{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:23:47Z","timestamp":1791228227731,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":508,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"crossref","award":["1-11-BS-17"],"award-info":[{"award-number":["1-11-BS-17"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AA014623"],"award-info":[{"award-number":["R01AA014623"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL099014"],"award-info":[{"award-number":["HL099014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HL078825"],"award-info":[{"award-number":["HL078825"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R37AA010762"],"award-info":[{"award-number":["R37AA010762"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P01AA017103"],"award-info":[{"award-number":["P01AA017103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.jacc.2011.12.034","type":"journal-article","created":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T20:29:44Z","timestamp":1334003384000},"page":"1477-1486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":91,"title":["Angiotensin II Plays a Critical Role in Alcohol-Induced Cardiac Nitrative Damage, Cell Death, Remodeling, and Cardiomyopathy in a Protein Kinase C\/Nicotinamide Adenine Dinucleotide Phosphate Oxidase\u2013Dependent Manner"],"prefix":"10.1016","volume":"59","author":[{"given":"Yi","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanth D.","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Brittian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"McClain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanxiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2011.12.034_bib1","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.hrthm.2011.06.031","article-title":"Causes of nonischemic sudden cardiac death in the current era","volume":"8","author":"Hookana","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacc.2011.12.034_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.alcohol.2009.09.028","article-title":"Alcoholism and alcohol abstinence: N-acetylcysteine to improve energy expenditure, myocardial oxidative stress, and energy metabolism in alcoholic heart disease","volume":"43","author":"Seiva","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.jacc.2011.12.034_bib3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2613.2009.00647.x","article-title":"Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy","volume":"90","author":"Gurtl","year":"2009","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.jacc.2011.12.034_bib4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.RES.71.2.346","article-title":"Myocardial mechanical, biochemical, and structural alterations induced by chronic ethanol ingestion in rats","volume":"71","author":"Capasso","year":"1992","journal-title":"Circ Res"},{"key":"10.1016\/j.jacc.2011.12.034_bib5","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.humpath.2006.03.022","article-title":"Evidence of apoptosis in alcoholic cardiomyopathy","volume":"37","author":"Fernandez-Sola","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jacc.2011.12.034_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jacc.2011.12.034_bib7","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.freeradbiomed.2011.01.003","article-title":"Redox signaling in cardiac myocytes","volume":"50","author":"Santos","year":"2011","journal-title":"Free Radical Biol Med"},{"key":"10.1016\/j.jacc.2011.12.034_bib8","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1111\/j.1742-4658.2008.06488.x","article-title":"Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species","volume":"275","author":"Sumimoto","year":"2008","journal-title":"FEBS J"},{"key":"10.1016\/j.jacc.2011.12.034_bib9","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.2337\/diabetes.54.6.1829","article-title":"Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy","volume":"54","author":"Cai","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jacc.2011.12.034_bib10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jacc.2008.05.019","article-title":"Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart","volume":"52","author":"Zhou","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2011.12.034_bib11","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","article-title":"NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2011.12.034_bib12","doi-asserted-by":"crossref","first-page":"18121","DOI":"10.1073\/pnas.1009700107","article-title":"NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jacc.2011.12.034_bib13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/CIRCULATIONAHA.105.596494","article-title":"Angiotensin II type 1 receptor blockade prevents alcoholic cardiomyopathy","volume":"114","author":"Cheng","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.12.034_bib14","doi-asserted-by":"crossref","first-page":"e8391","DOI":"10.1371\/journal.pone.0008391","article-title":"Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes","volume":"4","author":"Ichikawa","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jacc.2011.12.034_bib15","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/CIRCULATIONAHA.105.537894","article-title":"Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation","volume":"113","author":"Wang","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2011.12.034_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11010-011-1022-z","article-title":"Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy","volume":"359","author":"Jing","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jacc.2011.12.034_bib17","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/00005344-200412000-00012","article-title":"Oxidative stress and apoptosis in cardiomyocyte induced by high-dose alcohol","volume":"44","author":"Guan","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jacc.2011.12.034_bib18","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.biochi.2008.03.001","article-title":"Ethanol induces peroxynitrite-mediated toxicity through inactivation of NADP+-dependent isocitrate dehydrogenase and superoxide dismutase","volume":"90","author":"Yang","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/j.jacc.2011.12.034_bib19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/jmcc.2001.1518","article-title":"Expression of activated PKC epsilon (PKC epsilon) protects the ischemic heart, without attenuating ischemic H(+) production","volume":"34","author":"Cross","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jacc.2011.12.034_bib20","doi-asserted-by":"crossref","first-page":"H165","DOI":"10.1152\/ajpheart.00408.2001","article-title":"Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt","volume":"283","author":"Zhou","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jacc.2011.12.034_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10549-008-0299-4","article-title":"Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model","volume":"118","author":"Grossoni","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.jacc.2011.12.034_bib22","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1111\/j.1530-0277.2008.00781.x","article-title":"Expression of renin-angiotensin system and peroxisome proliferator-activated receptors in alcoholic cardiomyopathy","volume":"32","author":"Jing","year":"2008","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jacc.2011.12.034_bib23","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1111\/j.1582-4934.2008.00448.x","article-title":"Cytosolic renin is targeted to mitochondria and induces apoptosis in H9c2 rat cardiomyoblasts","volume":"13","author":"Wanka","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jacc.2011.12.034_bib24","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1172\/JCI316","article-title":"Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell","volume":"101","author":"Leri","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jacc.2011.12.034_bib25","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1097\/01.alc.0000175043.67463.e5","article-title":"Effect of chronic ethanol ingestion and gender on heart left ventricular p53 gene expression","volume":"29","author":"Jankala","year":"2005","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712004858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712004858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:50:33Z","timestamp":1760014233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109712004858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":25,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0735109712004858"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2011.12.034","relation":{},"ISSN":["0735-1097"],"issn-type":[{"value":"0735-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin II Plays a Critical Role in Alcohol-Induced Cardiac Nitrative Damage, Cell Death, Remodeling, and Cardiomyopathy in a Protein Kinase C\/Nicotinamide Adenine Dinucleotide Phosphate Oxidase\u2013Dependent Manner","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2011.12.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}