{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:38:04Z","timestamp":1760056684293,"version":"build-2065373602"},"reference-count":18,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":508,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jacc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American College of Cardiology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.jacc.2012.01.012","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:22:42Z","timestamp":1332807762000},"page":"1302-1303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["What Causes Atrial Fibrillation and Why Do We Fail With Ablation?"],"prefix":"10.1016","volume":"59","author":[{"given":"Samuel J.","family":"Asirvatham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jacc.2012.01.012_bib1","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.jacc.2011.11.051","article-title":"Impact of metabolic syndrome on procedural outcomes in patients with atrial fibrillation undergoing catheter ablation","volume":"59","author":"Mohanty","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.01.012_bib2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0025-6196(11)60754-4","article-title":"Contemporary management of atrial fibrillation: update on anticoagulation and invasive management strategies","volume":"84","author":"Crandall","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jacc.2012.01.012_bib3","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1540-8167.2010.01786.x","article-title":"Long-term outcome of atrial fibrillation ablation: impact and predictors of very late recurrence","volume":"21","author":"Wokhlu","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jacc.2012.01.012_bib4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/jama.287.3.356","article-title":"Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey","volume":"287","author":"Ford","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2012.01.012_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ahj.2004.07.013","article-title":"Metabolic syndrome: definition, pathophysiology, and mechanisms","volume":"149","author":"Miranda","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2012.01.012_bib6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/eurjhf\/hfq022","article-title":"Effect of diabetes and hypertension on left ventricular diastolic function in a high-risk population without evidence of heart disease","volume":"12","author":"Russo","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jacc.2012.01.012_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000087636","article-title":"The association of metabolic syndrome with atrial fibrillation: an emerging epidemiological and pathophysiological hypothesis","volume":"104","author":"Korantzopoulos","year":"2005","journal-title":"Cardiology"},{"key":"10.1016\/j.jacc.2012.01.012_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0002-8703(59)90274-1","article-title":"Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge","volume":"58","author":"Moe","year":"1959","journal-title":"Am Heart J"},{"key":"10.1016\/j.jacc.2012.01.012_bib9","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.jacc.2003.12.054","article-title":"A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate","volume":"43","author":"Nademanee","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.01.012_bib10","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1093\/eurheartj\/ehl360","article-title":"Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: implications for development of atrial fibrillation","volume":"27","author":"Kistler","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jacc.2012.01.012_bib11","first-page":"1974","article-title":"Obesity and the risk of new-onset atrial fibrillation","volume":"293","author":"Parish","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jacc.2012.01.012_bib12","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1161\/01.CIR.0000068337.25994.21","article-title":"Obstructive sleep apnea and the recurrence of atrial fibrillation","volume":"107","author":"Kanagala","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jacc.2012.01.012_bib13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/europace\/eun309","article-title":"Pre-ablative predictors of atrial fibrillation recurrence following pulmonary vein isolation: the potential role of inflammation","volume":"11","author":"Letsas","year":"2009","journal-title":"Europace"},{"key":"10.1016\/j.jacc.2012.01.012_bib14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1253\/circj.CJ-08-0832","article-title":"Metabolic syndrome and risk of recurrence of atrial fibrillation after catheter ablation","volume":"73","author":"Tang","year":"2009","journal-title":"Circ J"},{"key":"10.1016\/j.jacc.2012.01.012_bib15","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.jacc.2011.06.060","article-title":"Wrinkles in the atrium: age, atrial fibrillation, or something else","volume":"58","author":"Asirvatham","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jacc.2012.01.012_bib16","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/j.jacc.2005.01.057","article-title":"Autonomically induced conversion of pulmonary vein focal firing into atrial fibrillation","volume":"45","author":"Scherlag","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"Suppl","key":"10.1016\/j.jacc.2012.01.012_bib17","first-page":"S454","article-title":"Nonthermal modification of cardiac ganglia as a novel atrial fibrillation ablation strategy","volume":"8","author":"Gard","year":"2011","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.jacc.2012.01.012_bib18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.healun.2005.07.017","article-title":"Prevalence, pathophysiology, and clinical significance of post-heart transplant atrial fibrillation and atrial flutter","volume":"25","author":"Ahmari","year":"2006","journal-title":"J Heart Lung Transplant"}],"container-title":["Journal of the American College of Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712002823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0735109712002823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:50:32Z","timestamp":1760014232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0735109712002823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":18,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0735109712002823"],"URL":"https:\/\/doi.org\/10.1016\/j.jacc.2012.01.012","relation":{},"ISSN":["0735-1097"],"issn-type":[{"type":"print","value":"0735-1097"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What Causes Atrial Fibrillation and Why Do We Fail With Ablation?","name":"articletitle","label":"Article Title"},{"value":"Journal of the American College of Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2012.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jacc.2011.11.051","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}