{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:55:04Z","timestamp":1790398504494,"version":"4.1.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1598,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.jacc.2008.11.050","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T05:34:03Z","timestamp":1237959243000},"page":"1089-1100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Genomics and Cardiovascular Drug Development"],"prefix":"10.1016","volume":"53","author":[{"given":"Andrew S.","family":"Plump","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pek Yee","family":"Lum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2008.11.050_bib4","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrd1470","article-title":"Can the pharmaceutical industry reduce attrition rates?","volume":"3","author":"Kola","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jacc.2008.11.050_bib5","series-title":"The Truth About Drug Innovation: Thirty-Five Summary Case Histories on Private Sector Contributions to Pharmaceutical Science","author":"Zycher","year":"2008"},{"key":"10.1016\/j.jacc.2008.11.050_bib6","series-title":"The Pharmacological Basis of Therapeutics","year":"1985"},{"key":"10.1016\/j.jacc.2008.11.050_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0167-6296(02)00126-1","article-title":"The price of innovation: new estimates of drug development costs","volume":"22","author":"DiMasi","year":"2003","journal-title":"J Health Econ"},{"key":"10.1016\/j.jacc.2008.11.050_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1527-3466.2007.00015.x","article-title":"Challenges for cardiovascular drug research","volume":"259","author":"Scriabine","year":"2007","journal-title":"Cardiovasc Drug Rev"},{"key":"10.1016\/j.jacc.2008.11.050_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.75","article-title":"Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans","volume":"40","author":"Kathiresan","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng.76","article-title":"Newly identified loci that influence lipid concentrations and risk of coronary artery disease","volume":"40","author":"Willer","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib11","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1093\/hmg\/ddn108","article-title":"Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes","volume":"17","author":"Fahmi","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ng1984","article-title":"Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL","volume":"39","author":"Romeo","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib13","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMoa054013","article-title":"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease","volume":"354","author":"Cohen","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.11.050_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1189\/jlb.1206761","article-title":"Chemokine regulation of atherosclerosis","volume":"82","author":"Barlic","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jacc.2008.11.050_bib15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/29788","article-title":"Decreased lesion formation in CCR2\u2212\/\u2212 mice reveals a role for chemokines in the initiation of atherosclerosis","volume":"394","author":"Boring","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2008.11.050_bib16","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/ng1589","article-title":"An integrative genomics approach to infer causal associations between gene expression and disease","volume":"37","author":"Schadt","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib17","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(04)15690-0","article-title":"Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions","volume":"363","author":"Collins","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2008.11.050_bib18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jacc.2007.10.017","article-title":"Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study","volume":"51","author":"Iakoubova","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.11.050_bib19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jacc.2007.05.057","article-title":"Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials","volume":"51","author":"Iakoubova","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.11.050_bib20","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/ATVBAHA.107.142570","article-title":"Mouse models for atherosclerosis and pharmaceutical modifiers","volume":"27","author":"Zadelaar","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2008.11.050_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00041433-200104000-00010","article-title":"Mouse models of atherosclerosis","volume":"12","author":"Reardon","year":"2001","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jacc.2008.11.050_bib22","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1411543","article-title":"Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E","volume":"258","author":"Zhang","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jacc.2008.11.050_bib23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0092-8674(92)90362-G","article-title":"Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells","volume":"71","author":"Plump","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.jacc.2008.11.050_bib24","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1172\/JCI116663","article-title":"Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery","volume":"92","author":"Ishibashi","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2008.11.050_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/01.ATV.14.1.141","article-title":"Atherosclerosis in mice lacking apo E","volume":"14","author":"Reddick","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.jacc.2008.11.050_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.ATV.14.1.133","article-title":"ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree","volume":"14","author":"Nakashima","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.jacc.2008.11.050_bib27","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.2741\/3155","article-title":"Control of atherosclerotic plaque vulnerability: insights from transgenic mice","volume":"13","author":"Heeneman","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.jacc.2008.11.050_bib28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0021-9150(00)00515-3","article-title":"Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse","volume":"154","author":"Johnson","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2008.11.050_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/path.915","article-title":"Spontaneous plaque rupture and secondary thrombosis in apolipoprotein E-deficient and LDL receptor-deficient mice","volume":"195","author":"Calara","year":"2001","journal-title":"J Pathol"},{"key":"10.1016\/j.jacc.2008.11.050_bib30","series-title":"Atherosclerosis and Coronary Artery Disease","first-page":"355","article-title":"New mouse models of lipoprotein disorders and atherosclerosis","author":"Plump","year":"2005"},{"key":"10.1016\/j.jacc.2008.11.050_bib33","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1073\/pnas.92.18.8264","article-title":"Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E","volume":"92","author":"Smith","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jacc.2008.11.050_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0021-9150(98)00263-9","article-title":"Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice: an immunohistochemical study","volume":"143","author":"Gijbels","year":"1999","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jacc.2008.11.050_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0002-9149(99)00826-7","article-title":"Raising low levels of high-density lipoprotein cholesterol is an important target of therapy","volume":"85","author":"Boden","year":"2000","journal-title":"Am J Cardiol"},{"issue":"Suppl 9A","key":"10.1016\/j.jacc.2008.11.050_bib36","doi-asserted-by":"crossref","first-page":"22Q","DOI":"10.1016\/S0002-9149(98)00770-X","article-title":"Triglyceride as a risk factor for coronary artery disease","volume":"82","author":"Gotto","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2008.11.050_bib37","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1001\/jama.299.21.2524","article-title":"Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease","volume":"299","author":"Frikke-Schmidt","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2008.11.050_bib38","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1172\/JCI118751","article-title":"Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels","volume":"97","author":"Zhong","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2008.11.050_bib39","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1056\/NEJMoa070635","article-title":"Effect of torcetrapib on the progression of coronary atherosclerosis","volume":"356","author":"Nissen","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.11.050_bib40","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1056\/NEJMoa071359","article-title":"Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia","volume":"356","author":"Kastelein","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.11.050_bib41","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1056\/NEJMoa0706628","article-title":"Effects of torcetrapib in patients at high risk for coronary events","volume":"357","author":"Barter","year":"2007","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"10.1016\/j.jacc.2008.11.050_bib42","first-page":"S68","article-title":"Nicotinic acid: an old drug with a promising future","volume":"153","author":"Bodor","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacc.2008.11.050_bib43","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1161\/ATVBAHA.107.148106","article-title":"Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice","volume":"27","author":"Wang","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2008.11.050_bib44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/genetics\/122.1.163","article-title":"Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice","volume":"122","author":"Paigen","year":"1989","journal-title":"Genetics"},{"key":"10.1016\/j.jacc.2008.11.050_bib45","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1073\/pnas.84.11.3763","article-title":"Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice","volume":"84","author":"Paigen","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jacc.2008.11.050_bib46","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/BF00502607","article-title":"Genetic analysis of strains C57BL\/6J and BALB\/cJ for Ath-1, a gene determining atherosclerosis susceptibility in mice","volume":"25","author":"Paigen","year":"1987","journal-title":"Biochem Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib47","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1016\/S0021-9258(19)42341-7","article-title":"Binding and degradation of low density lipoproteins by cultured human fibroblasts","volume":"249","author":"Goldstein","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2008.11.050_bib48","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1126\/science.185.4145.61","article-title":"Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man","volume":"185","author":"Brown","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.jacc.2008.11.050_bib49","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins","volume":"366","author":"Baigent","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2008.11.050_bib50","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1136370","article-title":"LRP6 mutation in a family with early coronary disease and metabolic risk factors","volume":"315","author":"Mani","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jacc.2008.11.050_bib51","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.1060458","article-title":"Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein","volume":"292","author":"Garcia","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jacc.2008.11.050_bib52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng1509","article-title":"Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9","volume":"37","author":"Cohen","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib53","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/ng2127","article-title":"New models of collaboration in genome-wide association studies: the Genetic Association Information Network","volume":"39","author":"Manolio","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib54","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa072366","article-title":"Genomewide association analysis of coronary artery disease","volume":"357","author":"Samani","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.11.050_bib55","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature06758","article-title":"Genetics of gene expression and its effect on disease","volume":"452","author":"Emilsson","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2008.11.050_bib56","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00335-006-1100-9","article-title":"The genetics of gene expression","volume":"17","author":"Churchill","year":"2006","journal-title":"Mamm Genome"},{"key":"10.1016\/j.jacc.2008.11.050_bib57","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1523\/JNEUROSCI.4602-05.2006","article-title":"Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associations","volume":"26","author":"Letwin","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.jacc.2008.11.050_bib58","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1101\/sqb.2003.68.403","article-title":"Genetics of quantitative variation in human gene expression","volume":"68","author":"Cheung","year":"2003","journal-title":"Cold Spring Harbor Symp Quant Biol"},{"key":"10.1016\/j.jacc.2008.11.050_bib59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/422269a","article-title":"Genomics: gene expression meets genetics","volume":"422","author":"Darvasi","year":"2003","journal-title":"Nature"},{"issue":"Suppl","key":"10.1016\/j.jacc.2008.11.050_bib60","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/ng1036","article-title":"The genetics of variation in gene expression","volume":"32","author":"Cheung","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib61","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.pbio.0060107","article-title":"Mapping the genetic architecture of gene expression in human liver","volume":"6","author":"Schadt","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1016\/j.jacc.2008.11.050_bib62","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1142842","article-title":"A common variant on chromosome 9p21 affects the risk of myocardial infarction","volume":"316","author":"Helgadottir","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jacc.2008.11.050_bib63","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1142447","article-title":"A common allele on chromosome 9 associated with coronary heart disease","volume":"316","author":"McPherson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jacc.2008.11.050_bib64","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/hmg\/ddm352","article-title":"Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p","volume":"17","author":"Broadbent","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib65","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1158\/0008-5472.CAN-06-2004","article-title":"Characterization of a germ-line deletion, including the entire INK4\/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF","volume":"67","author":"Pasmant","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jacc.2008.11.050_bib66","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nature06757","article-title":"Variations in DNA elucidate molecular networks that cause disease","volume":"452","author":"Chen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2008.11.050_bib67","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nature01434","article-title":"Genetics of gene expression surveyed in maize, mouse and man","volume":"422","author":"Schadt","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2008.11.050_bib68","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000078209","article-title":"An integrative genomics approach to the reconstruction of gene networks in segregating populations","volume":"105","author":"Zhu","year":"2004","journal-title":"Cytogenet Genome Res"},{"key":"10.1016\/j.jacc.2008.11.050_bib69","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1371\/journal.pcbi.0030069","article-title":"Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations","volume":"3","author":"Zhu","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.jacc.2008.11.050_bib70","doi-asserted-by":"crossref","first-page":"e1000034","DOI":"10.1371\/journal.pgen.1000034","article-title":"Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling","volume":"4","author":"Ferrara","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib71","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1161\/CIRCRESAHA.107.152975","article-title":"Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data","volume":"101","author":"Wang","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2008.11.050_bib72","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1126\/science.1078563","article-title":"Systems biology","volume":"298","author":"Oltvai","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jacc.2008.11.050_bib73","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1056\/NEJMe078114","article-title":"Network medicine\u2014from obesity to the \u201cdiseasome.\u201d","volume":"357","author":"Barabasi","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.11.050_bib74","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/scientificamerican0503-60","article-title":"Scale-free networks","volume":"288","author":"Barabasi","year":"2003","journal-title":"Sci Am"},{"key":"10.1016\/j.jacc.2008.11.050_bib75","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1161\/CIRCULATIONAHA.106.637025","article-title":"Network analysis of human in-stent restenosis","volume":"114","author":"Ashley","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.050_bib76","doi-asserted-by":"crossref","first-page":"e1000036","DOI":"10.1371\/journal.pgen.1000036","article-title":"Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes","volume":"4","author":"Skogsberg","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jacc.2008.11.050_bib77","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1152\/physiolgenomics.00101.2005","article-title":"Pathway analysis of coronary atherosclerosis","volume":"23","author":"King","year":"2005","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.jacc.2008.11.050_bib78","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/01.RES.0000028008.99774.7F","article-title":"Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice","volume":"91","author":"Mehrabian","year":"2002","journal-title":"Circ Res"},{"issue":"Suppl 3","key":"10.1016\/j.jacc.2008.11.050_bib79","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.1301\/nr.2007.dec.S253-S259","article-title":"Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: implications for longevity","volume":"65","author":"Ridker","year":"2007","journal-title":"Nutr Rev"},{"key":"10.1016\/j.jacc.2008.11.050_bib80","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10654-008-9249-z","article-title":"Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation","volume":"23","year":"2008","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jacc.2008.11.050_bib81","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/S0140-6736(05)67786-0","article-title":"C-reactive protein and its role in metabolic syndrome: Mendelian randomisation study","volume":"366","author":"Timpson","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2008.11.050_bib82","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1056\/NEJMoa0707402","article-title":"Genetically elevated C-reactive protein and ischemic vascular disease","volume":"359","author":"Zacho","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.11.050_bib83","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/S0140-6736(05)67767-7","article-title":"Nature's randomised trials","volume":"366","author":"Hingorani","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2008.11.050_bib84","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(08)60763-1","article-title":"Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial","volume":"371","author":"Tardif","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2008.11.050_bib85","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1161\/01.ATV.0000190672.36490.7b","article-title":"Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, is elevated in coronary artery disease and is reduced during statin therapy","volume":"25","author":"Damas","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jacc.2008.11.050_bib86","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1161\/CIRCULATIONAHA.106.628396","article-title":"Transcriptional profiling in coronary artery disease: indications for novel markers of coronary collateralization","volume":"114","author":"Chittenden","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2008.11.050_bib87","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1152\/physiolgenomics.00001.2005","article-title":"Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease","volume":"22","author":"Tabibiazar","year":"2005","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.jacc.2008.11.050_bib88","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1172\/JCI26206","article-title":"Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL","volume":"117","author":"Vaisar","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2008.11.050_bib90","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nature06803","article-title":"Imaging of atherosclerotic cardiovascular disease","volume":"451","author":"Sanz","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2008.11.050_bib91","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1592\/phco.28.9.1084","article-title":"Warfarin pharmacogenetics","volume":"28","author":"Limdi","year":"2008","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jacc.2008.11.050_bib93","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1056\/NEJMoa0801936","article-title":"SLCO1B1 variants and statin-induced myopathy\u2014a genomewide study","volume":"359","author":"Link","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2008.11.050_bib94","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s00210-006-0040-y","article-title":"Pharmacogenomics of human OATP transporters","volume":"372","author":"Konig","year":"2006","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.jacc.2008.11.050_bib95","doi-asserted-by":"crossref","first-page":"e2522","DOI":"10.1371\/journal.pone.0002522","article-title":"Statin induced myopathy and myalgia: time trend analysis and comparison of risk associated with statin class from 1991\u20132006","volume":"3","author":"Molokhia","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jacc.2008.11.050_bib96","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jacc.2007.09.044","article-title":"A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study","volume":"51","author":"Shiffman","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2008.11.050_bib98","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/02841860701203545","article-title":"Nordic biological specimen banks as basis for studies of cancer causes and control\u2014more than 2 million sample donors, 25 million person years and 100,000 prospective cancers","volume":"46","author":"Pukkala","year":"2007","journal-title":"Acta Oncol"},{"key":"10.1016\/j.jacc.2008.11.050_bib99","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nm0803-982b","article-title":"Japan launches controversial Biobank project","volume":"9","author":"Triendl","year":"2003","journal-title":"Nat Med"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510970900103X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073510970900103X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:31:12Z","timestamp":1760013072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S073510970900103X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":91,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S073510970900103X"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2008.11.050","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomics and Cardiovascular Drug Development","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2008.11.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}