{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:38:30Z","timestamp":1770064710894,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":2875,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.jacc.2005.05.060","type":"journal-article","created":{"date-parts":[[2005,8,10]],"date-time":"2005-08-10T14:08:39Z","timestamp":1123682919000},"page":"770-775","source":"Crossref","is-referenced-by-count":17,"title":["The Effect of Losartan Versus Atenolol on Cardiovascular Morbidity and Mortality in Patients With Hypertension Taking Aspirin"],"prefix":"10.1016","volume":"46","author":[{"given":"Eigil","family":"Fossum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Moan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre E.","family":"Kjeldsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Devereux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stevo","family":"Julius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Snapinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Edelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"de Faire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frej","family":"Fyhrquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Ibsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krister","family":"Kristianson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Lederballe-Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars H.","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku S.","family":"Nieminen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Omvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Oparil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Wedel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Dahl\u00f6f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2005.05.060_bib1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0895-7061(97)88956-X","article-title":"The Losartan Intervention For Endpoint reduction (LIFE) in Hypertension study: rationale, design, and methods. The LIFE Study Group","volume":"10","author":"Dahl\u00f6f","year":"1997","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacc.2005.05.060_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1291\/hypres.22.147","article-title":"Angiotensin II receptor antagonists","volume":"22","author":"Timmermans","year":"1999","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jacc.2005.05.060_bib3","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/0895-7061(95)00081-Y","article-title":"Efficacy and tolerability of losartan potassium and atenolol in patients with mild to moderate essential hypertension","volume":"8","author":"Dahl\u00f6f","year":"1995","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacc.2005.05.060_bib4","first-page":"57","article-title":"Randomised trial of intravenous atenolol among 16,027 cases of suspected acute myocardial infarction: ISIS-1. First International Study of Infarct Survival Collaboration Group","volume":"2","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2005.05.060_bib5","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","article-title":"Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE)","volume":"359","author":"Dahl\u00f6f","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2005.05.060_bib6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0735-1097(97)00502-0","article-title":"Antiplatelet agents and survival","volume":"31","author":"Al-Khadra","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.05.060_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9149(96)00696-0","article-title":"Interaction between enalapril and aspirin on mortality after acute myocardial infarction","volume":"79","author":"Nguyen","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2005.05.060_bib8","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/00004872-200205000-00038","article-title":"Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy","volume":"20","author":"Zanchetti","year":"2002","journal-title":"J Hypertens"},{"key":"10.1016\/j.jacc.2005.05.060_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.jhh.1001406","article-title":"Clinical evidence of dose-dependent interaction between aspirin and angiotensin-converting enzyme inhibitors","volume":"16","author":"Fisman","year":"2002","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.jacc.2005.05.060_bib10","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0140-6736(02)11138-X","article-title":"Effects of long-term treatment with angiotensin-converting-enzyme inhibitors in the presence or absence of aspirin","volume":"360","author":"Teo","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2005.05.060_bib11","first-page":"989","article-title":"Characteristics of 9,194 patients with left ventricular hypertrophy: the LIFE study. Losartan Intervention For Endpoint Reduction in Hypertension","volume":"32","author":"Dahl\u00f6f","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2005.05.060_bib12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0735-1097(94)00371-V","article-title":"Electrocardiographic identification of increased left ventricular mass by simple voltage-duration products","volume":"25","author":"Okin","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.05.060_bib13","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/01.CIR.83.1.356","article-title":"An updated coronary risk profile. A statement for health professionals","volume":"83","author":"Anderson","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.05.060_bib14","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0895-7061(99)00037-0","article-title":"Effect of aspirin on blood pressure in hypertensive patients taking enalapril or losartan","volume":"12","author":"Nawarskas","year":"1999","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jacc.2005.05.060_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3317\/jraas.2003.005","article-title":"Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function","volume":"4","author":"Zhu","year":"2003","journal-title":"J Renin Angiotensin Aldosteron Syst"},{"key":"10.1016\/j.jacc.2005.05.060_bib16","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1159\/000159187","article-title":"The role of angiotensin II and prostaglandins in arcade formation in a developing microvascular network","volume":"33","author":"le Noble","year":"1996","journal-title":"J Vasc Res"},{"key":"10.1016\/j.jacc.2005.05.060_bib17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.HYP.31.1.349","article-title":"AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism","volume":"31","author":"Gohlke","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.jacc.2005.05.060_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0167-0115(99)00023-3","article-title":"The AT2 receptor","volume":"81","author":"de Gasparo","year":"1999","journal-title":"Regul Peptides"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109705013197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109705013197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T20:58:35Z","timestamp":1548277115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109705013197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0735109705013197"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2005.05.060","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}