{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:33:27Z","timestamp":1792784007798,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":715,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Italian Ministry of Education, University and Scientific Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.jacc.2011.03.049","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T00:06:11Z","timestamp":1312329971000},"page":"752-761","source":"Crossref","is-referenced-by-count":84,"title":["Aspirin Extrusion From Human Platelets Through Multidrug Resistance Protein-4\u2013Mediated Transport"],"prefix":"10.1016","volume":"58","author":[{"given":"Teresa","family":"Mattiello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Guerriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia Vittoria","family":"Lotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Trifir\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Felli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Barbarulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Pucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gazzaniga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Frati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio M.","family":"Pulcinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2011.03.049_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.324.7329.71","article-title":"Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients","volume":"324","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.jacc.2011.03.049_bib2","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/j.1538-7836.2005.01351.x","article-title":"Aspirin resistance: position paper of the Working Group on Aspirin Resistance","volume":"3","author":"Michelson","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacc.2011.03.049_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/ncpcardio0728","article-title":"Drug insight: aspirin resistance\u2014fact or fashion?","volume":"4","author":"Patrono","year":"2007","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"10.1016\/j.jacc.2011.03.049_bib4","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1161\/CIRCULATIONAHA.106.675991","article-title":"Variable platelet response to aspirin and clopidogrel in atherothrombotic disease","volume":"115","author":"Maree","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.03.049_bib5","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jacc.2003.08.062","article-title":"Inhibition of platelet aggregation by Aspirin progressively decreases in long-term treated patients","volume":"43","author":"Pulcinelli","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.03.049_bib6","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1161\/01.CIR.0000013777.21160.07","article-title":"Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events","volume":"105","author":"Eikelboom","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.03.049_bib7","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1161\/CIRCULATIONAHA.108.768283","article-title":"Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk","volume":"118","author":"Eikelboom","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.03.049_bib8","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1161\/CIRCULATIONAHA.109.900589","article-title":"Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization","volume":"120","author":"Frelinger","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.03.049_bib9","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1111\/j.1538-7836.2005.01633.x","article-title":"Persistent production of platelet thromboxane A2 in patients chronically treated with aspirin","volume":"3","author":"Pulcinelli","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jacc.2011.03.049_bib10","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/01.CIR.0000081770.51929.5A","article-title":"Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery","volume":"108","author":"Zimmermann","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.03.049_bib11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tips.2008.01.006","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4): a versatile efflux transporter for drugs and signalling molecules","volume":"29","author":"Russel","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jacc.2011.03.049_bib12","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1182\/blood-2003-12-4330","article-title":"The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage","volume":"104","author":"Jedlitschky","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jacc.2011.03.049_bib13","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/12487","article-title":"MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs","volume":"5","author":"Schuetz","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.jacc.2011.03.049_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00007691-198706000-00020","article-title":"Determination of aspirin and salicylic acid in uremic patients' plasma using reversed-phase high-performance liquid chromatography","volume":"9","author":"Gaspari","year":"1987","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.jacc.2011.03.049_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1083\/jcb.77.2.389","article-title":"An improved method for the isolation of dense storage granules from human platelets","volume":"77","author":"Fukami","year":"1978","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jacc.2011.03.049_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jim.2007.08.010","article-title":"Subfractionation and purification of intracellular granule-structures of human platelets: an improved method based on magnetic sorting","volume":"328","author":"Niessen","year":"2007","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jacc.2011.03.049_bib17","doi-asserted-by":"crossref","first-page":"R2382","DOI":"10.1152\/ajpregu.00029.2007","article-title":"Transport of a fluorescent cAMP analog in teleost proximal tubules","volume":"293","author":"Reichel","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jacc.2011.03.049_bib18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1172\/JCI108132","article-title":"The mechanism of the effect of Aspirin on human platelets","volume":"56","author":"Roth","year":"1975","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2011.03.049_bib19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s000110050655","article-title":"Assay of cyclooxygenase-1 and 2 in human monocytes","volume":"49","author":"Demasi","year":"2000","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jacc.2011.03.049_bib20","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1182\/blood.V86.10.3725.bloodjournal86103725","article-title":"Unilineage megakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture","volume":"86","author":"Guerriero","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.jacc.2011.03.049_bib21","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1182\/blood.V97.9.2587","article-title":"Stromal cell-derived factor 1alpha increases polyploidization of megakaryocytes generated by human hematopoietic progenitor cells","volume":"97","author":"Guerriero","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jacc.2011.03.049_bib22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/jpet.107.131342","article-title":"ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4)","volume":"324","author":"Rius","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jacc.2011.03.049_bib23","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.1074\/jbc.M209936200","article-title":"Identification of a novel domain of fibroblast growth factor 2 controlling its angiogenic properties","volume":"278","author":"Facchiano","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2011.03.049_bib24","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1074\/jbc.M805408200","article-title":"Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate","volume":"284","author":"Cattaneo","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jacc.2011.03.049_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S1357-2725(03)00236-X","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4) mediates efflux of bimane-glutathione","volume":"36","author":"Bai","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jacc.2011.03.049_bib26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11010-009-0126-1","article-title":"COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells","volume":"330","author":"Radilova","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jacc.2011.03.049_bib27","doi-asserted-by":"crossref","first-page":"9244","DOI":"10.1073\/pnas.1033060100","article-title":"The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs","volume":"100","author":"Reid","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2011.03.049_bib28","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1161\/01.STR.0000231683.43347.ec","article-title":"Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers","volume":"37","author":"Cox","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jacc.2011.03.049_bib29","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1172\/JCI110576","article-title":"Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects","volume":"69","author":"Patrignani","year":"1982","journal-title":"J Clin Invest"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109711018808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109711018808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T02:24:07Z","timestamp":1656728647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109711018808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0735109711018808"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2011.03.049","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}