{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:39:31Z","timestamp":1790419171612,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":3065,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.jacc.2005.01.012","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T07:25:02Z","timestamp":1113549902000},"page":"1251-1258","source":"Crossref","is-referenced-by-count":355,"title":["Multicenter study of the efficacy and safety of disopyramide in obstructive hypertrophic cardiomyopathy"],"prefix":"10.1016","volume":"45","author":[{"given":"Mark V.","family":"Sherrid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Barac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry M.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaughan","family":"Dickie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Chojnowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry J.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2005.01.012_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0033-0620(85)90024-6","article-title":"Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review","volume":"28","author":"Wigle","year":"1985","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacc.2005.01.012_bib2","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1161\/01.CIR.92.7.1680","article-title":"Hypertrophic cardiomyopathy\u2014clinical spectrum and treatment","volume":"92","author":"Wigle","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.01.012_bib3","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/S0735-1097(03)00941-0","article-title":"American College of Cardiology\/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy","volume":"42","author":"Maron","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib4","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S0735-1097(00)00830-5","article-title":"Systolic anterior motion begins at low left ventricular outflow tract velocity in obstructive hypertrophic cardiomyopathy","volume":"36","author":"Sherrid","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib5","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.287.10.1308","article-title":"Hypertrophic cardiomyopathy","volume":"287","author":"Maron","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2005.01.012_bib6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1056\/NEJMoa021332","article-title":"Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy","volume":"348","author":"Maron","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2005.01.012_bib7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.CIR.29.1.84","article-title":"Effects of beta adrenergic blockade on the circulation with particular reference to observations in patients with hypertrophic subaortic stenosis","volume":"29","author":"Harrison","year":"1964","journal-title":"Circulation"},{"issue":"Suppl 4","key":"10.1016\/j.jacc.2005.01.012_bib8","first-page":"3","article-title":"Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients","volume":"30","author":"Braunwald","year":"1964","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.01.012_bib9","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1136\/bmj.1.5492.895","article-title":"Adrenergic blockade in hypertrophic obstructive cardiomyopathy","volume":"1","author":"Cherian","year":"1966","journal-title":"Br Med J"},{"key":"10.1016\/j.jacc.2005.01.012_bib10","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0002-9149(73)90012-X","article-title":"Hypertrophic subaortic stenosis. Clinical and hemodynamic effects of long-term propranolol therapy","volume":"31","author":"Stenson","year":"1973","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/hrt.32.6.804","article-title":"Long-term propranolol therapy in muscular subaortic stenosis","volume":"32","author":"Adelman","year":"1979","journal-title":"Br Heart J"},{"key":"10.1016\/j.jacc.2005.01.012_bib12","series-title":"Diagnosis and Management of Hypertrophic Cardiomyopathy","first-page":"200","article-title":"Pharmacologic treatment of symptomatic hypertrophic cardiomyopathy","author":"Sherrid","year":"2004"},{"key":"10.1016\/j.jacc.2005.01.012_bib13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0002-9149(81)90086-2","article-title":"Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. III. Effects of long-term administration","volume":"48","author":"Rosing","year":"1981","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/01.CIR.64.3.437","article-title":"Verapamil","volume":"64","author":"Epstein","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.01.012_bib15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/01.CIR.66.2.447","article-title":"The cardiac effects of d- and l-Disopyramide in normal subjects","volume":"66","author":"Pollick","year":"1982","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.01.012_bib16","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJM198210143071607","article-title":"Muscular subaortic stenosis","volume":"307","author":"Pollick","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2005.01.012_bib17","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0002-9149(88)90553-X","article-title":"Oral disopyramide therapy for obstructive hypertrophic cardiomyopathy","volume":"62","author":"Sherrid","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib18","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/0002-9149(88)90268-8","article-title":"Disopyramide in hypertrophic cardiomyopathy I. Hemodynamic assessment after intravenous administration","volume":"62","author":"Pollick","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib19","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/0002-9149(88)90269-X","article-title":"Disopyramide in hypertrophic cardiomyopathy. II. Noninvasive assessment after oral administration","volume":"62","author":"Pollick","year":"1988","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/01.CIR.97.1.41","article-title":"The mechanism of benefit of negative inotropes in obstructive hypertrophic cardiomyopathy","volume":"97","author":"Sherrid","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.01.012_bib21","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/0002-8703(93)90760-7","article-title":"Acute dose-response effects of intravenous disopyramide in hypertrophic obstructive cardiomyopathy","volume":"125","author":"Kimball","year":"1993","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2005.01.012_bib22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF02767128","article-title":"Disopyramide improves the balance between myocardial oxygen supply and demand in patients with hypertrophic obstructive cardiomyopathy","volume":"12","author":"Niki","year":"1997","journal-title":"Heart Vessels"},{"key":"10.1016\/j.jacc.2005.01.012_bib23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/0735-1097(95)00229-W","article-title":"Salutary effect of disopyramide on left ventricular diastolic function in hypertrophic cardiomyopathy","volume":"26","author":"Matsubara","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib24","first-page":"81","article-title":"Disopyramide as a negative inotrope in obstructive cardiomyopathy in children","volume":"7","author":"Duncan","year":"1991","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib25","first-page":"33","article-title":"Combination of disopyramide and propranolol in hypertrophic cardiomyopathy","volume":"5","author":"Cokkinos","year":"1989","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib26","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1001\/archinte.1981.00340070126029","article-title":"Disopyramide-induced Torsade de Pointes","volume":"141","author":"Tzivoni","year":"1981","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jacc.2005.01.012_bib27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0140-6736(00)04005-8","article-title":"Relation between severity of left ventricular hypertrophy and prognosis in patients with hypertrophic cardiomyopathy","volume":"357","author":"Elliott","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2005.01.012_bib28","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1056\/NEJM200006153422403","article-title":"Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy","volume":"342","author":"Spirito","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2005.01.012_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.7326\/0003-4819-127-4-199708150-00004","article-title":"Risk of initiating antiarrhythmic drug therapy for atrial fibrillation in patients admitted to a university hospital","volume":"127","author":"Maisel","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jacc.2005.01.012_bib30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/00132580-200105000-00004","article-title":"Inpatient or outpatient initiation of antiarrhythmic medications","volume":"3","author":"Zimetbaum","year":"2001","journal-title":"Heart Dis"},{"key":"10.1016\/j.jacc.2005.01.012_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0002-9149(87)90998-2","article-title":"Occurrence and significance of progressive left ventricular wall thinning and relative cavity dilatation in hypertrophic cardiomyopathy","volume":"60","author":"Spirito","year":"1987","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib32","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/0735-1097(88)90207-0","article-title":"Doppler echocardiographic determination of the pressure gradient in hypertrophic cardiomyopathy","volume":"11","author":"Sasson","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib33","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/0002-9149(83)90676-8","article-title":"Effects of disopyramide on left ventricular function","volume":"51","author":"Gottdiener","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000174983","article-title":"Effect of propranolol and disopyramide on left ventricular function at rest and during exercise in hypertrophic cardiomyopathy","volume":"80","author":"Hartmann","year":"1992","journal-title":"Cardiology"},{"key":"10.1016\/j.jacc.2005.01.012_bib35","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0002-8703(87)90701-0","article-title":"An integrated mechanism for SAM of the mitral valve in hypertrophic cardiomyopathy based on echocardiographic observations","volume":"113","author":"Jiang","year":"1987","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2005.01.012_bib36","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/01.CIR.91.4.1189","article-title":"Papillary muscle displacement causes systolic anterior motion of the mitral valve","volume":"91","author":"Levine","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.01.012_bib37","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0735-1097(93)90196-8","article-title":"An echocardiographic study of the fluid mechanics of obstruction in hypertrophic cardiomyopathy","volume":"22","author":"Sherrid","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib38","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/01.CIR.79.4.766","article-title":"Effect of surgical reduction of left ventricular outflow obstruction on hemodynamics, coronary flow, and myocardial metabolism in hypertrophic cardiomyopathy","volume":"79","author":"Cannon","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.01.012_bib39","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0894-7317(97)70112-3","article-title":"Mid-systolic drop in left ventricular ejection velocity in obstructive hypertrophic cardiomyopathy\u2014the lobster claw abnormality","volume":"10","author":"Sherrid","year":"1997","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2005.01.012_bib40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.echo.2003.12.012","article-title":"Biphasic left ventricular outflow and its mechanism in hypertrophic obstructive cardiomyopathy","volume":"17","author":"Conklin","year":"2004","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jacc.2005.01.012_bib41","doi-asserted-by":"crossref","first-page":"166A","DOI":"10.1016\/S0735-1097(04)90706-1","article-title":"By relieving obstruction, disopyramide increases extent and duration of systolic shortening in obstructive hypertrophic cardiomyopathy","volume":"43","author":"Upadya","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib42","doi-asserted-by":"crossref","first-page":"185B","DOI":"10.1016\/0002-9149(85)90630-7","article-title":"Use of calcium-channel blocking drugs in hypertrophic cardiomyopathy","volume":"55","author":"Rosing","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib43","first-page":"137","article-title":"10-year results and survival of patients with hypertrophic cardiomyopathy treated with calcium antagonists","volume":"76","author":"Hopf","year":"1987","journal-title":"Z Kardiol"},{"key":"10.1016\/j.jacc.2005.01.012_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0002-9343(85)90169-X","article-title":"Use of calcium channel blockers in hypertrophic cardiomyopathy","volume":"78","author":"Lorell","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.jacc.2005.01.012_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/heart.87.2.169","article-title":"Hypertrophic cardiomyopathy","volume":"87","author":"McKenna","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2005.01.012_bib46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2125.1980.tb04799.x","article-title":"Quantitative analysis of the disopyramide concentration-effect relationship","volume":"9","author":"Whiting","year":"1980","journal-title":"Br J Pharm"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109705002147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109705002147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T04:21:05Z","timestamp":1548562865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109705002147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0735109705002147"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2005.01.012","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}