{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:12:11Z","timestamp":1790122331489,"version":"4.0.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1598,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.jacc.2008.11.025","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T05:33:22Z","timestamp":1235540002000},"page":"733-740","source":"Crossref","is-referenced-by-count":172,"title":["Eisenmenger Syndrome"],"prefix":"10.1016","volume":"53","author":[{"given":"Maurice","family":"Beghetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazzareno","family":"Gali\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2008.11.025_bib1","first-page":"1","article-title":"Die angeborenen Defecte der Kammerscheidewand des Herzens","volume":"32","author":"Eisenmenger","year":"1897","journal-title":"Z Klin Med"},{"key":"10.1016\/j.jacc.2008.11.025_bib2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1136\/bmj.2.5098.701","article-title":"The Eisenmenger syndrome or pulmonary hypertension with reversed central shunt","volume":"2","author":"Wood","year":"1958","journal-title":"Br Med J"},{"key":"10.1016\/j.jacc.2008.11.025_bib3","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1053\/euhj.1998.1046","article-title":"Eisenmenger syndrome","volume":"19","author":"Daliento","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib4","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/CIRCULATIONAHA.105.592386","article-title":"Pulmonary vascular disease in adults with congenital heart disease","volume":"115","author":"Diller","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.025_bib5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.7326\/0003-4819-128-9-199805010-00008","article-title":"The Eisenmenger syndrome in adults","volume":"128","author":"Vongpatanasin","year":"1998","journal-title":"Ann Intern Med"},{"issue":"Suppl","key":"10.1016\/j.jacc.2008.11.025_bib6","first-page":"I38","article-title":"Second natural history study of congenital heart defects","volume":"87","author":"Kidd","year":"1993","journal-title":"Circulation"},{"issue":"Suppl S","key":"10.1016\/j.jacc.2008.11.025_bib7","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/j.jacc.2004.02.029","article-title":"Cellular and molecular pathobiology of pulmonary arterial hypertension","volume":"43","author":"Humbert","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMra040291","article-title":"Treatment of pulmonary arterial hypertension","volume":"351","author":"Humbert","year":"2004","journal-title":"N Engl J Med"},{"issue":"Suppl S","key":"10.1016\/j.jacc.2008.11.025_bib9","doi-asserted-by":"crossref","first-page":"25S","DOI":"10.1016\/j.jacc.2004.02.033","article-title":"Pathologic assessment of vasculopathies in pulmonary hypertension","volume":"43","author":"Pietra","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl S","key":"10.1016\/j.jacc.2008.11.025_bib10","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/j.jacc.2004.02.037","article-title":"Clinical classification of pulmonary hypertension","volume":"43","author":"Simonneau","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib11","first-page":"100","article-title":"Comparison of the hemodynamics and survival of adults with severe primary pulmonary hypertension or Eisenmenger syndrome","volume":"15","author":"Hopkins","year":"1996","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2008.11.025_bib12","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1161\/CIRCULATIONAHA.104.509869","article-title":"Pulmonary neovascularity: a distinctive radiographic finding in Eisenmenger syndrome","volume":"112","author":"Sheehan","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.025_bib13","first-page":"250","article-title":"A 38-year-old man with pulmonary hypertension, who had undergone atrial septal closure 26 years previously","volume":"52","author":"Satoh","year":"2003","journal-title":"Keio J Med"},{"key":"10.1016\/j.jacc.2008.11.025_bib14","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0195-668X(03)00131-3","article-title":"Management of grown up congenital heart disease","volume":"24","author":"Deanfield","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jacc.2007.04.056","article-title":"Pulmonary arterial thrombosis in Eisenmenger syndrome is associated with biventricular dysfunction and decreased pulmonary flow velocity","volume":"50","author":"Broberg","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib16","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.ehj.2004.09.014","article-title":"Guidelines on diagnosis and treatment of pulmonary arterial hypertension","volume":"25","author":"Gali\u00e8","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1053\/pcad.2002.127492","article-title":"Eisenmenger's syndrome: current management","volume":"45","author":"Berman","year":"2002","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.jacc.2008.11.025_bib18","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S1053-2498(01)00420-X","article-title":"Heart\u2013lung or lung transplantation for Eisenmenger syndrome","volume":"21","author":"Waddell","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2008.11.025_bib19","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/S0003-4975(01)03099-5","article-title":"Heart-lung transplantation for Eisenmenger syndrome: early and long-term results","volume":"72","author":"Stoica","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jacc.2008.11.025_bib20","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/eurheartj\/ehl017","article-title":"Advanced therapy may delay the need for transplantation in patients with the Eisenmenger syndrome","volume":"27","author":"Adriaenssens","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib21","first-page":"279","article-title":"Successful reversal of pulmonary hypertension in Eisenmenger complex","volume":"68","author":"Batista","year":"1997","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib22","first-page":"205","article-title":"Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension","volume":"3","author":"Mocellin","year":"1975","journal-title":"Eur J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.athoracsur.2004.06.107","article-title":"Flap valve double patch closure of ventricular septal defects in children with increased pulmonary vascular resistance","volume":"79","author":"Novick","year":"2005","journal-title":"Ann Thoracic Surg"},{"key":"10.1016\/j.jacc.2008.11.025_bib24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/021849230601400612","article-title":"Valved patch for ventricular septal defect with pulmonary arterial hypertension","volume":"14","author":"Afrasiabi","year":"2006","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"10.1016\/j.jacc.2008.11.025_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.106.630715","article-title":"Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study","volume":"114","author":"Gali\u00e8","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.025_bib26","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1378\/chest.06-2674","article-title":"Medical therapy for pulmonary arterial hypertension: updated ACCP evidence-based clinical practice guidelines","volume":"131","author":"Badesch","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jacc.2008.11.025_bib27","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.ehj.2004.07.005","article-title":"Responsiveness to inhaled nitric oxide is a predictor for mid-term survival in adult patients with congenital heart defects and pulmonary arterial hypertension","volume":"25","author":"Post","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib28","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/heart.86.5.553","article-title":"Residual pulmonary vasoreactivity to inhaled nitric oxide in patients with severe obstructive pulmonary hypertension and Eisenmenger syndrome","volume":"86","author":"Budts","year":"2001","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2008.11.025_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.amjcard.2004.03.081","article-title":"Initial experience with bosentan therapy in patients with the Eisenmenger syndrome","volume":"94","author":"Christensen","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijcard.2004.08.025","article-title":"Safety and tolerability of bosentan in adults with Eisenmenger physiology","volume":"98","author":"Gatzoulis","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib31","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ahj.2005.07.005","article-title":"Adult patients with congenital heart disease and pulmonary arterial hypertension: first open prospective multicenter study of bosentan therapy","volume":"150","author":"Schulze-Neick","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijcard.2007.04.078","article-title":"Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: results of the BREATHE-5 open-label extension study","volume":"127","author":"Gatzoulis","year":"2008","journal-title":"Int J Cardiol"},{"issue":"Suppl A","key":"10.1016\/j.jacc.2008.11.025_bib33","first-page":"254A","article-title":"Subgroup analysis of patients with atrial septal vs. ventricular septal defects in the BREATHE-5 placebo-controlled study of pulmonary arterial hypertension associated with Eisenmenger's syndrome","volume":"49","author":"Berger","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib34","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/hrt.2006.097360","article-title":"Long term effects of bosentan treatment in adult patients with pulmonary arterial hypertension related to congenital heart disease (Eisenmenger physiology): safety, tolerability, clinical, and haemodynamic effect","volume":"93","author":"D'Alto","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2008.11.025_bib35","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/hrt.2006.089185","article-title":"Long-term safety, tolerability and efficacy of bosentan in adults with pulmonary arterial hypertension associated with congenital heart disease","volume":"93","author":"Diller","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2008.11.025_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/hrt.2006.100388","article-title":"Long-term oral bosentan treatment in patients with pulmonary arterial hypertension related to congenital heart disease: a 2-year study","volume":"93","author":"Apostolopoulou","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.jacc.2008.11.025_bib37","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1378\/chest.129.4.1009","article-title":"Efficacy of bosentan in a small cohort of adult patients with pulmonary arterial hypertension related to congenital heart disease","volume":"129","author":"Benza","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jacc.2008.11.025_bib38","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.ahj.2007.06.003","article-title":"Long-term effect of bosentan in adults versus children with pulmonary arterial hypertension associated with systemic-to-pulmonary shunt: does the beneficial effect persist?","volume":"154","author":"Van Loon","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1017\/S1047951107000522","article-title":"Treatment of patients with Eisenmenger's syndrome with Bosentan","volume":"17","author":"Brun","year":"2007","journal-title":"Cardiol Young"},{"issue":"Suppl","key":"10.1016\/j.jacc.2008.11.025_bib40","first-page":"II457","article-title":"Sitaxsentan treatment in patients with Eisenmenger syndrome","volume":"116","author":"Rosenzweig","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.025_bib41","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijcard.2006.10.018","article-title":"Effects of chronic sildenafil in patients with Eisenmenger syndrome versus idiopathic pulmonary arterial hypertension","volume":"120","author":"Chau","year":"2007","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib42","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ijcard.2006.10.017","article-title":"Role of oral sildenafil in severe pulmonary arterial hypertension: clinical efficacy and dose response relationship","volume":"120","author":"Garg","year":"2007","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib43","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/01.crd.0000181618.29506.1e","article-title":"Use of long-term combined therapy with inhaled iloprost and oral sildenafil in an adult patient with Eisenmenger syndrome","volume":"13","author":"Okyay","year":"2005","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.jacc.2008.11.025_bib44","doi-asserted-by":"crossref","first-page":"851.e1","DOI":"10.1016\/j.ahj.2005.09.006","article-title":"A randomized, placebo-controlled, double-blind, crossover study to evaluate the efficacy of oral sildenafil therapy in severe pulmonary artery hypertension","volume":"151","author":"Singh","year":"2006","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijcard.2006.06.045","article-title":"Sildenafil therapy for pulmonary arterial hypertension associated with atrial septal defects","volume":"118","author":"Lim","year":"2007","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib46","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.105.603001","article-title":"Phosphodiesterase-5 inhibitor in Eisenmenger syndrome: a preliminary observational study","volume":"114","author":"Mukhopadhyay","year":"2006","journal-title":"Circulation"},{"issue":"Suppl","key":"10.1016\/j.jacc.2008.11.025_bib47","first-page":"308","article-title":"Effects of sildenafil treatment in patients with pulmonary hypertension associated with congenital cardiac shunts","volume":"28","author":"Palazzini","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2008.11.025_bib48","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1161\/01.CIR.99.14.1858","article-title":"Long-term prostacyclin for pulmonary hypertension with associated congenital heart defects","volume":"99","author":"Rosenzweig","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.025_bib49","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0002-9149(02)03328-3","article-title":"Usefulness of epoprostenol therapy in the severely ill adolescent\/adult with Eisenmenger physiology","volume":"91","author":"Fernandes","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib50","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.healun.2004.02.004","article-title":"Reversal of pulmonary hypertension and subsequent repair of atrial septal defect after treatment with continuous intravenous epoprostenol","volume":"24","author":"Frost","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.jacc.2008.11.025_bib51","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijcard.2005.05.062","article-title":"Atrial septal defect closure in a patient with \u201cirreversible\u201d pulmonary hypertensive arteriopathy","volume":"110","author":"Schwerzmann","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib52","first-page":"55","article-title":"Comparative studies of hemodynamics under prostacyclin and nifedipine in patients with Eisenmenger syndrome","volume":"84","author":"Gildein","year":"1995","journal-title":"Z Kardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib53","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0002-9149(03)00991-3","article-title":"Comparison of acute hemodynamic effects of aerosolized and intravenous iloprost in secondary pulmonary hypertension in children with congenital heart disease","volume":"92","author":"Hallioglu","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib54","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00246-005-0925-4","article-title":"Beraprost therapy in children with pulmonary hypertension secondary to congenital heart disease","volume":"26","author":"Limsuwan","year":"2005","journal-title":"Pediatr Cardiol"},{"issue":"Suppl 1","key":"10.1016\/j.jacc.2008.11.025_bib55","first-page":"78","article-title":"Inhaled iloprost in children with pulmonary arterial hypertension","volume":"17","author":"Beghetti","year":"2007","journal-title":"Cardiol Young"},{"key":"10.1016\/j.jacc.2008.11.025_bib56","first-page":"333","article-title":"Long-term experience with treprostinil infusion treatment in patients with pulmonary arterial hypertension in the Czech Republic","volume":"53","author":"Jansa","year":"2007","journal-title":"Vnitr Lek"},{"key":"10.1016\/j.jacc.2008.11.025_bib57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jacc.2007.09.031","article-title":"Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension","volume":"51","author":"Ivy","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.11.025_bib58","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/S0022-5223(95)70206-7","article-title":"Pulmonary vascular resistance during exercise late after repair of large ventricular septal defects","volume":"109","author":"Ikawa","year":"1995","journal-title":"Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jacc.2008.11.025_bib59","series-title":"Pulmonary Arterial Hypertension Related to Congenital Heart Disease","first-page":"82","article-title":"Pathophysiology of postoperative pulmonary hypertension","author":"Adatia","year":"2006"},{"key":"10.1016\/j.jacc.2008.11.025_bib60","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1164\/rccm.200502-296OC","article-title":"Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension","volume":"172","author":"Schermuly","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jacc.2008.11.025_bib61","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIRCULATIONAHA.106.676809","article-title":"Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy","volume":"115","author":"Schermuly","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.025_bib62","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/CIRCULATIONAHA.105.581405","article-title":"Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling","volume":"113","author":"Dumitrascu","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.025_bib63","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1165\/rcmb.2005-0115OC","article-title":"Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer","volume":"35","author":"Zhao","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jacc.2008.11.025_bib64","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI23203","article-title":"Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension","volume":"115","author":"McMurtry","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2008.11.025_bib65","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJMc051946","article-title":"Imatinib for the treatment of pulmonary arterial hypertension","volume":"353","author":"Ghofrani","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.11.025_bib66","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1172\/JCI17500","article-title":"Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension","volume":"111","author":"Petkov","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2008.11.025_bib67","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1161\/CIRCULATIONAHA.105.534073","article-title":"Systemic endothelial dysfunction in adults with cyanotic congenital heart disease","volume":"112","author":"Oechslin","year":"2005","journal-title":"Circulation"},{"issue":"Suppl","key":"10.1016\/j.jacc.2008.11.025_bib68","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2362.2006.01692.x","article-title":"First experience with an oral combination therapy using bosentan and sildenafil for pulmonary arterial hypertension","volume":"36","author":"Lunze","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jacc.2008.11.025_bib69","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0140-6736(08)60919-8","article-title":"Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan: results of the EARLY study","volume":"371","author":"Gali\u00e8","year":"2008","journal-title":"Lancet"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510970803934X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510970803934X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T06:56:08Z","timestamp":1545375368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073510970803934X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":69,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S073510970803934X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2008.11.025","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}