{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T17:58:33Z","timestamp":1772301513272,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jacbts.2026.101484","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:22:51Z","timestamp":1771874571000},"page":"101484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of a New PRKG1 Mutation Associated With Thoracic Aortic Aneurysm and Dissection"],"prefix":"10.1016","volume":"11","author":[{"given":"Darren E.","family":"Casteel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2026.101484_bib1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCRESAHA.118.312436","article-title":"Genetics of thoracic and abdominal aortic diseases","volume":"124","author":"Pinard","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101484_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-62703-459-3_2","article-title":"cGMP-dependent protein kinases (cGK)","volume":"1020","author":"Hofmann","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jacbts.2026.101484_bib3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ajhg.2013.06.019","article-title":"Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections","volume":"93","author":"Guo","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jacbts.2026.101484_bib4","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1038\/s41467-019-11389-1","article-title":"Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B(12) analog","volume":"10","author":"Schwaerzer","year":"2019","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.jacbts.2026.101484_bib5","article-title":"Activating PRKG1 variant enhances smooth muscle cell deformability to cause aortopathy","volume":"11","author":"Jost","year":"2026","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.jacbts.2026.101484_bib6","doi-asserted-by":"crossref","first-page":"34048","DOI":"10.1074\/jbc.M202761200","article-title":"A conserved serine juxtaposed to the pseudosubstrate site of type I cGMP-dependent protein kinase contributes strongly to autoinhibition and lower cGMP affinity","volume":"277","author":"Busch","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacbts.2026.101484_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000159231","article-title":"Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype","volume":"34","author":"Boerth","year":"1997","journal-title":"J Vasc Res"},{"key":"10.1016\/j.jacbts.2026.101484_bib8","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/ATVBAHA.114.304412","article-title":"Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome","volume":"35","author":"Crosas-Molist","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacbts.2026.101484_bib9","article-title":"Cardiac involvement in a patient with aortic aneurysm, familial thoracic-8","volume":"30","author":"Sayama","year":"2025","journal-title":"JACC Case Rep"},{"key":"10.1016\/j.jacbts.2026.101484_bib10","article-title":"Human stem cell models for Marfan syndrome: a brief overview of the rising star in disease modelling","volume":"12","author":"Aalders","year":"2024","journal-title":"Front Cell Dev Biol"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X26000021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X26000021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T17:05:57Z","timestamp":1772298357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X26000021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2452302X26000021"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101484","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of a New PRKG1 Mutation Associated With Thoracic Aortic Aneurysm and Dissection","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101484","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2025.101452","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101484"}}