{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:45:22Z","timestamp":1790948722164,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jacbts.2026.101639","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:29:05Z","timestamp":1790623745000},"page":"101639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Single-Cell Transcriptomics Reveals the Immune Pathogenesis of Isolated Coronary Arteritis Presenting as Refractory In-Stent Restenosis"],"prefix":"10.1016","volume":"11","author":[{"given":"Miao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Feng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Shun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Zhuang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Song","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Dong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Gang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6155-8118","authenticated-orcid":false,"given":"Hong-Zhao","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7352-022X","authenticated-orcid":false,"given":"Wei-Xian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2026.101639_bib1","first-page":"2","article-title":"SCAI Expert Consensus Statement on Management of In-Stent Restenosis and Stent Thrombosis","author":"Klein","year":"2023","journal-title":"Journal of the Society for Cardiovascular Angiography & Interventions"},{"key":"10.1016\/j.jacbts.2026.101639_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tcm.2025.07.009","article-title":"Precision management of coronary in-stent restenosis","volume":"36","author":"Wilson","year":"2026","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jacbts.2026.101639_bib3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pcad.2024.12.003","article-title":"Recurrent drug eluting stent, in-stent restenosis (DES-ISR): epidemiology, pathophysiology & treatment","volume":"88","author":"Gupta","year":"2025","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacbts.2026.101639_bib4","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jacc.2020.08.035","article-title":"In-stent restenosis in the United States","volume":"76","author":"Kastrati","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2026.101639_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2022.101465","article-title":"Current evidence in the diagnosis and management of coronary arteritis presenting as acute coronary syndrome","volume":"48","author":"Lin","year":"2023","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.jacbts.2026.101639_bib6","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.jacc.2024.04.030","article-title":"Association of autoimmune diseases with coronary atherosclerosis severity and ischemic events","volume":"83","author":"Mortensen","year":"2024","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2026.101639_bib7","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s12265-023-10388-4","article-title":"Isolated coronary arteritis in adults: a single-center experience from China","volume":"16","author":"Liu","year":"2023","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.jacbts.2026.101639_bib8","first-page":"180","article-title":"Rapid recurrences of coronary unexplained in-stent restenosis (RECUR): a novel pathologically-evidenced coronary inflammatory disease. Rev Esp Cardiol (Engl","volume":"79","author":"Lin","year":"2026","journal-title":"Ed)"},{"key":"10.1016\/j.jacbts.2026.101639_bib9","doi-asserted-by":"crossref","first-page":"102102","DOI":"10.1016\/j.jaccas.2023.102102","article-title":"Isolated coronary arteritis treated with FDG-PET\/CT-Guided immunosuppressant to break the vicious cycle of In-Stent restenosis","volume":"28","author":"Takasaki","year":"2023","journal-title":"JACC Case Rep"},{"key":"10.1016\/j.jacbts.2026.101639_bib10","doi-asserted-by":"crossref","first-page":"4950","DOI":"10.1007\/s00330-023-10527-0","article-title":"Prediction value of pericoronary fat attenuation index for coronary in-stent restenosis","volume":"34","author":"Lu","year":"2024","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jacbts.2026.101639_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jcin.2021.12.031","article-title":"Acute myocardial infarction associated with diffuse coronary lesions with takayasu arteritis in a teenager","volume":"15","author":"Sato","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jacbts.2026.101639_bib12","doi-asserted-by":"crossref","first-page":"105062","DOI":"10.1016\/j.jaccas.2025.105062","article-title":"Coronary artery vasculitis: a nightmare complicating percutaneous coronary intervention","volume":"30","author":"Zhang","year":"2025","journal-title":"JACC Case Rep"},{"key":"10.1016\/j.jacbts.2026.101639_bib13","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jacc.2022.05.017","article-title":"Coronary In-Stent restenosis: JACC State-of-the-Art Review","volume":"80","author":"Giustino","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacbts.2026.101639_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036065","article-title":"Stent underexpansion is an underestimated cause of intrastent restenosis: insights from RESTO registry","volume":"13","author":"Souteyrand","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacbts.2026.101639_bib15","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.4244\/EIJ-D-23-00107","article-title":"Mechanisms and treatment outcomes of ostial right coronary artery in-stent restenosis","volume":"19","author":"Yamamoto","year":"2023","journal-title":"EuroIntervention"},{"key":"10.1016\/j.jacbts.2026.101639_bib16","doi-asserted-by":"crossref","first-page":"e026492","DOI":"10.1161\/JAHA.122.026492","article-title":"Intravascular imaging for guiding In-Stent restenosis and stent thrombosis therapy","volume":"11","author":"Erdogan","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacbts.2026.101639_bib17","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A scalable SCENIC workflow for single-cell gene regulatory network analysis","volume":"15","author":"Van de Sande","year":"2020","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jacbts.2026.101639_bib18","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jacbts.2026.101639_bib19","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jacbts.2026.101639_bib20","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.240180","article-title":"Coronary arteritis in immunoglobulin G4-related disease","volume":"312","author":"Zhang","year":"2024","journal-title":"Radiology"},{"key":"10.1016\/j.jacbts.2026.101639_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1003322","article-title":"Hypersensitivity and in-stent restenosis in coronary stent materials","volume":"10","author":"Hu","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jacbts.2026.101639_bib22","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202012409","article-title":"Psoriatic skin inflammation is promoted by c-Jun\/AP-1-dependent CCL2 and IL-23 expression in dendritic cells","volume":"13","author":"Novoszel","year":"2021","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jacbts.2026.101639_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12974-025-03412-8","article-title":"Correction: progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2\/Pim1 axis","volume":"22","author":"Liu","year":"2025","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jacbts.2026.101639_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13858","article-title":"AP-1 is a regulatory transcription factor of inflammaging in the murine kidney and liver","volume":"22","author":"Yu","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.jacbts.2026.101639_bib25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.alit.2023.12.006","article-title":"Topical application of activator protein-1 inhibitor T-5224 suppresses inflammation and improves skin barrier function in a murine atopic dermatitis-like dermatitis","volume":"73","author":"Sasakura","year":"2024","journal-title":"Allergol Int"},{"key":"10.1016\/j.jacbts.2026.101639_bib26","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1080\/10408398.2018.1552244","article-title":"Cellular and molecular mechanisms of curcumin in prevention and treatment of disease","volume":"60","author":"Patel","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jacbts.2026.101639_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/eurheartj\/ehad534","article-title":"The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture","volume":"45","author":"Luo","year":"2024","journal-title":"Eur Heart J"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X26001592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X26001592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:14:24Z","timestamp":1790896464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X26001592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2452302X26001592"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101639","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-Cell Transcriptomics Reveals the Immune Pathogenesis of Isolated Coronary Arteritis Presenting as Refractory In-Stent Restenosis","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101639","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101639"}}