{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:21:04Z","timestamp":1761740464600},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2912,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.jacc.2005.05.063","type":"journal-article","created":{"date-parts":[[2005,8,17]],"date-time":"2005-08-17T11:05:28Z","timestamp":1124276728000},"page":"799-806","source":"Crossref","is-referenced-by-count":36,"title":["Enhanced Plasma Levels of Oxidized Low-Density Lipoprotein Increase Circulating Nuclear Factor-Kappa B Activation in Patients With Unstable Angina"],"prefix":"10.1016","volume":"46","author":[{"given":"Luciano","family":"Cominacini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Anselmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulisse","family":"Garbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Fratta Pasini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Stranieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Fusaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierfrancesco","family":"Agostoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dritan","family":"Keta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Zardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Sawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Lo Cascio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2005.05.063_bib1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2005.05.063_bib2","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kB\u2014a pivotal transcriptional factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2005.05.063_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0092-8674(89)90833-7","article-title":"NF-kB","volume":"58","author":"Lenardo","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2005.05.063_bib4","first-page":"2061","article-title":"The IkB proteins","volume":"7","author":"Beg","year":"1993","journal-title":"Genes Dev"},{"key":"10.1016\/j.jacc.2005.05.063_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2005.05.063_bib6","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1161\/01.ATV.17.10.1901","article-title":"Dysregulation of monocytic nuclear factor-kB by oxidized low-density lipoprotein","volume":"17","author":"Brand","year":"1997","journal-title":"Arterioscl Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2005.05.063_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0021-9150(01)00546-9","article-title":"Nuclear factor-kB immunoreactivity is present in human coronary plaque and enhanced in patients with unstable angina pectoris","volume":"160","author":"Wilson","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2005.05.063_bib8","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1161\/01.CIR.98.17.1707","article-title":"Nuclear factor-kB is selectively and markedly activated in humans with unstable angina pectoris","volume":"98","author":"Ritchie","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.05.063_bib9","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/01.CIR.98.15.1487","article-title":"Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease","volume":"98","author":"Holvoet","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.05.063_bib10","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/01.ATV.0000033829.14012.18","article-title":"Oxidized LDL in carotid plaques and plasma associates with plaque instability","volume":"22","author":"Nishi","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2005.05.063_bib11","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1161\/01.CIR.103.15.1955","article-title":"Elevated levels of low density lipoprotein show a positive relationship with the severity of acute coronary syndromes","volume":"103","author":"Ehara","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2005.05.063_bib12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00726-003-0029-5","article-title":"Scavenger receptors for oxidized and glycated proteins","volume":"25","author":"Horiuchi","year":"2003","journal-title":"Amino Acids"},{"key":"10.1016\/j.jacc.2005.05.063_bib13","doi-asserted-by":"crossref","first-page":"49982","DOI":"10.1074\/jbc.M209649200","article-title":"Scavenger receptors class A-I\/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages","volume":"277","author":"Kunjathoor","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2005.05.063_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1749-6632.2001.tb03941.x","article-title":"Role of oxidized LDL in atherosclerosis","volume":"947","author":"Kita","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jacc.2005.05.063_bib15","doi-asserted-by":"crossref","first-page":"12633","DOI":"10.1074\/jbc.275.17.12633","article-title":"Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species","volume":"275","author":"Cominacini","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2005.05.063_bib16","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/01.CIR.80.2.410","article-title":"Unstable angina","volume":"80","author":"Braunwald","year":"1989","journal-title":"Circulation"},{"issue":"Suppl 97","key":"10.1016\/j.jacc.2005.05.063_bib17","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"21","author":"Boyum","year":"1968","journal-title":"Scand J Clin Lab"},{"key":"10.1016\/j.jacc.2005.05.063_bib18","doi-asserted-by":"crossref","first-page":"E21","DOI":"10.1093\/nar\/29.4.e21","article-title":"Development of a sensitive multi-well colorimetric assay for active NF-kB","volume":"29","author":"Renard","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jacc.2005.05.063_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1128\/AAC.45.1.44-47.2001","article-title":"Clarithromicin inhibits NF-kB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells","volume":"45","author":"Ichiyama","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jacc.2005.05.063_bib20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/01.ATV.18.1.100","article-title":"Oxidized low density lipoproteins in patients with transplant-associated coronary artery disease","volume":"18","author":"Holvoet","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2005.05.063_bib21","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI103182","article-title":"The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum","volume":"34","author":"Havel","year":"1955","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2005.05.063_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/386073a0","article-title":"An endothelial receptor for oxidized low-density lipoprotein","volume":"386","author":"Sawamura","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2005.05.063_bib23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0735-1097(02)02769-9","article-title":"Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes","volume":"41","author":"Tsimikas","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2005.05.063_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/geno.1998.5561","article-title":"The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile","volume":"54","author":"Yamanaka","year":"1998","journal-title":"Genomics"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109705013240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109705013240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T17:27:17Z","timestamp":1548264437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109705013240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0735109705013240"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2005.05.063","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}