{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:12:44Z","timestamp":1791965564219,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JACC: Basic to Translational Science"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jacbts.2026.101714","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:15:56Z","timestamp":1791494156000},"page":"101714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Histone Demethylase KDM5A Is Activated and Pathogenic in a Mouse Model of LMNA-Cardiomyopathy"],"prefix":"10.1016","volume":"11","author":[{"given":"Manisha","family":"Deogharia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra Lekha","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritapa","family":"Chaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manogna Sai","family":"Chirasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav K.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Rouhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Marian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyatansh","family":"Gurha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacbts.2026.101714_bib1","first-page":"e41","article-title":"2025 heart disease and stroke statistics: a report of US and global data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2026.101714_bib2","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/ejhf.3710","article-title":"Insights into the European heart failure epidemiology","volume":"27","author":"Seferovic","year":"2025","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacbts.2026.101714_bib3","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart--an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacbts.2026.101714_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yjmcc.2004.10.010","article-title":"Mouse models of mitochondrial dysfunction and heart failure","volume":"38","author":"Russell","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacbts.2026.101714_bib5","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/eurjhf\/hfs172","article-title":"Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction","volume":"15","author":"Stride","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacbts.2026.101714_bib6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/cvr\/cvr052","article-title":"Metabolic remodelling in human heart failure","volume":"90","author":"Tuunanen","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib7","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI120849","article-title":"Mitochondrial dysfunction in pathophysiology of heart failure","volume":"128","author":"Zhou","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacbts.2026.101714_bib8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/HCO.0000000000001150","article-title":"Epigenetic regulation of heart failure","volume":"39","author":"Deogharia","year":"2024","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.jacbts.2026.101714_bib9","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1172\/JCI135922","article-title":"BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A\/C-deficient mice","volume":"130","author":"Auguste","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacbts.2026.101714_bib10","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/CIRCHEARTFAILURE.114.001193","article-title":"Epigenetic mechanisms in heart failure pathogenesis","volume":"7","author":"Di Salvo","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacbts.2026.101714_bib11","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1161\/CIRCULATIONAHA.111.040071","article-title":"Distinct epigenomic features in end-stage failing human hearts","volume":"124","author":"Movassagh","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jacbts.2026.101714_bib12","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nrcardio.2010.104","article-title":"Epigenetics and cardiovascular disease","volume":"7","author":"Ordovas","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jacbts.2026.101714_bib13","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.15252\/embr.201541113","article-title":"Histone demethylases in chromatin biology and beyond","volume":"16","author":"Dimitrova","year":"2015","journal-title":"EMBO Rep"},{"key":"10.1016\/j.jacbts.2026.101714_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41576-022-00468-7","article-title":"Histone post-translational modifications - cause and consequence of genome function","volume":"23","author":"Millan-Zambrano","year":"2022","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jacbts.2026.101714_bib15","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1242\/dev.139139","article-title":"Impaired removal of H3K4 methylation affects cell fate determination and gene transcription","volume":"143","author":"Lussi","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.jacbts.2026.101714_bib16","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.cell.2007.02.003","article-title":"RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3","volume":"128","author":"Christensen","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jacbts.2026.101714_bib17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ydbio.2009.08.017","article-title":"Histone H3 lysine 4 (H3K4) methylation in development and differentiation","volume":"339","author":"Eissenberg","year":"2010","journal-title":"Dev Biol"},{"key":"10.1016\/j.jacbts.2026.101714_bib18","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.celrep.2015.11.007","article-title":"The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif","volume":"13","author":"Liu","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jacbts.2026.101714_bib19","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.118.314177","article-title":"Genomic reorganization of lamin-associated domains in cardiac myocytes is associated with differential gene expression and DNA methylation in human dilated cardiomyopathy","volume":"124","author":"Cheedipudi","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib20","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.015690","article-title":"Identification of genes and pathways regulated by lamin A in heart","volume":"9","author":"Coste Pradas","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jacbts.2026.101714_bib21","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jacbts.2022.06.015","article-title":"Genetic ablation of the DNA damage response pathway attenuates lamin-associated dilated cardiomyopathy in mice","volume":"7","author":"Cheedipudi","year":"2022","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.jacbts.2026.101714_bib22","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/CIRCRESAHA.117.312052","article-title":"Suppression of activated FOXO transcription factors in the heart prolongs survival in a mouse model of laminopathies","volume":"122","author":"Auguste","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib23","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1093\/cvr\/cvae063","article-title":"DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in LMNA-cardiomyopathy","volume":"121","author":"Cathcart","year":"2025","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46314","article-title":"Improved CUT&RUN chromatin profiling tools","volume":"8","author":"Meers","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jacbts.2026.101714_bib25","first-page":"15","article-title":"The WNT\/beta-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes","volume":"2","author":"Olcum","year":"2022","journal-title":"J Cardiovasc Aging"},{"key":"10.1016\/j.jacbts.2026.101714_bib26","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/CIRCRESAHA.118.314238","article-title":"DNA damage Response\/TP53 pathway is activated and contributes to the pathogenesis of dilated cardiomyopathy associated with LMNA (Lamin A\/C) mutations","volume":"124","author":"Chen","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib27","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCRESAHA.116.308422","article-title":"Knockdown of plakophilin 2 downregulates miR-184 through CpG hypermethylation and suppression of the E2F1 pathway and leads to enhanced adipogenesis in vitro","volume":"119","author":"Gurha","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib28","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/cvr\/cvae014","article-title":"Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization","volume":"120","author":"Deogharia","year":"2024","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.yjmcc.2007.11.008","article-title":"Lamin A\/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease","volume":"44","author":"Wolf","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacbts.2026.101714_bib30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI200419448","article-title":"Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A\/C-deficient mice","volume":"113","author":"Nikolova","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacbts.2026.101714_bib31","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1161\/CIRCRESAHA.121.318157","article-title":"The complex and diverse genetic architecture of dilated cardiomyopathy","volume":"128","author":"Hershberger","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.yjmcc.2019.04.012","article-title":"Epigenetic therapies in heart failure","volume":"130","author":"Alexanian","year":"2019","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacbts.2026.101714_bib33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/cvr\/cvr077","article-title":"Spotlight on metabolic remodelling in heart failure","volume":"90","author":"Doenst","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.20517\/jca.2022.34","article-title":"PANoptosis is a prominent feature of desmoplakin cardiomyopathy","volume":"3","author":"Olcum","year":"2023","journal-title":"J Cardiovasc Aging"},{"key":"10.1016\/j.jacbts.2026.101714_bib35","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1021\/acs.jproteome.7b00165","article-title":"Comprehensive myocardial proteogenomics profiling reveals C\/EBPalpha as the key factor in the lipid storage of ARVC","volume":"16","author":"Chen","year":"2017","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib36","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/s12276-022-00904-y","article-title":"Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression","volume":"54","author":"Wang","year":"2022","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jacbts.2026.101714_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.929030","article-title":"Transcriptomic and ChIP-seq integrative analysis identifies KDM5A-Target genes in cardiac fibroblasts","volume":"9","author":"Jiang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jacbts.2026.101714_bib38","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1161\/CIRCRESAHA.119.316100","article-title":"A critical role for estrogen-related receptor signaling in cardiac maturation","volume":"126","author":"Sakamoto","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s44161-025-00775-2","article-title":"A reduced TBX5-dependent gene regulatory network links atrial fibrillation and heart failure","volume":"5","author":"Lazarevic","year":"2026","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jacbts.2026.101714_bib40","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.devcel.2016.01.009","article-title":"The cardiac TBX5 interactome reveals a chromatin remodeling network essential for cardiac septation","volume":"36","author":"Waldron","year":"2016","journal-title":"Dev Cell"},{"key":"10.1016\/j.jacbts.2026.101714_bib41","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2017.04.022","article-title":"Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression","volume":"169","author":"van Steensel","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jacbts.2026.101714_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad4991","article-title":"Laminopathies disrupt epigenomic developmental programs and cell fate","volume":"8","author":"Perovanovic","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jacbts.2026.101714_bib43","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cell.2013.07.013","article-title":"BET bromodomains mediate transcriptional pause release in heart failure","volume":"154","author":"Anand","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jacbts.2026.101714_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114991","article-title":"ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancer","volume":"43","author":"DiCiaccio","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.jacbts.2026.101714_bib45","doi-asserted-by":"crossref","first-page":"E3741","DOI":"10.1073\/pnas.1716029115","article-title":"Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase","volume":"115","author":"McBrayer","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2026.101714_bib46","doi-asserted-by":"crossref","first-page":"28956","DOI":"10.1074\/jbc.M114.573725","article-title":"Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex","volume":"289","author":"Nishibuchi","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacbts.2026.101714_bib47","doi-asserted-by":"crossref","first-page":"18499","DOI":"10.1073\/pnas.1216724109","article-title":"Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation","volume":"109","author":"Beshiri","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacbts.2026.101714_bib48","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1056\/NEJM199912023412302","article-title":"Missense mutations in the rod domain of the lamin A\/C gene as causes of dilated cardiomyopathy and conduction-system disease","volume":"341","author":"Fatkin","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacbts.2026.101714_bib49","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1172\/JCI29042","article-title":"Activation of MAPK pathways links LMNA mutations to cardiomyopathy in emery-dreifuss muscular dystrophy","volume":"117","author":"Muchir","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacbts.2026.101714_bib50","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.molcel.2005.05.012","article-title":"Binding of pRB to the PHD protein RBP2 promotes cellular differentiation","volume":"18","author":"Benevolenskaya","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.jacbts.2026.101714_bib51","first-page":"7256","article-title":"Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein","volume":"14","author":"Kim","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jacbts.2026.101714_bib52","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1101\/gad.264036.115","article-title":"Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells","volume":"29","author":"Varaljai","year":"2015","journal-title":"Genes Dev"},{"key":"10.1016\/j.jacbts.2026.101714_bib53","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1128\/MCB.02464-05","article-title":"Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest","volume":"26","author":"Nitta","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jacbts.2026.101714_bib54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-4899-8032-8_6","article-title":"RB and lamins in cell cycle regulation and aging","volume":"773","author":"Kennedy","year":"2014","journal-title":"Adv Exp Med Biol"}],"container-title":["JACC: Basic to Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X2600238X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452302X2600238X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:41:08Z","timestamp":1791578468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452302X2600238X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2452302X2600238X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101714","relation":{},"ISSN":["2452-302X"],"issn-type":[{"value":"2452-302X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone Demethylase KDM5A Is Activated and Pathogenic in a Mouse Model of LMNA-Cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"JACC: Basic to Translational Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacbts.2026.101714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier on behalf of the American College of Cardiology Foundation.  .","name":"copyright","label":"Copyright"}],"article-number":"101714"}}