{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T17:56:03Z","timestamp":1783187763919,"version":"3.54.6"},"reference-count":82,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL127646-01A1"],"award-info":[{"award-number":["R01 HL127646-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL140973-01"],"award-info":[{"award-number":["R01 HL140973-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL138982-01A1"],"award-info":[{"award-number":["R01 HL138982-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jacbts.2019.08.009","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T14:02:25Z","timestamp":1584972145000},"page":"300-313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Iron and Heart\u00a0Failure"],"prefix":"10.1016","volume":"5","author":[{"given":"Kambiz","family":"Ghafourian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason S.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Ardehali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2019.08.009_bib1","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","article-title":"Systemic iron homeostasis","volume":"93","author":"Ganz","year":"2013","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jacbts.2019.08.009_bib2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0002-9343(68)90069-7","article-title":"Body iron excretion in man: a collaborative study","volume":"45","author":"Green","year":"1968","journal-title":"Am J Med"},{"key":"10.1016\/j.jacbts.2019.08.009_bib3","doi-asserted-by":"crossref","first-page":"21613","DOI":"10.1002\/jcp.28820","article-title":"Iron and the heart: a paradigm shift from systemic to cardiomyocyte abnormalities","volume":"234","author":"Paterek","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib4","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1182\/blood-2008-02-139915","article-title":"Immunoassay for human serum hepcidin","volume":"112","author":"Ganz","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jacbts.2019.08.009_bib5","first-page":"S21","article-title":"Markers of iron status in chronic kidney disease","volume":"21 Suppl 1","author":"Gaweda","year":"2017","journal-title":"Hemodial Int"},{"key":"10.1016\/j.jacbts.2019.08.009_bib6","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1093\/ndt\/gfr410","article-title":"Hepcidin: another culprit for complications in patients with chronic kidney disease?","volume":"26","author":"Nakanishi","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jacbts.2019.08.009_bib7","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1093\/ndt\/gfq760","article-title":"Hepcidin as well as TNF-alpha are significant predictors of arterial stiffness in patients on maintenance hemodialysis","volume":"26","author":"Kuragano","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jacbts.2019.08.009_bib8","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1093\/ndt\/gfs488","article-title":"Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patients","volume":"28","author":"van der Weerd","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jacbts.2019.08.009_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187065","article-title":"Hepcidin in morbidly obese women with non-alcoholic fatty liver disease","volume":"12","author":"Auguet","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2019.08.009_bib10","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.bbrc.2017.11.103","article-title":"Interplay of adipocyte and hepatocyte: leptin upregulates hepcidin","volume":"495","author":"Yamamoto","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jacbts.2019.08.009_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to tango: regulation of Mammalian iron metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jacbts.2019.08.009_bib12","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1073\/pnas.1422373112","article-title":"Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function","volume":"112","author":"Lakhal-Littleton","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2019.08.009_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19804","article-title":"An essential cell-autonomous role for hepcidin in cardiac iron homeostasis","volume":"5","author":"Lakhal-Littleton","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.jacbts.2019.08.009_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.celrep.2015.09.023","article-title":"Lethal cardiomyopathy in mice lacking transferrin receptor in the heart","volume":"13","author":"Xu","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jacbts.2019.08.009_bib15","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1021\/bi052443r","article-title":"Iron(II) and hydrogen peroxide detoxification by human H-chain ferritin. An EPR spin-trapping study","volume":"45","author":"Zhao","year":"2006","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.jacbts.2019.08.009_bib16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10741-019-09788-z","article-title":"Influence of mitochondrial and systemic iron levels in heart failure pathology","volume":"24","author":"Lupu","year":"2019","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jacbts.2019.08.009_bib17","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/01.RES.84.11.1302","article-title":"Modulation of iron uptake in heart by L-type Ca2+ channel modifiers: possible implications in iron overload","volume":"84","author":"Tsushima","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2019.08.009_bib18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0008-6363(00)00017-1","article-title":"Reexpression of T-type Ca2+ channel gene and current in post-infarction remodeled rat left ventricle","volume":"46","author":"Huang","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2019.08.009_bib19","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/eurheartj\/ehq158","article-title":"Iron deficiency: an ominous sign in patients with systolic chronic heart failure","volume":"31","author":"Jankowska","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2019.08.009_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004519","article-title":"Definition of iron deficiency based on the gold standard of bone marrow iron staining in heart failure patients","volume":"11","author":"Grote Beverborg","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacbts.2019.08.009_bib21","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1093\/eurheartj\/ehu235","article-title":"Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure","volume":"35","author":"Jankowska","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2019.08.009_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ahj.2013.01.017","article-title":"Iron deficiency in chronic heart failure: an international pooled analysis","volume":"165","author":"Klip","year":"2013","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacbts.2019.08.009_bib23","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","volume":"70","author":"Yancy","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib24","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2019.08.009_bib25","first-page":"1342","article-title":"2017 comprehensive update of the Canadian Cardiovascular Society guidelines for the management of heart failure","volume":"33","author":"Ezekowitz","year":"2017","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib26","first-page":"36","article-title":"Iron deficiency in heart failure: an overview","volume":"7","author":"von Haehling","year":"2019","journal-title":"J\u00a0Am Coll Cardiol HF"},{"key":"10.1016\/j.jacbts.2019.08.009_bib27","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1016\/S0272-6386(01)70008-X","article-title":"IV. NKF-K\/DOQI clinical practice guidelines for anemia of chronic kidney disease: update 2000","volume":"37","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jacbts.2019.08.009_bib28","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.2215\/CJN.01490506","article-title":"Assessing iron status: beyond serum ferritin and transferrin saturation","volume":"1 Suppl 1","author":"Wish","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/HYPERTENSIONAHA.116.07307","article-title":"Inflammation in heart failure: the Holy Grail?","volume":"68","author":"Mehta","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.jacbts.2019.08.009_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10741-016-9533-z","article-title":"The role of inflammation and cell death in the pathogenesis, progression and treatment of heart failure","volume":"21","author":"Briasoulis","year":"2016","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jacbts.2019.08.009_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11883-017-0660-3","article-title":"Role of inflammation in heart failure","volume":"19","author":"Shirazi","year":"2017","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.jacbts.2019.08.009_bib32","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/eurheartj\/ehs224","article-title":"Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives","volume":"34","author":"Jankowska","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2019.08.009_bib33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijcard.2011.08.006","article-title":"Myocardial iron homeostasis in advanced chronic heart failure patients","volume":"159","author":"Leszek","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/ejhf.640","article-title":"Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis","volume":"19","author":"Melenovsky","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacbts.2019.08.009_bib35","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.jacc.2013.02.012","article-title":"Heme levels are increased in human\u00a0failing hearts","volume":"61","author":"Khechaduri","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.15252\/emmm.201505748","article-title":"Reduction in mitochondrial iron alleviates cardiac damage during injury","volume":"8","author":"Chang","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jacbts.2019.08.009_bib37","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric carboxymaltose in patients with heart failure and iron deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jacbts.2019.08.009_bib38","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/eurheartj\/ehu385","article-title":"Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiencydagger","volume":"36","author":"Ponikowski","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2019.08.009_bib39","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/CIRCULATIONAHA.117.027497","article-title":"Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency","volume":"136","author":"van Veldhuisen","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2019.08.009_bib40","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.jacc.2007.07.029","article-title":"Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency","volume":"50","author":"Toblli","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jacc.2007.09.036","article-title":"Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial","volume":"51","author":"Okonko","year":"2008","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib42","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/ejhf.473","article-title":"Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials","volume":"18","author":"Jankowska","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacbts.2019.08.009_bib43","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1016\/j.ijcard.2013.04.181","article-title":"IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia","volume":"168","author":"Beck-da-Silva","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ejhf.823","article-title":"Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis","volume":"20","author":"Anker","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacbts.2019.08.009_bib45","doi-asserted-by":"crossref","first-page":"H156","DOI":"10.1152\/ajpheart.00076.2019","article-title":"Phospholipid oxidation products in ferroptotic myocardial cell death","volume":"317","author":"Stamenkovic","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib46","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2019.08.009_bib47","doi-asserted-by":"crossref","first-page":"18792","DOI":"10.1002\/jcp.28518","article-title":"Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages","volume":"234","author":"Hu","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib48","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1161\/01.CIR.99.9.1222","article-title":"Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice","volume":"99","author":"Lee","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2019.08.009_bib49","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/sj.ki.5000046","article-title":"Iron sucrose augments homocysteine-induced endothelial dysfunction in normal subjects","volume":"69","author":"Zheng","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.jacbts.2019.08.009_bib50","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000334939","article-title":"Iron sucrose promotes endothelial injury and dysfunction and monocyte adhesion\/infiltration","volume":"35","author":"Kamanna","year":"2012","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib51","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1681\/ASN.2013080838","article-title":"Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD","volume":"25","author":"Kuo","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib52","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2362.2002.0320s1009.x","article-title":"Ferric saccharate induces oxygen radical stress and endothelial dysfunction in\u00a0vivo","volume":"32 Suppl 1","author":"Rooyakkers","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jacbts.2019.08.009_bib53","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1161\/01.CIR.103.23.2799","article-title":"Iron chelation improves endothelial function in patients with coronary artery disease","volume":"103","author":"Duffy","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2019.08.009_bib54","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MNH.0000000000000329","article-title":"Iron-induced hypophosphatemia: an emerging complication","volume":"26","author":"Zoller","year":"2017","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.jacbts.2019.08.009_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167146","article-title":"Choice of high-dose intravenous iron preparation determines hypophosphatemia risk","volume":"11","author":"Schaefer","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2019.08.009_bib56","doi-asserted-by":"crossref","first-page":"468675","DOI":"10.1155\/2015\/468675","article-title":"Intravenous iron administration and hypophosphatemia in clinical practice","volume":"2015","author":"Hardy","year":"2015","journal-title":"Int J Rheumatol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib57","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.2169\/internalmedicine.51.7450","article-title":"Fibroblast growth factor 23-related osteomalacia caused by the prolonged administration of saccharated ferric oxide","volume":"51","author":"Yamamoto","year":"2012","journal-title":"Intern Med"},{"key":"10.1016\/j.jacbts.2019.08.009_bib58","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1507\/endocrj.45.431","article-title":"Saccharated ferric oxide-induced osteomalacia in Japan: iron-induced osteopathy due to nephropathy","volume":"45","author":"Sato","year":"1998","journal-title":"Endocr J"},{"key":"10.1016\/j.jacbts.2019.08.009_bib59","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jacbts.2019.08.009_bib60","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1681\/ASN.2013050465","article-title":"Fibroblast growth factor-23 and cardiovascular events in CKD","volume":"25","author":"Scialla","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib61","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacbts.2019.08.009_bib62","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.cmet.2015.09.002","article-title":"Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy","volume":"22","author":"Grabner","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.jacbts.2019.08.009_bib63","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jacc.2012.03.040","article-title":"Fibroblast growth factor-23 and death, heart failure, and cardiovascular events in community-living individuals: CHS (Cardiovascular Health Study)","volume":"60","author":"Ix","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib64","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.jacc.2014.03.026","article-title":"Fibroblast growth factor-23, cardiovascular prognosis, and benefit of angiotensin-converting enzyme inhibition in stable ischemic heart disease","volume":"63","author":"Udell","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib65","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/ajh\/hpy142","article-title":"Fibroblast growth factor-23, heart failure risk, and renin-angiotensin-aldosterone-system blockade in hypertension: the MESA Study","volume":"32","author":"Akhabue","year":"2019","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacbts.2019.08.009_bib66","doi-asserted-by":"crossref","first-page":"124486","DOI":"10.1172\/jci.insight.124486","article-title":"Randomized trial of intravenous iron-induced hypophosphatemia","volume":"3","author":"Wolf","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.jacbts.2019.08.009_bib67","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.cardfail.2015.05.006","article-title":"Repletion of iron stores with the use of oral iron supplementation in patients with systolic heart failure","volume":"21","author":"Niehaus","year":"2015","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jacbts.2019.08.009_bib68","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1001\/jama.2017.5427","article-title":"Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency: the IRONOUT HF Randomized Clinical Trial","volume":"317","author":"Lewis","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jacbts.2019.08.009_bib69","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ejps.2017.10.021","article-title":"Sucrosomial\u00ae iron absorption studied by in\u00a0vitro and ex-vivo models","volume":"111","author":"Fabiano","year":"2018","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.jacbts.2019.08.009_bib70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12185-017-2373-3","article-title":"Modern iron replacement therapy: clinical and pathophysiological insights","volume":"107","author":"Girelli","year":"2018","journal-title":"Int J Hematol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib71","first-page":"2779","article-title":"Oral sucrosomial iron versus intravenous iron in anemic cancer patients without iron deficiency receiving darbepoetin alfa: a pilot study","volume":"25","author":"Mafodda","year":"2017","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jacbts.2019.08.009_bib72","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1681\/ASN.2016101053","article-title":"Effects of ferric citrate in patients with nondialysis-dependent CKD and iron deficiency anemia","volume":"28","author":"Fishbane","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib73","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1182\/blood-2015-05-642223","article-title":"Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young women","volume":"126","author":"Moretti","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jacbts.2019.08.009_bib74","doi-asserted-by":"crossref","first-page":"e524","DOI":"10.1016\/S2352-3026(17)30182-5","article-title":"Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: 2 open-label, randomised controlled trials","volume":"4","author":"Stoffel","year":"2017","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib75","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1600-0609.2012.01779.x","article-title":"T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice","volume":"88","author":"Kumfu","year":"2012","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib76","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1113\/EP085517","article-title":"Dual T-type and L-type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron-overloaded thalassaemic mice","volume":"101","author":"Kumfu","year":"2016","journal-title":"Exp Physiol"},{"key":"10.1016\/j.jacbts.2019.08.009_bib77","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1182\/blood-2016-06-721183","article-title":"A\u00a0randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major","volume":"128","author":"Fernandes","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jacbts.2019.08.009_bib78","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00380-014-0621-5","article-title":"Association of dietary iron restriction with left ventricular remodeling after myocardial infarction in mice","volume":"31","author":"Eguchi","year":"2016","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jacbts.2019.08.009_bib79","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12265-015-9633-5","article-title":"N-acetylcysteine plus deferoxamine improves cardiac function in Wistar rats after non-reperfused acute myocardial infarction","volume":"8","author":"Phaelante","year":"2015","journal-title":"J\u00a0Cardiovasc Transl Res"},{"key":"10.1016\/j.jacbts.2019.08.009_bib80","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bbrc.2017.03.127","article-title":"Deferiprone attenuates inflammation and myocardial fibrosis in diabetic cardiomyopathy rats","volume":"486","author":"Zou","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jacbts.2019.08.009_bib81","first-page":"IV390","article-title":"Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans","volume":"82","author":"Menasche","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2019.08.009_bib82","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/eurheartj\/ehi028","article-title":"Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance","volume":"26","author":"Paraskevaidis","year":"2005","journal-title":"Eur Heart J"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X19302645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X19302645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:23:59Z","timestamp":1778891039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X19302645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":82,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S2452302X19302645"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2019.08.009","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron and Heart\u00a0Failure","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2019.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}