{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:37:17Z","timestamp":1787960237519,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"COST","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020407","name":"European Research Area Network on Cardiovascular Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Nederlandse Hartstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005971","name":"German Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jacbts.2025.101355","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T20:20:53Z","timestamp":1754425253000},"page":"101355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4255-8224","authenticated-orcid":false,"given":"Constance C.F.M.J.","family":"Baaten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wollenhaupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias M.","family":"Henning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Vondenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas R.","family":"Schr\u00f6er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Stamellou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgay","family":"Saritas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berkan","family":"Kurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Boger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Antwerpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdolna","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Sternkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Miriam","family":"Buhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Raffetseder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola E.J.","family":"van der Meijden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke J.E.","family":"Kuijpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri M.H.","family":"Spronk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan J.","family":"Schunk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Jankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Fliser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thimoteus","family":"Speer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Kramann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kahles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Floege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Noels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2025.101355_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41569-018-0110-0","article-title":"Platelet biology and functions: new concepts and clinical perspectives","volume":"16","author":"van der Meijden","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacbts.2025.101355_bib2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1055\/s-2004-835678","article-title":"Platelet dysfunction in renal failure","volume":"30","author":"Boccardo","year":"2004","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jacbts.2025.101355_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/jth.13904","article-title":"Chronic kidney disease and bleeding risk in patients at high cardiovascular risk: a cohort study","volume":"16","author":"Ocak","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacbts.2025.101355_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2215\/CJN.04100321","article-title":"Platelet abnormalities in CKD and their implications for antiplatelet therapy","volume":"17","author":"Baaten","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jacbts.2025.101355_bib5","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1681\/ASN.2020101440","article-title":"Platelet function in CKD: a systematic review and meta-analysis","volume":"32","author":"Baaten","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jacbts.2025.101355_bib6","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jcp.25.9.745","article-title":"A clinical and experimental study of platelet function in chronic renal failure","volume":"25","author":"Evans","year":"1972","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jacbts.2025.101355_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212237","article-title":"Evaluation of hemostasis in patients with end-stage renal disease","volume":"14","author":"G\u00e4ckler","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jacbts.2025.101355_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2369-14-72","article-title":"Coagulation activation, depletion of platelet granules and endothelial integrity in case of uraemia and haemodialysis treatment","volume":"14","author":"Schoorl","year":"2013","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.jacbts.2025.101355_bib9","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-014294","article-title":"Blood coagulation system in patients with chronic kidney disease: a prospective observational study","volume":"7","author":"Huang","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.jacbts.2025.101355_bib10","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/CIRCRESAHA.123.321752","article-title":"Endothelial cell dysfunction and increased cardiovascular risk in patients with chronic kidney disease","volume":"132","author":"Baaten","year":"2023","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2025.101355_bib11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ki.2015.27","article-title":"High estimated pulmonary artery systolic pressure predicts adverse cardiovascular outcomes in stage 2-4 chronic kidney disease","volume":"88","author":"Bolignano","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.jacbts.2025.101355_bib12","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1681\/ASN.2018040405","article-title":"Dickkopf-3 (DKK3) in urine identifies patients with short-term risk of eGFR loss","volume":"29","author":"Zewinger","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jacbts.2025.101355_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102459","article-title":"Pro-oxidative priming but maintained cardiac function in a broad spectrum of murine models of chronic kidney disease","volume":"56","author":"Wollenhaupt","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.jacbts.2025.101355_bib14","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1182\/blood-2010-01-261669","article-title":"Procoagulant platelets: are they necrotic?","volume":"116","author":"Jackson","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jacbts.2025.101355_bib15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.thromres.2021.04.014","article-title":"Multiparameter microfluidics assay of thrombus formation reveals increased sensitivity to contraction and antiplatelet agents at physiological temperature","volume":"203","author":"Herfs","year":"2021","journal-title":"Thromb Res"},{"key":"10.1016\/j.jacbts.2025.101355_bib16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/jth.14360","article-title":"Red blood cells: the forgotten player in hemostasis and thrombosis","volume":"17","author":"Weisel","year":"2019","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacbts.2025.101355_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112002","article-title":"Lipocalin-2: structure, function, distribution and role in metabolic disorders","volume":"142","author":"Jaberi","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jacbts.2025.101355_bib18","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1161\/ATVBAHA.119.313645","article-title":"Native, intact glucagon-like peptide 1 is a natural suppressor of thrombus growth under physiological flow conditions","volume":"40","author":"Sternkopf","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacbts.2025.101355_bib19","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1055\/s-0040-1705138","article-title":"Assessment of thrombotic and bleeding tendency in two mouse models of chronic kidney disease: adenine-diet and 5\/6th nephrectomy","volume":"4","author":"Makhloufi","year":"2020","journal-title":"TH Open"},{"key":"10.1016\/j.jacbts.2025.101355_bib20","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1055\/s-0040-1714101","article-title":"Receptor for advanced glycation end products is involved in platelet hyperactivation and arterial thrombosis during chronic kidney disease","volume":"120","author":"Ortillon","year":"2020","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jacbts.2025.101355_bib21","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1182\/blood-2005-09-3687","article-title":"Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo","volume":"107","author":"Dubois","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jacbts.2025.101355_bib22","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41581-021-00423-5","article-title":"Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations","volume":"17","author":"Noels","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jacbts.2025.101355_bib23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3324\/haematol.2017.176974","article-title":"Variable impairment of platelet functions in patients with severe, genetically linked immune deficiencies","volume":"103","author":"Nagy","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.jacbts.2025.101355_bib24","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1182\/blood-2016-10-744060","article-title":"Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease-associated thrombosis in mice","volume":"129","author":"Yang","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jacbts.2025.101355_bib25","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.3389\/fphys.2018.01623","article-title":"Indoxyl sulfate promotes arterial thrombosis in rat model via increased levels of complex TF\/VII, PAI-1, platelet activation as well as decreased contents of SIRT1 and SIRT3","volume":"9","author":"Karbowska","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.jacbts.2025.101355_bib26","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1681\/ASN.2017080929","article-title":"Uremic solute-aryl hydrocarbon receptor-tissue factor axis associates with thrombosis after vascular injury in humans","volume":"29","author":"Kolachalama","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jacbts.2025.101355_bib27","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1038\/s41598-017-03130-z","article-title":"Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD)","volume":"7","author":"Kim","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacbts.2025.101355_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46724-5","article-title":"Contribution of the uremic milieu to an increased pro-inflammatory monocytic phenotype in chronic kidney disease","volume":"9","author":"Borges Bonan","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacbts.2025.101355_bib29","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1182\/blood-2024-203793","article-title":"Bone marrow remodeling and pro-inflammatory megakaryocytes in a murine model of chronic kidney disease (abstr)","volume":"144","author":"Carminita","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.jacbts.2025.101355_bib30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/00365513.2011.558106","article-title":"Platelet depletion, platelet activation and coagulation during treatment with hemodialysis","volume":"71","author":"Schoorl","year":"2011","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.jacbts.2025.101355_bib31","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1093\/ndt\/gfn137","article-title":"Platelet activation in clinical haemodialysis: LMWH as a major contributor to bio-incompatibility?","volume":"23","author":"Gritters","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jacbts.2025.101355_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.thromres.2012.12.010","article-title":"Investigation of a potential protective mechanism against heparin-induced thrombocytopenia in patients on chronic intermittent hemodialysis","volume":"131","author":"Tanhehco","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.jacbts.2025.101355_bib33","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.blre.2017.07.004","article-title":"Platelet populations and priming in hematological diseases","volume":"31","author":"Baaten","year":"2017","journal-title":"Blood Rev"},{"key":"10.1016\/j.jacbts.2025.101355_bib34","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.jtha.2023.01.006","article-title":"Repeated platelet activation and the potential of previously activated platelets to contribute to thrombus formation","volume":"21","author":"De Simone","year":"2023","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacbts.2025.101355_bib35","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1161\/CIRCRESAHA.122.321761","article-title":"Fibrosis in pathology of heart and kidney: from deep RNA-sequencing to novel molecular targets","volume":"132","author":"Schreibing","year":"2023","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2025.101355_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-51905-3","article-title":"Collagen turnover profiles in chronic kidney disease","volume":"9","author":"Rasmussen","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacbts.2025.101355_bib37","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1182\/blood-2015-04-641654","article-title":"Fibrin activates GPVI in human and mouse platelets","volume":"126","author":"Alshehri","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jacbts.2025.101355_bib38","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.thromres.2008.03.024","article-title":"Hypercoagulability in chronic kidney disease is associated with coagulation activation but not endothelial function","volume":"123","author":"Adams","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.jacbts.2025.101355_bib39","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1182\/bloodadvances.2017011171","article-title":"Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI","volume":"2","author":"Montague","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.jacbts.2025.101355_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejim.2016.11.009","article-title":"Different impact of aspirin on renal progression in patients with predialysis advanced chronic kidney disease with or without previous stroke","volume":"39","author":"Hsiao","year":"2017","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jacbts.2025.101355_bib41","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.jacc.2010.02.068","article-title":"Aspirin is beneficial in hypertensive patients with chronic kidney disease: a post-hoc subgroup analysis of a randomized controlled trial","volume":"56","author":"Jardine","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2025.101355_bib42","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.kint.2022.09.023","article-title":"Effects of aspirin on cardiovascular outcomes in patients with chronic kidney disease","volume":"103","author":"Mann","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.jacbts.2025.101355_bib43","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1038\/s41598-021-86192-4","article-title":"Low-dose aspirin was associated with an increased risk of cardiovascular events in patients with chronic kidney disease patients and low bodyweight: results from KNOW-CKD study","volume":"11","author":"Oh","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jacbts.2025.101355_bib44","first-page":"CD008834","article-title":"Antiplatelet agents for chronic kidney disease","volume":"2","author":"Natale","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jacbts.2025.101355_bib45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s13063-022-06132-z","volume":"23","author":"Gallagher","year":"2022","journal-title":"Trials"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X25003080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X25003080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:34:03Z","timestamp":1762626843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X25003080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2452302X25003080"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2025.101355","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired Secondary Platelet Response in Chronic Kidney Disease as a Consequence of Prior Platelet Activation","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2025.101355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101355"}}