{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:12:01Z","timestamp":1787314321649,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T00:00:00Z","timestamp":1640563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771627"],"award-info":[{"award-number":["81771627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770312"],"award-info":[{"award-number":["81770312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871432"],"award-info":[{"award-number":["31871432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170305"],"award-info":[{"award-number":["82170305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971061"],"award-info":[{"award-number":["81971061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873481"],"award-info":[{"award-number":["81873481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jacbts.2021.12.007","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T14:32:50Z","timestamp":1650897170000},"page":"348-362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-6912","authenticated-orcid":false,"given":"Ke","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Quan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Na","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dong","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hao","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2021.12.007_bib1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/CIRCRESAHA.116.309386","article-title":"Pediatric cardiomyopathies","volume":"121","author":"Lee","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2021.12.007_bib2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/CIRCRESAHA.117.309711","article-title":"Classification, epidemiology, and global burden of cardiomyopathies","volume":"121","author":"McKenna","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2021.12.007_bib3","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/CIRCRESAHA.117.311812","article-title":"Cardiomyopathies: an overview","volume":"121","author":"Braunwald","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2021.12.007_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacbts.2021.12.007_bib5","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1016\/j.jacc.2020.12.072","article-title":"Contemporary and future approaches to precision medicine in inherited cardiomyopathies: JACC focus seminar 3\/5","volume":"77","author":"Fatkin","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2021.12.007_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41569-020-0428-2","article-title":"Epidemiology of the inherited cardiomyopathies","volume":"18","author":"McKenna","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacbts.2021.12.007_bib7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.cardfail.2012.01.017","article-title":"Pediatric cardiomyopathy: importance of genetic and metabolic evaluation","volume":"18","author":"Kindel","year":"2012","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.jacbts.2021.12.007_bib8","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.jacc.2018.08.2171","article-title":"Genetic basis of severe childhood-onset cardiomyopathies","volume":"72","author":"Vasilescu","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2021.12.007_bib9","first-page":"640","article-title":"Cardiomyopathy: an overview","volume":"96","author":"Brieler","year":"2017","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jacbts.2021.12.007_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jtemb.2014.09.011","article-title":"Selenium deficiency associated porcine and human cardiomyopathies","volume":"31","author":"Oropeza-Moe","year":"2015","journal-title":"J\u00a0Trace Elem Med Biol"},{"key":"10.1016\/j.jacbts.2021.12.007_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-physiol-021115-105045","article-title":"The biochemistry and physiology of mitochondrial fatty acid \u03b2-oxidation and its genetic disorders","volume":"78","author":"Houten","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jacbts.2021.12.007_bib12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ymgme.2017.02.002","article-title":"Lethal neonatal case and review of primary\u00a0short-chain enoyl-CoA hydratase (SCEH) deficiency associated with secondary lymphocyte pyruvate dehydrogenase complex (PDC)\u00a0deficiency","volume":"120","author":"Bedoyan","year":"2017","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jacbts.2021.12.007_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejpn.2020.07.007","article-title":"Phenotypic spectrum of short-chain enoyl-Coa hydratase-1 (ECHS1) deficiency","volume":"28","author":"Masnada","year":"2020","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.jacbts.2021.12.007_bib14","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCULATIONAHA.120.049438","article-title":"Short-chain enoyl-CoA hydratase mediates histone crotonylation and contributes to cardiac homeostasis","volume":"143","author":"Tang","year":"2021","journal-title":"Circulation."},{"key":"10.1016\/j.jacbts.2021.12.007_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1158\/0008-5472.CAN-19-1023","article-title":"Inactivation of the AMPK-GATA3-ECHS1 pathway induces fatty acid synthesis that promotes clear cell renal cell carcinoma growth","volume":"80","author":"Qu","year":"2020","journal-title":"Cancer Res"},{"key":"10.1016\/j.jacbts.2021.12.007_bib16","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41467-017-00489-5","article-title":"Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jacbts.2021.12.007_bib17","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jacbts.2021.12.007_bib18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jacc.2020.05.070","article-title":"Targeting RNA with antisense oligonucleotides and small interfering RNA: JACC State-of-the-Art Review","volume":"76","author":"Katzmann","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2021.12.007_bib19","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.309202","article-title":"A\u00a0Simplified, Langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart","volume":"119","author":"Ackers-Johnson","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2021.12.007_bib20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/CIRCRESAHA.119.315999","article-title":"Glutamyl-prolyl-tRNA synthetase regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis","volume":"127","author":"Wu","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2021.12.007_bib21","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/nprot.2007.202","article-title":"Extraction, purification and analysis of histones","volume":"2","author":"Shechter","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jacbts.2021.12.007_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2014.04.046","article-title":"A\u00a0nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation","volume":"158","author":"Sutendra","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jacbts.2021.12.007_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-anchem-061516-045357","article-title":"Relative and absolute quantitation in mass spectrometry\u2013based proteomics","volume":"11","author":"Ankney","year":"2018","journal-title":"Annu Rev Anal Chem"},{"key":"10.1016\/j.jacbts.2021.12.007_bib24","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1038\/s41467-021-23827-0","article-title":"Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jacbts.2021.12.007_bib25","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1038\/s41467-019-10375-x","article-title":"APC\/C(CDH1) synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression","volume":"10","author":"Li","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jacbts.2021.12.007_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41392-020-0114-1","article-title":"SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation","volume":"5","author":"Palomer","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"179","key":"10.1016\/j.jacbts.2021.12.007_bib27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jprot.2018.03.007","article-title":"Serum proteome profiling in canine idiopathic dilated cardiomyopathy using TMT-based quantitative proteomics approach","volume":"15","author":"Bili\u0107","year":"2018","journal-title":"J\u00a0Proteomics"},{"key":"10.1016\/j.jacbts.2021.12.007_bib28","doi-asserted-by":"crossref","first-page":"916","DOI":"10.14336\/AD.2020.0401","article-title":"P300 in cardiac development and accelerated cardiac aging","volume":"11","author":"Ghosh","year":"2020","journal-title":"Aging Dis"},{"key":"10.1016\/j.jacbts.2021.12.007_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/JCI136488","article-title":"Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy","volume":"131","author":"Guenantin","year":"2021","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jacbts.2021.12.007_bib30","doi-asserted-by":"crossref","first-page":"107514","DOI":"10.1016\/j.pharmthera.2020.107514","article-title":"Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases","volume":"210","author":"Schiano","year":"2020","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jacbts.2021.12.007_bib31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41418-019-0381-y","article-title":"The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1alpha","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jacbts.2021.12.007_bib32","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/hep.30668","article-title":"p300 acetyltransferase is a cytoplasm-to-nucleus shuttle for SMAD2\/3 and TAZ nuclear transport in transforming growth factor \u03b2-stimulated hepatic stellate cells","volume":"70","author":"Wang","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jacbts.2021.12.007_bib33","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCRESAHA.118.312498","article-title":"Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular diseases","volume":"123","author":"Kane","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2021.12.007_bib34","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1161\/CIRCULATIONAHA.116.022495","article-title":"Normalization of NAD+ redox balance as a therapy for heart failure","volume":"134","author":"Lee","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2021.12.007_bib35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pharmthera.2016.03.005","article-title":"Epigenetics and obesity cardiomyopathy: from pathophysiology to prevention and management","volume":"161","author":"Zhang","year":"2016","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jacbts.2021.12.007_bib36","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jnutbio.2015.06.006","article-title":"Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3","volume":"26","author":"Bagul","year":"2015","journal-title":"J\u00a0Nutr Biochem"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X21004289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X21004289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:24:03Z","timestamp":1778891043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X21004289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S2452302X21004289"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2021.12.007","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2021.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}