{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:44:59Z","timestamp":1791917099750,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":752,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MDS Nordion"},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MDS Nordion"},{"DOI":"10.13039\/100008270","name":"Lantheus Medical Imaging","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008270","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MDS Nordion"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.jacc.2011.01.065","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T00:10:01Z","timestamp":1312330201000},"page":"740-748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":558,"title":["Impaired Myocardial Flow Reserve on Rubidium-82 Positron Emission Tomography Imaging Predicts Adverse Outcomes in Patients Assessed for Myocardial Ischemia"],"prefix":"10.1016","volume":"58","author":[{"given":"Maria C.","family":"Ziadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"deKemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.W.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Renaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence D.","family":"Ruddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niroshi","family":"Sarveswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Tee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob S.B.","family":"Beanlands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2011.01.065_bib1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.nuclcard.2006.08.017","article-title":"Predicting therapeutic benefit from myocardial revascularization procedures: are measurements of both resting left ventricular ejection fraction and stress induced myocardial ischemia necessary?","volume":"13","author":"Hachamovitch","year":"2006","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib2","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1161\/CIRCULATIONAHA.108.817387","article-title":"Prognostic implications of myocardial perfusion single photon emission computed tomography in the elderly","volume":"120","author":"Hachamovitch","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.01.065_bib3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0002-9149(97)00537-7","article-title":"Incremental value of rubidium-82 positron emission tomography for prognostic assessment of known or suspected coronary artery disease","volume":"80","author":"Marwick","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib4","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jacc.2006.06.025","article-title":"What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography?","volume":"48","author":"Yoshinaga","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.nuclcard.2008.06.168","article-title":"Independent and incremental prognostic value of left ventricular ejection fraction determined by stress gated rubidium 82 PET imaging in patients with known or suspected coronary artery disease","volume":"15","author":"Lertsburapa","year":"2008","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib6","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jcmg.2009.04.009","article-title":"Incremental prognostic value of gated Rb-82 positron emission tomography myocardial perfusion imaging over clinical variables and rest LVEF","volume":"2","author":"Dorbala","year":"2009","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.jacc.2011.01.065_bib7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.nuclcard.2007.05.008","article-title":"Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease","volume":"14","author":"Berman","year":"2007","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib8","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.nuclcard.2004.04.005","article-title":"Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease","volume":"11","author":"Parkash","year":"2004","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib9","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMra061889","article-title":"Coronary microvascular dysfunction","volume":"356","author":"Camici","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.01.065_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/hc0202.102119","article-title":"Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction","volume":"105","author":"Neglia","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.01.065_bib11","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0002-9149(99)00329-X","article-title":"Prognostic utility of myocardial blood flow assessed by N-13 ammonia positron emission tomography in patients with idiopathic dilated cardiomyopathy","volume":"84","author":"Shikama","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib12","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jacc.2005.10.050","article-title":"Relevance of coronary microvascular flow impairment to long-term remodeling and systolic dysfunction in hypertrophic cardiomyopathy","volume":"47","author":"Olivotto","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib13","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMoa025050","article-title":"Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy","volume":"349","author":"Cecchi","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.01.065_bib14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jacc.2009.02.069","article-title":"Long-term prognostic value of 13N-ammonia myocardial perfusion PET: added value of coronary flow reserve","volume":"54","author":"Herzog","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2967\/jnumed.108.054395","article-title":"Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease","volume":"50","author":"Tio","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jacc.2011.01.065_bib16","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s12350-010-9225-3","article-title":"Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 PET and a highly automated analysis program","volume":"17","author":"Klein","year":"2010","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s12350-009-9094-9","article-title":"PET myocardial perfusion and metabolism clinical imaging","volume":"16","author":"Dilsizian","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s12350-009-9062-4","article-title":"Imaging guidelines for nuclear cardiology procedures: stress protocols and tracers","volume":"16","author":"Henzlova","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib19","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2967\/jnumed.107.044099","article-title":"Absolute quantification of myocardial blood flow with 13N-ammonia and 3-dimensional PET","volume":"48","author":"Schepis","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jacc.2011.01.065_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1088\/0031-9155\/52\/3\/009","article-title":"Precision-controlled elution of a 82Sr\/82Rb generator for cardiac perfusion imaging with positron emission tomography","volume":"52","author":"Klein","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.jacc.2011.01.065_bib21","first-page":"5215","article-title":"3D list mode cardiac PET for simultaneous quantification of myocardial blood flow and ventricular function","volume":"1","author":"deKemp","year":"2008","journal-title":"IEEE Nucl Sci Symp Conf Record"},{"key":"10.1016\/j.jacc.2011.01.065_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1088\/0967-3334\/17\/2\/004","article-title":"Automated determination of the left ventricular long axis in cardiac positron emission tomography","volume":"17","author":"deKemp","year":"1996","journal-title":"Physiol Meas"},{"key":"10.1016\/j.jacc.2011.01.065_bib23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/hc0402.102975","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.01.065_bib24","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00259-007-0478-2","article-title":"Quantification of myocardial blood flow with 82-Rb dynamic PET imaging","volume":"34","author":"Lortie","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jacc.2011.01.065_bib25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0735-1097(94)90629-7","article-title":"Positron emission tomographic measurements of absolute regional myocardial blood flow permits identification of nonviable myocardium in patients with chronic myocardial infarction","volume":"23","author":"Gewirtz","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib26","first-page":"1883","article-title":"American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"106","author":"Gibbons","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.01.065_bib27","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.jacc.2007.09.006","article-title":"F-18fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2)","volume":"50","author":"Beanlands","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.01.065_bib28","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s00259-008-0793-2","article-title":"Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity","volume":"35","author":"Anagnostopoulos","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.jacc.2011.01.065_bib29","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.2967\/jnumed.104.007831","article-title":"Reproducibility and accuracy of quantitative myocardial blood flow assessment with 82Rb PET: comparison with 13N-ammonia PET","volume":"50","author":"El Fakhri","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jacc.2011.01.065_bib30","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s00259-008-0972-1","article-title":"Rubidium-82 PET-CT for quantitative assessment of myocardial blood flow: validation in a canine model of coronary artery stenosis","volume":"36","author":"Lautamaki","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109711018687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109711018687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:45:51Z","timestamp":1760013951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109711018687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0735109711018687"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2011.01.065","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired Myocardial Flow Reserve on Rubidium-82 Positron Emission Tomography Imaging Predicts Adverse Outcomes in Patients Assessed for Myocardial Ischemia","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2011.01.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}