{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:13:51Z","timestamp":1793103231647,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jacbts.2023.03.014","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:58:55Z","timestamp":1688565535000},"page":"1123-1137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling"],"prefix":"10.1016","volume":"8","author":[{"given":"Jessica","family":"Gambardella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislovas S.","family":"Jankauskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urna","family":"Kansakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Varzideh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Avvisato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nella","family":"Prevete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Sidoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Mone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xujun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Santulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2023.03.014_bib1","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1093\/ehjcvp\/pvac029","article-title":"Updated ACC\/AHA\/HFSA 2022 guidelines on heart failure: what is new? From epidemiology to clinical management","volume":"8","author":"Santulli","year":"2022","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"key":"10.1016\/j.jacbts.2023.03.014_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106035","article-title":"Current and future therapeutic perspective in chronic heart failure","volume":"175","author":"Mascolo","year":"2022","journal-title":"Pharmacol Res"},{"issue":"22","key":"10.1016\/j.jacbts.2023.03.014_bib3","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1161\/CIRCULATIONAHA.121.055781","article-title":"Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming and the development of human dilated cardiomyopathy","volume":"145","author":"Feng","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2023.03.014_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106038","article-title":"Mitochondrial dysfunction and mitochondrial therapies in heart failure","volume":"175","author":"Wu","year":"2022","journal-title":"Pharmacol Res"},{"issue":"36","key":"10.1016\/j.jacbts.2023.03.014_bib5","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"10.1016\/j.jacbts.2023.03.014_bib6","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1073\/pnas.96.14.8144","article-title":"Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy","volume":"96","author":"Narula","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.jacbts.2023.03.014_bib7","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3390\/ijms24043534","article-title":"Ketone bodies and cardiovascular disease: an alternate fuel\u00a0source to the rescue","volume":"24","author":"Manolis","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jacbts.2023.03.014_bib8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12974-020-01948-5","article-title":"\u03b2-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology","volume":"17","author":"Shippy","year":"2020","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.jacbts.2023.03.014_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.681513","article-title":"Beta-hydroxybutyrate, friend or foe for stressed hearts","volume":"2","author":"Chu","year":"2021","journal-title":"Front Aging"},{"issue":"9","key":"10.1016\/j.jacbts.2023.03.014_bib10","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI17061","article-title":"Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A","volume":"111","author":"Holtwick","year":"2003","journal-title":"J\u00a0Clin Invest"},{"issue":"43","key":"10.1016\/j.jacbts.2023.03.014_bib11","doi-asserted-by":"crossref","first-page":"36455","DOI":"10.1074\/jbc.M112.412932","article-title":"S-adenosylmethionine-dependent protein methylation is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes","volume":"287","author":"Jackson","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jacbts.2023.03.014_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41497","article-title":"ASH1-catalyzed H3K36 methylation drives gene repression and marks H3K27me2\/3-competent chromatin","volume":"7","author":"Bicocca","year":"2018","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.jacbts.2023.03.014_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.127111","article-title":"CBX5\/G9a\/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis","volume":"5","author":"Ligresti","year":"2019","journal-title":"JCI Insight"},{"issue":"7908","key":"10.1016\/j.jacbts.2023.03.014_bib14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41586-022-04649-6","article-title":"\u03b2-Hydroxybutyrate suppresses colorectal cancer","volume":"605","author":"Dmitrieva-Posocco","year":"2022","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jacbts.2023.03.014_bib15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic diet reduces midlife mortality and improves memory in aging mice","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metab"},{"issue":"23","key":"10.1016\/j.jacbts.2023.03.014_bib16","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.3390\/nu14235003","article-title":"The role of ketogenic diet in the treatment of neurological diseases","volume":"14","author":"Dynka","year":"2022","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jacbts.2023.03.014_bib17","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/advances\/nmaa180","article-title":"The efficacy of ketogenic therapies in the clinical management of people with neurodegenerative disease: a systematic review","volume":"12","author":"Dewsbury","year":"2021","journal-title":"Adv Nutr"},{"issue":"2","key":"10.1016\/j.jacbts.2023.03.014_bib18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.jacbts.2023.03.014_bib19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12916-022-02352-x","article-title":"Ketone body beta-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway","volume":"20","author":"Huang","year":"2022","journal-title":"BMC Med"},{"issue":"3","key":"10.1016\/j.jacbts.2023.03.014_bib20","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/nu15030524","article-title":"\u03b2-Hydroxybutyrate regulates activated microglia to alleviate neurodegenerative processes in neurological diseases: a scoping review","volume":"15","author":"Jayashankar","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.jacbts.2023.03.014_bib21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fnmol.2016.00122","article-title":"Tumor metabolism, the ketogenic diet and \u03b2-hydroxybutyrate: novel approaches to adjuvant brain tumor therapy","volume":"9","author":"Woolf","year":"2016","journal-title":"Front Mol Neurosci"},{"issue":"18","key":"10.1016\/j.jacbts.2023.03.014_bib22","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1161\/CIRCULATIONAHA.118.036459","article-title":"Cardiovascular effects of treatment with the ketone body 3-hydroxybutyrate in chronic heart failure patients","volume":"139","author":"Nielsen","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2023.03.014_bib23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejphar.2018.04.019","article-title":"Treatment with D-beta-hydroxybutyrate protects heart from ischemia\/reperfusion injury in mice","volume":"829","author":"Yu","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"10.1016\/j.jacbts.2023.03.014_bib24","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.molmet.2014.07.010","article-title":"Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling","volume":"3","author":"Schugar","year":"2014","journal-title":"Mol Metab"},{"issue":"18","key":"10.1016\/j.jacbts.2023.03.014_bib25","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1093\/cvr\/cvac142","article-title":"Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development","volume":"118","author":"McKinsey","year":"2023","journal-title":"Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.jacbts.2023.03.014_bib26","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3390\/antiox10071153","article-title":"\u03b2-Hydroxybutyrate, a ketone body, potentiates the antioxidant defense via thioredoxin 1 upregulation in cardiomyocytes","volume":"10","author":"Oka","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"12","key":"10.1016\/j.jacbts.2023.03.014_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004417","article-title":"Cardiac-specific Bdh1 overexpression ameliorates oxidative stress and cardiac remodeling in pressure overload-induced heart failure","volume":"10","author":"Uchihashi","year":"2017","journal-title":"Circ Heart Fail"},{"issue":"2","key":"10.1016\/j.jacbts.2023.03.014_bib28","doi-asserted-by":"crossref","first-page":"dvx009","DOI":"10.1093\/eep\/dvx009","article-title":"An emerging role for epigenetic regulation of Pgc-1alpha expression in\u00a0environmentally stimulated brown adipose thermogenesis","volume":"3","author":"Gill","year":"2017","journal-title":"Environ Epigenet"},{"key":"10.1016\/j.jacbts.2023.03.014_bib29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fcvm.2020.00002","article-title":"Multiple levels of PGC-1alpha dysregulation in heart failure","volume":"7","author":"Oka","year":"2020","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"10.1016\/j.jacbts.2023.03.014_bib30","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/ehjcvp\/pvab039","article-title":"SGLT2 inhibitors in cardiovascular medicine","volume":"7","author":"Varzideh","year":"2021","journal-title":"Eur Heart J Cardiovasc Pharmacother"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X23001201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X23001201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:27:44Z","timestamp":1762820864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X23001201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2452302X23001201"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2023.03.014","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ketone Bodies Rescue Mitochondrial Dysfunction Via Epigenetic Remodeling","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2023.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}