{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:13:45Z","timestamp":1793146425741,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":478,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.jacc.2011.11.063","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T19:07:51Z","timestamp":1335208071000},"page":"1598-1603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":281,"title":["Eplerenone and Atrial Fibrillation in Mild Systolic Heart Failure"],"prefix":"10.1016","volume":"59","author":[{"given":"Karl","family":"Swedberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faiez","family":"Zannad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.V.","family":"McMurray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Krum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"van Veldhuisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram","family":"Pitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2011.11.063_bib1","first-page":"VI102","article-title":"The influence of atrial fibrillation on prognosis in mild to moderate heart failure","volume":"87","author":"Carson","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.11.063_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/01.CIR.84.1.40","article-title":"Prognostic significance of atrial fibrillation in advanced heart failure","volume":"84","author":"Middlekauff","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.11.063_bib3","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1093\/eurheartj\/ehn361","article-title":"Permanent atrial fibrillation affects exercise capacity in chronic heart failure patients","volume":"29","author":"Agostoni","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2011.11.063_bib4","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0735-1097(97)00254-4","article-title":"Hemodynamic effects of an irregular sequence of ventricular cycle lengths during atrial fibrillation","volume":"30","author":"Clark","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.11.063_bib5","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1161\/01.CIR.82.5.1730","article-title":"Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality","volume":"82","author":"Swedberg","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.11.063_bib6","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jacc.2009.09.045","article-title":"Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation","volume":"55","author":"Tsai","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.11.063_bib7","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/j.1476-5381.2010.00675.x","article-title":"Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation","volume":"159","author":"Lendeckel","year":"2010","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jacc.2011.11.063_bib8","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.jacc.2004.11.070","article-title":"Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis","volume":"45","author":"Healey","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.11.063_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1540-8159.2010.02942.x","article-title":"Upstream effect for atrial fibrillation: still a dilemma?","volume":"34","author":"Calo","year":"2011","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.jacc.2011.11.063_bib10","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1056\/NEJMoa0805710","article-title":"Valsartan for prevention of recurrent atrial fibrillation","volume":"360","author":"Disertori","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.11.063_bib11","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJMoa1008816","article-title":"Irbesartan in patients with atrial fibrillation","volume":"364","author":"Yusuf","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.11.063_bib12","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1056\/NEJM199909023411009","article-title":"Aldosterone and spironolactone in heart failure","volume":"341","author":"Weber","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.11.063_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms","volume":"364","author":"Zannad","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.11.063_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.11.063_bib15","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.11.063_bib16","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.amjcard.2010.07.037","article-title":"Effect of combined spironolactone-beta-blocker +\/- enalapril treatment on occurrence of symptomatic atrial fibrillation episodes in patients with a history of paroxysmal atrial fibrillation (SPIR-AF study)","volume":"106","author":"Dabrowski","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jacc.2011.11.063_bib17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/eurjhf\/hfq049","article-title":"Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF)","volume":"12","author":"Zannad","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2011.11.063_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(03)13800-7","article-title":"Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial","volume":"362","author":"Poole-Wilson","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2011.11.063_bib19","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(10)61198-1","article-title":"Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study","volume":"376","author":"Swedberg","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jacc.2011.11.063_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1445-5994.2009.01991.x","article-title":"Atrial fibrillation and the risk of death in patients with heart failure: a literature-based meta-analysis","volume":"40","author":"Wasywich","year":"2010","journal-title":"Intern Med J"},{"key":"10.1016\/j.jacc.2011.11.063_bib21","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1093\/eurheartj\/ehm341","article-title":"Management of atrial fibrillation in patients with heart failure","volume":"28","author":"Neuberger","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2011.11.063_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/eurheartj\/ehl484","article-title":"Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis","volume":"28","author":"Nasr","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2011.11.063_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005049.pub2","article-title":"Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation","author":"Lafuente-Lafuente","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jacc.2011.11.063_bib24","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1056\/NEJMoa0800456","article-title":"Increased mortality after dronedarone therapy for severe heart failure","volume":"358","author":"Kober","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jacc.2011.11.063_bib25","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1093\/eurheartj\/ehi478","article-title":"Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction","volume":"26","author":"Milliez","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2011.11.063_bib26","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1111\/j.1476-5381.2009.00551.x","article-title":"Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing","volume":"159","author":"Zhao","year":"2010","journal-title":"Br J Pharmacol"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712006298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712006298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:51:09Z","timestamp":1760014269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109712006298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":26,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0735109712006298"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2011.11.063","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eplerenone and Atrial Fibrillation in Mild Systolic Heart Failure","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2011.11.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}