{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:38:53Z","timestamp":1792082333683,"version":"4.4.0"},"reference-count":106,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jacbts.2023.12.003","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T12:33:12Z","timestamp":1712579592000},"page":"522-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases"],"prefix":"10.1016","volume":"9","author":[{"given":"Manish","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Kuchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jacbts.2023.12.003_bib1","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1161\/CIR.0000000000001123","article-title":"Heart disease and stroke statistics-2023 update: a report from the American Heart Association","volume":"147","author":"Tsao","year":"2023","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jacbts.2023.12.003_bib2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.cger.2009.07.007","article-title":"The burden of cardiovascular disease in the elderly: morbidity, mortality, and costs","volume":"25","author":"Yazdanyar","year":"2009","journal-title":"Clin Geriatr Med"},{"issue":"15","key":"10.1016\/j.jacbts.2023.12.003_bib3","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.jacc.2017.01.064","article-title":"the aging cardiovascular system: understanding it at the cellular and clinical levels","volume":"69","author":"Paneni","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jacbts.2023.12.003_bib4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12551-017-0255-9","article-title":"Cardiac aging and heart\u00a0disease in humans","volume":"9","author":"Steenman","year":"2017","journal-title":"Biophys Rev"},{"issue":"2","key":"10.1016\/j.jacbts.2023.12.003_bib5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"Lopez-Otin","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tcb.2022.04.011","article-title":"The heterogeneity of cellular senescence: insights at the single-cell level","volume":"33","author":"Cohn","year":"2023","journal-title":"Trends Cell Biol"},{"issue":"10","key":"10.1016\/j.jacbts.2023.12.003_bib7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s43587-021-00121-8","article-title":"Strategies for targeting senescent cells in human disease","volume":"1","author":"Gasek","year":"2021","journal-title":"Nat Aging"},{"issue":"10","key":"10.1016\/j.jacbts.2023.12.003_bib8","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/s43587-021-00107-6","article-title":"An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in\u00a0vivo","volume":"1","author":"Wang","year":"2021","journal-title":"Nat Aging"},{"issue":"6311","key":"10.1016\/j.jacbts.2023.12.003_bib9","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"issue":"7589","key":"10.1016\/j.jacbts.2023.12.003_bib10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cmet.2021.11.002","article-title":"Targeting p21(Cip1) highly expressing cells in adipose tissue alleviates insulin resistance in obesity","volume":"34","author":"Wang","year":"2022","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.jacbts.2023.12.003_bib12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev Cell"},{"issue":"7814","key":"10.1016\/j.jacbts.2023.12.003_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-020-2403-9","article-title":"Senolytic CAR T cells reverse senescence-associated pathologies","volume":"583","author":"Amor","year":"2020","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.jacbts.2023.12.003_bib14","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/s43587-021-00151-2","article-title":"Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice","volume":"1","author":"Suda","year":"2021","journal-title":"Nat Aging"},{"issue":"6526","key":"10.1016\/j.jacbts.2023.12.003_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.abb5916","article-title":"Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders","volume":"371","author":"Johmura","year":"2021","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.jacbts.2023.12.003_bib16","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.ccell.2023.05.006","article-title":"Senescent alveolar macrophages promote early-stage lung tumorigenesis","volume":"41","author":"Prieto","year":"2023","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.jacbts.2023.12.003_bib17","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles' heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.jacbts.2023.12.003_bib18","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nm.4010","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","volume":"22","author":"Chang","year":"2016","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2017.02.031","article-title":"Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging","volume":"169","author":"Baar","year":"2017","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jacbts.2023.12.003_bib21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-99852-2","article-title":"Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker","volume":"11","author":"Poblocka","year":"2021","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jacbts.2023.12.003_bib23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.atherosclerosis.2007.09.040","article-title":"Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease","volume":"198","author":"Satoh","year":"2008","journal-title":"Atherosclerosis"},{"issue":"13","key":"10.1016\/j.jacbts.2023.12.003_bib24","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/01.CIR.0000013836.85741.17","article-title":"Endothelial cell senescence in human atherosclerosis: role of telomere in\u00a0endothelial dysfunction","volume":"105","author":"Minamino","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2023.12.003_bib25","doi-asserted-by":"crossref","first-page":"g4227","DOI":"10.1136\/bmj.g4227","article-title":"Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis","volume":"349","author":"Haycock","year":"2014","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.jacbts.2023.12.003_bib26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1474-9728.2004.00105.x","article-title":"Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal\/mesenchymal defects and accelerated atherosclerosis","volume":"3","author":"Csoka","year":"2004","journal-title":"Aging Cell"},{"issue":"23","key":"10.1016\/j.jacbts.2023.12.003_bib27","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1002\/ajmg.a.31346","article-title":"Hutchinson-Gilford progeria syndrome: review of the phenotype","volume":"140","author":"Hennekam","year":"2006","journal-title":"Am J Med Genet A"},{"issue":"8","key":"10.1016\/j.jacbts.2023.12.003_bib28","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s43587-021-00089-5","article-title":"Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis","volume":"1","author":"Childs","year":"2021","journal-title":"Nat Aging"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-022-00906-w","article-title":"Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics","volume":"55","author":"Han","year":"2023","journal-title":"Exp Mol Med"},{"issue":"Suppl 2","key":"10.1016\/j.jacbts.2023.12.003_bib30","doi-asserted-by":"crossref","first-page":"S166","DOI":"10.1055\/s-2001-18579","article-title":"The endothelium as a metabolic and endocrine organ: its relation with insulin resistance","volume":"109","author":"Baumgartner-Parzer","year":"2001","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"6","key":"10.1016\/j.jacbts.2023.12.003_bib31","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.3390\/ijms23063346","article-title":"Pathophysiology of atherosclerosis","volume":"23","author":"Jebari-Benslaiman","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.jacbts.2023.12.003_bib32","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1253\/circj.CJ-14-0621","article-title":"Macrophage phenotypes and their modulation in atherosclerosis","volume":"78","author":"De Paoli","year":"2014","journal-title":"Circ J"},{"issue":"7","key":"10.1016\/j.jacbts.2023.12.003_bib33","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.bbadis.2018.08.015","article-title":"Vascular smooth muscle cell senescence and age-related diseases: state of the art","volume":"1865","author":"Chi","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"31","key":"10.1016\/j.jacbts.2023.12.003_bib34","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1093\/eurheartj\/ehz919","article-title":"Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis","volume":"41","author":"Stojanovic","year":"2020","journal-title":"Eur Heart J"},{"issue":"10","key":"10.1016\/j.jacbts.2023.12.003_bib35","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.mayocp.2014.05.017","article-title":"Association of coronary artery calcium and coronary heart disease events in young and elderly participants in the multi-ethnic study of atherosclerosis: a secondary analysis of a prospective, population-based cohort","volume":"89","author":"Tota-Maharaj","year":"2014","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"10.1016\/j.jacbts.2023.12.003_bib36","first-page":"e31","article-title":"Atypical manifestation of myocardial ischemia in the elderly","volume":"102","author":"Ochiai","year":"2014","journal-title":"Arq Bras Cardiol"},{"issue":"18","key":"10.1016\/j.jacbts.2023.12.003_bib37","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.jacc.2017.12.068","article-title":"Coronary artery disease in patients >\/=80 years of age","volume":"71","author":"Madhavan","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jacbts.2023.12.003_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12931","article-title":"Aged-senescent cells contribute to impaired heart regeneration","volume":"18","author":"Lewis-McDougall","year":"2019","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.jacbts.2023.12.003_bib39","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/01.RES.0000117306.10142.50","article-title":"Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression","volume":"94","author":"Torella","year":"2004","journal-title":"Circ Res"},{"issue":"19","key":"10.1016\/j.jacbts.2023.12.003_bib40","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1113\/JP274775","article-title":"Decline in cellular function of aged mouse c-kit(+) cardiac progenitor cells","volume":"595","author":"Castaldi","year":"2017","journal-title":"J\u00a0Physiol"},{"issue":"10","key":"10.1016\/j.jacbts.2023.12.003_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13249","article-title":"Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery","volume":"19","author":"Dookun","year":"2020","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.jacbts.2023.12.003_bib42","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12945","article-title":"Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction","volume":"18","author":"Walaszczyk","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.jacbts.2023.12.003_bib43","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.actbio.2021.08.028","article-title":"Local delivery of a senolytic drug in ischemia and reperfusion-injured heart attenuates cardiac remodeling and restores impaired cardiac function","volume":"135","author":"Lee","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jacbts.2023.12.003_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2022.111740","article-title":"Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice","volume":"208","author":"Salerno","year":"2022","journal-title":"Mech Ageing Dev"},{"issue":"6","key":"10.1016\/j.jacbts.2023.12.003_bib45","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1536\/ihj.19-131","article-title":"Fisetin alleviates atrial inflammation, remodeling, and vulnerability to atrial fibrillation after myocardial infarction","volume":"60","author":"Liu","year":"2019","journal-title":"Int Heart J"},{"issue":"12","key":"10.1016\/j.jacbts.2023.12.003_bib46","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","article-title":"Myocardial ischaemia\u2013reperfusion injury and cardioprotection in perspective","volume":"17","author":"Heusch","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"10.1016\/j.jacbts.2023.12.003_bib47","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1200\/JCO.2010.31.6208","article-title":"Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors","volume":"29","author":"Gandhi","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"4","key":"10.1016\/j.jacbts.2023.12.003_bib48","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jacc.2022.05.017","article-title":"Coronary in-stent restenosis: JACC State-of-the-Art Review","volume":"80","author":"Giustino","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jacbts.2023.12.003_bib49","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1021\/acsbiomaterials.1c01611","article-title":"A\u00a0senolytic-eluting coronary stent for the prevention of in-stent restenosis","volume":"8","author":"Kim","year":"2022","journal-title":"ACS Biomater Sci Eng"},{"issue":"18","key":"10.1016\/j.jacbts.2023.12.003_bib50","article-title":"Postinfarction hearts are protected by premature senescent cardiomyocytes via GATA 4-dependent CCN 1 secretion","volume":"7","author":"Cui","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"9","key":"10.1016\/j.jacbts.2023.12.003_bib51","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.18632\/aging.101931","article-title":"Aging and ischemic stroke","volume":"11","author":"Yousufuddin","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.05.022","article-title":"Risk factors among stroke subtypes in Brazil","volume":"22","author":"Porcello Marrone","year":"2013","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"issue":"3-4","key":"10.1016\/j.jacbts.2023.12.003_bib53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000353125","article-title":"Ischemia-reperfusion injury in stroke","volume":"1","author":"Nour","year":"2013","journal-title":"Interv Neurol"},{"issue":"21","key":"10.1016\/j.jacbts.2023.12.003_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111967","article-title":"Senolytic therapy for cerebral ischemia-reperfusion injury","volume":"22","author":"Lim","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-95344-5","article-title":"Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype","volume":"11","author":"Torres-Querol","year":"2021","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.jacbts.2023.12.003_bib56","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.7150\/ijbs.84060","article-title":"Ability of local clearance of senescent cells in ipsilateral hemisphere to mitigate acute ischemic brain injury in mice","volume":"19","author":"Lu","year":"2023","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jacbts.2023.12.003_bib57","article-title":"Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice","volume":"17","author":"Wang","year":"2023","journal-title":"Front Neurosci"},{"issue":"7","key":"10.1016\/j.jacbts.2023.12.003_bib58","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/cvr\/cvab208","article-title":"Efficacy and limitations of senolysis in atherosclerosis","volume":"118","author":"Garrido","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.jacbts.2023.12.003_bib59","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/acel.12458","article-title":"Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice","volume":"15","author":"Roos","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.jacbts.2023.12.003_bib60","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.arr.2016.01.007","article-title":"Hypertension and aging","volume":"26","author":"Buford","year":"2016","journal-title":"Ageing Res Rev"},{"issue":"2","key":"10.1016\/j.jacbts.2023.12.003_bib61","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0735-1097(94)90305-0","article-title":"Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women","volume":"24","author":"Celermajer","year":"1994","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"14","key":"10.1016\/j.jacbts.2023.12.003_bib62","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jacc.2010.12.017","article-title":"Aortic stiffness: current understanding and future directions","volume":"57","author":"Cavalcante","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.jacbts.2023.12.003_bib63","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jacc.2020.11.023","article-title":"Cardiovascular aging and longevity: JACC State-of-the-Art Review","volume":"77","author":"Pietri","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib64","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/HYPERTENSIONAHA.111.176560","article-title":"Relationship between sympathetic baroreflex sensitivity and arterial stiffness in elderly men and women","volume":"59","author":"Okada","year":"2012","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.jacbts.2023.12.003_bib65","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1161\/HYPERTENSIONAHA.114.03348","article-title":"Endothelial sodium channels trigger endothelial salt sensitivity with aging","volume":"64","author":"Paar","year":"2014","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/01.HYP.18.1.67","article-title":"Sodium and volume sensitivity of blood pressure. Age and pressure change over time","volume":"18","author":"Weinberger","year":"1991","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.jacbts.2023.12.003_bib67","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.jacc.2005.07.037","article-title":"Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT)","volume":"46","author":"McEniery","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jacbts.2023.12.003_bib68","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2165\/00002512-199303030-00005","article-title":"Age-related changes in the renin-aldosterone system. Physiological effects and clinical implications","volume":"3","author":"Bauer","year":"1993","journal-title":"Drugs Aging"},{"issue":"6","key":"10.1016\/j.jacbts.2023.12.003_bib69","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1097\/HJH.0000000000000157","article-title":"Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping","volume":"32","author":"Morgan","year":"2014","journal-title":"J\u00a0Hypertens"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib70","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1161\/HYPERTENSIONAHA.107.099432","article-title":"Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a","volume":"52","author":"Westhoff","year":"2008","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.jacbts.2023.12.003_bib71","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1161\/CIRCULATIONAHA.106.626606","article-title":"Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway","volume":"114","author":"Kunieda","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2023.12.003_bib72","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: a systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med Rev"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib73","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12967-021-02935-x","article-title":"Heart failure with preserved ejection fraction based on aging and comorbidities","volume":"19","author":"Lin","year":"2021","journal-title":"J\u00a0Transl Med"},{"issue":"4","key":"10.1016\/j.jacbts.2023.12.003_bib74","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00059-022-05123-9","article-title":"Comorbidities in heart failure with preserved ejection fraction","volume":"47","author":"Deichl","year":"2022","journal-title":"Herz"},{"issue":"3","key":"10.1016\/j.jacbts.2023.12.003_bib75","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/01.CIR.0000048894.99865.02","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.jacbts.2023.12.003_bib76","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1161\/CIRCULATIONAHA.123.064071","article-title":"Sarcopenia and cardiovascular diseases","volume":"147","author":"Damluji","year":"2023","journal-title":"Circulation"},{"issue":"Suppl 3","key":"10.1016\/j.jacbts.2023.12.003_bib77","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1038\/sj.ejcn.1601025","article-title":"Fat and protein redistribution with aging: metabolic considerations","volume":"54","author":"Beaufrere","year":"2000","journal-title":"Eur J Clin Nutr"},{"issue":"5","key":"10.1016\/j.jacbts.2023.12.003_bib78","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/ajcn\/82.5.923","article-title":"Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society","volume":"82","author":"Villareal","year":"2005","journal-title":"Am J Clin Nutr"},{"issue":"11","key":"10.1016\/j.jacbts.2023.12.003_bib79","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/ejhf.1294","article-title":"The epicardial adipose inflammatory triad: coronary atherosclerosis, atrial fibrillation, and heart failure with a preserved ejection fraction","volume":"20","author":"Packer","year":"2018","journal-title":"Eur J Heart Fail"},{"issue":"5","key":"10.1016\/j.jacbts.2023.12.003_bib80","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/CIRCULATIONAHA.116.024825","article-title":"Contemporary assessment of left ventricular diastolic function in older adults: the Atherosclerosis Risk in Communities Study","volume":"135","author":"Shah","year":"2017","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib81","article-title":"Effect of aging and sex on cardiovascular structure and function in wildtype mice assessed with echocardiography","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.jacbts.2023.12.003_bib82","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100492","article-title":"Length-independent telomere damage drives post-mitotic cardiomyocyte senescence","volume":"38","author":"Anderson","year":"2019","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.jacbts.2023.12.003_bib83","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.55838","article-title":"Prevalence and incidence of atrial fibrillation among older primary care patients","volume":"6","author":"Khurshid","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"2","key":"10.1016\/j.jacbts.2023.12.003_bib84","first-page":"158","article-title":"Aging and cardiac fibrosis","volume":"2","author":"Biernacka","year":"2011","journal-title":"Aging Dis"},{"issue":"3","key":"10.1016\/j.jacbts.2023.12.003_bib85","first-page":"179","article-title":"Predisposing factors for atrial fibrillation in the elderly","volume":"14","author":"Wasmer","year":"2017","journal-title":"J\u00a0Geriatr Cardiol"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib86","first-page":"36","article-title":"Atrial fibrillation progression is associated with cell senescence burden as determined by p53 and p16 expression","volume":"9","author":"Jesel","year":"2019","journal-title":"J\u00a0Clin Med"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib87","doi-asserted-by":"crossref","first-page":"298","DOI":"10.14336\/AD.2021.0619","article-title":"Atrial fibrillation underlies cardiomyocyte senescence and contributes to deleterious atrial remodeling during disease progression","volume":"13","author":"Adili","year":"2022","journal-title":"Aging Dis"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib88","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.hrthm.2015.07.032","article-title":"Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study","volume":"13","author":"Carlquist","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacbts.2023.12.003_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153774","article-title":"Quercetin improves atrial fibrillation through inhibiting TGF-beta\/Smads pathway via promoting MiR-135b expression","volume":"93","author":"Wang","year":"2021","journal-title":"Phytomedicine"},{"issue":"6660","key":"10.1016\/j.jacbts.2023.12.003_bib90","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1126\/science.ade4961","article-title":"Aging impairs the neurovascular interface in the heart","volume":"381","author":"Wagner","year":"2023","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib91","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1038\/s41467-019-12888-x","article-title":"Identification and characterization of cardiac glycosides as senolytic compounds","volume":"10","author":"Triana-Mart\u00ednez","year":"2019","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.jacbts.2023.12.003_bib92","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s42255-019-0122-z","article-title":"Cardiac glycosides are broad-spectrum senolytics","volume":"1","author":"Guerrero","year":"2019","journal-title":"Nat Metab"},{"issue":"10","key":"10.1016\/j.jacbts.2023.12.003_bib93","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jacc.2017.12.060","article-title":"Digoxin and mortality in patients with atrial fibrillation","volume":"71","author":"Lopes","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jacbts.2023.12.003_bib94","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.amjcard.2018.09.036","article-title":"Meta-analysis of effects of digoxin on survival in patients with atrial fibrillation or heart failure: an update","volume":"123","author":"Vamos","year":"2019","journal-title":"Am J Cardiol"},{"issue":"11","key":"10.1016\/j.jacbts.2023.12.003_bib95","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study","volume":"62","author":"Osnabrugge","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacbts.2023.12.003_bib96","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/ATVBAHA.119.313067","article-title":"Aortic valve stenosis: from basic mechanisms to novel therapeutic targets","volume":"40","author":"Goody","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"21","key":"10.1016\/j.jacbts.2023.12.003_bib97","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/01.CIR.101.21.2497","article-title":"New insights into the progression of aortic stenosis: implications for secondary prevention","volume":"101","author":"Palta","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2023.12.003_bib98","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.atherosclerosis.2018.08.029","article-title":"Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease","volume":"277","author":"Cho","year":"2018","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.jacbts.2023.12.003_bib99","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s40520-020-01681-2","article-title":"The role of inflammation and metabolic risk factors in the pathogenesis of calcific aortic valve stenosis","volume":"33","author":"Conte","year":"2021","journal-title":"Aging Clin Exp Res"},{"issue":"12","key":"10.1016\/j.jacbts.2023.12.003_bib100","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1001\/jamacardio.2021.3718","article-title":"Association of mortality with aortic stenosis severity in outpatients: results from the VALVENOR study","volume":"6","author":"Coisne","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"9","key":"10.1016\/j.jacbts.2023.12.003_bib101","article-title":"Causes of\u00a0death following transcatheter aortic valve replacement: a systematic review and meta-analysis","volume":"4","author":"Xiong","year":"2015","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"21","key":"10.1016\/j.jacbts.2023.12.003_bib102","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.3390\/cells11213389","article-title":"Cellular senescence, aging and non-aging processes in calcified aortic valve stenosis: from bench-side to bedside","volume":"11","author":"Moln\u00e1r","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.jacbts.2023.12.003_bib103","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/eurheartj\/ehn501","article-title":"Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair","volume":"30","author":"Matsumoto","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2023.12.003_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.carpath.2021.107318","article-title":"Cellular senescence evaluated by P16INK4a immunohistochemistry is a prevalent phenomenon in advanced calcific aortic valve disease","volume":"52","author":"Oh","year":"2021","journal-title":"Cardiovasc Pathol"},{"issue":"Suppl_1","key":"10.1016\/j.jacbts.2023.12.003_bib105","article-title":"Abstract 12544:\u00a0Enhanced senescence expression in the aortic valve of experimental metabolic syndrome porcine","volume":"140","author":"Go","year":"2019","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.jacbts.2023.12.003_bib106","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/s41591-023-02543-w","article-title":"Senolytic therapy in mild Alzheimer\u2019s disease: a phase 1 feasibility trial","volume":"29","author":"Gonzales","year":"2023","journal-title":"Nat Med"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X23005296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X23005296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T07:46:05Z","timestamp":1715154365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X23005296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":106,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S2452302X23005296"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2023.12.003","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2023.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}