic cardiac catheterization and percutaneous coronary intervention in the United States: a report from the CathPCI Registry of the National Cardiovascular Data Registry, 2010 through June 2011","volume":"60","author":"Dehmer","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2017.04.003_bib8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jcin.2015.04.006","article-title":"\u201cVirtual\u201d (computed) fractional flow reserve: current challenges and limitations","volume":"8","author":"Morris","year":"2015","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacbts.2017.04.003_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcin.2012.08.024","article-title":"Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve From Coronary Angiography) study","volume":"6","author":"Morris","year":"2013","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacbts.2017.04.003_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0002-8703(51)90002-6","article-title":"Hydraulic formula for calculation of the area of the stenotic mitral valve, other cardiac valves, and central circulatory shunts. I","volume":"41","author":"Gorlin","year":"1951","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacbts.2017.04.003_bib11","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jcin.2014.03.004","article-title":"Fractional flow reserve calculation from 3-dimensional quantitative coronary angiography and TIMI frame count: a fast computer model to quantify the functional significance of moderately obstructed coronary arteries","volume":"7","author":"Tu","year":"2014","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacbts.2017.04.003_bib12","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4244\/EIJY14M07_01","article-title":"Fast virtual functional assessment of intermediate coronary lesions using routine angiographic data and blood flow simulation in humans: comparison with pressure wire: fractional flow reserve","volume":"10","author":"Papafaklis","year":"2014","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacbts.2017.04.003_bib13","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.jcin.2016.07.013","article-title":"Diagnostic accuracy of fast computational approaches to derive fractional flow reserve from diagnostic coronary angiography: the international multicenter FAVOR pilot study","volume":"9","author":"Tu","year":"2016","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacbts.2017.04.003_bib14","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jacc.2013.11.043","article-title":"Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps)","volume":"63","author":"Norgaard","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2017.04.003_bib15","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/01.CIR.87.4.1354","article-title":"Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty","volume":"87","author":"Pijls","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2017.04.003_bib16","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.jbiomech.2014.07.024","article-title":"MRI model-based non-invasive differential diagnosis in pulmonary hypertension","volume":"47","author":"Lungu","year":"2014","journal-title":"J\u00a0Biomech"},{"key":"10.1016\/j.jacbts.2017.04.003_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0378-4754(00)00270-6","article-title":"Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates","volume":"55","author":"Sobol","year":"2001","journal-title":"Math Comput Simul"},{"key":"10.1016\/j.jacbts.2017.04.003_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0010-4655(02)00280-1","article-title":"Making best use of model evaluations to compute sensitivity indices","volume":"145","author":"Saltelli","year":"2002","journal-title":"Physics Communications"},{"key":"10.1016\/j.jacbts.2017.04.003_bib19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.jacbts.2017.04.003_bib20","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ejcts.2006.01.047","article-title":"Current percutaneous coronary intervention and coronary artery bypass grafting practices for three-vessel and left main coronary artery disease: insights from the SYNTAX run-in phase","volume":"29","author":"Kappetein","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.jacbts.2017.04.003_bib21","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jacc.2005.09.071","article-title":"A risk score to predict in-hospital mortality for percutaneous coronary interventions","volume":"47","author":"Wu","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2017.04.003_bib22","doi-asserted-by":"crossref","first-page":"041014","DOI":"10.1115\/1.2937744","article-title":"A\u00a0study\u00a0on the compliance of a right coronary artery and its impact on wall shear stress","volume":"130","author":"Zeng","year":"2008","journal-title":"Journal\u00a0of biomechanical engineering"},{"key":"10.1016\/j.jacbts.2017.04.003_bib23","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1161\/01.CIR.94.8.1842","article-title":"Simultaneous coronary pressure and flow velocity measurements in humans. Feasibility, reproducibility, and hemodynamic dependence of coronary flow velocity reserve, hyperemic flow versus pressure slope index, and fractional flow reserve","volume":"94","author":"de Bruyne","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2017.04.003_bib24","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jcin.2011.03.013","article-title":"Optimal\u00a0intravascular ultrasound criteria and their accuracy for defining the functional significance of intermediate coronary stenoses of different locations","volume":"4","author":"Koo","year":"2011","journal-title":"J\u00a0Am Coll Cardiol Intv"},{"key":"10.1016\/j.jacbts.2017.04.003_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.carrev.2011.12.003","article-title":"Intravascular ultrasound lumen area parameters for assessment of physiological ischemia by fractional flow reserve in intermediate coronary artery stenosis","volume":"13","author":"Ben-Dor","year":"2012","journal-title":"Cardiovascular revascularization medicine : including molecular interventions"},{"key":"10.1016\/j.jacbts.2017.04.003_bib26","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jacc.2011.09.078","article-title":"Morphometric assessment of coronary stenosis relevance with optical coherence tomography: a comparison with fractional flow reserve and intravascular ultrasound","volume":"59","author":"Gonzalo","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X17301353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X17301353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:19:08Z","timestamp":1762820348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X17301353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S2452302X17301353"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2017.04.003","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fast Virtual Fractional Flow Reserve Based\u00a0Upon Steady-State Computational Fluid Dynamics Analysis","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2017.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}