{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:56:46Z","timestamp":1792799806049,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003385","name":"Georg-August-Universit\u00e4t G\u00f6ttingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"AHA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005626","name":"Universit\u00e4t Regensburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005626","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jacbts.2026.101577","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:42:15Z","timestamp":1782157335000},"page":"101577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased Arrhythmic Risk in Obesity Is Transduced by Adipose Tissue\u2013Derived Extracellular Vesicles"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-9906","authenticated-orcid":false,"given":"Worawan B.","family":"Limpitikul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garcia-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Spangler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Betti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanhu","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Pabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Sossalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeli","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Ellinor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Gamazon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumya","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2026.101577_bib1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3,663 population-representative studies with 222 million children, adolescents, and adults","volume":"403","author":"Phelps","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jacbts.2026.101577_bib2","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1001\/jama.292.20.2471","article-title":"Obesity and the risk of new-onset atrial fibrillation","volume":"292","author":"Wang","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jacbts.2026.101577_bib3","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/j.jacc.2010.02.029","article-title":"The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (Women's Health Study)","volume":"55","author":"Tedrow","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib4","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.025984","article-title":"Body mass index in adolescence and long-term risk of early incident atrial fibrillation and subsequent mortality, heart failure, and ischemic stroke","volume":"11","author":"Djekic","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacbts.2026.101577_bib5","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1093\/eurheartj\/ehn324","article-title":"Obesity as a risk factor for the progression of paroxysmal to permanent atrial fibrillation: a longitudinal cohort study of 21 years","volume":"29","author":"Tsang","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacbts.2026.101577_bib6","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/imj.14874","article-title":"Adherence to guidelines regarding anticoagulation and risk factors for progression of atrial fibrillation in a nurse-led clinic","volume":"51","author":"Olivia","year":"2021","journal-title":"Intern Med J"},{"key":"10.1016\/j.jacbts.2026.101577_bib7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10654-017-0353-9","article-title":"Body mass index, abdominal fatness, and the risk of sudden cardiac death: a systematic review and dose-response meta-analysis of prospective studies","volume":"33","author":"Aune","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/2047487315591442","article-title":"Obesity and exercise-induced ectopic ventricular arrhythmias in apparently healthy middle aged adults","volume":"23","author":"Sabbag","year":"2016","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib9","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.orcp.2016.09.005","article-title":"Association of corrected QT interval with body mass index, and the impact of this association on mortality: results from the Third National Health and Nutrition Examination Survey","volume":"11","author":"Waheed","year":"2017","journal-title":"Obes Res Clin Pract"},{"key":"10.1016\/j.jacbts.2026.101577_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.amjcard.2010.10.018","article-title":"Relation of obesity to recurrence rate and burden of atrial fibrillation","volume":"107","author":"Guglin","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1540-8167.2009.01653.x","article-title":"A prospective study evaluating the role of obesity and obstructive sleep apnea for outcomes after catheter ablation of atrial fibrillation","volume":"21","author":"Chilukuri","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jamacardio.2019.4513","article-title":"Association between obesity-mediated atrial fibrillation and therapy with sodium channel blocker antiarrhythmic drugs","volume":"5","author":"Ornelas-Loredo","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib13","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.007626","article-title":"Impact of bariatric surgery on atrial fibrillation type","volume":"13","author":"Donnellan","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib14","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1016\/j.jacc.2016.09.940","article-title":"Bariatric surgery and the risk of new-onset atrial fibrillation in Swedish obese subjects","volume":"68","author":"Jamaly","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib15","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1001\/jama.2013.280521","article-title":"Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity in patients with atrial fibrillation: a randomized clinical trial","volume":"310","author":"Abed","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.jacbts.2026.101577_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12933-019-0976-0","article-title":"Impaired myocardial deformation and ventricular vascular coupling in obese adolescents with dysglycemia","volume":"18","author":"Brar","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jacbts.2026.101577_bib17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jchf.2014.03.014","article-title":"Impact of general and central adiposity on ventricular-arterial aging in women and men","volume":"2","author":"Wohlfahrt","year":"2014","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jacbts.2026.101577_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/antiox13010117","article-title":"Oxidative stress, inflammation, and mitochondrial dysfunction: a link between obesity and atrial fibrillation","volume":"13","author":"Balan","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jacbts.2026.101577_bib19","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1161\/CIRCULATIONAHA.116.024921","article-title":"Genetic obesity and the risk of atrial fibrillation: causal estimates from Mendelian randomization","volume":"135","author":"Chatterjee","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2026.101577_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal2658","article-title":"Detecting human coronary inflammation by imaging perivascular fat","volume":"9","author":"Antonopoulos","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jacbts.2026.101577_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.xgen.2025.100925","article-title":"The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity","author":"Chatterjee","year":"2025","journal-title":"Cell Genom"},{"key":"10.1016\/j.jacbts.2026.101577_bib22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.81.4.512","article-title":"Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation","volume":"81","author":"Yue","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101577_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.656631","article-title":"Inhibition of KCa3.1 channels suppresses atrial fibrillation via the attenuation of macrophage pro-inflammatory polarization in a canine model with prolonged rapid atrial pacing","volume":"8","author":"He","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jacbts.2026.101577_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1467089","article-title":"Cardiac macrophages in maintaining heart homeostasis and regulating ventricular remodeling of heart diseases","volume":"15","author":"Kang","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jacbts.2026.101577_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.900094","article-title":"Cardiac macrophages and their effects on arrhythmogenesis","volume":"13","author":"Xia","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.vesic.2023.100030","article-title":"Exomap1 mouse: a transgenic model for in vivo studies of exosome biology","volume":"2","author":"Fordjour","year":"2023","journal-title":"Extracell Vesicle"},{"key":"10.1016\/j.jacbts.2026.101577_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s00395-020-0780-8","article-title":"Inhibition of Na(V)1.8 prevents atrial arrhythmogenesis in human and mice","volume":"115","author":"Pabel","year":"2020","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib28","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCRESAHA.118.313249","article-title":"Metabolic maturation of human pluripotent stem cell\u2013derived cardiomyocytes by inhibition of HIF1alpha and LDHA","volume":"123","author":"Hu","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101577_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/CIRCRESAHA.116.309283","article-title":"A precision medicine approach to the rescue of function on malignant calmodulinopathic long-QT syndrome","volume":"120","author":"Limpitikul","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101577_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100026","article-title":"Subtype-directed differentiation of human iPSCs into atrial and ventricular cardiomyocytes","volume":"1","author":"Kleinsorge","year":"2020","journal-title":"STAR Protoc"},{"key":"10.1016\/j.jacbts.2026.101577_bib31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/7651_2020_300","article-title":"Generation of quiescent cardiac fibroblasts derived from human induced pluripotent stem cells","volume":"2454","author":"Zhang","year":"2022","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jacbts.2026.101577_bib32","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.ymthe.2022.03.008","article-title":"IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity","volume":"30","author":"Phu","year":"2022","journal-title":"Mol Ther"},{"key":"10.1016\/j.jacbts.2026.101577_bib33","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jacbts.2026.101577_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1126\/science.abq3061","article-title":"Recruited macrophages elicit atrial fibrillation","volume":"381","author":"Hulsmans","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.jacbts.2026.101577_bib35","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. journal"},{"key":"10.1016\/j.jacbts.2026.101577_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jacbts.2026.101577_bib37","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jacbts.2026.101577_bib38","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1002\/imt2.43","article-title":"Complex heatmap visualization","volume":"1","author":"Gu","year":"2022","journal-title":"Imeta"},{"key":"10.1016\/j.jacbts.2026.101577_bib39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jacbts.2026.101577_bib40","article-title":"ComBat-seq: batch effect adjustment for RNA-seq count data","volume":"2","author":"Zhang","year":"2020","journal-title":"NAR Genom Bioinform"},{"key":"10.1016\/j.jacbts.2026.101577_bib41","doi-asserted-by":"crossref","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jacbts.2026.101577_bib42","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2026.101577_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyac157","article-title":"A large genome-wide association study of QT interval length utilizing electronic health records","volume":"222","author":"Hoffmann","year":"2022","journal-title":"Genetics"},{"key":"10.1016\/j.jacbts.2026.101577_bib44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41588-024-02072-3","article-title":"Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases","volume":"57","author":"Roselli","year":"2025","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacbts.2026.101577_bib45","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41467-018-03621-1","article-title":"Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics","volume":"9","author":"Barbeira","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jacbts.2026.101577_bib46","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s41588-020-0706-2","article-title":"A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis","volume":"52","author":"Zhou","year":"2020","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacbts.2026.101577_bib47","article-title":"Minimum entropy framework identifies a novel class of genomic functional elements and reveals regulatory mechanisms at human disease loci","author":"Betti","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.jacbts.2026.101577_bib48","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41586-020-03145-z","article-title":"Regulatory genomic circuitry of human disease loci by integrative epigenomics","volume":"590","author":"Boix","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jacbts.2026.101577_bib49","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature23884","article-title":"The 4D nucleome project","volume":"549","author":"Dekker","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jacbts.2026.101577_bib50","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/nmeth.2148","article-title":"Iterative correction of Hi-C data reveals hallmarks of chromosome organization","volume":"9","author":"Imakaev","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jacbts.2026.101577_bib51","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/bioinformatics\/btz540","article-title":"Cooler: scalable storage for Hi-C data and other genomically labeled arrays","volume":"36","author":"Abdennur","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jacbts.2026.101577_bib52","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jacbts.2026.101577_bib53","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/FJC.0b013e3182116e39","article-title":"Fibroblasts and myofibroblasts: what are we talking about?","volume":"57","author":"Baum","year":"2011","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jacbts.2026.101577_bib54","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.160885","article-title":"Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation","volume":"7","author":"Bapat","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jacbts.2026.101577_bib55","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-derived circulating miRNAs regulate gene expression in other tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jacbts.2026.101577_bib56","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.023517","article-title":"PRRX1 Loss-of-function mutations underlying familial atrial fibrillation","volume":"10","author":"Guo","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacbts.2026.101577_bib57","doi-asserted-by":"crossref","DOI":"10.1080\/19336950.2024.2355121","article-title":"Cardiac L-type calcium channel regulation by Leucine-Rich Repeat-Containing Protein 10","volume":"18","author":"Siri-Angkul","year":"2024","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.jacbts.2026.101577_bib58","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.3390\/biomedicines10112963","article-title":"Adenosine and adenosine receptors: advances in atrial fibrillation","volume":"10","author":"Maille","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jacbts.2026.101577_bib59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0002-9149(97)00256-7","article-title":"Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology","volume":"79","author":"Shryock","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib60","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s12471-013-0435-6","article-title":"Signalling in sarcomeres in development and disease","volume":"21","author":"van Eldik","year":"2013","journal-title":"Neth Heart J"},{"key":"10.1016\/j.jacbts.2026.101577_bib61","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/cvr\/cvv022","article-title":"TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1","volume":"106","author":"Doleschal","year":"2015","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2026.101577_bib62","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1073\/pnas.0808793106","article-title":"Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound","volume":"106","author":"Kiyonaka","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2026.101577_bib63","article-title":"Stress in obesity and associated metabolic and cardiovascular disorders","author":"Holvoet","year":"2012","journal-title":"Scientifica (Cairo). 2012"},{"issue":"16","key":"10.1016\/j.jacbts.2026.101577_bib64","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jacc.2025.06.055","article-title":"The Adipokine hypothesis of heart failure with a preserved ejection fraction: a novel framework to explain pathogenesis and guide treatment","volume":"86","author":"Packer","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib65","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.3390\/ijms25158407","article-title":"Obesity arrhythmias: role of IL-6 trans-signaling","volume":"25","author":"Aromolaran","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jacbts.2026.101577_bib66","first-page":"89","article-title":"Obesity is associated with left atrial enlargement, E\/A reversal and left ventricular hypertrophy","volume":"13","author":"Movahed","year":"2008","journal-title":"Exp Clin Cardiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib67","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.pcad.2013.09.003","article-title":"Impact of obesity and weight loss on cardiac performance and morphology in adults","volume":"56","author":"Alpert","year":"2014","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacbts.2026.101577_bib68","doi-asserted-by":"crossref","first-page":"S4221","DOI":"10.21037\/jtd.2018.12.63","article-title":"Cardiac rhythm disorders in obstructive sleep apnea","volume":"10","author":"Geovanini","year":"2018","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.jacbts.2026.101577_bib69","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3390\/jpm13091323","article-title":"Metabolic syndrome and atrial fibrillation: different entities or combined disorders","volume":"13","author":"Zakynthinos","year":"2023","journal-title":"J Pers Med"},{"key":"10.1016\/j.jacbts.2026.101577_bib70","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1038\/s41366-025-01837-y","article-title":"Impact of diabetes on proteomic changes in circulating extracellular vesicles in individuals with obesity before and after bariatric surgery","volume":"49","author":"Lee","year":"2025","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jacbts.2026.101577_bib71","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/oby.21709","article-title":"Circulating adipocyte-derived exosomal microRNAs associated with decreased insulin resistance after gastric bypass","volume":"25","author":"Hubal","year":"2017","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jacbts.2026.101577_bib72","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/oby.22379","article-title":"Bariatric surgery alters microRNA content of circulating exosomes in patients with obesity","volume":"27","author":"Bae","year":"2019","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jacbts.2026.101577_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115732","article-title":"Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: implications for metabolic regulation and adipose tissue function","volume":"44","author":"Le Lay","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.jacbts.2026.101577_bib74","doi-asserted-by":"crossref","first-page":"7422","DOI":"10.7150\/thno.42167","article-title":"Current understanding of the role of adipose-derived extracellular vesicles in metabolic homeostasis and diseases: communication from the distance between cells\/tissues","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jacbts.2026.101577_bib75","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.2337\/db09-0216","article-title":"Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance","volume":"58","author":"Deng","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jacbts.2026.101577_bib76","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1161\/CIRCULATIONAHA.120.052009","article-title":"Extracellular vesicles from epicardial fat facilitate atrial fibrillation","volume":"143","author":"Shaihov-Teper","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2026.101577_bib77","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.hroo.2023.10.007","article-title":"MicroRNAs in extracellular vesicles released from epicardial adipose tissue promote arrhythmogenic conduction slowing","volume":"4","author":"Ernault","year":"2023","journal-title":"Heart Rhythm O2"},{"key":"10.1016\/j.jacbts.2026.101577_bib78","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.joa.2015.05.004","article-title":"Effects of a high-fat diet on the electrical properties of porcine atria","volume":"31","author":"Okumura","year":"2015","journal-title":"J Arrhythm"},{"key":"10.1016\/j.jacbts.2026.101577_bib79","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/jce.14955","article-title":"Effect of obesity and epicardial fat\/fatty infiltration on electrical and structural remodeling associated with atrial fibrillation in a novel canine model of obesity and atrial fibrillation: a comparative study","volume":"32","author":"Otsuka","year":"2021","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib80","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/s41366-021-00742-4","article-title":"Phospho-ablation of cardiac sodium channel Na(v)1.5 mitigates susceptibility to atrial fibrillation and improves glucose homeostasis under conditions of diet-induced obesity","volume":"45","author":"Dewal","year":"2021","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jacbts.2026.101577_bib81","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.119.008161","article-title":"Heterogeneity in conduction underlies obesity-related atrial fibrillation vulnerability","volume":"13","author":"Schram-Serban","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib82","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.032277","article-title":"Impact of obesity on atrial fibrillation pathogenesis and treatment options","volume":"13","author":"Sha","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacbts.2026.101577_bib83","doi-asserted-by":"crossref","first-page":"H2006","DOI":"10.1152\/ajpheart.00694.2011","article-title":"High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents","volume":"301","author":"Ma","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacbts.2026.101577_bib84","article-title":"Human heart-on-a-chip microphysiological system comprising endothelial cells, fibroblasts, and iPSC-derived cardiomyocytes","volume":"14","author":"Liu","year":"2024","journal-title":"Sci Rep"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X26000963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X26000963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:18:02Z","timestamp":1783552682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X26000963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":84,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2452302X26000963"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101577","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Arrhythmic Risk in Obesity Is Transduced by Adipose Tissue\u2013Derived Extracellular Vesicles","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101577","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101577"}}