{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:37:30Z","timestamp":1792013850973,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1932,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.jacc.2007.12.045","type":"journal-article","created":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T14:49:50Z","timestamp":1209048590000},"page":"1663-1671","source":"Crossref","is-referenced-by-count":221,"title":["Inspiratory Muscle Training Improves Blood Flow to Resting and Exercising Limbs in Patients With Chronic Heart Failure"],"prefix":"10.1016","volume":"51","author":[{"given":"Gaspar R.","family":"Chiappa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno T.","family":"Roseguini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo J.C.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano N.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane R.","family":"Winkelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elton L.","family":"Ferlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge P.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2007.12.045_bib1","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1161\/01.CIR.103.17.2153","article-title":"Respiratory muscle dysfunction in congestive heart failure: clinical correlation and prognostic significance","volume":"103","author":"Meyer","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2007.12.045_bib2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jacc.2005.09.052","article-title":"Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial","volume":"47","author":"Dall'Ago","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib3","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.91.2.320","article-title":"Benefic of selective inspiratory muscle training on exercise capacity in patients with chronic congestive heart failure","volume":"91","author":"Mancini","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2007.12.045_bib4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00149831-200412000-00008","article-title":"Inspiratory muscle training using an incremental endurance test alleviates dyspnea and improves functional status in patients with chronic heart failure","volume":"11","author":"Laoutaris","year":"2004","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1016\/j.jacc.2007.12.045_bib5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.resp.2005.12.015","article-title":"Consequences of exercise-induced respiratory muscle work","volume":"151","author":"Dempsey","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1469-7793.2001.0277k.x","article-title":"Fatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans","volume":"537","author":"Sheel","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib7","doi-asserted-by":"crossref","first-page":"H1732","DOI":"10.1152\/ajpheart.00798.2001","article-title":"Threshold effects of respiratory muscle work on limb vascular resistance","volume":"282","author":"Sheel","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1469-7793.2000.00493.x","article-title":"Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans","volume":"529","author":"St Croix","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib9","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1152\/jappl.1997.82.5.1573","article-title":"Respiratory muscle work compromises leg blood flow during maximal exercise","volume":"82","author":"Harms","year":"1997","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/jappl.1998.85.2.609","article-title":"Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise","volume":"85","author":"Harms","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/jappl.2000.89.1.131","article-title":"Effects of respiratory muscle work on exercise performance","volume":"89","author":"Harms","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib12","doi-asserted-by":"crossref","first-page":"H580","DOI":"10.1152\/ajpheart.00211.2006","article-title":"The effects of inspiratory intrathoracic pressure production on the cardiovascular response to submaximal exercise in health and chronic heart failure","volume":"292","author":"Miller","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0033-0620(82)90012-3","article-title":"Alterations in vasomotor tone in congestive heart failure","volume":"24","author":"Zelis","year":"1982","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacc.2007.12.045_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10741-007-9056-8","article-title":"Implications of chronic heart failure on peripheral vasculature and skeletal muscle before and after exercise training","volume":"13","author":"Duscha","year":"2008","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jacc.2007.12.045_bib15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1113\/jphysiol.2006.117614","article-title":"The influence of inspiratory muscle work history and specific inspiratory muscle training upon human limb muscle fatigue","volume":"577","author":"McConnell","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1113\/jphysiol.2007.140855","article-title":"Inspiratory muscle training attenuates the human respiratory muscle metaboreflex","volume":"584","author":"Witt","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1055\/s-2001-18523","article-title":"Reliability of gas exchange measurement from two different spiroergometry systems","volume":"22","author":"Meyer","year":"2001","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.jacc.2007.12.045_bib18","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1152\/jappl.1989.67.4.1560","article-title":"Diaphragmatic thickness-lung volume relationship in vivo","volume":"67","author":"Wait","year":"1989","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib19","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1164\/ajrccm.152.6.8520771","article-title":"Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders","volume":"152","author":"Hamilton","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jacc.2007.12.045_bib20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1164\/rccm.166.4.518","article-title":"Statement on respiratory muscle testing","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jacc.2007.12.045_bib21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/01.CIR.82.2.465","article-title":"Muscle blood flow during forearm exercise in patients with severe heart failure","volume":"82","author":"Arnold","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2007.12.045_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1249\/mss.0b013e3181590bd9","article-title":"Attenuation of muscle metaboreflex in chronic obstructive pulmonary disease","volume":"40","author":"Roseguini","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jacc.2007.12.045_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1249\/00003677-200607000-00002","article-title":"Challenges for future research in exercise physiology as applied to the respiratory system","volume":"34","author":"Dempsey","year":"2006","journal-title":"Exerc Sport Sci Rev"},{"key":"10.1016\/j.jacc.2007.12.045_bib24","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/0735-1097(91)90605-9","article-title":"Respiratory muscle deoxygenation during exercise in patients with heart failure demonstrated by near-infrared spectroscopy","volume":"18","author":"Mancini","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/ptj\/86.3.345","article-title":"Effect of high-intensity inspiratory muscle training on lung volumes, diaphragm thickness, and exercise capacity in subjects who are healthy","volume":"86","author":"Enright","year":"2006","journal-title":"Phys Ther"},{"key":"10.1016\/j.jacc.2007.12.045_bib26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1253\/circj.71.465","article-title":"Blood flow redistribution during exercise contributes to exercise tolerance in patients with chronic heart failure","volume":"71","author":"Myiazaki","year":"2007","journal-title":"Circ J"},{"key":"10.1016\/j.jacc.2007.12.045_bib27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1152\/jappl.1999.87.2.643","article-title":"Influence of respiratory muscle work on VO2 and leg blood flow during submaximal exercise","volume":"87","author":"Wetter","year":"1999","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1113\/jphysiol.1994.sp020027","article-title":"Active forearm blood flow adjustments to handgrip exercise in young and older healthy men","volume":"474","author":"Jasperse","year":"1994","journal-title":"J Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1113\/jphysiol.2006.124313","article-title":"Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans","volume":"579","author":"Schrage","year":"2007","journal-title":"J Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib30","first-page":"H344","article-title":"Sympathetic neural reactivity to stress does not increase with age in healthy humans","volume":"267","author":"Ng","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jacc.2007.12.045_bib31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1475-097X.2007.00756.x","article-title":"Muscle metaboreflex contribution to resting limb haemodynamic control is preserved in older subjects","volume":"27","author":"Roseguini","year":"2007","journal-title":"Clin Physiol Funct Imaging"},{"key":"10.1016\/j.jacc.2007.12.045_bib32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000179075","article-title":"Local blood flux in skin and muscle during voluntary hyperventilation in healthy controls and patients with hyperventilation syndrome","volume":"15","author":"Steurer","year":"1995","journal-title":"Int J Microcirc Clin Exp"},{"key":"10.1016\/j.jacc.2007.12.045_bib33","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1152\/ajplegacy.1966.211.5.1255","article-title":"Hyperventilation and human calf blood flow","volume":"211","author":"Coffman","year":"1966","journal-title":"Am J Physiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109708005676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109708005676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T19:06:03Z","timestamp":1588619163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109708005676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":33,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0735109708005676"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2007.12.045","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}