{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:21:50Z","timestamp":1790976110118,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"20","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1755,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.jacc.2008.07.056","type":"journal-article","created":{"date-parts":[[2008,11,8]],"date-time":"2008-11-08T01:48:13Z","timestamp":1226108893000},"page":"1640-1648","source":"Crossref","is-referenced-by-count":155,"title":["Continental Differences in Clinical Characteristics, Management, and Outcomes in Patients Hospitalized With Worsening Heart Failure"],"prefix":"10.1016","volume":"52","author":[{"given":"John E.A.","family":"Blair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin A.","family":"Konstam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Traver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John C.","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Grinfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Krasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo P.","family":"Maggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Swedberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Udelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Gheorghiade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2008.07.056_bib1","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1161\/CIRCULATIONAHA.106.179918","article-title":"Heart disease and stroke statistics\u20142007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"115","author":"Rosamond","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.056_bib2","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/eurheartj\/ehi204","article-title":"Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): the Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology","volume":"26","author":"Swedberg","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0167-5273(01)00497-1","article-title":"The epidemiological features of heart failure in developing countries: a review of the literature","volume":"80","author":"Mendez","year":"2001","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2008.07.056_bib4","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1161\/CIRCULATIONAHA.107.696906","article-title":"Influence of nonfatal hospitalization for heart failure on subsequent mortality in patients with chronic heart failure","volume":"116","author":"Solomon","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.056_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cardfail.2007.12.001","article-title":"Incident heart failure hospitalization and subsequent mortality in chronic heart failure: a propensity-matched study","volume":"14","author":"Ahmed","year":"2008","journal-title":"J Card Fail"},{"key":"10.1016\/j.jacc.2008.07.056_bib6","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1161\/CIRCULATIONAHA.105.590091","article-title":"Acute heart failure syndromes: current state and framework for future research","volume":"112","author":"Gheorghiade","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.056_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ahj.2004.08.005","article-title":"Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)","volume":"149","author":"Adams","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib8","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0195-668X(02)00823-0","article-title":"The EuroHeart Failure survey programme\u2014a survey on the quality of care among patients with heart failure in Europe","volume":"24","author":"Cleland","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib9","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1001\/jama.296.18.2217","article-title":"Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure","volume":"296","author":"Gheorghiade","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2008.07.056_bib10","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/eurheartj\/ehl193","article-title":"EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population","volume":"27","author":"Nieminen","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib11","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/eurheartj\/ehi845","article-title":"Nationwide survey on acute heart failure in cardiology ward services in Italy","volume":"27","author":"Tavazzi","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ahj.2005.03.010","article-title":"Overview of acute decompensated heart failure in Argentina: lessons learned from 5 registries during the last decade","volume":"151","author":"Perna","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ejheart.2006.01.001","article-title":"Clinical profile, contemporary management and one-year mortality in patients with severe acute heart failure syndromes: the EFICA study","volume":"8","author":"Zannad","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2008.07.056_bib14","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1001\/jama.297.12.1332","article-title":"Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST clinical status trials","volume":"297","author":"Gheorghiade","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2008.07.056_bib15","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1001\/jama.297.12.1319","article-title":"Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome trial","volume":"297","author":"Konstam","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2008.07.056_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cardfail.2005.03.009","article-title":"Rationale and design of the multicenter, randomized, double-blind, placebo-controlled study to evaluate the Efficacy of Vasopressin antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST)","volume":"11","author":"Gheorghiade","year":"2005","journal-title":"J Card Fail"},{"key":"10.1016\/j.jacc.2008.07.056_bib17","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/eurheartj\/ehl542","article-title":"Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry","volume":"28","author":"Gheorghiade","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib18","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.amjcard.2004.06.041","article-title":"Effect of elevated admission serum creatinine and its worsening on outcome in hospitalized patients with decompensated heart failure","volume":"94","author":"Akhter","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2008.07.056_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/CIRCHEARTFAILURE.107.746933","article-title":"Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF)","volume":"1","author":"Klein","year":"2008","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jacc.2008.07.056_bib20","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.jacc.2005.11.084","article-title":"Renal impairment and outcomes in heart failure: systematic review and meta-analysis","volume":"47","author":"Smith","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.07.056_bib21","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.jacc.2007.02.037","article-title":"Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure","volume":"49","author":"Fonarow","year":"2007","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl 6","key":"10.1016\/j.jacc.2008.07.056_bib22","first-page":"VI5","article-title":"Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure","volume":"87","author":"Cohn","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.07.056_bib23","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ehj.2003.10.030","article-title":"The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT","volume":"25","author":"Latini","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib24","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2005.08.022","volume":"46","author":"Hunt","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.07.056_bib25","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/euhj.2001.2783","article-title":"Guidelines for the diagnosis and treatment of chronic heart failure","volume":"22","author":"Remme","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib26","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0195-668X(02)00700-5","article-title":"The EuroHeart Failure Survey programme\u2014a survey on the quality of care among patients with heart failure in Europe","volume":"24","author":"Komajda","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.07.056_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/pds.1216","article-title":"Prescribing for chronic heart failure in Europe: does the country make the difference?","volume":"16","author":"Sturm","year":"2007","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jacc.2008.07.056_bib28","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0735-1097(02)02968-6","article-title":"Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study","volume":"41","author":"Felker","year":"2003","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109708028738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109708028738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T16:26:49Z","timestamp":1545668809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109708028738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":28,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0735109708028738"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2008.07.056","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}