{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:53:18Z","timestamp":1793040798219,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018088","name":"School of Medicine, University of Virginia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jacbts.2026.101554","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:42:34Z","timestamp":1778010154000},"page":"101554","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Semaglutide Reverses Ectopic Lipid Accumulation, Impaired Myocardial Perfusion Reserve, and Diastolic Dysfunction in a Mouse Model of Cardiometabolic Heart Disease"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3607-4661","authenticated-orcid":false,"given":"Thomas P.","family":"Skacel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nemati R.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin M.","family":"Pavelec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Quach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh A.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E.","family":"Bresticker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick H.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jacbts.2026.101554_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/CIRCULATIONAHA.116.026807","article-title":"Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction","volume":"136","author":"Obokata","year":"2017","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.jacbts.2026.101554_bib2","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1093\/cvr\/cvac120","article-title":"Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets","volume":"118","author":"Borlaug","year":"2022","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.jacbts.2026.101554_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2024-002711","article-title":"Adiposity, fat-free mass and incident heart failure in 500 000 individuals","volume":"11","author":"Oguntade","year":"2024","journal-title":"Open Heart"},{"issue":"16","key":"10.1016\/j.jacbts.2026.101554_bib4","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jacc.2025.06.055","article-title":"The adipokine hypothesis of heart failure with a preserved ejection fraction","volume":"86","author":"Packer","year":"2025","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.jacbts.2026.101554_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ejhf.1617","article-title":"Myocardial adipose deposition and the development of heart failure with preserved ejection fraction","volume":"22","author":"Wu","year":"2020","journal-title":"Eur J Heart Fail"},{"issue":"9","key":"10.1016\/j.jacbts.2026.101554_bib6","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41569-022-00679-9","article-title":"Epicardial adipose tissue in contemporary cardiology","volume":"19","author":"Iacobellis","year":"2022","journal-title":"Nat Rev Cardiol"},{"issue":"4","key":"10.1016\/j.jacbts.2026.101554_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.jacbts.2026.101554_bib8","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1002\/oby.20865","article-title":"Association of the degree of adiposity and duration of obesity with measures of cardiac structure and function: the CARDIA study","volume":"22","author":"Reis","year":"2014","journal-title":"Obesity (Silver Spring)"},{"issue":"7","key":"10.1016\/j.jacbts.2026.101554_bib9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.numecd.2015.03.016","article-title":"Visceral adiposity and left ventricular remodeling: the multi-ethnic study of atherosclerosis","volume":"25","author":"Abbasi","year":"2015","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"18","key":"10.1016\/j.jacbts.2026.101554_bib10","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1177\/2047487319891286","article-title":"Influence of visceral adiposity accumulation on adverse left and right ventricular mechanics in the community","volume":"27","author":"Sawada","year":"2020","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"10.1016\/j.jacbts.2026.101554_bib11","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1038\/s41598-018-37137-x","article-title":"The significance of the effect of visceral adiposity on left ventricular diastolic function in the general population","volume":"9","author":"Sawada","year":"2019","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.jacbts.2026.101554_bib12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMoa2032183","article-title":"Once-weekly semaglutide in adults with overweight or obesity","volume":"384","author":"Wilding","year":"2021","journal-title":"N Engl J Med"},{"issue":"24","key":"10.1016\/j.jacbts.2026.101554_bib13","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1056\/NEJMoa2307563","article-title":"Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes","volume":"389","author":"Lincoff","year":"2023","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jacbts.2026.101554_bib14","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1056\/NEJMoa2313917","article-title":"Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes","volume":"390","author":"Kosiborod","year":"2024","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.jacbts.2026.101554_bib15","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1056\/NEJMoa2306963","article-title":"Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity","volume":"389","author":"Kosiborod","year":"2023","journal-title":"N Engl J Med"},{"issue":"10456","key":"10.1016\/j.jacbts.2026.101554_bib16","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(24)01643-X","article-title":"Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials","volume":"404","author":"Kosiborod","year":"2024","journal-title":"Lancet"},{"issue":"17","key":"10.1016\/j.jacbts.2026.101554_bib17","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.jacc.2024.08.021","article-title":"Effect of semaglutide on cardiac structure and function in patients with obesity-related heart failure","volume":"84","author":"Solomon","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.jacbts.2026.101554_bib18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jacc.2024.05.065","article-title":"Effect of semaglutide on epicardial adipose tissue in type 2 diabetes","volume":"84","author":"Manubolu","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jacbts.2026.101554_bib19","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvz042","article-title":"Effects of semaglutide versus dulaglutide on epicardial fat thickness in subjects with type 2 diabetes and obesity","volume":"4","author":"Iacobellis","year":"2020","journal-title":"J Endocr Soc"},{"issue":"10","key":"10.1016\/j.jacbts.2026.101554_bib20","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.jacbts.2023.05.012","article-title":"The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF","volume":"8","author":"Withaar","year":"2023","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.jacbts.2026.101554_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocmr.2025.101947","article-title":"Preclinical MRI of proinflammatory epicardial adipose tissue: Accelerated methods for simultaneous fatty acid composition and relaxation parameter mapping with relationships to tissue biomarkers","author":"Bresticker","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"issue":"1","key":"10.1016\/j.jacbts.2026.101554_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12968-016-0273-y","article-title":"Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet","volume":"18","author":"Naresh","year":"2016","journal-title":"J Cardiovasc Magn Reson"},{"issue":"4","key":"10.1016\/j.jacbts.2026.101554_bib23","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/mrm.29348","article-title":"Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity-induced coronary microvascular disease","volume":"88","author":"Shah","year":"2022","journal-title":"Magn Reson Med"},{"issue":"5","key":"10.1016\/j.jacbts.2026.101554_bib24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jacbts.2022.11.005","article-title":"Obesity-induced coronary microvascular disease is prevented by iNOS deletion and reversed by iNOS inhibition","volume":"8","author":"Shah","year":"2023","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.jacbts.2026.101554_bib25","series-title":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals","year":"2011"},{"issue":"6","key":"10.1016\/j.jacbts.2026.101554_bib26","doi-asserted-by":"crossref","first-page":"e133429","DOI":"10.1172\/jci.insight.133429","article-title":"Semaglutide lowers body weight in rodents via distributed neural pathways","volume":"5","author":"Gabery","year":"2020","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.jacbts.2026.101554_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cmet.2010.06.001","article-title":"Assessment of feeding behavior in laboratory mice","volume":"12","author":"Ellacott","year":"2010","journal-title":"Cell Metab"},{"issue":"5","key":"10.1016\/j.jacbts.2026.101554_bib28","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/mrm.24565","article-title":"Cine-ASL: a steady-pulsed arterial spin labeling method for myocardial perfusion mapping in mice. Part I. Experimental study","volume":"70","author":"Troalen","year":"2013","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.jacbts.2026.101554_bib29","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1148\/radiol.2303021213","article-title":"Myocardial tissue tracking with two-dimensional cine displacement-encoded MR imaging: development and initial evaluation","volume":"230","author":"Kim","year":"2004","journal-title":"Radiology"},{"issue":"5","key":"10.1016\/j.jacbts.2026.101554_bib30","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/mrm.20487","article-title":"Black blood gradient echo cine magnetic resonance imaging of the mouse heart","volume":"53","author":"Berr","year":"2005","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jacbts.2026.101554_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocmr.2024.100801","article-title":"Respiratory self-gated radial arterial spin labeling for reduced variability in mouse myocardial perfusion mapping","volume":"26","author":"Skacel","year":"2024","journal-title":"J Cardiovasc Magn Reson"},{"issue":"1","key":"10.1016\/j.jacbts.2026.101554_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1109\/TMI.2006.884215","article-title":"Tracking myocardial motion from cine DENSE images using spatiotemporal phase unwrapping and temporal fitting","volume":"26","author":"Spottiswoode","year":"2007","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.jacbts.2026.101554_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1095159","article-title":"Improved computation of Lagrangian tissue displacement and strain for cine DENSE MRI using a regularized spatiotemporal least squares method","volume":"10","author":"Ghadimi","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"10.1016\/j.jacbts.2026.101554_bib34","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1002\/mrm.27694","article-title":"High-dimensionality undersampled patch-based reconstruction (HD-PROST) for accelerated multi-contrast MRI","volume":"81","author":"Bustin","year":"2019","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.jacbts.2026.101554_bib35","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/mrm.26479","article-title":"Multi-scale graph-cut algorithm for efficient water-fat separation","volume":"78","author":"Berglund","year":"2017","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.jacbts.2026.101554_bib36","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/mrm.27557","article-title":"Accurate fatty acid composition estimation of adipose tissue in the abdomen based on bipolar multi-echo MRI","volume":"81","author":"Schneider","year":"2019","journal-title":"Magn Reson Med"},{"issue":"2","key":"10.1016\/j.jacbts.2026.101554_bib37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/mrm.30285","article-title":"Fatty acid composition MRI of epicardial adipose tissue: methods and detection of proinflammatory biomarkers in ST-segment elevation myocardial infarction patients","volume":"93","author":"Echols","year":"2025","journal-title":"Magn Reson Med"},{"issue":"7","key":"10.1016\/j.jacbts.2026.101554_bib38","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/nbm.1622","article-title":"In vivo characterization of the liver fat 1H MR spectrum","volume":"24","author":"Hamilton","year":"2011","journal-title":"NMR Biomed"},{"issue":"10","key":"10.1016\/j.jacbts.2026.101554_bib39","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1007\/s00125-012-2639-5","article-title":"The ratio of visceral to subcutaneous fat, a metric of body fat distribution, is a unique correlate of cardiometabolic risk","volume":"55","author":"Kaess","year":"2012","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.jacbts.2026.101554_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/CIRCULATIONAHA.106.675355","article-title":"Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study","volume":"116","author":"Fox","year":"2007","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.jacbts.2026.101554_bib41","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.2337\/dc08-2280","article-title":"Abdominal subcutaneous adipose tissue: a protective fat depot?","volume":"32","author":"Porter","year":"2009","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.jacbts.2026.101554_bib42","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1210\/clinem\/dgad604","article-title":"Characteristics of abdominal visceral adipose tissue, metabolic health and the gut microbiome in adults","volume":"109","author":"U-Din","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.jacbts.2026.101554_bib43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/met.2008.0056","article-title":"Fatty acid composition of epicardial and subcutaneous human adipose tissue","volume":"7","author":"Pezeshkian","year":"2009","journal-title":"Metab Syndr Relat Disord"},{"issue":"1","key":"10.1016\/j.jacbts.2026.101554_bib44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13340-015-0212-4","article-title":"Glucose area under the curve during oral glucose tolerance test as an index of glucose intolerance","volume":"7","author":"Sakaguchi","year":"2015","journal-title":"Diabetol Int"},{"issue":"7","key":"10.1016\/j.jacbts.2026.101554_bib45","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s42255-025-01324-8","article-title":"CagriSema drives weight loss in rats by reducing energy intake and preserving energy expenditure","volume":"7","author":"Jacobsen","year":"2025","journal-title":"Nat Metab"},{"key":"10.1016\/j.jacbts.2026.101554_bib46","doi-asserted-by":"crossref","DOI":"10.1113\/JP289449","article-title":"Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet-induced obesity","author":"Jeromson","year":"2025","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.jacbts.2026.101554_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/cph4.70083","article-title":"Advantage of semaglutide: comprehensive analysis of metabolic impact of semaglutide-treated and pair-fed rats","volume":"15","author":"Byun","year":"2025","journal-title":"Compr Physiol"},{"issue":"2","key":"10.1016\/j.jacbts.2026.101554_bib48","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2337\/db25-0678","article-title":"Prolonged semaglutide treatment reveals stage-dependent changes to feeding behavior and metabolic adaptations in male mice","volume":"75","author":"Shah","year":"2025","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.jacbts.2026.101554_bib49","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.3390\/ijms25052961","article-title":"Semaglutide improves liver steatosis and de novo lipogenesis markers in obese and type-2-diabetic mice with metabolic-dysfunction-associated steatotic liver disease","volume":"25","author":"Soto-Catal\u00e1n","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jacbts.2026.101554_bib50","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/S0022-2275(20)39200-2","article-title":"Selective mobilization of adipose tissue fatty acids during energy depletion in the rat","volume":"36","author":"Raclot","year":"1995","journal-title":"J Lipid Res"},{"issue":"Pt 3","key":"10.1016\/j.jacbts.2026.101554_bib51","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1042\/bj3240911","article-title":"Selective release of human adipocyte fatty acids according to molecular structure","volume":"324","author":"Raclot","year":"1997","journal-title":"Biochem J"},{"issue":"8","key":"10.1016\/j.jacbts.2026.101554_bib52","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/cbf.3751","article-title":"Semaglutide (GLP-1 receptor agonist) stimulates browning on subcutaneous fat adipocytes and mitigates inflammation and endoplasmic reticulum stress in visceral fat adipocytes of obese mice","volume":"40","author":"Martins","year":"2022","journal-title":"Cell Biochem Funct"},{"issue":"9","key":"10.1016\/j.jacbts.2026.101554_bib53","article-title":"Semaglutide modulates proinflammatory epicardial adipogenesis with paracrine effects on hiPSC-atrial cardiomyocytes","volume":"10","author":"Basdas","year":"2025","journal-title":"JACC Basic Transl Sci"},{"issue":"37","key":"10.1016\/j.jacbts.2026.101554_bib54","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/eurheartj\/ehy531","article-title":"Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF","volume":"39","author":"Shah","year":"2018","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.jacbts.2026.101554_bib55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12968-015-0198-x","article-title":"Time course of cardiometabolic alterations in a high fat high sucrose diet mice model and improvement after GLP-1 analog treatment using multimodal cardiovascular magnetic resonance","volume":"17","author":"Abdesselam","year":"2015","journal-title":"J Cardiovasc Magn Reson"},{"issue":"6","key":"10.1016\/j.jacbts.2026.101554_bib56","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jacc.2024.04.064","article-title":"Liraglutide improves myocardial perfusion and energetics and exercise tolerance in patients with type 2 diabetes","volume":"84","author":"Chowdhary","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.jacbts.2026.101554_bib57","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.molmet.2017.08.010","article-title":"The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice","volume":"6","author":"Baggio","year":"2017","journal-title":"Mol Metab"},{"issue":"10","key":"10.1016\/j.jacbts.2026.101554_bib58","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.118.006740","article-title":"Modulation of cardiac ventricular excitability by GLP-1 (glucagon-like peptide-1)","volume":"11","author":"Ang","year":"2018","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"12","key":"10.1016\/j.jacbts.2026.101554_bib59","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/cvr\/cvae120","article-title":"Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node","volume":"120","author":"Lubberding","year":"2024","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.jacbts.2026.101554_bib60","doi-asserted-by":"crossref","first-page":"H235","DOI":"10.1152\/ajpheart.00809.2024","article-title":"Heart and health behavior responses to GLP-1 receptor agonists: a 12-wk study using wearable technology and causal inference","volume":"328","author":"Grosicki","year":"2025","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacbts.2026.101554_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocmr.2025.101940","article-title":"SCMR expert consensus statement on quantitative myocardial perfusion cardiovascular magnetic resonance imaging","author":"Chiribiri","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.jacbts.2026.101554_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocmr.2025.101972","article-title":"Multiparametric CMR identifies macrophage NOS2-mediated benefits of preventive SGLT2 inhibition in a mouse model of metabolic heart disease","author":"Bresticker","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.jacbts.2026.101554_bib63","series-title":"Cardiac MRI to investigate proinflammatory epicardial adipose tissue, macrophage involvement, and treatment response in cardiometabolic HFpEF. Doctor of Philosophy","author":"Bresticker","year":"2025"},{"key":"10.1016\/j.jacbts.2026.101554_bib64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12968-018-0477-4","article-title":"Associations and prognostic significance of diffuse myocardial fibrosis by cardiovascular magnetic resonance in heart failure with preserved ejection fraction","volume":"20","author":"Roy","year":"2018","journal-title":"J Cardiovasc Magn Reson"},{"issue":"5","key":"10.1016\/j.jacbts.2026.101554_bib65","doi-asserted-by":"crossref","first-page":"H1219","DOI":"10.1152\/ajpheart.00467.2023","article-title":"Sex-based differences in short- and longer-term diet-induced metabolic heart disease","volume":"326","author":"Croft","year":"2024","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"9","key":"10.1016\/j.jacbts.2026.101554_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046057","article-title":"Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue","volume":"7","author":"Pettersson","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jacbts.2026.101554_bib67","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3390\/cells14120870","article-title":"The loss of gonadal hormones has a different impact on aging female and male mice submitted to heart failure-inducing metabolic hypertensive stress","volume":"14","author":"Teou","year":"2025","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.jacbts.2026.101554_bib68","doi-asserted-by":"crossref","first-page":"H719","DOI":"10.1152\/ajpheart.00575.2024","article-title":"An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency","volume":"328","author":"Methawasin","year":"2025","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X26000720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X26000720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:18:12Z","timestamp":1783552692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X26000720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2452302X26000720"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101554","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Semaglutide Reverses Ectopic Lipid Accumulation, Impaired Myocardial Perfusion Reserve, and Diastolic Dysfunction in a Mouse Model of Cardiometabolic Heart Disease","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101554","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101554"}}