{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:48:51Z","timestamp":1779929331926,"version":"3.53.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.jacbts.2018.08.008","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T16:19:56Z","timestamp":1546273196000},"page":"728-740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells"],"prefix":"10.1016","volume":"3","author":[{"given":"Kai-Chun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Breitbart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J.","family":"De Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hofsteen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Futakuchi-Tsuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Schopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Razumova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Boucek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lil","family":"Pabon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Reinecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Carter","family":"Ralphe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Regnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Murry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2018.08.008_bib1","first-page":"e28","article-title":"Heart disease and stroke statistics\u20142014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2018.08.008_bib2","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/eurheartj\/eht066","article-title":"Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND","volume":"34","author":"Brouwers","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2018.08.008_bib3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/GIM.0b013e3181f2481f","article-title":"Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals","volume":"12","author":"Hershberger","year":"2010","journal-title":"Genet Med"},{"key":"10.1016\/j.jacbts.2018.08.008_bib4","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1253\/circj.CJ-14-0182","article-title":"Modeling inherited cardiac disorders","volume":"78","author":"Sallam","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.jacbts.2018.08.008_bib5","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.jacc.2016.07.779","article-title":"Patient-specific and genome-edited induced pluripotent stem cell-derived cardiomyocytes elucidate single-cell phenotype of Brugada syndrome","volume":"68","author":"Liang","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2018.08.008_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jacbts.2018.08.008_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nprot.2016.153","article-title":"Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells","volume":"12","author":"Palpant","year":"2017","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jacbts.2018.08.008_bib8","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1161\/01.CIR.90.3.1200","article-title":"Left ventricular wall thickness and regional systolic function in patients with hypertrophic cardiomyopathy. A three-dimensional tagged magnetic resonance imaging study","volume":"90","author":"Dong","year":"1994","journal-title":"Circulation"},{"issue":"5 Pt 2","key":"10.1016\/j.jacbts.2018.08.008_bib9","first-page":"H1492","article-title":"Three-dimensional mapping of acute ischemic regions using MRI: wall thickening versus motion analysis","volume":"259","author":"Azhari","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jacbts.2018.08.008_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1073\/pnas.0906504107","article-title":"Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs","volume":"107","author":"Kim","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2018.08.008_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/CIRCRESAHA.110.237206","article-title":"Growth of engineered human myocardium with mechanical loading and vascular coculture\/novelty and significance","volume":"109","author":"Tulloch","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2018.08.008_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1085\/jgp.201311018","article-title":"E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction","volume":"142","author":"De Lange","year":"2013","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.jacbts.2018.08.008_bib13","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jmb.2008.09.065","article-title":"Myosin binding protein C positioned to play a key role in regulation of muscle contraction: structure and interactions of domain C1","volume":"384","author":"Ababou","year":"2008","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.jacbts.2018.08.008_bib14","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0025-6196(11)60890-2","article-title":"Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy","volume":"83","author":"Olivotto","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jacbts.2018.08.008_bib15","doi-asserted-by":"crossref","first-page":"17713","DOI":"10.1073\/pnas.0606741103","article-title":"Crystal structures of human cardiac beta-myosin II S2-delta provide insight into the functional role of the S2 subfragment","volume":"103","author":"Blankenfeldt","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2018.08.008_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12265-011-9266-2","article-title":"How do mutations in contractile proteins cause the primary familial cardiomyopathies?","volume":"4","author":"Marston","year":"2011","journal-title":"J\u00a0Cardiovasc Transl Res"},{"key":"10.1016\/j.jacbts.2018.08.008_bib17","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1089\/scd.2012.0490","article-title":"Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells","volume":"22","author":"Lundy","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jacbts.2018.08.008_bib18","first-page":"130ra147","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci Translat Med"},{"key":"10.1016\/j.jacbts.2018.08.008_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2012.10.010","article-title":"Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells","volume":"12","author":"Lan","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jacbts.2018.08.008_bib20","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.yjmcc.2014.04.005","article-title":"Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells","volume":"72","author":"Yang","year":"2014","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jacbts.2018.08.008_bib21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00395-016-0587-9","article-title":"Stiff matrix induces switch to pure beta-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes","volume":"111","author":"Weber","year":"2016","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacbts.2018.08.008_bib22","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/ar.22973","article-title":"Structural implications of beta-cardiac myosin heavy chain mutations in human disease","volume":"297","author":"Colegrave","year":"2014","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.jacbts.2018.08.008_bib23","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nm.3545","article-title":"Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies","volume":"20","author":"Wang","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jacbts.2018.08.008_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature11799","article-title":"Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs","volume":"494","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jacbts.2018.08.008_bib25","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa0908679","article-title":"Patient-specific induced pluripotent stem-cell models for long-QT syndrome","volume":"363","author":"Moretti","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacbts.2018.08.008_bib26","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1073\/pnas.1220693110","article-title":"Transgenic overexpression of ribonucleotide reductase improves cardiac performance","volume":"110","author":"Nowakowski","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2018.08.008_bib27","doi-asserted-by":"crossref","first-page":"e24634","DOI":"10.7554\/eLife.24634","article-title":"Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes","volume":"6","author":"Alamo","year":"2017","journal-title":"eLife"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X18302298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X18302298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:19:36Z","timestamp":1762820376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X18302298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S2452302X18302298"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2018.08.008","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2018.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}