{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:26:13Z","timestamp":1786991173022,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"21","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":988,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MGP 6957"],"award-info":[{"award-number":["MGP 6957"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"crossref","award":["ENAFRA-Network, 07\/CVD\/03"],"award-info":[{"award-number":["ENAFRA-Network, 07\/CVD\/03"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MITACS Network"},{"name":"Nihon Kohden\/St. Jude Medical and Japan Heart Foundation\/Japanese Society of Electrocardiology"},{"name":"St. Jude Medical, Boston Scientific Corporation"},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.jacc.2010.05.051","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T04:28:17Z","timestamp":1289363297000},"page":"1728-1736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Roles of the Left Atrial Roof and Pulmonary Veins in the Anatomic Substrate for Persistent Atrial Fibrillation and Ablation in a Canine Model"],"prefix":"10.1016","volume":"56","author":[{"given":"Kunihiro","family":"Nishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Sarrazin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Fujiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Oral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Morady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Nattel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2010.05.051_bib1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/01.CIR.98.10.946","article-title":"Impact of atrial fibrillation on the risk of death: the Framingham Heart Study","volume":"98","author":"Benjamin","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/415219a","article-title":"New ideas about atrial fibrillation 50 years on","volume":"415","author":"Nattel","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jacc.2010.05.051_bib3","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","article-title":"Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins","volume":"339","author":"Haissaguerre","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2010.05.051_bib4","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1161\/hc0902.104712","article-title":"Pulmonary vein isolation for paroxysmal and persistent atrial fibrillation","volume":"105","author":"Oral","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/CIRCULATIONAHA.104.517011","article-title":"Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans","volume":"112","author":"Sanders","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib6","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jacc.2007.10.056","article-title":"Characterization of electrograms associated with termination of chronic atrial fibrillation by catheter ablation","volume":"51","author":"Takahashi","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib7","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/01.CIR.0000095796.45180.88","article-title":"Catheter ablation for paroxysmal atrial fibrillation: segmental pulmonary vein ostial ablation versus left atrial ablation","volume":"108","author":"Oral","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib8","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1161\/CIRCULATIONAHA.105.541052","article-title":"Techniques, evaluation, and consequences of linear block at the left atrial roof in paroxysmal atrial fibrillation: a prospective randomized study","volume":"112","author":"Hocini","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib9","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1056\/NEJMoa050955","article-title":"Circumferential pulmonary-vein ablation for chronic atrial fibrillation","volume":"354","author":"Oral","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2010.05.051_bib10","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.jacc.2006.11.033","article-title":"Effects of stepwise ablation of chronic atrial fibrillation on atrial electrical and mechanical properties","volume":"49","author":"Takahashi","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib11","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/eurheartj\/ehp063","article-title":"Long-term follow-up of persistent atrial fibrillation ablation using termination as a procedural endpoint","volume":"30","author":"O'Neill","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2010.05.051_bib12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.81.4.512","article-title":"Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation","volume":"81","author":"Yue","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2010.05.051_bib13","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.RES.84.7.776","article-title":"Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation","volume":"84","author":"Yue","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2010.05.051_bib14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1161\/01.CIR.102.1.104","article-title":"Contrasting efficacy of dofetilide in differing experimental models of atrial fibrillation","volume":"102","author":"Li","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib15","doi-asserted-by":"crossref","first-page":"H1489","DOI":"10.1152\/ajpheart.01054.2007","article-title":"Mechanisms of atrial fibrillation termination by rapidly unbinding Na+channel blockers: insights from mathematical models and experimental correlates","volume":"295","author":"Comtois","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib16","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.hrthm.2005.08.003","article-title":"Randomized comparison of encircling and nonencircling left atrial ablation for chronic atrial fibrillation","volume":"2","author":"Oral","year":"2005","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacc.2010.05.051_bib17","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1161\/01.CIR.91.8.2235","article-title":"Arrhythmias\/radiofrequency ablation: radiofrequency catheter ablation of the atria reduces inducibility and duration of atrial fibrillation in dogs","volume":"91","author":"Elvan","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib18","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1161\/01.CIR.95.11.2573","article-title":"Efferent vagal innervation of the canine atria and sinus and atrioventricular nodes: the third fat pad","volume":"95","author":"Chiou","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib19","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/01.CIR.96.5.1675","article-title":"Radiofrequency catheter ablation of the atria eliminates pacing-induced sustained atrial fibrillation and reduces connexin 43 in dogs","volume":"96","author":"Elvan","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib20","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/01.CIR.97.12.1176","article-title":"Linear atrial ablations in a canine model of chronic atrial fibrillation: morphological and electrophysiological observations","volume":"97","author":"Mitchell","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib21","doi-asserted-by":"crossref","first-page":"H2072","DOI":"10.1152\/ajpheart.00595.2003","article-title":"Thoracic vein ablation terminates chronic atrial fibrillation in dogs","volume":"286","author":"Park","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib22","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/01.CIR.0000155240.05251.D0","article-title":"Atrial tachycardia remodeling of pulmonary vein cardiomyocytes: comparison with left atrium and potential relation to arrhythmogenesis","volume":"111","author":"Cha","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/CIRCULATIONAHA.107.737023","article-title":"Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia","volume":"117","author":"Lemola","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib24","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/01.CIR.0000048140.31785.02","article-title":"Characterization of left atrial activation in the intact human heart","volume":"107","author":"Markides","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.jacc.2007.05.026","article-title":"The role of left atrial muscular bundles in catheter ablation of atrial fibrillation","volume":"50","author":"Chang","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1046\/j.1540-8167.2002.00571.x","article-title":"Simultaneous biatrial computerized mapping during permanent atrial fibrillation in patients with organic heart disease","volume":"13","author":"Wu","year":"2002","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib27","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.jacc.2003.12.054","article-title":"A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate","volume":"43","author":"Nademanee","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib28","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1161\/CIRCULATIONAHA.107.691386","article-title":"Radiofrequency catheter ablation of chronic atrial fibrillation guided by complex electrograms","volume":"115","author":"Oral","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib29","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1161\/CIRCULATIONAHA.105.575340","article-title":"Mechanisms of wave fractionation at boundaries of high-frequency excitation in the posterior left atrium of the isolated sheep heart during atrial fibrillation","volume":"113","author":"Kalifa","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib30","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/CIRCRESAHA.107.153858","article-title":"Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure","volume":"101","author":"Tanaka","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2010.05.051_bib31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/01.CIR.0000112641.16340.C7","article-title":"Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation","volume":"109","author":"Pappone","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib32","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1161\/01.CIR.102.22.2774","article-title":"Catheter ablation of cardiac autonomic nerves for prevention of vagal atrial fibrillation","volume":"102","author":"Schauerte","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib33","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/01.CIR.0000141369.50476.D3","article-title":"Mechanisms of organized left atrial tachycardias occurring after pulmonary vein isolation","volume":"110","author":"Gerstenfeld","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1161\/01.CIR.0000151289.73085.36","article-title":"Recovered pulmonary vein conduction as a dominant factor for recurrent atrial tachyarrhythmias after complete circular isolation of the pulmonary veins: lessons from double Lasso technique","volume":"111","author":"Ouyang","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2010.05.051_bib35","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.jacc.2007.07.044","article-title":"Atrial tachycardia after circumferential pulmonary vein ablation of atrial fibrillation: mechanistic insights, results of catheter ablation, and risk factors for recurrence","volume":"50","author":"Chae","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib36","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jacc.2004.05.072","article-title":"Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation: electroanatomic characterization and treatment","volume":"44","author":"Mesas","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2010.05.051_bib37","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1161\/01.CIR.0000147186.83715.95","article-title":"Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation: a prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach","volume":"110","author":"Pappone","year":"2004","journal-title":"Circulation"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109710038209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109710038209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:40:54Z","timestamp":1760013654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109710038209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":37,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0735109710038209"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2010.05.051","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of the Left Atrial Roof and Pulmonary Veins in the Anatomic Substrate for Persistent Atrial Fibrillation and Ablation in a Canine Model","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2010.05.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}