{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:59:52Z","timestamp":1793303992960,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004961","name":"Tecnol\u00f3gico de Monterrey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jacbts.2024.12.009","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T14:45:58Z","timestamp":1739976358000},"page":"800-821","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cannabidiol Prevents Heart Failure Dysfunction and Remodeling Through Preservation of Mitochondrial Function and Calcium Handling"],"prefix":"10.1016","volume":"10","author":[{"given":"Gerardo","family":"Garc\u00eda-Rivas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-5779","authenticated-orcid":false,"given":"Omar","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Bernal-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Silva-Platas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Salazar-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"M\u00e9ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Morales-Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-6265","authenticated-orcid":false,"given":"Hugo","family":"Alves-Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn Rogelio","family":"Ramos-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor","family":"Rubio-Infante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"V\u00e1zquez-Garza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Lu\u00e9vano-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"L\u00f3pez-Mor\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Chapoy-Villanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Luis","family":"Velasco-Bolom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Mendoza-Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio F.","family":"Contreras-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-5653","authenticated-orcid":false,"given":"Carlos","family":"Jerjes-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Torre-Amione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2024.12.009_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/01.RES.61.1.70","article-title":"Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure","volume":"61","author":"Gwathmey","year":"1987","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2024.12.009_bib2","first-page":"0","article-title":"Mitochondrial calcium regulation of cardiac metabolism in health and disease","volume":"39","author":"Balderas","year":"2024","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.jacbts.2024.12.009_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00395-007-0666-z","article-title":"Excitation-contraction coupling and mitochondrial energetics","volume":"102","author":"Maack","year":"2007","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib4","article-title":"ACTIN anchors the highly oligomeric DRP1 at mitochondria-sarcoplasmic reticulum contact sites in adult murine heart: its functional implication","author":"Fernandez-Sanz","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.jacbts.2024.12.009_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijcard.2018.05.054","article-title":"Mitochondrial calcium uniporter inhibition provides cardioprotection in pressure overload-induced heart failure through autophagy enhancement","volume":"271","author":"Yu","year":"2018","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib6","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1111\/jcmm.14227","article-title":"The mechanical effects of CRT promoting autophagy via mitochondrial calcium uniporter down-regulation and mitochondrial dynamics alteration","volume":"23","author":"Yu","year":"2019","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jacbts.2024.12.009_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13946","article-title":"Targeting the mitochondrial Ca","volume":"237","author":"Lozano","year":"2023","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.jacbts.2024.12.009_bib8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jacbts.2024.01.007","article-title":"Mitochondrial Ca","volume":"9","author":"Alves-Figueiredo","year":"2024","journal-title":"JACC Basic Transl Sci"},{"issue":"18","key":"10.1016\/j.jacbts.2024.12.009_bib9","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.3390\/ijms21186740","article-title":"The effects of cannabidiol, a non-intoxicating compound of cannabis, on the cardiovascular system in health and disease","volume":"21","author":"Kicman","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jacbts.2024.12.009_bib10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41419-019-2024-0","article-title":"Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia","volume":"10","author":"Olivas-Aguirre","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jacbts.2024.12.009_bib11","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1523\/JNEUROSCI.4212-08.2009","article-title":"Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels","volume":"29","author":"Ryan","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.jacbts.2024.12.009_bib12","first-page":"283","article-title":"Cannabidiol impairs brain mitochondrial metabolism and neuronal integrity","volume":"8","author":"Drummond-Main","year":"2023","journal-title":"Cannabis Cannabinoid Res"},{"key":"10.1016\/j.jacbts.2024.12.009_bib13","doi-asserted-by":"crossref","first-page":"H3602","DOI":"10.1152\/ajpheart.00098.2007","article-title":"Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury","volume":"293","author":"Durst","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib14","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/j.1476-5381.2010.00755.x","article-title":"Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion","volume":"160","author":"Walsh","year":"2010","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib15","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/FJC.0000000000000287","article-title":"Pharmacologic effects of cannabidiol on acute reperfused myocardial infarction in rabbits: evaluated with 3.0T cardiac magnetic resonance imaging and histopathology","volume":"66","author":"Feng","year":"2015","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.784","article-title":"Cannabidiol-mediated RISK PI3K\/AKT and MAPK\/ERK pathways decreasing reperfusion myocardial damage","volume":"9","author":"Franco-Vadillo","year":"2021","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.jacbts.2024.12.009_bib17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.etap.2013.04.018","article-title":"Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity","volume":"36","author":"Fouad","year":"2013","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2119\/molmed.2014.00261","article-title":"Cannabidiol protects against doxorubicin- induced cardiomyopathy by modulating mitochondrial function and biogenesis","volume":"21","author":"Hao","year":"2015","journal-title":"Mol Med"},{"key":"10.1016\/j.jacbts.2024.12.009_bib19","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.jacc.2010.07.033","article-title":"Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy","volume":"56","author":"Rajesh","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2119\/molmed.2016.00007","article-title":"Cannabidiol limits T cell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation","volume":"22","author":"Lee","year":"2016","journal-title":"Mol Med"},{"key":"10.1016\/j.jacbts.2024.12.009_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4587024","article-title":"Therapeutic applications of cannabinoids in cardiomyopathy and heart failure","volume":"2020","author":"Garza-Cervantes","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jacbts.2024.12.009_bib22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ejhf.463","article-title":"A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics","volume":"18","author":"Ruiz-Esparza","year":"2016","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"10.1016\/j.jacbts.2024.12.009_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002484","article-title":"Full expression of cardiomyopathy is partly dependent on B-cells: a pathway that involves cytokine activation, immunoglobulin deposition, and activation of apoptosis","volume":"5","author":"Cordero-Reyes","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacbts.2024.12.009_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009543","article-title":"Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism","volume":"5","author":"Yuen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2024.12.009_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0292687","article-title":"Exploring the mechanisms underlying stroke volume variability reduction in a murine model of heart failure with reduced ejection fraction","volume":"18","author":"Fern\u00e1ndez-Mendoza","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2024.12.009_bib26","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/nprot.2008.138","article-title":"Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats","volume":"3","author":"Pacher","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jacbts.2024.12.009_bib27","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.309202","article-title":"A simplified, langendorff-free method for concomitant isolation of viable cardiac myocytes and nonmyocytes from the adult mouse heart","volume":"119","author":"Ackers-Johnson","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2024.12.009_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10863-015-9640-x","article-title":"Antineoplastic copper coordinated complexes (Casiopeinas) uncouple oxidative phosphorylation and induce mitochondrial permeability transition in cardiac mitochondria and cardiomyocytes","volume":"48","author":"Silva-Platas","year":"2016","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.jacbts.2024.12.009_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9912434","article-title":"Resveratrol prevents right ventricle dysfunction, calcium mishandling, and energetic failure via SIRT3 stimulation in pulmonary arterial hypertension","volume":"2021","author":"Bernal-Ram\u00edrez","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jacbts.2024.12.009_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2019.102138","article-title":"Simultaneous assessment of calcium handling and contractility dynamics in isolated ventricular myocytes of a rat model of post-acute isoproterenol-induced cardiomyopathy","volume":"86","author":"P\u00e9rez-Trevi\u00f1o","year":"2020","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jacbts.2024.12.009_bib31","doi-asserted-by":"crossref","first-page":"C1073","DOI":"10.1152\/ajpcell.00586.2006","article-title":"SparkMaster: automated calcium spark analysis with ImageJ","volume":"293","author":"Picht","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib32","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1089\/thy.2018.0668","article-title":"Changes in the stoichiometry of uniplex decrease mitochondrial calcium overload and contribute to tolerance of cardiac ischemia\/reperfusion injury in hypothyroidism","volume":"29","author":"Chapoy-Villanueva","year":"2019","journal-title":"Thyroid"},{"issue":"5","key":"10.1016\/j.jacbts.2024.12.009_bib33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/antibiotics11050557","article-title":"Computational design of inhibitors targeting the catalytic \u03b2 subunit of Escherichia coli F O F 1 -ATP synthase","volume":"11","author":"Avila-Barrientos","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.jacbts.2024.12.009_bib34","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005659","article-title":"OpenMM 7: rapid development of high performance algorithms for molecular dynamics","volume":"13","author":"Eastman","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib36","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/acs.jctc.9b00591","article-title":"ff19SB: amino-acid-specific protein backbone parameters trained against quantum mechanics energy surfaces in solution","volume":"16","author":"Tian","year":"2020","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.jacbts.2024.12.009_bib37","series-title":"Amber 2022","author":"Case","year":"2022"},{"key":"10.1016\/j.jacbts.2024.12.009_bib38","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1021\/ct300418h","article-title":"MMPBSA.py: an efficient program for end-state free energy calculations","volume":"8","author":"Miller","year":"2012","journal-title":"J Chem Theory Comput"},{"key":"10.1016\/j.jacbts.2024.12.009_bib39","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.3389\/fimmu.2019.02315","article-title":"Immunity, inflammation and heart failure: their role on cardiac function and iron status","volume":"10","author":"Perticone","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib40","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1093\/cvr\/cvy088","article-title":"Hyperactive ryanodine receptors in human heart failure and ischaemic cardiomyopathy reside outside of couplons","volume":"114","author":"Dries","year":"2018","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2024.12.009_bib41","doi-asserted-by":"crossref","first-page":"H645","DOI":"10.1152\/ajpheart.00564.2016","article-title":"Silica nanoparticles induce cardiotoxicity interfering with energetic status and Ca","volume":"312","author":"Guerrero-Beltr\u00e1n","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.bjp.0707442","article-title":"The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9- tetrahydrocannabivarin","volume":"153","author":"Pertwee","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/sj.bjp.0707133","article-title":"Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro","volume":"150","author":"Thomas","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib44","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1111\/bph.13250","article-title":"Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor","volume":"172","author":"Laprairie","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib45","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1111\/bph.14440","article-title":"Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol-dimethylheptyl at the type 1 and type 2 cannabinoid receptors","volume":"176","author":"Tham","year":"2019","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101301","article-title":"Cannabinoids and cannabinoid receptors: the story so far","volume":"23","author":"Shahbazi","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.jacbts.2024.12.009_bib47","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1111\/bph.13497","article-title":"An update on PPAR activation by cannabinoids","volume":"173","author":"O'Sullivan","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib48","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jacbts.2019.07.009","article-title":"Targeting the mitochondria in heart failure: a translational perspective","volume":"5","author":"Sabbah","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.jacbts.2024.12.009_bib49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1177\/1074248414532013","article-title":"The effect of cannabidiol on ischemia\/reperfusion-induced ventricular arrhythmias: the role of adenosine A1 receptors","volume":"20","author":"Gonca","year":"2015","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.jacbts.2024.12.009_bib50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1021\/ja00730a036","article-title":"The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish","volume":"93","author":"Gaoni","year":"1971","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.jacbts.2024.12.009_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166753","article-title":"Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor \u03b2 pathway in monocrotaline-induced pulmonary hypertension in rats","volume":"1869","author":"Krzy\u017cewska","year":"2023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jacbts.2024.12.009_bib52","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1097\/j.pain.0000000000001896","article-title":"A randomized, double-blind, placebo- controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain","volume":"161","author":"Verrico","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.jacbts.2024.12.009_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.875546","article-title":"High-CBD extract (CBD-X) downregulates cytokine storm systemically and locally in inflamed lungs","volume":"13","author":"Aswad","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib54","doi-asserted-by":"crossref","first-page":"985","DOI":"10.21037\/atm-22-4082","article-title":"Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA\/CREB pathway in rats","volume":"10","author":"Nie","year":"2022","journal-title":"Ann Transl Med"},{"issue":"1","key":"10.1016\/j.jacbts.2024.12.009_bib55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/antiox9010021","article-title":"Antioxidative and anti-inflammatory properties of cannabidiol","volume":"9","author":"Atalay","year":"2019","journal-title":"Antioxidants (Basel)"},{"issue":"4","key":"10.1016\/j.jacbts.2024.12.009_bib56","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3390\/ijms21041295","article-title":"Chronic cannabidiol administration fails to diminish blood pressure in rats with primary and secondary hypertension despite its effects on cardiac and plasma endocannabinoid system, oxidative stress and lipid metabolism","volume":"21","author":"Remiszewski","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jacbts.2024.12.009_bib57","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.redox.2016.12.029","article-title":"Cannabidiol attenuates OGD\/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons","volume":"11","author":"Sun","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2018.01.014","article-title":"Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: reversal by cannabidiol","volume":"139","author":"da Silva","year":"2018","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.jacbts.2024.12.009_bib59","first-page":"4906","article-title":"Purified Cannabidiol, the main non- psychotropic component of Cannabis sativa, alone, counteracts neuronal apoptosis in experimental multiple sclerosis","volume":"19","author":"Giacoppo","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jacbts.2024.12.009_bib60","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2024.12.009_bib61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u03baB in Oxidative stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib62","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00395-020-0797-z","article-title":"Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS","volume":"115","author":"Hamilton","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.734210","article-title":"RyR2 and calcium release in heart failure","volume":"12","author":"Benitah","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib64","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.yjmcc.2015.06.009","article-title":"Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity","volume":"85","author":"Oda","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib65","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ceca.2010.10.007","article-title":"The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte","volume":"48","author":"Greensmith","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jacbts.2024.12.009_bib66","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000184","article-title":"Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart","volume":"2","author":"Qin","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacbts.2024.12.009_bib67","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.celrep.2018.07.022","article-title":"Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting ncx1-mediated mitochondrial calcium overload","volume":"24","author":"Lu","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.jacbts.2024.12.009_bib68","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00395-019-0726-1","article-title":"Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion","volume":"114","author":"Cao","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib69","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.freeradbiomed.2015.11.013","article-title":"Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy","volume":"90","author":"Ni","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jacbts.2024.12.009_bib70","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0707460","article-title":"The orphan receptor GPR55 is a novel cannabinoid receptor","volume":"152","author":"Ryberg","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib71","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.487","article-title":"l-\u03b1-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia\/reperfusion injury via a GPR55\/ROCK-dependent pathway","volume":"7","author":"Robertson-Gray","year":"2019","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.jacbts.2024.12.009_bib72","doi-asserted-by":"crossref","first-page":"22481","DOI":"10.1074\/jbc.M113.456178","article-title":"Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55","volume":"288","author":"Yu","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacbts.2024.12.009_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108999","article-title":"GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses","volume":"9","author":"Walsh","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2024.12.009_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-93755-y","article-title":"Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling","volume":"11","author":"Puhl","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacbts.2024.12.009_bib75","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ejphar.2009.03.010","article-title":"Time-dependent vascular actions of cannabidiol in the rat aorta","volume":"612","author":"O'Sullivan","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jacbts.2024.12.009_bib76","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1161\/CIRCULATIONAHA.119.042267","article-title":"Female sex is protective in a preclinical model of heart failure with preserved ejection fraction","volume":"140","author":"Tong","year":"2019","journal-title":"Circulation"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X24004595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X24004595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:33:40Z","timestamp":1762626820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X24004595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2452302X24004595"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2024.12.009","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabidiol Prevents Heart Failure Dysfunction and Remodeling Through Preservation of Mitochondrial Function and Calcium Handling","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2024.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}]}}