{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:19:36Z","timestamp":1792225176760,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jacbts.2021.10.002","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T15:09:57Z","timestamp":1640617797000},"page":"984-999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment"],"prefix":"10.1016","volume":"6","author":[{"given":"Nicholas A.","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias P.","family":"Doulamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elamaran","family":"Meibalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Peiseler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Melero-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garc\u00eda-Carde\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro J.","family":"del Nido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Friehs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2021.10.002_bib1","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.amjcard.2010.08.022","article-title":"Assessment of left ventricular endocardial fibroelastosis in fetuses with aortic stenosis and evolving hypoplastic left heart syndrome","volume":"106","author":"McElhinney","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jtcvs.2017.02.070","article-title":"Hemodynamic parameters predict adverse outcomes following biventricular conversion with single-ventricle palliation takedown","volume":"154","author":"Herrin","year":"2017","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacbts.2021.10.002_bib3","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.jacc.2012.07.041","article-title":"Staged left ventricular recruitment after single-ventricle palliation in patients with borderline left heart hypoplasia","volume":"60","author":"Emani","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib4","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.jtcvs.2009.08.009","article-title":"Primary LV rehabilitation is effective in maintaining two-ventricle physiology in the borderline left heart","volume":"138","author":"Emani","year":"2010","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacbts.2021.10.002_bib5","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1161\/CIRCULATIONAHA.114.009032","article-title":"Fetal aortic valvuloplasty for evolving hypoplastic left heart syndrome: postnatal outcomes of the first 100 patients","volume":"130","author":"Freud","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2021.10.002_bib6","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/CIRCRESAHA.116.305629","article-title":"Endocardial fibroelastosis is caused by aberrant endothelial to mesenchymal transition","volume":"116","author":"Xu","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2021.10.002_bib7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41569-018-0023-y","article-title":"Reassessing endothelial-to-mesenchymal transition in cardiovascular diseases","volume":"15","author":"Li","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/dvdy.24521","article-title":"Endocardial fibroelastosis is secondary to hemodynamic alterations in the chick embryonic model of hypoplastic left heart syndrome","volume":"247","author":"Pesevski","year":"2018","journal-title":"Dev Dyn"},{"key":"10.1016\/j.jacbts.2021.10.002_bib9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jtcvs.2019.08.101","article-title":"Flow disturbances and the development of endocardial fibroelastosis","volume":"159","author":"Weixler","year":"2020","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacbts.2021.10.002_bib10","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/cr.2017.103","article-title":"Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium","volume":"27","author":"Zhang","year":"2017","journal-title":"Cell Res"},{"key":"10.1016\/j.jacbts.2021.10.002_bib11","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1007\/s00246-017-1650-5","article-title":"Hypoplastic left heart syndrome sequencing reveals a novel NOTCH1 mutation in a family with single ventricle defects","volume":"38","author":"Durbin","year":"2017","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1017\/S1047951110000181","article-title":"Changing concepts of endocardial fibroelastosis","volume":"20","author":"Lurie","year":"2010","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jacbts.2021.10.002_bib13","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.jacc.2007.07.021","article-title":"Hypoplastic left heart syndrome is heritable","volume":"50","author":"Hinton","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib14","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.amjcard.2015.08.045","article-title":"Familial incidence of cardiovascular malformations in hypoplastic left heart syndrome","volume":"116","author":"Kelle","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1115\/1.1486468","article-title":"A\u00a0new in\u00a0vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms","volume":"124","author":"Blackman","year":"2002","journal-title":"J\u00a0Biomech Eng"},{"key":"10.1016\/j.jacbts.2021.10.002_bib16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4161\/org.27483","article-title":"Cilia and coordination of signaling networks during heart development","volume":"10","author":"Koefoed","year":"2014","journal-title":"Organogenesis"},{"key":"10.1016\/j.jacbts.2021.10.002_bib17","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/01.ATV.12.11.1254","article-title":"Vascular endothelium responds to fluid shear stress gradients","volume":"12","author":"DePaola","year":"1992","journal-title":"Arterioscler Thromb"},{"issue":"4","key":"10.1016\/j.jacbts.2021.10.002_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1039\/C7IB00023E","article-title":"Real-time quantification of endothelial response to shear stress and vascular modulators","volume":"9","author":"DeStefano","year":"2017","journal-title":"Integr Biol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/cvr\/cvv175","article-title":"Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress","volume":"108","author":"Moonen","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2021.10.002_bib20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jss.2012.07.069","article-title":"An animal model of endocardial fibroelastosis","volume":"182","author":"Friehs","year":"2013","journal-title":"J Surg Res"},{"issue":"3-4","key":"10.1016\/j.jacbts.2021.10.002_bib21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000447691","article-title":"Development of a vascularized heterotopic neonatal rat heart transplantation model","volume":"57","author":"Shimada","year":"2016","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.jacbts.2021.10.002_bib22","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1161\/CIRCULATIONAHA.111.040352","article-title":"Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease","volume":"125","author":"Kovacic","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2021.10.002_bib23","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1136\/thx.2005.051946","article-title":"Losartan attenuates bleomycin induced lung fibrosis by increasing prostaglandin E2 synthesis","volume":"61","author":"Molina-Molina","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.jacbts.2021.10.002_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0055427","article-title":"Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model","volume":"8","author":"Gay-Jordi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2021.10.002_bib25","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0168-8278(02)00307-0","article-title":"Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and\/or portal hypertension","volume":"37","author":"Croquet","year":"2002","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.01213","article-title":"Losartan alleviates renal fibrosis and inhibits endothelial-to-mesenchymal transition (EMT) under high-fat diet-induced hyperglycemia","volume":"9","author":"Yao","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib27","first-page":"1","article-title":"Losartan attenuates myocardial endothelial-to-mesenchymal transition in spontaneous hypertensive rats via inhibiting TGF-\u03b2\/Smad signaling","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2021.10.002_bib28","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1161\/ATVBAHA.114.303422","article-title":"Shear stress-initiated signaling and its regulation of endothelial function","volume":"34","author":"Zhou","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic shear stress and the endothelium in cardiovascular Pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"10.1016\/j.jacbts.2021.10.002_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2001.tb03924.x","article-title":"Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis?","volume":"947","author":"Garc\u00eda-Carde\u00f1a","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jacbts.2021.10.002_bib31","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1152\/ajpheart.00828.2005","article-title":"Heterogeneous response of microvascular endothelial cells to shear stress","volume":"290","author":"Hong","year":"2006","journal-title":"Am J Physiol Hear Circ Physiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib32","first-page":"1","article-title":"Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation","volume":"23","author":"Wu","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2021.10.002_bib33","article-title":"Integrated regional cardiac hemodynamic imaging and RNA sequencing reveal corresponding heterogeneity of ventricular wall shear stress and endocardial transcriptome","volume":"5","author":"McCormick","year":"2016","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"suppl 1","key":"10.1016\/j.jacbts.2021.10.002_bib34","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jacc.2011.09.022","article-title":"Hypoplastic left heart syndrome: current considerations and expectations","volume":"59","author":"Feinstein","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib35","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jacc.2017.07.734","article-title":"Effect of losartan on mitral valve changes after myocardial infarction","volume":"70","author":"Bartko","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2021.10.002_bib36","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(00)02213-3","article-title":"ELITE II \u2014 effect of losartan compared with captopril on mortality in patients with symptomatic heart failure","volume":"355","author":"Pitt","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jacbts.2021.10.002_bib37","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.stem.2020.07.015","article-title":"Intrinsic endocardial defects contribute to hypoplastic left heart syndrome","volume":"27","author":"Miao","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jacbts.2021.10.002_bib38","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1021\/acsbiomaterials.8b00628","article-title":"Vascular endothelial cell\u00a0behavior in complex mechanical microenvironments","volume":"4","author":"James","year":"2018","journal-title":"ACS Biomater Sci Eng"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X21003053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X21003053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:25:21Z","timestamp":1762820721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X21003053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S2452302X21003053"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2021.10.002","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abnormal Flow Conditions Promote Endocardial Fibroelastosis Via Endothelial-to-Mesenchymal Transition, Which Is Responsive to Losartan Treatment","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2021.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}