{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:57:22Z","timestamp":1777946242715,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1749,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.jacc.2008.07.034","type":"journal-article","created":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T05:47:08Z","timestamp":1224654428000},"page":"1381-1388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of Ile164 Polymorphism of Beta2-Adrenergic Receptor Gene on Coronary Artery Disease"],"prefix":"10.1016","volume":"52","author":[{"given":"Federico","family":"Piscione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Iaccarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Galasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersilia","family":"Cipolletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Assunta","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregorio","family":"Brevetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Piccolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Trimarco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Chiariello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2008.07.034_bib1","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1164\/ajrccm.161.supplement_2.a1q4-10","article-title":"Beta(2)-adrenergic receptor pharmacogenetics","volume":"161","author":"Liggett","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jacc.2008.07.034_bib2","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1021\/bi00198a006","article-title":"Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties","volume":"33","author":"Green","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.jacc.2008.07.034_bib3","doi-asserted-by":"crossref","first-page":"23116","DOI":"10.1016\/S0021-9258(19)49434-9","article-title":"A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor","volume":"268","author":"Green","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2008.07.034_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1165\/ajrcmb.13.1.7598936","article-title":"Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells","volume":"13","author":"Green","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jacc.2008.07.034_bib5","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1073\/pnas.93.19.10483","article-title":"Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice","volume":"93","author":"Turki","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2008.07.034_bib6","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1161\/01.CIR.103.8.1048","article-title":"Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors","volume":"103","author":"Brodde","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.034_bib7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s003950170003","article-title":"Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart","volume":"96","author":"Brodde","year":"2001","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jacc.2008.07.034_bib8","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0031-6997(24)01425-X","article-title":"Adrenergic and muscarinic receptors in the human heart","volume":"51","author":"Brodde","year":"1999","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jacc.2008.07.034_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/phrs.1993.1026","article-title":"Beta 1 and beta 2 adrenoceptors are involved in mediating vasodilation in the human coronary artery","volume":"27","author":"Monopoli","year":"1993","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jacc.2008.07.034_bib10","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1161\/01.RES.0000191541.06788.bb","article-title":"Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system","volume":"97","author":"Iaccarino","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2008.07.034_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/01213011-200505000-00001","article-title":"Beta2-adrenoceptor gene polymorphisms","volume":"15","author":"Brodde","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.jacc.2008.07.034_bib12","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/01.hjh.0000226185.06063.80","article-title":"The beta2-adrenoceptor gene and hypertension: is it the promoter or the coding region or neither?","volume":"24","author":"Hahntow","year":"2006","journal-title":"J Hypertens"},{"key":"10.1016\/j.jacc.2008.07.034_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.atherosclerosis.2004.03.009","article-title":"Prevalence, risk factors and cardiovascular comorbidity of symptomatic peripheral arterial disease in Italy","volume":"175","author":"Brevetti","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2008.07.034_bib14","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1161\/01.CIR.103.24.3019","volume":"103","author":"Smith","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.034_bib15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/01.CIR.76.1.142","article-title":"Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase","volume":"76","author":"Chesebro","year":"1987","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.034_bib16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/01.CIR.82.4.1193","article-title":"Coronary morphologic and clinical determinants of procedural outcome with angioplasty for multivessel coronary disease","volume":"82","author":"Ellis","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.034_bib17","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1097\/00004872-200411000-00013","article-title":"The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension","volume":"22","author":"Iaccarino","year":"2004","journal-title":"J Hypertens"},{"key":"10.1016\/j.jacc.2008.07.034_bib18","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.jacc.2003.09.063","article-title":"Echolucent carotid plaques predict future coronary events in patients with coronary artery disease","volume":"43","author":"Honda","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.07.034_bib19","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/sj.tpj.6500324","article-title":"Beta-blockade and increased dyslipidemia in patients bearing Glu27 variant of beta2 adrenergic receptor gene","volume":"5","author":"Iaccarino","year":"2005","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.jacc.2008.07.034_bib20","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","article-title":"A simplified system for generating recombinant adenoviruses","volume":"95","author":"He","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2008.07.034_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0022-2836(83)80284-8","article-title":"Studies on transformation of escherichia coli with plasmids","volume":"166","author":"Hanahan","year":"1983","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jacc.2008.07.034_bib22","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.CIR.0000022690.55143.56","article-title":"Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension","volume":"106","author":"Iaccarino","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.034_bib23","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1073\/pnas.96.7.3945","article-title":"Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis","volume":"96","author":"Iaccarino","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2008.07.034_bib24","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/01.CIR.98.17.1783","article-title":"Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade","volume":"98","author":"Iaccarino","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.034_bib25","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/eurheartj\/ehi175","article-title":"Atherosclerosis regression and TP receptor inhibition: effect of S18886 on plaque size and composition\u2014a magnetic resonance imaging study","volume":"26","author":"Viles-Gonzalez","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.034_bib26","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","article-title":"The pathogenesis of atherosclerosis: a perspective for the 1990s","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2008.07.034_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0033-0620(97)80002-3","article-title":"The molecular bases of restenosis","volume":"40","author":"Libby","year":"1997","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacc.2008.07.034_bib28","first-page":"360","article-title":"Kinetics of cellular proliferation after arterial injury","volume":"60","author":"Clowes","year":"1989","journal-title":"Lab Investfs"},{"key":"10.1016\/j.jacc.2008.07.034_bib29","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0735-1097(98)00283-6","article-title":"Mast cell infiltration in acute coronary syndromes: implications for plaque rupture","volume":"32","author":"Kaartinen","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.07.034_bib30","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/01.CIR.102.7.766","article-title":"Quantitative ultrasonic tissue characterization can identify high-risk atherosclerotic alteration in human carotid arteries","volume":"102","author":"Takiuchi","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.034_bib31","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1093\/eurheartj\/ehm244","article-title":"Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings","volume":"28","author":"Amato","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.034_bib32","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/HJH.0b013e328013cd67","article-title":"The Pl(A1\/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients","volume":"25","author":"Lanni","year":"2007","journal-title":"J Hypertens"},{"key":"10.1016\/j.jacc.2008.07.034_bib33","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1093\/eurheartj\/ehm297","article-title":"Late loss of early benefit from drug-eluting stents when compared with bare-metal stents and coronary artery bypass surgery: 3 years follow-up of the ERACI III registry","volume":"28","author":"Rodriguez","year":"2007","journal-title":"Eur Heart J"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109708026326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109708026326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:30:07Z","timestamp":1760013007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109708026326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":33,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0735109708026326"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2008.07.034","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Ile164 Polymorphism of Beta2-Adrenergic Receptor Gene on Coronary Artery Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2008.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}