{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:16:38Z","timestamp":1792656998778,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":3308,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.jacc.2004.05.049","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T15:38:03Z","timestamp":1092411483000},"page":"837-845","source":"Crossref","is-referenced-by-count":83,"title":["Altered myocardial Ca2+cycling after left ventricular assist device support in the failing human heart"],"prefix":"10.1016","volume":"44","author":[{"given":"Khuram W.","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric I.","family":"Rossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Valentino","family":"Piacentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Kenessey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Gaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaie","family":"Ojamaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Bers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Houser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Margulies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2004.05.049_bib1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1053-2498(01)00390-4","article-title":"Molecular mechanisms of reduced sarcoplasmic reticulum Ca(2+) uptake in human failing left ventricular myocardium","volume":"21","author":"Mishra","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2004.05.049_bib2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s003950050208","article-title":"Influence of SR Ca(2+)-ATPase and Na(+)-Ca(2+)-exchanger on the force-frequency relation","volume":"93","author":"Schillinger","year":"1998","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/01.RES.85.1.38","article-title":"Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium","volume":"85","author":"Pieske","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2004.05.049_bib4","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.75.3.434","article-title":"Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium","volume":"75","author":"Hasenfuss","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2004.05.049_bib5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1161\/01.CIR.99.5.641","article-title":"Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium","volume":"99","author":"Hasenfuss","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib6","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1161\/01.CIR.97.23.2316","article-title":"Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure","volume":"97","author":"Dipla","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib7","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1161\/01.CIR.102.22.2713","article-title":"Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure","volume":"102","author":"Heerdt","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.CIR.98.7.656","article-title":"Regression of cellular hypertrophy after left ventricular assist device support","volume":"98","author":"Zafeiridis","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/ar.1092150414","article-title":"Regional differences in myocyte size in normal rat heart","volume":"215","author":"Gerdes","year":"1986","journal-title":"Anatom Record"},{"key":"10.1016\/j.jacc.2004.05.049_bib10","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1152\/physrev.1999.79.4.1089","article-title":"Measurement of intracellular calcium","volume":"79","author":"Takahashi","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jacc.2004.05.049_bib11","doi-asserted-by":"crossref","first-page":"H1690","DOI":"10.1152\/ajpheart.2001.281.4.H1690","article-title":"Differential regulation of SR calcium transporters by thyroid hormone in rat atria and ventricles","volume":"281","author":"Shenoy","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib12","first-page":"H1481","article-title":"The trabecula culture system","volume":"274","author":"Janssen","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib13","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1006\/jmcc.1999.0978","article-title":"Preservation of contractile characteristics of human myocardium in multi-day cell culture","volume":"31","author":"Janssen","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yjmcc.2003.09.001","article-title":"Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium","volume":"36","author":"Rossman","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00794074","article-title":"Contributions of Ca(2+)-influx via the L-type Ca(2+)-current and Ca(2+)-release from the sarcoplasmic reticulum to [Ca2+]i-transients in human myocytes","volume":"92","author":"Beuckelmann","year":"1997","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib16","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.RES.84.4.435","article-title":"The sarcoplasmic reticulum and the Na+\/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes","volume":"84","author":"Dipla","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2004.05.049_bib17","first-page":"H714","article-title":"Sodium\/calcium exchange contributes to contraction and relaxation in failed human ventricular myocytes","volume":"277","author":"Gaughan","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0008-6363(97)00271-X","article-title":"Contribution of reverse-mode sodium-calcium exchange to contractions in failing human left ventricular myocytes","volume":"37","author":"Mattiello","year":"1998","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2004.05.049_bib19","doi-asserted-by":"crossref","first-page":"C944","DOI":"10.1152\/ajpcell.1990.258.5.C944","article-title":"Intracellular Ca transients in rat cardiac myocytes","volume":"258","author":"Bers","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib20","doi-asserted-by":"crossref","first-page":"C271","DOI":"10.1152\/ajpcell.1995.268.1.C271","article-title":"Kinetics of [Ca]i decline in cardiac myocytes depend on peak [Ca]i","volume":"268","author":"Bers","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib21","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/01.RES.87.8.690","article-title":"Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure","volume":"87","author":"Hobai","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2004.05.049_bib22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1006\/jmcc.1997.0626","article-title":"Calcium content of the sarcoplasmic reticulum in isolated ventricular myocytes from patients with terminal heart failure","volume":"30","author":"Lindner","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib23","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/0002-8703(95)90316-X","article-title":"Altered diastolic [Ca2+]i handling in human ventricular myocytes from patients with terminal heart failure","volume":"129","author":"Beuckelmann","year":"1995","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2004.05.049_bib24","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/hc3201.092285","article-title":"Heart failure after myocardial infarction","volume":"104","author":"Gomez","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib25","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1006\/jmcc.1997.0422","article-title":"Cellular basis of contractile derangements of hypertrophied feline ventricular myocytes","volume":"29","author":"Bailey","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib26","first-page":"H2765","article-title":"Sarcoplasmic reticulum and Na+\/Ca2+ exchanger function during early and late relaxation in ventricular myocytes","volume":"273","author":"Yao","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib27","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/01.RES.0000062469.83985.9B","article-title":"Cellular basis of abnormal calcium transients of failing human ventricular myocytes","volume":"92","author":"Piacentino","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2004.05.049_bib28","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/hc3101.093903","article-title":"Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure","volume":"104","author":"Barbone","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib29","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/hc3301.094911","article-title":"Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart","volume":"104","author":"Ogletree-Hughes","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0008-6363(98)00241-7","article-title":"Enhanced phosphorylation of phospholamban and downregulation of sarco\/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure","volume":"41","author":"Currie","year":"1999","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2004.05.049_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00795357","article-title":"Calcium cycling proteins and force-frequency relationship in heart failure","volume":"91","author":"Hasenfuss","year":"1996","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib32","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/01.CIR.92.5.1169","article-title":"Alterations in intracellular calcium handling associated with the inverse force-frequency relation in human dilated cardiomyopathy","volume":"92","author":"Pieske","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib33","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1172\/JCI118849","article-title":"Diminished post-rest potentiation of contractile force in human dilated cardiomyopathy","volume":"98","author":"Pieske","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2004.05.049_bib34","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1006\/jmcc.1998.0690","article-title":"Frequency-dependent changes in contribution of SR Ca2+ to Ca2+ transients in failing human myocardium assessed with ryanodine","volume":"30","author":"Schlotthauer","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2004.05.049_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1536\/jhj.41.103","article-title":"A mechanistic analysis of reduced mechanical performance in human heart failure","volume":"41","author":"Alpert","year":"2000","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.jacc.2004.05.049_bib36","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/01.CIR.0000023042.50192.F4","article-title":"Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium","volume":"106","author":"Pieske","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2004.05.049_bib37","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev.physiol.59.1.551","article-title":"The cellular and molecular response of cardiac myocytes to mechanical stress","volume":"59","author":"Sadoshima","year":"1997","journal-title":"Ann Rev Physiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109704011167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109704011167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T22:51:53Z","timestamp":1549320713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109704011167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0735109704011167"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2004.05.049","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}