{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:23:17Z","timestamp":1791238997649,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1604,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.jacc.2008.10.064","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T05:03:34Z","timestamp":1238562214000},"page":"1219-1226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"title":["Cardiac Deletion of the Coxsackievirus-Adenovirus Receptor Abolishes Coxsackievirus B3 Infection and Prevents Myocarditis In Vivo"],"prefix":"10.1016","volume":"53","author":[{"given":"Yu","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Lisewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Wrackmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Radke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Tsch\u00f6pe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Poller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gotthardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2008.10.064_bib1","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"Bergelson","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jacc.2008.10.064_bib2","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1073\/pnas.94.7.3352","article-title":"HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses","volume":"94","author":"Tomko","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2008.10.064_bib3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/bbrc.1997.6449","article-title":"Purification of the putative coxsackievirus B receptor from HeLa cells","volume":"233","author":"Carson","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jacc.2008.10.064_bib4","doi-asserted-by":"crossref","first-page":"9844","DOI":"10.1128\/jvi.71.12.9844-9848.1997","article-title":"A decay-accelerating factor-binding strain of coxsackievirus B3 requires the coxsackievirus-adenovirus receptor protein to mediate lytic infection of rhabdomyosarcoma cells","volume":"71","author":"Shafren","year":"1997","journal-title":"J Virol"},{"key":"10.1016\/j.jacc.2008.10.064_bib5","doi-asserted-by":"crossref","first-page":"15191","DOI":"10.1073\/pnas.261452898","article-title":"The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction","volume":"98","author":"Cohen","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2008.10.064_bib6","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1074\/jbc.M205927200","article-title":"The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)","volume":"278","author":"Sollerbrant","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2008.10.064_bib7","doi-asserted-by":"crossref","first-page":"48079","DOI":"10.1074\/jbc.M409061200","article-title":"The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction","volume":"279","author":"Coyne","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2008.10.064_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virol.2004.12.010","article-title":"Internalization and trafficking mechanisms of coxsackievirus B3 in HeLa cells","volume":"333","author":"Chung","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.jacc.2008.10.064_bib9","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/sj.gt.3301030","article-title":"Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers","volume":"6","author":"Fechner","year":"1999","journal-title":"Gene Ther"},{"key":"10.1016\/j.jacc.2008.10.064_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/gene.20127","article-title":"Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development","volume":"42","author":"Asher","year":"2005","journal-title":"Genesis"},{"key":"10.1016\/j.jacc.2008.10.064_bib11","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1242\/jcs.02476","article-title":"Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development","volume":"118","author":"Dorner","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jacc.2008.10.064_bib12","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/01.RES.0000218041.41932.e3","article-title":"Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves","volume":"98","author":"Chen","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2008.10.064_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cell.2005.10.035","article-title":"Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions","volume":"124","author":"Coyne","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2008.10.064_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/1096-9071(200009)62:1<70::AID-JMV11>3.0.CO;2-R","article-title":"Group B coxsackievirus myocarditis and pancreatitis: connection between viral virulence phenotypes in mice","volume":"62","author":"Tracy","year":"2000","journal-title":"J Med Virol"},{"key":"10.1016\/j.jacc.2008.10.064_bib15","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1074\/jbc.M211723200","article-title":"Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure","volume":"278","author":"Gotthardt","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2008.10.064_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein","volume":"89","author":"Sohal","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2008.10.064_bib17","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1073\/pnas.82.14.4818","article-title":"Molecular cloning of the genome of a cardiotropic Coxsackie B3 virus: full-length reverse-transcribed recombinant cDNA generates infectious virus in mammalian cells","volume":"82","author":"Kandolf","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2008.10.064_bib18","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1073\/pnas.89.1.314","article-title":"Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation","volume":"89","author":"Klingel","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2008.10.064_bib19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1089\/dna.1.1988.7.307","article-title":"Expression of coxsackievirus B3 capsid proteins in Escherichia coli and generation of virus-specific antisera","volume":"7","author":"Werner","year":"1988","journal-title":"DNA"},{"key":"10.1016\/j.jacc.2008.10.064_bib20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1083\/jcb.200601014","article-title":"M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere","volume":"173","author":"Weinert","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jacc.2008.10.064_bib21","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2337\/db06-1163","article-title":"Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism","volume":"56","author":"Westermann","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jacc.2008.10.064_bib22","doi-asserted-by":"crossref","first-page":"H755","DOI":"10.1152\/ajpheart.2001.281.2.H755","article-title":"Hypertonic saline method accurately determines parallel conductance for dual-field conductance catheter","volume":"281","author":"Steendijk","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2008.10.064_bib23","doi-asserted-by":"crossref","first-page":"8888","DOI":"10.1128\/jvi.70.12.8888-8895.1996","article-title":"Pathogenesis of murine enterovirus myocarditis: virus dissemination and immune cell targets","volume":"70","author":"Klingel","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.jacc.2008.10.064_bib24","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJM200011093431908","article-title":"Myocarditis","volume":"343","author":"Feldman","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.10.064_bib25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ymeth.2006.07.009","article-title":"Coxsackievirus-induced myocarditis in mice: a model of autoimmune disease for studying immunotoxicity","volume":"41","author":"Fairweather","year":"2007","journal-title":"Methods"},{"key":"10.1016\/j.jacc.2008.10.064_bib26","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1161\/CIRCULATIONAHA.105.536433","article-title":"Myeloid differentiation factor-88 plays a crucial role in the pathogenesis of Coxsackievirus B3-induced myocarditis and influences type I interferon production","volume":"112","author":"Fuse","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.10.064_bib27","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1086\/382598","article-title":"Soluble recombinant coxsackievirus and adenovirus receptor abrogates coxsackievirus b3-mediated pancreatitis and myocarditis in mice","volume":"189","author":"Yanagawa","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jacc.2008.10.064_bib28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/JVI.72.1.415-419.1998","article-title":"The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses","volume":"72","author":"Bergelson","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.jacc.2008.10.064_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/excr.1999.4761","article-title":"Expression of the adenovirus receptor and its interaction with the fiber knob","volume":"255","author":"Tomko","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jacc.2008.10.064_bib30","doi-asserted-by":"crossref","first-page":"25392","DOI":"10.1074\/jbc.M009531200","article-title":"Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting","volume":"276","author":"Cohen","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2008.10.064_bib31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1128\/JVI.79.1.655-660.2005","article-title":"Interaction with coxsackievirus and adenovirus receptor, but not with decay-accelerating factor (DAF), induces A-particle formation in a DAF-binding coxsackievirus B3 isolate","volume":"79","author":"Milstone","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.jacc.2008.10.064_bib32","doi-asserted-by":"crossref","first-page":"12897","DOI":"10.1073\/pnas.0506211102","article-title":"The erythrocyte viral trap: transgenic expression of viral receptor on erythrocytes attenuates coxsackievirus B infection","volume":"102","author":"Asher","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2008.10.064_bib33","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s00109-006-0076-y","article-title":"Treatment of coxsackievirus-B3-infected BALB\/c mice with the soluble coxsackie adenovirus receptor CAR4\/7 aggravates cardiac injury","volume":"84","author":"Dorner","year":"2006","journal-title":"J Mol Med"},{"key":"10.1016\/j.jacc.2008.10.064_bib34","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cardiores.2006.05.016","article-title":"Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis","volume":"71","author":"Lim","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jacc.2008.10.064_bib35","doi-asserted-by":"crossref","first-page":"12016","DOI":"10.1128\/JVI.79.18.12016-12024.2005","article-title":"Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered particle formation, and competition with cellular receptors","volume":"79","author":"Goodfellow","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.jacc.2008.10.064_bib36","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1172\/JCI34777","article-title":"Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart","volume":"118","author":"Lim","year":"2008","journal-title":"J Clin Invest"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109709001910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109709001910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:30:38Z","timestamp":1760013038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109709001910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":36,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0735109709001910"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2008.10.064","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac Deletion of the Coxsackievirus-Adenovirus Receptor Abolishes Coxsackievirus B3 Infection and Prevents Myocarditis In Vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2008.10.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}