{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T18:23:37Z","timestamp":1774203817138,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2425,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.jacc.2006.10.018","type":"journal-article","created":{"date-parts":[[2006,12,30]],"date-time":"2006-12-30T12:07:18Z","timestamp":1167480438000},"page":"195-197","source":"Crossref","is-referenced-by-count":9,"title":["The Role of C-Reactive Protein Activation of Nuclear Factor Kappa-B in the Pathogenesis of Unstable Angina\u204e\u204eEditorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology."],"prefix":"10.1016","volume":"49","author":[{"given":"Ishwarlal","family":"Jialal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridevi","family":"Devaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2006.10.018_bib1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2006.10.018_bib2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00109-004-0555-y","article-title":"Nuclear factor-kappaB: its role in health and disease","volume":"82","author":"Kumar","year":"2004","journal-title":"J Mol Med"},{"key":"10.1016\/j.jacc.2006.10.018_bib3","first-page":"2135","article-title":"Is C-reactive protein an innocent bystander or proatherogenic culprit?","volume":"113","author":"Verma","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2006.10.018_bib4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jacc.2006.07.071","volume":"49","author":"Liuzzo","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2006.10.018_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.yjmcc.2003.12.005","article-title":"Effect of C-reactive protein on chemokine expression in human aortic endothelial cells","volume":"36","author":"Devaraj","year":"2004","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2006.10.018_bib6","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1161\/01.ATV.0000183607.50230.9f","article-title":"Rho\/Rho-kinase pathway contributes to C-reactive protein-induced plasminogen activator inhibitor-1 expression in endothelial cells","volume":"25","author":"Nakakuki","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2006.10.018_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2005.01.057","article-title":"C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells","volume":"185","author":"Kawanami","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2006.10.018_bib8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.yjmcc.2005.12.008","article-title":"C-reactive protein activates the nuclear factor-kappaB pathway and induces vascular cell adhesion molecule-1 expression through CD32 in human umbilical vein endothelial cells and aortic endothelial cells","volume":"40","author":"Liang","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2006.10.018_bib9","doi-asserted-by":"crossref","first-page":"H1170","DOI":"10.1152\/ajpheart.00150.2006","article-title":"CRP promotes monocyte-endothelial cell adhesion via Fc gamma receptors in human aortic endothelial cells under static and shear flow conditions","volume":"291","author":"Devaraj","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2006.10.018_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0008-6363(02)00855-6","article-title":"Vascular smooth muscle cell activation by C-reactive protein","volume":"58","author":"Hattori","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2006.10.018_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cardiores.2005.05.010","article-title":"C-Reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation","volume":"68","author":"Cirillo","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2006.10.018_bib12","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1161\/01.CIR.103.15.1933","article-title":"Effect of HMG-CoA reductase inhibitor therapy on high sensitive C-reactive protein levels","volume":"103","author":"Jialal","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2006.10.018_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.45.120403.095748","article-title":"Pleiotropic effects of statins","volume":"45","author":"Liao","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jacc.2006.10.018_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa042378","article-title":"C-reactive protein levels and outcomes after statin therapy","volume":"352","author":"Ridker","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2006.10.018_bib15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.2353\/ajpath.2006.051175","article-title":"Sources of CRP in atherosclerotic lesions","volume":"168","author":"Jialal","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jacc.2006.10.018_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/01.STR.0000150643.08420.78","article-title":"Concurrent treatment with renin-angiotensin system blockers and acetylsalicylic acid reduces nuclear factor \u03baB activation and C-reactive protein expression in human carotid artery plaques","volume":"36","author":"Sattler","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jacc.2006.10.018_bib17","first-page":"199","article-title":"Regulation of the human C-reactive protein gene, a major marker of inflammation and cancer","volume":"7","author":"Toniatti","year":"1990","journal-title":"Mol Biol Med"},{"key":"10.1016\/j.jacc.2006.10.018_bib18","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jacc.2006.01.034","article-title":"CRP and the vascular endothelium","volume":"47","author":"Jialal","year":"2006","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109706025149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109706025149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T12:24:10Z","timestamp":1547123050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109706025149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0735109706025149"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2006.10.018","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}